Abstract: The present disclosure relates to using green solvents to synthesize an array of imines, imine-related and imine-derived compounds in an efficient and eco-friendly matter, satisfying green chemistry requirements. Reaction embodiments are performed using solvents, such as ethyl lactate and dimethyl isosorbide, which are both individually characterized as green. In embodiments, solvents include lactic whey and/or water as co-solvents. In these green solvents, the synthesis process discussed herein can produce up to quantitative yields of product at room temperature in a short duration. Embodiments include a method of forming an imine, imine-related or imine-derived compound product. In embodiments, the methods include mixing an aldehyde reactant with a nucleophilic/nitrogen-containing reactant in a green solvent at a temperature between negative twenty degrees Celsius (?20° C.) and positive fifty degrees Celsius (50° C.
Type:
Grant
Filed:
April 19, 2021
Date of Patent:
January 31, 2023
Assignee:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Abstract: The present technology addresses the problem of quickly and safely improving policies in online reinforcement learning domains. As its solution, an exploration strategy comprising diverse exploration (DE) is employed, which learns and deploys a diverse set of safe policies to explore the environment. DE theory explains why diversity in behavior policies enables effective exploration without sacrificing exploitation. An empirical study shows that an online policy improvement algorithm framework implementing the DE strategy can achieve both fast policy improvement and safe online performance.
Type:
Grant
Filed:
January 24, 2019
Date of Patent:
January 31, 2023
Assignee:
The Research Foundation for The State University of New York
Abstract: A microwave microstrip resonator apparatus including a housing; a resonator within the housing; an output conductor within the housing and spaced apart from the resonator so as to define a capacitive gap therebetween; a reaction vessel configured to reside with the capacitive gap; and a power supply coupled to the resonator whereby contents within the reaction vessel are heated when energy is supplied to the resonator by the power supply. A mass spectrometer may also be coupled to an outlet end of the reaction vessel such that the contents within the reaction vessel are, simultaneously, delivered to the mass spectrometer for analysis.
Type:
Grant
Filed:
May 11, 2020
Date of Patent:
January 31, 2023
Assignee:
The Research Foundation for the State University of New York
Inventors:
Steven J. Ray, Maria Elisa Rivera-Albarran
Abstract: A suturing device includes a hollow needle. The hollow needle has a length extending between a proximal end and a distal end and defining a lumen having an inner diameter. The suturing device further includes a length of surgical suture having a leading end and a trailing end and an outer diameter smaller than the inner diameter of the lumen. At least a portion of the surgical suture is located within the lumen of the hollow needle. A surgical kit including the suturing device and methods of using the suturing device of the present invention are also disclosed.
Type:
Grant
Filed:
April 13, 2018
Date of Patent:
January 24, 2023
Assignee:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Abstract: The method of the present application is directed towards a method for suppressing an allergic response in response to an allergic trigger. This method comprises the following steps; applying, topically, to an affected area an effective amount of a minocycline composition so that the minocycline composition contacts the affected area for an effective amount of time and removing the minocycline composition from the affected area.
Type:
Application
Filed:
September 15, 2022
Publication date:
January 19, 2023
Applicant:
The Research Foundation for The State University of New York
Abstract: This invention provides a method of treating a subject afflicted with a cancer comprising periodically administering to the subject an amount of a FABP5 inhibitor and an amount of an anticancer therapy, wherein the amounts when taken together are effective to treat the subject. This invention also provides FABP5 inhibitors for use as an add-on therapy or in combination with an anticancer therapy or in treating a subject afflicted with a cancer. This invention also provides the use of a FABP5 inhibitor in the manufacturing of a medicament for use in combination or as an add on with an anticancer therapy in treating a subject afflicted with cancer, wherein the FABP5 inhibitor and the anticancer therapy are administered simultaneously, contemporaneously or concomitantly.
