Patents Assigned to Research Triangle Institute
  • Patent number: 5800620
    Abstract: A method and apparatus for generating plasmas adapted for chemical vapor deposition, etching and other operations, and in particular to the deposition of large-area diamond films, wherein a chamber defined by sidewalls surrounding a longitudinal axis is encircled by an axially-extending array of current-carrying conductors that are substantially transverse to the longitudinal axis of the chamber, and a gaseous material is provided in the chamber. A high-frequency current is produced in the conductors to magnetically induce ionization of the gaseous material in the chamber and form a plasma sheath that surrounds and extends along the longitudinal axis and conforms to the sidewalls of the chamber. A work surface extending in the direction of the longitudinal axis of the chamber is positioned adjacent a sidewall, exposed to the plasma sheath and treated by the plasma.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: September 1, 1998
    Assignee: Research Triangle Institute
    Inventors: Ronald Alan Rudder, Robert Carlisle Hendry, George Carlton Hudson
  • Patent number: 5798088
    Abstract: A method for producing elemental sulfur and reduced/oxidized sulfur compounds from sulfur containing gases. The method comprises mixing a primary gas stream of sulfur-containing gases with a secondary gas stream to produce a combined gas stream having a preselected stoichiometry and contacting the combined gas stream with a catalyst at a pressure of 7 to 100 atmospheres and a temperature of 540.degree. to 700.degree. C. The catalyst is selected from the group consisting of silica, titania, alumina, sodium/alumina, zinc titanate, alumina or titania promoted with transition metals nickel, cobalt, molybdenum, tungsten, alloys and mixtures thereof and mixture of such catalysts.
    Type: Grant
    Filed: December 12, 1995
    Date of Patent: August 25, 1998
    Assignee: Research Triangle Institute
    Inventors: Thomas P. Dorchak, Santosh K. Gangwal, Scott M. Harkins
  • Patent number: 5780880
    Abstract: An optoelectronic semiconductor device using stimulated emission and absorption to achieve the functions of detection, modulation, generation and/or amplification of light. In one embodiment, the device includes a waveguide heterojunction bipolar transistor (HBT) biased in the active mode where the minority carrier concentration in the base is designed with bandgap engineering to optimize optical gain in this region. This HBT configuration allows optical modulation at considerably higher frequencies and/or with improved efficiency compared to the prior art, and is particularly suited to the fabrication of direct or external modulated wideband fiber optic links.
    Type: Grant
    Filed: May 22, 1996
    Date of Patent: July 14, 1998
    Assignee: Research Triangle Institute
    Inventor: Paul M. Enquist
  • Patent number: 5747503
    Abstract: The present invention provides a compound having the structure: ##STR1## wherein X, Y, and Z are independently H, Cl, Br, F, OCH.sub.3, I, or an alkyl group having 1 to 6 carbon atoms; and R is ##STR2## wherein n is 0 to 6, X' and Y' are independently H, Cl, F, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, C.sub.4 H.sub.9, OCH.sub.3, OH, CF.sub.3, OCF.sub.3, NO.sub.2, NH.sub.2, N(CH.sub.3).sub.2, NHCOCH.sub.3, NCS, NHCOCH.sub.2 Br, or N.sub.3, and (CH.sub.2).sub.n, if present, may be substituted with OH, OCH.sub.3, or an alkyl or alkenyl group having 1 to 3 carbon atoms. The present invention also provides a pharmaceutical composition comprising the compound above and a pharmaceutically acceptable carrier. The present invention further provides a method for treating a disease characterized by a dopamine deficiency which comprises administering to a subject in need of such treatment an amount of the pharmaceutical composition above effective to treat the disease.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: May 5, 1998
    Assignees: The United States of America as represented by the Department of Health and Human Services, Research Triangle Institute
    Inventors: Richard Rothman, Frank I. Carroll, Bruce Blough, Samuel W. Mascarella
  • Patent number: 5736123
    Abstract: Novel compounds useful as intermediates in the synthesis of compounds having high affinity for specific cocaine receptors in the brain have the formula ##STR1## wherein R is (CH.sub.2).sub.n CH.sub.2 Y, and wherein Y is H or F, X is a pharmaceutically acceptable anion, andwherein Sn (R.sup.1, R.sup.2, R.sup.3) is ortho, meta or para and wherein R.sup.1, R.sup.2, R.sup.3 are independently alkyl of 1-6 carbon atoms and n is an integer of 0-5.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: April 7, 1998
