Abstract: Disclosed herein are monoclonal antibodies targeting specific tau epitopes, particularly, phosphorylated tau epitopes. Also disclosed are methods of detecting tau protein in a subject, comprising performing an assay using the antibodies or antigen binding fragments thereof on the subject or on a biological sample obtained from the subject. Assay kits containing the disclosed antibodies are also provided. Further, methods of treating or preventing a tauopathy in a subject by administering to the subject tau antibodies or antigen-binding fragments thereof are provided.

Abstract: Sialic acid recognizing-affinity reagents engineered from the neuraminidase NanB have lectin-like properties and defined specificities for sialic acid.

Abstract: Methods for assessing fiber and bundle orientations and mechanical properties of fiber reinforced composite materials using Thermal Digital Image Correlation (TDIC) are disclosed. In some examples, the method comprises exposing the composite material to a temperature change; imaging the composite material at a plurality of time points before, during and/or after the temperature change; and assessing the characteristic of the composite material based on the imaging. In others, temperature changes naturally occur during the cooling process after manufacturing can be employed for this method such as compression molding process, injection molding process, resin transfer molding processes and its variants.

Abstract: A multi-phase coupled inductor can include: an upper E core including a first upper limb, a second upper limb, and a third upper limb; a lower E core including a first lower limb, a second lower limb, and a third lower limb; a first winding to wind the first upper limb and the first lower limb; a second winding to wind the second upper limb and the second lower limb; a third winding to wind the third upper limb and the third lower limb; a fourth winding to wind the first lower limb; and a fifth winding to wind the third lower limb. A first phase current can flow from the first winding to the fifth winding, and a third phase current can flow from the third winding to the fourth winding.

Abstract: Methods and systems for the separation of hydrogen isotopes from one another are described. Methods include utilization of a hydrogen isotope selective separation membrane that includes a hydrogen isotope selective layer (e.g., graphene) and a hydrogen ion conductive supporting layer. An electronic driving force encourages passage of isotopes selectively across the membrane at an elevated separation temperature to enrich the product in a selected hydrogen isotope.

Abstract: The present document relates to multilayered dielectric composites for high-temperature applications and related methods.

Abstract: There is set forth herein an optoelectrical system comprising: a conductive path for supplying an input voltage to a photonics device, wherein the conductive path comprises a base structure through via extending through a substrate and a photonics structure through via, the photonics structure through via extending through a photonics device dielectric stack. There is set forth herein an optoelectrical system comprising: a second structure fusion bonded to an interposer base dielectric stack of a first structure. There is set forth herein a method comprising: fabricating a second wafer built structure using a second wafer, the second wafer built structure defining a photonics structure and having a photonics device integrated into a photonics device dielectric stack of the second wafer based structure; and wafer scale bonding the second wafer built structure to a first wafer built structure.

Abstract: Compounds, pharmaceutical compositions, and methods for treating cancer, in particular brain cancer, are provided, including amphiphilic fatty acid/alcohol ethers (AIPs) comprising endocannabinoid and FABP motifs covalently linked to a beta-adrenoreceptor antagonist motif in one molecule. The invention includes methods for inhibiting growth of brain cancer cells by contacting the compound(s) with brain cancer cells. The invention provides a method for treating both brain cancer and brain cancer metastases, and for suppression of regrowth of brain cancer cells after radiation, surgical treatment, or chemotherapy of brain cancer. The invention also comprises an optimized chemical synthesis of the AIP compounds and methods of using the compounds, alone or in combination with another agent, for suppressing the growth of brain cancer cells, and enhancing survival of normal CNS cells, or improving recuperation from radiation, surgical or chemotherapy.

Abstract: A method of determining moisture content in an emulsified asphalt-aggregate system is disclosed. The method includes: placing a first electrode in an emulsified asphalt-aggregate system (Mixture) at a first depth, placing a second electrode in the Mixture at a second depth, applying an alternating current (AC) signal between the first electrode and the second electrode, measuring impedance, determining the frequency which yields the minimum measured impedance, recording the minimum measured impedance, repeating the above steps at a predetermined time interval until the recorded minimum impedance is about 10 times of the first recorded minimum impedance, and alerting a user that the Mixture has sufficiently cured.

