Patents Assigned to Research Foundation of City University
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Patent number: 10980754Abstract: The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.Type: GrantFiled: April 19, 2017Date of Patent: April 20, 2021Assignees: SAINT LOUIS UNIVERSITY, RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORKInventors: Maureen J. Donlin, John Edwin Tavis, Ryan Murelli, Marvin J. Meyers
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Patent number: 10980460Abstract: The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, Parkinson's disease, brain injuries, spinal cord injuries, and cancer. The invention also provides methods of differentiating white matter from gray matter. In some embodiments, regions of the brain to be resected or targeted for pharmaceutical therapy are identified using sensors. The invention further provides methods of measuring the neurotoxicity of a material by comparing microvoltammograms of a neural tissue in the presence and absence of the material using the inventive sensors.Type: GrantFiled: February 15, 2017Date of Patent: April 20, 2021Assignees: Research Foundation of The City University of New York, New York University School of MedicineInventors: Patricia A. Broderick, Steven V. Pacia
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Patent number: 10967067Abstract: The present invention relates to a composition comprising a lysosomal enzyme conjugated to a negatively charged scavenger receptor ligand. In some embodiments, the lysosomal enzyme is conjugated to the scavenger receptor ligand by way of a linker. The present invention also relates to a composition comprising lysosomal enzyme encapsulated by a liposome, said liposome externally comprising a negatively charged scavenger receptor ligand. The invention further encompasses a method of treating a lysosomal storage disease with the compositions listed above. The ionvention further encompasses a method of treating a lysosomal storage disease with an acylated, acetylated, or aconitylated lysosomal enzyme.Type: GrantFiled: November 27, 2018Date of Patent: April 6, 2021Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORKInventors: David H. Calhoun, Lane Gilchrist
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Patent number: 10961988Abstract: A rotary engine that generates electricity using differences in relative humidity. A water-responsive material expands and contracts as water evaporates which drives the rotation of two wheels. The rotary motion drives an electrical generator which produces electricity. In another embodiment, the water-responsive material is used to actuate an artificial muscle of a robotic device.Type: GrantFiled: April 5, 2019Date of Patent: March 30, 2021Assignee: Research Foundation of the City University of New YorkInventors: Xi Chen, Zhi-Lun Liu, Mir Ahnaf Hussain, Zane Shatz
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Patent number: 10954607Abstract: The luminance of a transmission mode X-ray scintillator diamond plate is dominated by induced defect centers having an excited state lifetime less than 10 msec, and in embodiments less than 1 msec, 100 usec, 10 used, 1 used, 100 nsec, or even 50 nsec, thereby providing enhanced X-ray luminance response and an X-ray flux dynamic range that is linear with X-ray flux on a log-log scale over at least three orders of magnitude. The diamond plate can be a single crystal having a dislocation density of less than 104 per square centimeter, and having surfaces that are ion milled instead of mechanically polished. The defect centers can be SiV centers induced by silicon doping during CVD diamond formation, and/or NV0 centers formed by nitrogen doping followed by applying electron beam irradiation of the diamond plate and annealing.Type: GrantFiled: October 22, 2019Date of Patent: March 23, 2021Assignees: Euclid Techlabs, LLC, Center for Technology Licensing (“CTL”) at Cornell University, Research Foundation of The City University of New YorkInventors: Sergey Antipov, Stanislav Stoupin, Alexandre M. Zaitsev
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Patent number: 10947535Abstract: PVT1 exon 9 is overexpressed in aggressively tumorigenic prostate cancer cell lines and prostate tumor tissues. This exon provides a diagnostic tool for the detection and monitoring of aggressive prostate cancer. Several small interfering ribonucleic acids (siRNAs) are disclosed that are useful for treating prostate cancer.Type: GrantFiled: July 5, 2019Date of Patent: March 16, 2021Assignee: Research Foundation of the City University of New YorkInventors: Olorunseun O. Ogunwobi, Adeodat Ilboudo, Chunxiao Ying
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Patent number: 10916165Abstract: A display system that produces an image that encodes both machine-readable and human-readable data is described. The image has two underlying patterns that are changed at two different rates. The rapidly changing image encodes the machine-readable data and the slower changing image encodes the human-readable data.Type: GrantFiled: February 27, 2018Date of Patent: February 9, 2021Assignee: Research Foundation of the City University of New YorkInventor: Mark D. Feuer
