Patents Assigned to Research Triangle Institute
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Patent number: 5800620Abstract: A method and apparatus for generating plasmas adapted for chemical vapor deposition, etching and other operations, and in particular to the deposition of large-area diamond films, wherein a chamber defined by sidewalls surrounding a longitudinal axis is encircled by an axially-extending array of current-carrying conductors that are substantially transverse to the longitudinal axis of the chamber, and a gaseous material is provided in the chamber. A high-frequency current is produced in the conductors to magnetically induce ionization of the gaseous material in the chamber and form a plasma sheath that surrounds and extends along the longitudinal axis and conforms to the sidewalls of the chamber. A work surface extending in the direction of the longitudinal axis of the chamber is positioned adjacent a sidewall, exposed to the plasma sheath and treated by the plasma.Type: GrantFiled: June 30, 1997Date of Patent: September 1, 1998Assignee: Research Triangle InstituteInventors: Ronald Alan Rudder, Robert Carlisle Hendry, George Carlton Hudson
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Patent number: 5798088Abstract: A method for producing elemental sulfur and reduced/oxidized sulfur compounds from sulfur containing gases. The method comprises mixing a primary gas stream of sulfur-containing gases with a secondary gas stream to produce a combined gas stream having a preselected stoichiometry and contacting the combined gas stream with a catalyst at a pressure of 7 to 100 atmospheres and a temperature of 540.degree. to 700.degree. C. The catalyst is selected from the group consisting of silica, titania, alumina, sodium/alumina, zinc titanate, alumina or titania promoted with transition metals nickel, cobalt, molybdenum, tungsten, alloys and mixtures thereof and mixture of such catalysts.Type: GrantFiled: December 12, 1995Date of Patent: August 25, 1998Assignee: Research Triangle InstituteInventors: Thomas P. Dorchak, Santosh K. Gangwal, Scott M. Harkins
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Patent number: 5780880Abstract: An optoelectronic semiconductor device using stimulated emission and absorption to achieve the functions of detection, modulation, generation and/or amplification of light. In one embodiment, the device includes a waveguide heterojunction bipolar transistor (HBT) biased in the active mode where the minority carrier concentration in the base is designed with bandgap engineering to optimize optical gain in this region. This HBT configuration allows optical modulation at considerably higher frequencies and/or with improved efficiency compared to the prior art, and is particularly suited to the fabrication of direct or external modulated wideband fiber optic links.Type: GrantFiled: May 22, 1996Date of Patent: July 14, 1998Assignee: Research Triangle InstituteInventor: Paul M. Enquist
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Patent number: 5747503Abstract: The present invention provides a compound having the structure: ##STR1## wherein X, Y, and Z are independently H, Cl, Br, F, OCH.sub.3, I, or an alkyl group having 1 to 6 carbon atoms; and R is ##STR2## wherein n is 0 to 6, X' and Y' are independently H, Cl, F, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, C.sub.4 H.sub.9, OCH.sub.3, OH, CF.sub.3, OCF.sub.3, NO.sub.2, NH.sub.2, N(CH.sub.3).sub.2, NHCOCH.sub.3, NCS, NHCOCH.sub.2 Br, or N.sub.3, and (CH.sub.2).sub.n, if present, may be substituted with OH, OCH.sub.3, or an alkyl or alkenyl group having 1 to 3 carbon atoms. The present invention also provides a pharmaceutical composition comprising the compound above and a pharmaceutically acceptable carrier. The present invention further provides a method for treating a disease characterized by a dopamine deficiency which comprises administering to a subject in need of such treatment an amount of the pharmaceutical composition above effective to treat the disease.Type: GrantFiled: November 12, 1996Date of Patent: May 5, 1998Assignees: The United States of America as represented by the Department of Health and Human Services, Research Triangle InstituteInventors: Richard Rothman, Frank I. Carroll, Bruce Blough, Samuel W. Mascarella
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Patent number: 5736123Abstract: Novel compounds useful as intermediates in the synthesis of compounds having high affinity for specific cocaine receptors in the brain have the formula ##STR1## wherein R is (CH.sub.2).sub.n CH.sub.2 Y, and wherein Y is H or F, X is a pharmaceutically acceptable anion, andwherein Sn (R.sup.1, R.sup.2, R.sup.3) is ortho, meta or para and wherein R.sup.1, R.sup.2, R.sup.3 are independently alkyl of 1-6 carbon atoms and n is an integer of 0-5.Type: GrantFiled: May 8, 1995Date of Patent: April 7, 1998Assignee: Research Triangle InstituteInventor: Frank I. Carroll