Type:
Application
Filed:
November 24, 2020
Publication date:
January 19, 2023
Applicant:
The Research Foundation for The State University of New York
Inventors:
Iwao Ojima, Martin Kaczocha, Gregory Carbonetti
Abstract: There is set forth herein an integrated photonics structure having a waveguide disposed within a dielectric stack of the integrated photonics structure, wherein the integrated photonics structure further includes a field generating electrically conductive structure disposed within the dielectric stack; and a heterogenous structure attached to the integrated photonics structure, the heterogenous structure having field sensitive material that is sensitive to a field generated by the field generating electrically conductive structure.
Type:
Grant
Filed:
November 18, 2020
Date of Patent:
January 10, 2023
Assignees:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE, MORTON PHOTONICS INCORPORATION
Inventors:
Douglas Coolbaugh, Douglas La Tulipe, Paul A. Morton, Nicholas G. Usechak
Abstract: This invention provides highly attenuated influenza viruses and vaccines. The attenuated viruses and vaccines proliferate well and have high safety factors. The attenuated viruses providing protective immunity from challenge by virus of the same subtype, as well as cross protection against heterologous viruses.
Type:
Grant
Filed:
June 10, 2019
Date of Patent:
January 10, 2023
Assignee:
The Research Foundation for State University of New York
Inventors:
Steffen Mueller, Eckard Wimmer, Bruce Futcher, Steven Skiena, Chen Yang
Abstract: There is set forth herein a method including building a first photonics structure using a first wafer having a first substrate, wherein the building the first photonics structure includes integrally fabricating within a first photonics dielectric stack one or more photonics device, the one or more photonics device formed on the first substrate; building a second photonics structure using a second wafer having a second substrate, wherein the building the second photonics structure includes integrally fabricating within a second photonics dielectric stack a laser stack structure active region and one or more photonics device, the second photonics dielectric stack formed on the second substrate; and bonding the first photonics structure and the second photonics structure to define an optoelectrical system having the first photonics structure bonded the second photonics structure.
Type:
Grant
Filed:
September 19, 2019
Date of Patent:
January 10, 2023
Assignee:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventors:
William Charles, Douglas Coolbaugh, Douglas La Tulipe, Gerald L. Leake, Jr.
Abstract: A method of treating a biofilm on a surface, comprising: providing a surface having a biofilm; and administering to the surface a treatment that reduces a concentration of pyruvate of the biofilm, comprising pyruvate produced by at least a portion the biofilm, under conditions effective reducing maintenance of the biofilm on the surface. A composition, comprising purified enzyme, within a particle, effective for reducing pyruvate concentration in an aqueous suspension of the composition.
Type:
Grant
Filed:
May 31, 2019
Date of Patent:
January 3, 2023
Assignee:
The Research Foundation for The State University of New York
Abstract: Provided are vaccine compositions and methods against Streptococcus pneumoniae. The composition comprises liposomes which have polysaccharides from one or more serotypes and have proteins non-covalently attached to the surface and exposed to the exterior.
Type:
Grant
Filed:
October 12, 2018
Date of Patent:
January 3, 2023
Assignee:
The Research Foundation for The State University of New York
Abstract: A method for performing positron emission tomography (PET) image denoising using a dilated convolutional neural network system includes: obtaining, as an input to the dilated convolutional neural network system, a noisy image; performing image normalization to generate normalized image data corresponding to the noisy image; encoding the normalized image data using one or more convolutions in the dilated convolutional neural network, whereby a dilation rate is increased for each encoding convolution performed to generate encoded image data; decoding the encoded image data using one or more convolutions in the dilated convolutional neural network, whereby dilation rate is decreased for each decoding convolution performed to generate decoded image data; synthesizing the decoded image data to construct a denoised output image corresponding to the noisy image; and displaying the denoised output image on an image display device, the denoised output image having enhanced image quality compared to the noisy image.
