Abstract: A controlled release device which comprises:(i) a hydrogel; and incorporated therewith(ii) an active substance,at least part of at least one surface of the device comprising(iii) a layer which is impermeable to aqueous media.

Abstract: Disclosed is a new urethane polyacrylate having at least one terminal isocyanato acrylic pendent radical. Preferably the molecular chain within the acrylate caps has been extended with a polyhydroxy compound just before final end capping with isocyanato acrylic. The isocyanato acrylic is preferably isocyanato ethyl methacrylate and the urethane is diisocyanate capped polyether and the polyether radical is oxyalkylene. The method for producing the urethane polyacrylate involves end capping a polyol with diisocyanate yielding a reaction product with two reactive equivalents of isocyanate and then capping less than all of the isocyanate with a hydroxyacrylate, after which the remaining isocyanate is reacted with polyol to provide chain extension. The chain extending polyol is then capped with a isocyanato acrylic.

Abstract: An adhesive for bonding polymeric material to both collagen and calcium is provided. The adhesive contains a glutaraldehyde component for bonding to collagen and a monophosphate component for bonding to calcium. It has been found that in bonding polymeric filling materials to teeth that the adhesive substantially reduces microleakage around the filling.

Abstract: A device for administering oral fluid to a patient from a container (18) has a nipple (14) connected to the container (18) by a tube (16). The nipple (14) is provided with a soft reticulate mouthpiece (10) which fits between the lips and the gums or teeth to hold the nipple (14) on the patient's tongue. A valve (22) opens in response to the patient sucking or pressing the nipple (14) to admit fluid into the patient's mouth.

Abstract: Biocompatible, shelf-stable, polymerizable compositions which are especially useful for applications requiring direct contact with living pulpal tissue, bone or dentin, and methods for using the compositions are disclosed. The compositions are non-toxic, both before and after in situ polymerization, and include at least one polymerizable monomer or prepolymer which polymerized by a mechanism other than chelation or saponification. In one aspect, the compositions comprise at least one non-toxic polymerizable ethylenically unsaturated monomer or prepolymer and a catalytically effective amount of a free radical initiator system, and preferably, from about 5 to about 70% by weight of calcium hydroxide or calcium oxide.

Abstract: Permeability characterized in that the carboxy group at 1-position of the prostaglandin is combined with a cell membrane permeable substance having hydroxy group or amino group through the intermediation of an ester bond to the hydroxy group or an amide bond to the amino group are novel and have improved cell membrane permeability.

Abstract: A synthetic polypeptide, suitable for use in vaccination against or diagnosis of a disease caused by an enterovirus, is an octapeptide coded for by codons 93-100 in the RNA sequence coded for the structural capsid protein VP1 for poliovirus type 3 Sabin strain or by equivalent codons of another enterovirus or is an antigenic equivalent of such an octapeptide, the numbers of the codons being counted from the 5'-terminus of the nucleotide sequence for the VP1 capsid protein.

Abstract: A method of optical analysis of a test sample which comprises a sample material with light-absorbing, scattering, fluorescent, phosphorescent or luminescent properties, which sample is partly in a liquid phase and partly bound to an adjacent solid surface, to discriminate the respective parts of said sample material which are located in the liquid and bound to said solid surface: comprising the steps of providing as said solid surface a surface of a transparent solid optical waveguide, and measuring light from the sample material bound to said solid surface that has passed into and through said transparent solid optical waveguide with total internal reflections and emerged from said waveguide at an angle that deviates from the optical axis of said waveguide by an angle appreciably less than .alpha., where.alpha.=arcsin.sqroot.(n.sub.2.sup.2 -n.sub.1.sup.2)where n.sub.2 is the refractive index of the material of the waveguide and n.sub.

Abstract: Input signals representative of speech are unreliable as inputs for speech recognition if processed conventionally by, among other processes, filtering into separate frequency bands. Further processing according to the invention takes the output from a filter bank and after operations of rectification and integration provides a process of median filtering and smoothing which significantly reduces the sampling rate of the filtered signals while retaining the important acoustic features of the input speech.

Abstract: Powder mass flow rates are measured by constraining the powder to flow within an apparatus which injects a charge into the powder at a first position and measures at a plurality of positions downstream from the first position the charge remaining in the powder and means for calculating from the injected and remaining charge the powder mass flow.

Abstract: The profoundly deaf benefit in lipreading if the larynx frequencies of speech are presented to them by means of acoustic sine waves. In the present invention the sine waves required are generated using a microcomputer and analogue output circuits, with the microcomputer providing digital level samples for the required sine waves from a stored look-up table. The wide frequency range of sine waves required is achieved by omitting some samples in each cycle at high frequencies, and the wide range of output levels required is provided by employing two digital to analogue converters, one acting as an attenuator.