    Assignee: Research Triangle Institute
    Inventor: Frank I. Carroll
  • Patent number: 5714431
    Abstract: The present invention provides a zinc titanate sorbent material useful in desulfurization applications. The zinc titanate material is in the form of generally spherical particles of substantially uniform chemical distribution. The sorbent material is capable of absorbing sulfur compounds from a gaseous feed in an amount of at least about 15 weight percent based on the weight of the sorbent. The sorbent material is prepared by a process including: (a) forming a zinc oxide/titanium dioxide dry blend, (b) preparing a substantially uniform aqueous slurry comprising the zinc oxide/titanium dioxide dry blend, organic binder, and at least about 1 weight percent inorganic binder based on the solids weight of the slurry, (c) spray drying the slurry to produce substantially spherical particles, and (d) calcining the particles at a temperature of between about 750.degree. C. to about 950.degree. C. The dry blend is formed by mixing between about 0.
    Type: Grant
    Filed: October 19, 1994
    Date of Patent: February 3, 1998
    Assignee: Research Triangle Institute
    Inventors: Raghubir P. Gupta, Santosh K. Gangwal, Suresh C. Jain
  • Patent number: 5646159
    Abstract: Non-toxic camptothecin prodrugs are prepared by esterifying the 20-position hydroxyl group of camptothecin derivatives.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: July 8, 1997
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani
  • Patent number: 5643639
    Abstract: A method and apparatus for generating plasmas adapted for chemical vapor deposition, etching and other operations, and in particular to the deposition of large-area diamond films, wherein a chamber defined by sidewalls surrounding a longitudinal axis is encircled by an axially-extending array of current-carrying conductors that are substantially transverse to the longitudinal axis of the chamber, and a gaseous material is provided in the chamber. A high-frequency current is produced in the conductors to magnetically induce ionization of the gaseous material in the chamber and form a plasma sheath that surrounds and extends along the longitudinal axis and conforms to the sidewalls of the chamber. A work surface extending in the direction of the longitudinal axis of the chamber is positioned adjacent a sidewall, exposed to the plasma sheath and treated by the plasma.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: July 1, 1997
    Assignee: Research Triangle Institute
    Inventors: Ronald Alan Rudder, Robert Carlisle Hendry, George Carlton Hudson
  • Patent number: 5637653
    Abstract: Polymer blend materials composed of an aromatic polyamide and flexible polyamide wherein the aromatic polyamide molecules are uniformly dispersed in a matrix of the flexible polyamide which are produced by first blending the flexible polyamide and monomer(s) for the aromatic polyamide in a solvent, then next polymerizing the monomer(s) in the presence of a phosphite compound, resulting in a transparent gel product capable of being fabricated into useful shaped articles without causing marked phase separation observed in polymer blend materials obtained by conventional coagulation method. The in situ formed aromatic polyamide is uniformly dispersed in the flexible polyamide matrix even in fabricated forms, giving improved transparency over the starting flexible polyamide and improved resistance toward chemicals such as acids, especially after heat treatment.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: June 10, 1997
    Assignees: Dainippon Ink and Chemicals, Incorporated, Research Triangle Institute
    Inventors: Jack Preston, Satoshi Idemura
  • Patent number: 5614529
    Abstract: Camptothecin compounds are effective inhibitors of plasmodia growth and are useful in treating plasmodia infections in livestock, other domestic animals and humans.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: March 25, 1997
    Assignees: Research Triangle Institute, Robert R. Engle, Robert E. Miller
    Inventors: Monroe E. Wall, Mansukh C. Wani, Robert R. Engle, Robert E. Miller
  • Patent number: 5609736
    Abstract: The present invention provides methods and apparatus for decomposing toxic compounds so that reaction by-products produced thereby are selectively reduced. A method generally comprises: introducing a carrier gas, having a toxic compound entrained therein, into a packed-bed of ferroelectric pellets; and polarizing the pellets to produce a plasma which decomposes the toxic compound. The pellets are coated with a catalyst selected to react with by-products of the decomposition of the toxic compound and thereby produce non-toxic compounds.
