Abstract: Described herein are mass spectrometry systems and methods which utilize a dynamic a new data acquisition/instrument control methodology. These systems and methods employ novel artificial intelligence algorithms to greatly increase quantitative and/or identification accuracy during data acquisition. In an embodiment, the algorithms can adapt the instrument methods and systems during data acquisition to direct data acquisition resources to increase quantitative or identification accuracy of target analytes, such as proteins, peptides, and peptide fragments.
Type:
Grant
Filed:
April 3, 2012
Date of Patent:
May 26, 2015
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Joshua J. Coon, Michael S. Westphall, Graeme McAlister, Derek Bailey
Abstract: Disclosed herein, in certain instances, is a novel photovoltaic cell that uses unique micro-architectural and multi-layer functional designs. Further disclosed herein, in certain instances, is a 3-dimensional electrode. Disclosed herein, in certain instances, is a novel electroluminescent cell that uses unique micro-architectural and multi-layer functional designs. Further disclosed herein, in certain instances, is a 3-dimensional diode.
Type:
Grant
Filed:
September 26, 2012
Date of Patent:
May 26, 2015
Assignee:
San Diego State University Research Foundation
Inventors:
Kee Suk Moon, Samuel Kassegne, Khaled Morsi
Abstract: An airway of a patient is protected from intrusion of contaminants by monitoring muscles of the patient to detect an attempted cough or swallow, and applying an electrical stimulus to the neck of the patient, varying amplitude and/or frequency over time, the applied electrical stimulus operates to promote an efficacious cough or swallow. The electrical stimulus induces a voltage within a range of greater than zero volts and less than 20 volts, and the frequency have patterned changes between at least about 4 Hz to not more than about 30 Hz. The monitoring is carried out by an electronic device, and the patient may indicate to the electronic device that a swallow or cough is impending.
Type:
Grant
Filed:
August 30, 2013
Date of Patent:
May 26, 2015
Assignees:
University of Florida Research Foundation, Inc., The United States of America as represented by the Department of Veteran's Affairs
Inventors:
Warren E. Dixon, Donald Clementz Bolser, Teresa Elizabeth Pitts, Sean Conrad McCoy
Abstract: A method for treating an individual infected with XDR-TB, the method including administering to the individual an anti-XDR-TB drug which comprises a compound having a structure expressed by Structural Formula (1) below:
Type:
Grant
Filed:
March 30, 2011
Date of Patent:
May 26, 2015
Assignees:
Microbial Chemistry Research Foundation, Infectious Disease Research Institute
Abstract: A frequency tripler device is disclosed. The frequency tripler device includes a first graphene based field effect transistor (FET) of a first dopant type, having a gate, a drain, and a source, and a second graphene based FET of a second dopant type, having a gate, a drain, and a source, the gate of the first FET coupled to the gate of the second FET and coupled to an input signal having an alternating current (AC) signal of a first frequency, the combination of the first and second FETs generates an output signal with a dominant AC signal of a frequency of about three times the first frequency.
Abstract: Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof.
Type:
Grant
Filed:
January 27, 2012
Date of Patent:
May 26, 2015
Assignee:
The UAB Research Foundation
Inventors:
Scott Webster Ballinger, Danny R. Welch, Robert Allen Kesterson, Larry W. Johnson
Abstract: Disclosed are methods of purifying the compound (20R)-19-nor-24-difluoro-1?,25-dihydroxyvitamin D3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving a product containing the compound in a solvent comprising hexane and 2-propanol, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals.
Type:
Grant
Filed:
March 14, 2013
Date of Patent:
May 26, 2015
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Hector F. DeLuca, Agnieszka Flores, James B. Thoden, Hazel M. Holden
Abstract: Embodiments of the present disclosure relate to visible luminescent phosphors, visible luminescent nanobelt phosphors, methods of making visible luminescent phosphors, methods of making visible luminescent nanobelt phosphors, mixtures of visible luminescent phosphors, methods of using visible luminescent phosphors, waveguides including visible luminescent phosphors, white light emitting phosphors, and the like.
Type:
Grant
Filed:
February 10, 2011
Date of Patent:
May 26, 2015
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: The present invention relates to novel 1,2,3-triazolyl purine derivatives. The invention also relates to using the derivatives to treat cancer and various viral infections.
Type:
Grant
Filed:
July 8, 2013
Date of Patent:
May 26, 2015
Assignee:
Research Foundation of the City University of New York
Abstract: Methods, processes and systems of image reconstruction utilizing a hybrid local tomography (HLT) methodology for reconstructing internal body images in medical applications, and the like. The system and method of the present invention provides an image with emphasized edges, and the image provides estimations of the attenuation coefficient inside the object being scanned.
Type:
Grant
Filed:
December 1, 2014
Date of Patent:
May 26, 2015
Assignees:
University of Central Florida Research Foundation, Inc., iTomography Corporation
Abstract: A micro-electromechanical system-type (MEMS) sensor arrangement for wirelessly measuring temperatures is disclosed. The MEMS sensor arrangement includes a multimorph sensor, a sensor coil coupled to the multimorph sensor, and a readout coil configured to be magnetically coupled to the sensor coil to i) energize the sensor coil, and ii) provide a readout of the natural frequency of the multimorph sensor, the sensor coil and the readout coil.
