Patents Assigned to Research Development
  • Methods and compositions relating to restricted expression lentiviral vectors and their applications
    Patent number: 8748169
    Abstract: The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise promoters active to promote expression specific to cell types or tissues. Further, promoters are providing that are amenable to control by activators, enhancers, or repressors. These vectors are in a self-inactivating configuration for biosaftey. Additional promoters are also described. The vectors can also comprise additional transcription enhancing elements such as the wood chuck hepatitis virus post-transcriptional regulatory element, without any decrease in the specificity or control exerted by the promoters.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: June 10, 2014
    Assignee: Research Development Foundation
    Inventors: Didier Trono, Maciej Wiznerowicz
  • Compact proximity sensor suppressing internal reflection
    Patent number: 8748856
    Abstract: A proximity sensor includes a sensor package having an attachment pad with a radiation source and a radiation detector housed within the sensor package. The source and the detector are held in a fixed relation to the attachment pad, and are mounted by one of a direct or indirect attachment to the attachment pad. A portion of the attachment pad is adapted to form a baffle which forms at least part of an optical isolator. The optical isolator is adapted to substantially prevent the internal propagation of radiation between the source and the detector within the sensor package.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: June 10, 2014
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Colin Campbell, Ewan Findlay
  • Anti human immunodeficiency antibodies and uses thereof
    Patent number: 8747855
    Abstract: Provided are antibodies comprising an antigen recognition domain capable of binding an MHC molecule being complexed with a human immunodeficiency virus (HIV) peptide, wherein the antibody does not bind the MHC molecule in an absence of the complexed peptide, and wherein the antibody does not bind the peptide in an absence of the MHC molecule. Also provided are methods of using same for diagnosing HIV infection and treating AIDS.
    Type: Grant
    Filed: April 5, 2009
    Date of Patent: June 10, 2014
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Yoram Reiter, Maya Haus-Cohen
  • NEAR FIELD SUBWAVELENGTH FOCUSING SYNTHETIC APERTURE RADAR WITH CHEMICAL DETECTION MODE
    Publication number: 20140152486
    Abstract: Detection of objects such as a buried explosive device while operating from a moving platform using a radio frequency emission system having two modes. An electromagnetic wave emission and detection system operates in a first mode to locate objects of interest and in a second mode to determine if an object contains explosive materials. In the first mode, the emission and detection system preferably operates as a subwavelength focusing, wideband, superlens using a near field super gain synthetic aperture continuous wave (CW) swept radar. In the second mode the system preferably enabled after detection of an object in the first mode, uses chemical detection methods such as Nuclear Quadrupole Resonance (NQR).
    Type: Application
    Filed: December 5, 2012
    Publication date: June 5, 2014
    Applicant: AMI Research & Development, LLC
    Inventor: AMI Research & Development, LLC
  • INHIBITION OF FACTOR B, THE ALTERNATIVE COMPLEMENT PATHWAY AND METHODS RELATED THERETO
    Publication number: 20140154307
    Abstract: Disclosed are novel inhibitors of the alternative complement pathway and particularly, novel anti-factor B antibodies. Also disclosed is the use of such inhibitors to reduce or prevent airway hyperresponsiveness and/or airway inflammation by selectively inhibiting the alternative complement pathway, thereby treating diseases in which such conditions play a role. Also disclosed is the use of such inhibitors to reduce or prevent other diseases and conditions, including ischemia-reperfusion injury, by inhibition of the alternative complement pathway.