    Type: Grant
    Filed: September 26, 1995
    Date of Patent: March 11, 1997
    Assignee: Research Triangle Institute
    Inventor: Toshiaki Yamamoto
  • Patent number: 5585292
    Abstract: A thin film transistor comprises an insulator interposed between a gate electrode and a polycrystalline silicon semiconductor layer, with the polycrystalline silicon semiconductor layer having a source region and a drain region with a channel between the source region and the drain region. The insulator comprises an ONO structure having an interfacial oxide layer in contact with the polycrystalline silicon semiconductor layer, a cap oxide layer in contact with the gate electrode, and a nitride layer interposed between the interfacial oxide layer and the nitride layer.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: December 17, 1996
    Assignees: Sharp Kabushiki, Research Triangle Institute
    Inventors: Tatsuo Morita, Robert J. Markunas
  • Patent number: 5496953
    Abstract: Novel compounds show high affinity for specific cocaine receptors in the brain, particularly dopamine transporter sites, and have the formula ##STR1## Wherein Y=CONRR.sub.2, R.sub.1 =hydrogen, C.sub.1-5 alkyl,X=H, C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.1-4 alkoxy, C.sub.1-6 alkynyl, halogen, amino, acylamido,R and R.sup.2 may be saturated or unsaturated substituents of 1-6 carbon atoms, aromatic, or combine to form pyrrolidinyl, morpholinyl or piperidinyl moieties, andZ=H, I, Br, Cl, F, CN, CF.sub.3 NO.sub.2, N.sub.3, OR.sub.1, CO.sub.2 NH.sub.2, CO.sub.2 R.sub.1, C.sub.1-6 alkyl, NR.sub.4 R.sub.5, NHCOF.sub.5, NHCO.sub.2 R.sub.6,wherein R.sub.4 -R.sub.6 are each C.sub.1-6 alkyl.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: March 5, 1996
    Assignee: Research Triangle Institute
    Inventors: Michael J. Kuhar, Frank I. Carroll, Joh W. Boja, Anita H. Lewin, Philip Abraham
  • Patent number: 5496830
    Abstract: Camptothecin compounds are effective inhibitors of hemoflagellate growth and are useful in treating leishmaniasis and trypanosomiasis in livestock, other domestic animals and humans.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: March 5, 1996
    Assignees: Johns Hopkins University, Research Triangle Institute
    Inventors: Theresa A. Shapiro, Annette L. Bodley, Monroe E. Wall, Mansukh C. Wani
  • Patent number: 5480686
    Abstract: A chemical vapor deposition (CVD) process and apparatus for the growth of diamond films using vapor mixtures of selected compounds having desired moieties, specifically precursors that provide carbon and etchant species that remove graphite. The process involves two steps. In the first step, feedstock gas enters a conversion zone. In the second step, by-products from the conversion zone proceed to an atomization zone where diamond is produced. In a preferred embodiment a feedstock gas phase mixture including at least 20% water which provides the etchant species is reacted with an alcohol which provides the requisite carbon precursor at low temperature (55.degree.-1100.degree. C.) and low pressure (0.1 to 100 Torr), preferably in the presence of an organic acid (acetic acid) which contributes etchant species reactant. In the reaction process, the feedstock gas mixture is converted to H.sub.2, CO, C.sub.2 H.sub.2, no O.sub.2, with some residual water. Oxygen formerly on the water is transferred to CO.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: January 2, 1996
    Assignee: Research Triangle Institute
    Inventors: Ronald A. Rudder, George C. Hudson, Robert C. Hendry, Robert J. Markunas, Michael J. Mantini
  • Patent number: 5472550
    Abstract: An apparatus for processing a substrate surface in a process chamber wherein during chemical or physical altering of the substrate surface a laser beam is projected inside the processing chamber and along a trajectory which does not contact the substrate surface in order to capture particles by means of the photophoretic effect, particles which would otherwise impinge upon and contaminate the substrate surface.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: December 5, 1995