Abstract: Heating devices, systems, and methods of making and using a heating device. Such a heating device includes a tubular body having a passage therethrough, at least an inner layer surrounding the passage, and an outer layer surrounding the inner layer. The inner layer is electrically resistive and the outer layer is electrically insulating, and the passage is sized and configured to receive therethrough a tubing. The heating device further includes electrical contacts located at oppositely-disposed ends of the tubular body. The contacts are configured to functionally couple with a power source to provide an electrical current to the inner layer, such that applying an electrical current to the inner layer increases the temperature of the inner layer.

Abstract: Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes of the various embodiments of the present invention.

Abstract: Methods for producing oxide/metal composite components for use in high temperature systems, and components produced thereby. The methods use a fluid reactant and a porous preform that contains a solid oxide reactant. The fluid reactant contains yttrium as a displacing metal and the solid oxide reactant of the preform contains niobium oxide, of which niobium cations are displaceable species. The preform is infiltrated with the fluid reactant to react its yttrium with the niobium oxide of the solid oxide reactant and produce an yttria/niobium composite component, during which yttrium at least partially replaces the niobium cations of the solid oxide reactant to produce yttria and niobium metal, which together define a reaction product. The pore volume of the preform is at least partially filled by the reaction product, whose volume is greater than the volume lost by the solid oxide reactant as a result of reacting yttrium and niobium oxide.

Abstract: Systems and methods for harvesting tissue from a donor site include first and second conduits through which a flexible saw component is guided. Certain embodiments include a mechanism which facilitates insertion of a flexible cutting member component parallel to a transverse plane and slicing a graft parallel to the coronal plane to extract the graft.

Abstract: Systems and processes for producing one or more alkenes from shale gas. The process includes at least two dehydrogenation reactors whereby propane, or a mixture of propane and butane, can be dehydrogenated in a first reactor and ethane can be dehydrogenated in a second reactor. The lighter components which serve as chemical inert and thermal mass are separated from the dehydrogenated product after each reactor.

Abstract: A 3-dimensional flash memory device and methods of fabricating and driving the same are provided. The device includes: a channel layer extending over a substrate in a first direction perpendicular to a surface of the substrate; an information storing layer extending along a sidewall of the channel layer in the first direction; control gates each surrounding, the channel layer, with the information storing layer between the channel layer and the control gates; an insulating layer being between the control gates in the first direction and separating the control gates from each other; a fixed charge region disposed at an interface of the insulating layer and the information storing layer or in a portion of the information storing layer between the control gates in the first direction; and a doped region induced by the fixed charge region and disposed at a surface of the channel layer facing the fixed charge region.

Abstract: Methods of reducing blood brain barrier dysfunction involve inhibiting 5-LOX and COX-2.

Abstract: Provided herein are recombinant adeno-associated virus (rAAV) particles encoding microRNAs targeting the glucocorticoid receptor (GR) pathway, and in particular a microRNA17-92 (miR 17-92) cluster, and genes of interest. The modified genomes of these rAAV particles comprise heterologous nucleic acid sequences encoding microRNA structures. These particles exhibit enhanced transduction efficiencies in mammalian cells. Also provided herein are compositions of nucleic acids encoding the miR 17-92 cluster and nucleic acids encoding a gene of interest. Further provided herein are methods for administering these nucleic acid compositions to enhance transduction efficiencies.

Abstract: A transparent proxy for malware detection includes a monitor module, a protocol determination module, a challenge generation module, a response determination module, and a data control module. The monitor module examines data originating from an application towards a remote server. The protocol determination module identifies the protocol type used for the data. The challenge generation module produces a challenge for the application based upon the protocol type, sends the challenge to the application, and maintains a state related to the data and the challenge. The response determination module makes a determination if an automatic non-interactive application response is received in response to the challenge from the application. The data control module allows the first data to continue to the remote server when the determination is valid. The data control module reports malware detection and blocks the data to continue to the remote server when the determination is invalid.

Abstract: Disclosed herein is a voice coil actuator direct-drive resonant flapper system for flapping wing micro air vehicles and flapping fin autonomous underwater vehicles.