Type:
Grant
Filed:
January 22, 2013
Date of Patent:
May 26, 2015
Assignee:
Purdue Research Foundation
Inventors:
Dimitrios Peroulis, Andrew S Kovacs, David Joseph Koester, Farshid Sadeghi, Sean M Scott, Douglas Edward Adams
Abstract: The disclosure relates to a superhydrophobic surface. Methods of fabrication are disclosed including laminating a polymer sheet having a surface to a template having a textured surface or a layer of a nanomaterial (e.g., nanoparticles or nanofibers) to convert the surface of the polymer sheet to a hydrophobic surface having a water contact angle of at least about 150°.
Type:
Grant
Filed:
March 12, 2013
Date of Patent:
May 26, 2015
Assignee:
Research Foundation of the City University of New York
Abstract: Embodiments of the subject invention pertain to a method and apparatus for vibrational energy harvesting via electromagnetic induction using a magnet array. Specific embodiments of the subject invention incorporate at least one conductive coil and at least one magnet array. Magnets used in such magnet arrays can be permanent magnets of various shapes, such as arc-shaped, square, rectangular, wedge, or trapezoidal. These magnet arrays can then be, for example, circular, hexagonal, rectangular, or square in external shape and create various types of internal magnetic fields, such as dipole, quadrupole, hexapole, or octapole magnetic fields. Through use of a magnet array, embodiments of the invention can increase the strength of magnetic fields by approximately 10 times compared to typical vibrational energy harvesters. The 10 time increase in the strength of the magnetic fields can result in up to a 100-fold increase in power.
Type:
Grant
Filed:
December 15, 2010
Date of Patent:
May 26, 2015
Assignee:
University of Florida Research Foundation, Inc.
Abstract: Methods of treatment using D-serine to target brain cells expressing GluN3 subunit-containing triheteromeric NMDARs are disclosed. The methods include inhibiting calcium ion uptake by brain cells, treating epilepsy, and treating seizures by artificially administering D-serine.
Type:
Grant
Filed:
February 20, 2014
Date of Patent:
May 26, 2015
Assignee:
The Florida State University Research Foundation, Inc.
Abstract: An electrical device with light-responsive layers is disclosed. One or more electrically conducting stripes, each insulated from each other, are deposited on a smooth surface of a substrate. Then metal oxide layers, separated by a composite diffusion layer, are deposited. On top of the topmost metal oxide layer another set of elongated conductive strips are disposed in contact with the topmost metal oxide layer such that junctions are formed wherever the top and bottom conducting stripes cross. The resulting device is light responsive only when a certain sign of bias voltage is applied and may be used as a photodetector. An advantage that may be realized in the practice of some disclosed embodiments of the device is that this device may be formed without the use of conventional patterning, thereby significantly reducing manufacturing difficulty.
Type:
Grant
Filed:
July 17, 2013
Date of Patent:
May 26, 2015
Assignee:
Research Foundation of the City University of New York
Abstract: Presented herein is a method for obtaining a dissolved selenium liquid mixture from solid selenium. The method involves mixing an amine solvent and a thiol solvent with the solid selenium to produce a liquid intermediate solution and removing a sulfur containing compound from the liquid intermediate solution to produce a dissolved selenium liquid mixture. A method for obtaining dissolved sulfur liquid mixture by mixing an amine with a thiol to produce a liquid solution that dissolves sulfur to produce a dissolved sulfur liquid mixture is also presented. In addition, a method for obtaining a dissolved sulfur and selenium liquid mixture from solid selenium and solid sulfur by mixing an amine solvent with a thiol solvent is presented.
Abstract: An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions.
Type:
Application
Filed:
January 23, 2015
Publication date:
May 21, 2015
Applicant:
The Research Foundation for The State University of New York
Inventors:
Thomas E. Amidon, Raymond Francis, Gary M. Scott, Jeremy Bartholomew, Bandaru V. Ramarao, Christopher D. Wood
Abstract: Provided is a method for treating and reducing the recurrence of genital tract infections such as gonococcal infections. The method comprises local application of IL-12 incorporated in polymeric microspheres. The invention relates to compositions comprising IL-12 and methods for using such compositions for treatment of genital tract infections. Infections that can be treated by the present method include those that are caused by N. gonorrhoeae, C. trachomatis or both.
Type:
Application
Filed:
May 29, 2013
Publication date:
May 21, 2015
Applicant:
The Research Foundation for the The State University of New York
Inventors:
Michael W. Russell, Yingru Liu, Nejat K. Egilmez
Abstract: A new and distinct cultivar of flowering dogwood tree, which has fused bracts is provided. This dogwood tree is botanically known as Cornus kousa and referred to by the following cultivar name: ‘Pam's Mountain Bouquet’.
Type:
Grant
Filed:
May 3, 2012
Date of Patent:
May 26, 2015
Assignee:
University of Tennessee Research Foundation
Inventors:
Robert N. Trigiano, Phillip A. Wadl, Mark T. Windham, Richard M. Evans