Abstract: A conical grinding member (2) is caused to move over a grinding surface (1) and material deposited on the surface is ground by a crushing and shearing action. The mill finds particular application in the grinding of grain.

Abstract: An audio noise gate having a main audio circuit having a filter with a control terminal for determining frequency response and having at least two different roll-off frequencies including one that rolls-off high end content audio signals and one that passes high end content audio signals. The main circuit is controlled from two secondary circuits one including a high pass filter for determining high frequency content of the audio signal and the other comprising a signal detection circuit including a peak detector for determining absence or presence of a note. The signal detection circuit operates in combination with the high pass filter circuit to provide for automatic adjustment of the noise gate to control the release time, quickly for short notes and slowly for held notes. The output of the high pass filter circuit also includes a peak detector and a gain stage for controlling the frequency response of the main circuit.

Abstract: The brake control system for use in a vehicle includes a compression cylinder device, which communicates with a fluid passage between a gate valve and a wheel cylinder. A compression piston is reciprocately disposed inside of the compression cylinder device. A cut off valve member is disposed in the compression cylinder device, which closes a fluid supply passage between a fluid chamber of the compression cylinder device and the wheel cylinder of the brake device for the driven wheel. The system further includes a valve system provided between an accumulator and the compression cylinder device. The valve system is provided for selectively supplying the brake fluid pressure in the accumulator to the compression cylinder device during the lock-preventing and acceleration slip-preventing controls.

Abstract: This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of alkyl radicals and cycloalkyl radicals comprising from 1 to 20 carbon atoms and R is selected from the group consisting of alkyl radicals and cycloalkyl radicals comprising from 1 to 30 carbon atoms; provided, however, that the total number of carbon atoms in said compound is 15 or more and the total number of carbon atoms in R.sup.1 and R.sup.2 is 5 or more.

Abstract: In a semiconductor crystal growth apparatus, a growth vessel enclosing a substrate is evacuated to an ultrahigh vacuum, and gas molecules containing a component element of a semiconductor which should grow on the substrate is introduced according to a predetermined time sequence into the growth vessel from an external gas source. Infrared radiation from an infrared radiation emitting lamp associated with the growth vessel and controlled by a temperature control unit is directed toward and onto the substrate whose temperature is to be maintained at a predetermined setting. Crystal growth of one molecular layer after another can be achieved by the apparatus with dimensional accuracy of the thickness of a single molecular layer.

Abstract: The knife comprises a substantially hollow handle, a knife blade guided longitudinally movable in a knife blade guide track and at least one guided slider member coupled indirectly with the handle end of the longitudinally movable knife blade. A slider longitudinal slot which receives the slider member extends across the entire thickness of the handle. The slider member has an operating piece on each handle broad side. Both operating pieces receive between themselves at least one guide strip extending parallel to the handle longitudinal axis. The knife blade is held between both operating pieces. The knife blade is so structured that an ergonomically beneficial thumb operable slider mechanism operation is provided for a variety of working situations in a simple way.

Abstract: This invention provides an amorphous ferromagnetic oxide represented by the formulaA.sub.x.(MmOn).sub.y.(Fe.sub.2 O.sub.3).sub.zwherein A represents at least one of Bi.sub.2 O.sub.3, V.sub.2 O.sub.5, TeO.sub.2 and GeO.sub.2 ; M represents at least one of Mn, Fe, Co, Ni, Cu, Mg, Zn, Cd, Ca, Pb, Ba, Sr and rare earth elements; when M is not a rare earth element, m=1 and n=1; when M is a rare earth element, m=2 and n=3; O<x.ltoreq.80, O<y.ltoreq.60 and 5.ltoreq.z.ltoreq.60 and x+y+z=100, provided that when M is Co, O<x<60, O<y<60 and 40.ltoreq.z.ltoreq.60, and processes for preparing the same.

Abstract: A method for recording and reproducing information includes the steps of regularly arranging fine grains having a size less than 0.1 .mu.m on a substrate, which fine grains may be evaporated by being irradiated with electron beams, irradiating predetermined locations of the grain coated substrate by an electron beam modulated in response to information to be recorded by the method, by selectively evaporating fine grains at the predetermined locations irradiated by the electron beam, and irradiating the substrate on which information is recorded with the electron beam to detect the presence or absence of fine grains in order to reproduce the previously recorded information. According to the above described system, large recording densities may be obtained, such as approximately 10.sup.12 bits/cm.sup.2.

Abstract: The method of automatic milking comprising the step of drawing the milk from the teat past one or more non-return valves without the introduction of air into the milk flow upstream of the valve or valves. An automatic milking apparatus for carrying out the method comprises one or more one-way clawpieces and pneumatically-isolated teat liners.