    Assignee: Research Triangle Institute
    Inventor: Ravindran Periasamy
  • Patent number: 5439513
    Abstract: A device for controlling the motion of particles suspended in a gas stream is provided, including a pipe, through which at least a fraction of the gas stream flows, a source of AC voltage, a source of DC voltage, and a plurality of electrode sets positioned within the pipe in series, generating an inhomogeneous electric field to cause the particles suspended in the gas stream to concentrate into a narrow axial region in the center of the pipe. Each electrode set includes a first pair of opposed hyperboloidally shaped electrodes connected to the AC voltage source and a second pair of opposed hyperboloidally shaped electrodes connected to the DC voltage. The first and second pairs of opposed electrodes are positioned at spaced apart intervals around the circumference of the pipe to define an opening through which at least a fraction of the gas stream flows. The electrode sets are positioned within the pipe in series such that the gas stream flows through the openings defined by each successive electrode set.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: August 8, 1995
    Assignee: Research Triangle Institute
    Inventors: Ravindran Periasamy, David S. Ensor, Robert P. Donovan
  • Patent number: 5436243
    Abstract: Potentiating agents inhibit the development of multidrug resistance, reduce drug-resistance in drug-resistant tumors, or sensitize tumors to antineoplastic drugs, thereby potentiating the effect of antineoplastic agents. The potentiating agents are aminoanthraquinones, preferably 1,4-bis(N-substituted) amino anthraquinones, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 17, 1993
    Date of Patent: July 25, 1995
    Assignees: Research Triangle Institute Duke University, Pharmaceuticals Corporation
    Inventors: Clifford W. Sachs, Robert L. Fine, Lawrence M Ballas, R. Ivy Carroll, Robert Bell
  • Patent number: 5418018
    Abstract: A chemical vapor deposition (CVD) technique (process and apparatus) for the growth of diamond films using vapor mixtures of selected compounds having desired moieties, specifically precursors that provide carbon and etchant species that remove graphite disclosed. The selected compounds are reacted in a plasma created by a confined rf discharge to produce diamond films on a diamond or a non-diamond substrate. In a preferred embodiment a gas phase mixture including at least 20% water which provides the etchant species is reacted with an alcohol which provides the requisite carbon precursor at low temperature (300.degree.-650.degree. C.) and low pressure (0.1 to 10 Torr), preferably in the presence of an organic acid (acetic acid) which contributes etchant species reactant. In the preferred embodiment the volumetric mixtures have typically been 40-80% water and 60-20% alcohol. The gaseous mixture of H.sub.2 O and alcohol is dissociated to produce H, OH, and carbon radicals.
    Type: Grant
    Filed: May 14, 1993
    Date of Patent: May 23, 1995
    Assignee: Research Triangle Institute
    Inventors: Ronald A. Rudder, George C. Hudson, Robert C. Hendry, Robert J. Markunas
  • Patent number: 5413779
    Abstract: 3.beta.-[4-iodophenyl]-tropan-2.beta.-carboxylic acid methyl ester tartrate is a high affinity binding ligand for cocaine receptors in mammalian brains. It and its congeners may be employed for imaging and other brain scanning techniques that allow the determination of the presence of cocaine receptors, such as dopamine and serotonin transporters and the like.
    Type: Grant
    Filed: March 23, 1993
    Date of Patent: May 9, 1995
    Assignees: Research Triangle Institute, The United States of America represented by the Secretary of Health and Human Services
    Inventors: Michael J. Kuhar, Frank I. Carroll, John W. Boja, Anita H. Lewin, Philip Abraham