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Patent number: 10913959Abstract: A method for isomerizing a double bond is provided. A substrate is exposed to an isomerase enzyme, wherein the isomerase enzyme comprises a redox-regulated ligand switch and heme b cofactor. A reducing agent changes iron (III) to iron (II). The enzyme isomerizes double bonds in the iron (II) state but not in the iron (III) state. In one embodiment, the enzyme is homologous with 15-cis-?-carotene isomerase (Z-ISO).Type: GrantFiled: July 11, 2018Date of Patent: February 9, 2021Assignee: Research Foundation of the City University of New YorkInventors: Eleanore T. Wurtzel, Jesús Beltrán
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Patent number: 10910674Abstract: A rechargeable battery can include a cathode, an anode current collector, an anode comprising zinc, and an electrolyte in ionic communication with both the cathode and the anode current collector. The electrolyte can include an organic ammonium halide. The organic ammonium halide can include an ammonium bromide in some instances.Type: GrantFiled: October 20, 2016Date of Patent: February 2, 2021Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW NEW YORKInventors: Xia Wei, Michael Nyce, Gautam G. Yadav, Alexander Couzis, Sanjoy Banerjee
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Patent number: 10873090Abstract: A novel electrode current collector design that can improve performance and extend cycle life for rechargeable batteries based on metal electrodeposition is disclosed. The novel electrode current collector has a reduced effective surface area that can help to balance efficiencies between battery electrodes and to ensure non-uniform electrodeposition of metal onto the anode current collector during charge. One result is mitigation of internal short circuits that can cause a battery to fail prematurely.Type: GrantFiled: July 5, 2012Date of Patent: December 22, 2020Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORKInventors: Yasumasa Ito, Sanjoy Banerjee
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Publication number: 20200381690Abstract: An alkaline battery comprises an anode, a cathode, a separator disposed between the anode and the cathode, and an electrolyte in fluid communication with the anode, the cathode, and the separator. The separator comprises at least one ion selective layer that can include at least one of graphene, graphene oxide, reduced graphene oxide, functionalized graphene, or combinations thereof. This can allow the ion selective layer to be configured to selectively block zincate ions.Type: ApplicationFiled: August 30, 2018Publication date: December 3, 2020Applicant: Research Foundation of the City University of New YorkInventors: Jinchao HUANG, Gautam G. YADAV, Michael NYCE, Sanjoy BANERJEE
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Patent number: 10851360Abstract: In one embodiment, the invention provides a method of purifying recombinant alpha-galactosidase A. The method includes obtaining a lysate from cells recombinantly expressing alpha-galactosidase A grown in a cell culture medium having non-precipitating phosphate; contacting said lysate with a first chromatography media that binds ?-D-mannopyranosyl or ?-D-glucopyranosyl; eluting alpha-galactosidase A from the first chromatography media to generate a first eluate having alpha-galactosidase A, wherein said eluting includes at least one elution pause between 4 and 16 hours; contacting the first eluate with a second chromatography media that binds galactose binding proteins; and eluting alpha-galactosidase A from said second chromatography media to generate a second eluate containing said recombinant alpha-galactosidase A.Type: GrantFiled: March 5, 2018Date of Patent: December 1, 2020Assignee: Research Foundation of the City University of New YorkInventors: David H. Calhoun, Abass Abdullahi
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Patent number: 10835629Abstract: A device for generating singlet oxygen is provided. The device has elongated posts extending from a surface, the lateral sides of which have particles with a sensitizer that converts triplet oxygen to single oxygen upon exposure to light. An optical fiber conveys light to the sensitizer and a gas supply tube conveys oxygen to the sensitizer. The device is configured to keep the sensitizer from contacting external fluids, such as saliva.Type: GrantFiled: October 10, 2017Date of Patent: November 17, 2020Assignee: Research Foundation of the City University of New YorkInventors: Alan M. Lyons, Alexander Greer, QianFeng Xu
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Patent number: 10821195Abstract: Described herein is a chelator for radiolabels (e.g., 89Zr) for targeted PET imaging that is an alternative to DFO. In certain embodiments, the chelator for 89Zr is the ligand, 3,4,3-(LI-1,2-HOPO) (“HOPO”), which exhibits equal or superior stability compared to DFO in chemical and biological assays across a period of several days in vivo. As shown in FIG. 1, the HOPO is an octadentate chelator that stabilizes chelation of radiolabels (e.g., 89Zr). A bifunctional ligand comprising p-SCN-Bn-HOPO is shown in FIG. 4 and FIG. 5. Such a bifunctional ligand can eliminate (e.g., 89Zr) loss from the chelate in vivo and reduce uptake in bone and non-target tissue. Therefore, the bifunctional HOPO ligand can facilitate safer and improved PET imaging with radiolabeled antibodies.Type: GrantFiled: September 9, 2016Date of Patent: November 3, 2020Assignees: Memorial Sloan Kettering Cancer Center, Research Foundation of the City University of New YorkInventors: Jason S. Lewis, Melissa Deri, Lynn Francesconi, Shashikanth Ponnala