    Type: Application
    Filed: February 18, 2014
    Publication date: June 5, 2014
    Applicants: MUSC Foundation for Research Development, National Jewish Health, The Regents of the University of Colorado, a body corporate
    Inventors: V. Michael HOLERS, Joshua M. Thurman, Christian Taube, Erwin W. Gelfand, Gary Steven Gilkeson
  • Methods of and compositions for inhibiting the proliferation of mammalian cells
    Patent number: 8735127
    Abstract: A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: May 27, 2014
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • Leaky solar array with spatially separated collectors
    Patent number: 8735719
    Abstract: A leaky travelling wave array of optical elements provide a solar wavelength rectenna.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: May 27, 2014
    Assignee: AMI Research & Development, LLC
    Inventors: John T. Apostolos, Judy Feng, William Mouyos
  • Enhancement of development of oviparous species by in ovo feeding of enteric modulators
    Patent number: 8734837
    Abstract: The development and growth of oviparous species such as birds is enhanced by in ovo administration of an enteric modulator such as HMB. The enteric modulator is administered into the amnion, where it is then orally ingested by the subject. The enteric modulator enhances the enteric development of the subject prior to hatch, and enhances the growth of the animal before and after hatch.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: May 27, 2014
    Assignees: North Carolina State University, Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Zehava Uni, Peter R. Ferket
  • Methods of modulating production of phenylpropanoid compounds in plants
    Patent number: 8735650
    Abstract: A method of enhancing production of a phenylpropanoid compound in a plant or plant cell is disclosed. The method comprising: (a) expressing in the plant or plant cell a heterologous polynucleotide which produces a myb gene of the phenylpropanoid pathway; and (b) contacting the plant or plant cell with at least one substrate of the phenylpropanoid pathway, the substrate being upstream to the production of the phenylpropanoid compound, thereby enhancing the production of a phenylpropanoid compound in the plant or plant cell.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: May 27, 2014
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Alexander Vainstein, Michal Moyal-Ben-Zvi, Ben Rimon-Spitzer
  • SHORT ASYNCHRONOUS GLITCH
    Publication number: 20140140159
    Abstract: A circuit receives a parameter signal at a set or reset input, a clock signal at a clock input and a constant digital value at a data input. A synchronous signal is output from the circuit: wherein when the parameter signal is in a first state, then the output synchronous signal has the digital value; wherein when the parameter signal transitions to a second state, then the output synchronous signal transitions to an inverse of the digital value at substantially the same time; and wherein when the parameter signal transitions back to the first state, then the output synchronous signal transitions to the digital value on a next clock edge.
    Type: Application
    Filed: November 7, 2013
    Publication date: May 22, 2014
    Applicant: STMicroelectronics (Research & Development) Limited
    Inventor: Andrew James FISHLEIGH
  • PHARMACEUTICAL/COSMETIC COMPOSITIONS COMPRISING HYALURONIC ACID AND TREATMENT OF DERMATOLOGICAL CONDITIONS THEREWITH
    Publication number: 20140142062
    Abstract: Pharmaceutical/cosmetic compositions containing a dermatologically effective amount of hyaluronic acid, at least one retinoid and/or salt and/or derivative thereof, at least one oligosaccharide and at least one inhibitor of hyaluronic acid degradation, formulated into a physiologically acceptable medium therefor, are useful for the treatment of wrinkles, fine lines, fibroblast depletions and scars.
    Type: Application
    Filed: December 13, 2013
    Publication date: May 22, 2014
    Applicant: Galderma Research & Development
    Inventors: Marc MOUTET, Jean-Claude YADAN
  • ULTRASOUND GUIDED ROBOT FOR FLEXIBLE NEEDLE STEERING
    Publication number: 20140142429
    Abstract: A robotic system for flexible needle steering under ultrasound imaging. A robot is used to steer the needle along a predetermined curved trajectory by maneuvering the needle base. The needle tip position is detected by an ultrasound sensor and the tracking error of the needle tip from a predetermined needle path is input to a controller which solves the inverse kinematic based on the needle position, and the needle and tissue properties. The control algorithm uses a novel method to detect the elastic properties of the tissue by analyzing tissue motion at the region in front of the needle tip. The inverse kinematic solution may be performed on a model of the needle as a flexible beam having laterally connected virtual springs to simulate lateral forces exerted by the tissue elasticity. The system is able to direct the needle to a target within the tissue while circumventing forbidden regions.
    Type: Application
    Filed: January 27, 2014
    Publication date: May 22, 2014
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Zipi NEUBACH, Moshe SHOHAM
  • Pseudozyma aphidis As A Biocontrol Agent Against Various Plant Pathogens
    Publication number: 20140141976
    Abstract: Biocontrol agents are provided, which protect plant and plant material from pests and pathogens, and promote the growth of plants. Also provided are compositions comprising the same, methods for protecting plant and plant material and promoting growth in plants, and uses of said biocontrol agent in the preparation of a pesticidal composition and a growth-promoting composition.