Type:
Grant
Filed:
August 28, 2020
Date of Patent:
January 3, 2023
Assignee:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventors:
Chuan Huang, Karl Spuhler, Mario Serrano Sosa
Abstract: A method and system for the nitrification and denitrification of septic effluent, e.g. from a domestic septic tank, is disclosed comprising a variable speed pump system for constant continuous flow and a recycle mechanism to increase efficacy in producing a final denitrified effluent suitable for discharge to ground or surface waters.
Type:
Application
Filed:
January 5, 2021
Publication date:
December 29, 2022
Applicant:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Abstract: The current disclosure provides methods for detecting and analyzing K17 expression in a bladder sample obtained from a subject. The current disclosure also pertains to methods and kits for identifying a mammalian subject with bladder cancer by detecting the expression of K17 in a sample. The present methods include both cell-based and cell-free methods for determining the level of keratin 17 in a sample obtained from the bladder of a subject.
Type:
Application
Filed:
May 27, 2022
Publication date:
December 29, 2022
Applicants:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, KDX DIAGNOSTICS, INC.
Inventors:
Kenneth R. SHROYER, Luisa F. ESCOBAR-HOYOS, Nam KIM
Abstract: Provided are a computer mouse and a method for operating the computer mouse, with the computer mouse including a palm-rest on a first side thereof, a baseplate on a second side substantially opposite the first side, hinges positioned along an edge of the palm-rest, and finger-rests, with each finger-rest fixedly attached to one end of a respective hinge.
Type:
Grant
Filed:
August 7, 2019
Date of Patent:
December 27, 2022
Assignee:
The Research Foundation for The State University of New York
Abstract: Described herein are peptides that can be used to treat pain or increase pain sensitivity in subject in need of treatment. Additionally, peptides of the present disclosure can be administered with an analgesic agent and/or anesthetic agent. Peptides of the present disclosure are suitable for use when a subject in need of treatment has an injury, a chronic disease, a chronic inflammation, Morton's neuroma, operative/post-operative pain, or a combination thereof.
Type:
Grant
Filed:
December 13, 2018
Date of Patent:
December 27, 2022
Assignee:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Abstract: Structures operable to detect radiation are described. The structure may two screens with a phosphor layer, respective. The structure may further include a photosensor array disposed between the first screen and the second screen such that the photosensor array directly contacts the first screen or is directly attached to the first screen using an optical adhesive and directly contacts the second screen or is directly attached to the second screen using an optical adhesive.
Type:
Application
Filed:
August 23, 2022
Publication date:
December 22, 2022
Applicant:
The Research Foundation for The State University of New York
Inventors:
Anthony Lubinsky, Wei Zhao, John A. Rowlands, Adrian Howansky
Abstract: Preparation, characterization, and an electrochemical study of Mg0.1V2O5 prepared by a novel sol-gel method with no high-temperature post-processing are disclosed. Cyclic voltammetry showed the material to be quasi-reversible, with improved kinetics in an acetonitrile-, relative to a carbonate-, based electrolyte. Galvanostatic test data under a C/10 discharge showed a delivered capacity >250 mAh/g over several cycles. Based on these results, a magnesium anode battery, as disclosed, would yield an average operating voltage ˜3.2 Volts with an energy density ˜800 mWh/g for the cathode material, making the newly synthesized material a viable cathode material for secondary magnesium batteries.
Type:
Grant
Filed:
August 28, 2020
Date of Patent:
December 20, 2022
Assignee:
The Research Foundation for The State University of New York
Abstract: A metal sequestering material can be contacted with a reaction mixture of a metal-catalyzed reaction to remove transition metals or transition metal complexes. The reaction mixture contains transition metals and a reaction product in solution. These transition metals may be, for example, Pd, Ir, Ru, Rh, Pt, Au, or Hg. The concentration of transition metals in the reaction mixture is reduced to less than 100 ppm or even less than 10 ppm.
Type:
Grant
Filed:
September 30, 2014
Date of Patent:
December 6, 2022
Assignee:
The Research Foundation for The State University of New York