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Patent number: 10725135Abstract: A method of inducing spin polarization in an analyte is provided. The method exposes 14N spin defect centers embedded within 25 nm of a diamond surface to a magnetic field while an analyte is near the surface. The 14N spin defect centers are polarized by treatment with an electromagnetic wave protocol having a visible light pulse (p0); a microwave pulse (mw1), a radio frequency pulse (rf1), a microwave pulse (mw2) and a radio frequency pulse (rf2) resulting in polarization of the nuclear spins of the 14N spin defect centers. Polarized spins in the 14N spin defect centers induce spin polarization in the analyte.Type: GrantFiled: January 4, 2019Date of Patent: July 28, 2020Assignee: Research Foundation of the City University of New YorkInventors: Carlos A. Meriles, Daniela Pagliero, Abdelghani Laraoui
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Patent number: 10688556Abstract: Nanocages are formed by etching nancubes. The nanocubes are added to an aqueous system having an amphiphilic lipid dissolved in an organic solvent (e.g. a hydrophobic alcohol) to form reverse micelles. As the water evaporates the micelles shrink as etching of the flat surface of the nanocubes occurs. In this fashion hollow nanocages are produced. In one embodiment, the nanocage is covalently attached to a polymer shell (e.g. a dextran shell).Type: GrantFiled: April 3, 2017Date of Patent: June 23, 2020Assignee: Research Foundation of the City University of New YorkInventors: Hiroshi Matsui, Zengyan Wei, Justin Fang
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Publication number: 20200147086Abstract: In one aspect, the present disclosure provides methods of treating a bacterial infection using an inhibitor of the nucleotidyltransferase superfamily enzyme. In some embodiments, the compounds have one of the following formulas (I), (II), (III), or (IV) wherein R1, R2, and R3 are as defined herein or a pharmaceutically acceptable salt thereof. The compounds may be used to treat a bacterial infection including an infection of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species.Type: ApplicationFiled: May 16, 2018Publication date: May 14, 2020Applicants: Saint Louis University, U.S. Department of Veterans Affairs, Research Foundation of the City University of New YorkInventors: Feng CAO, John E. TAVIS, Maureen J. DONLIN, Marvin J. MEYERS, Ryan P. MURELLI, Cari ORTH, Bahaa ELGENDY
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Patent number: 10609057Abstract: A method for detecting intrusion is provided using a combination of two AIS algorithms: Negative Selection Algorithm (NSA) and Dendritic Cell Algorithm (DCA). The method includes the following steps, or some functional subset of these steps: periodic monitoring of a data processing system for anomalous behavior that may indicate the presence of an intruder or an undesirable software; using the NSA for the generation of a population of detectors that are used for detecting anomalies in the monitored system via a matching criterion; using the DCA (which runs in parallel to the NSA) to sample traffic and signals coming in or out of the data processing system; using an aggregation system to combine the individual decisions of the NSA and the DCA to form a single final decision.Type: GrantFiled: June 26, 2017Date of Patent: March 31, 2020Assignee: Research Foundation of the City University of New YorkInventors: Obinna Igbe, Tarek Saadawi, Ihab Darwish
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Patent number: 10585043Abstract: Technologies are described for methods to fabricate lasers to amplify light. The methods may comprise depositing nanoparticles on a substrate. The length, width, and height of the nanoparticles may be less than 100 nm. The methods may further comprise distributing the nanoparticles on the substrate to produce a film. The nanoparticles in the film may be coupled nanoparticles. The coupled nanoparticles may be in disordered contact with each other within the film. The distribution may be performed such that constructive interference of the light occurs by multiple scattering at the boundaries of the coupled nanoparticles within the film. The methods may comprise exposing the film to a power source.Type: GrantFiled: May 4, 2017Date of Patent: March 10, 2020Assignees: Brookhaven Science Associates, LCC, Research Foundation of The City University of New YorkInventors: Matthew Y. Sfeir, Kannatassen Appavoo, Xiaoze Liu, Vinod M. Menon
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Patent number: D898825Type: GrantFiled: April 30, 2019Date of Patent: October 13, 2020Assignee: Research Foundation of City University Of New YorkInventors: Kristen J. Grant, Dustin Wheeler