    Type: Application
    Filed: February 5, 2014
    Publication date: May 22, 2014
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Marganit Levy, Aviva Gafni
  • PROCESS OF PREPARING GRIGNARD REAGENT
    Publication number: 20140142332
    Abstract: A novel process of preparing a Grignard reagent is disclosed. The process is effected by electrochemically reacting a Grignard precursor with an electrode which comprises a metal for forming the Grignard reagent, in the presence an electrolyte solution that comprises a room temperature ionic liquid (RTIL). Electrochemical cells and systems for performing the process, and uses thereof in various applications are also disclosed.
    Type: Application
    Filed: November 19, 2013
    Publication date: May 22, 2014
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Yair Ein-Eli, Daniel Luder, Alexander Kraytsberg
  • SOLAR COMBINED CYCLE POWER SYSTEMS
    Publication number: 20140138959
    Abstract: Provided is a combined cycle power system including at least one solar power plant including a concentrating dish configured to concentrate solar radiation; a solar receiver disposed and configured to utilize concentrated solar radiation for heating a first working fluid, and a first turbine configured for generating electricity by expansion therein of the heated first working fluid, and at least one recovery power plant including a heat recovery unit configured for utilizing exhaust heat of the first turbine to heat a second working fluid, and a second turbine configured for generating electricity by expansion therein of the heated second working fluid.
    Type: Application
    Filed: February 3, 2014
    Publication date: May 22, 2014
    Applicants: Heliofocus Ltd., Yeda Research Development Co. Ltd.
    Inventors: Yotam ZOHAR, Eli MANDELBERG, Jacob KARNI
  • Derivatives of novel peroxides, method of preparation thereof and use thereof in human medicine as well as in cosmetics for the treatment or prevention of acne
    Patent number: 8729312
    Abstract: Compounds of the following general formula (I): are described. Also described, are methods of preparing the compounds and their use in therapeutics.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: May 20, 2014
    Assignee: Galderma Research & Development
    Inventors: Claire Bouix-Peter, Jean-Claude Pascal, Nicolas Rodeville
  • Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders
    Patent number: 8729127
    Abstract: Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: May 20, 2014
    Assignee: Galderma Research & Development
    Inventors: Michael Graeber, Janusz Czernielewski
  • Pointing devices
    Patent number: 8723816
    Abstract: A touch pad uses a plurality of optical mouse type sensors. The sensors are optimized for detection of motion along the predominant direction of a user's finger as the finger is moved around the touch pad. A first one of the sensors functions to optically sense motion in a first direction, while a second one of the sensors functions to optically sense motion in a second, different, direction. The first and second directions are oriented a closed, for example, circular, path.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: May 13, 2014
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Jeffrey Raynor, Arnaud Laflaquiere
  • Cache memory system including selectively accessible pre-fetch memory for pre-fetch of variable size data
    Patent number: 8725987
    Abstract: Systems and methods are disclosed for pre-fetching data into a cache memory system. These systems and methods comprise retrieving a portion of data from a system memory and storing a copy of the retrieved portion of data in a cache memory. These systems and methods further comprise monitoring data that has been placed into pre-fetch memory.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: May 13, 2014
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Andrew Michael Jones, Stuart Ryan
  • Single-source precursor for semiconductor nanocrystals
    Patent number: 8721926
    Abstract: A single-source solid precursor matrix for semiconductor nanocrystals includes 45-55% by weight of zinc, 28-35% by weight of oxygen, 0.70-1.2% by weight of carbon, 1.5-2.5% by weight of hydrogen, 4-6% by weight of nitrogen, 5-7% by weight of sulphur and 1-5% by weight of dopant ions with respect to the weight of zinc atoms. Doped semiconductor nanocrystals for multicolor displays and bio markers include 60-65% by weight of zinc, 30-32% by weight of sulphur, 1.2-1.3% by weight of copper and 1.2-1.3% by weight of dopant ions.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 13, 2014
    Assignee: The Director General Defence Research & Development Organisation
    Inventors: Manzoor Koyakutty, Aditya Verma, Sampat Raj Vedera, Narendra Kumar, Thundyil Raman Narayana Kutty