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Patent number: 5714431Abstract: The present invention provides a zinc titanate sorbent material useful in desulfurization applications. The zinc titanate material is in the form of generally spherical particles of substantially uniform chemical distribution. The sorbent material is capable of absorbing sulfur compounds from a gaseous feed in an amount of at least about 15 weight percent based on the weight of the sorbent. The sorbent material is prepared by a process including: (a) forming a zinc oxide/titanium dioxide dry blend, (b) preparing a substantially uniform aqueous slurry comprising the zinc oxide/titanium dioxide dry blend, organic binder, and at least about 1 weight percent inorganic binder based on the solids weight of the slurry, (c) spray drying the slurry to produce substantially spherical particles, and (d) calcining the particles at a temperature of between about 750.degree. C. to about 950.degree. C. The dry blend is formed by mixing between about 0.Type: GrantFiled: October 19, 1994Date of Patent: February 3, 1998Assignee: Research Triangle InstituteInventors: Raghubir P. Gupta, Santosh K. Gangwal, Suresh C. Jain
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Patent number: 5646159Abstract: Non-toxic camptothecin prodrugs are prepared by esterifying the 20-position hydroxyl group of camptothecin derivatives.Type: GrantFiled: July 20, 1994Date of Patent: July 8, 1997Assignee: Research Triangle InstituteInventors: Monroe E. Wall, Mansukh C. Wani
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Patent number: 5643639Abstract: A method and apparatus for generating plasmas adapted for chemical vapor deposition, etching and other operations, and in particular to the deposition of large-area diamond films, wherein a chamber defined by sidewalls surrounding a longitudinal axis is encircled by an axially-extending array of current-carrying conductors that are substantially transverse to the longitudinal axis of the chamber, and a gaseous material is provided in the chamber. A high-frequency current is produced in the conductors to magnetically induce ionization of the gaseous material in the chamber and form a plasma sheath that surrounds and extends along the longitudinal axis and conforms to the sidewalls of the chamber. A work surface extending in the direction of the longitudinal axis of the chamber is positioned adjacent a sidewall, exposed to the plasma sheath and treated by the plasma.Type: GrantFiled: December 22, 1994Date of Patent: July 1, 1997Assignee: Research Triangle InstituteInventors: Ronald Alan Rudder, Robert Carlisle Hendry, George Carlton Hudson
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Patent number: 5637653Abstract: Polymer blend materials composed of an aromatic polyamide and flexible polyamide wherein the aromatic polyamide molecules are uniformly dispersed in a matrix of the flexible polyamide which are produced by first blending the flexible polyamide and monomer(s) for the aromatic polyamide in a solvent, then next polymerizing the monomer(s) in the presence of a phosphite compound, resulting in a transparent gel product capable of being fabricated into useful shaped articles without causing marked phase separation observed in polymer blend materials obtained by conventional coagulation method. The in situ formed aromatic polyamide is uniformly dispersed in the flexible polyamide matrix even in fabricated forms, giving improved transparency over the starting flexible polyamide and improved resistance toward chemicals such as acids, especially after heat treatment.Type: GrantFiled: May 2, 1995Date of Patent: June 10, 1997Assignees: Dainippon Ink and Chemicals, Incorporated, Research Triangle InstituteInventors: Jack Preston, Satoshi Idemura
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Patent number: 5614529Abstract: Camptothecin compounds are effective inhibitors of plasmodia growth and are useful in treating plasmodia infections in livestock, other domestic animals and humans.Type: GrantFiled: September 22, 1994Date of Patent: March 25, 1997Assignees: Research Triangle Institute, Robert R. Engle, Robert E. MillerInventors: Monroe E. Wall, Mansukh C. Wani, Robert R. Engle, Robert E. Miller
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Patent number: 5609736Abstract: The present invention provides methods and apparatus for decomposing toxic compounds so that reaction by-products produced thereby are selectively reduced. A method generally comprises: introducing a carrier gas, having a toxic compound entrained therein, into a packed-bed of ferroelectric pellets; and polarizing the pellets to produce a plasma which decomposes the toxic compound. The pellets are coated with a catalyst selected to react with by-products of the decomposition of the toxic compound and thereby produce non-toxic compounds.Type: GrantFiled: September 26, 1995Date of Patent: March 11, 1997Assignee: Research Triangle InstituteInventor: Toshiaki Yamamoto
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Patent number: 5585292Abstract: A thin film transistor comprises an insulator interposed between a gate electrode and a polycrystalline silicon semiconductor layer, with the polycrystalline silicon semiconductor layer having a source region and a drain region with a channel between the source region and the drain region. The insulator comprises an ONO structure having an interfacial oxide layer in contact with the polycrystalline silicon semiconductor layer, a cap oxide layer in contact with the gate electrode, and a nitride layer interposed between the interfacial oxide layer and the nitride layer.Type: GrantFiled: February 3, 1995Date of Patent: December 17, 1996Assignees: Sharp Kabushiki, Research Triangle InstituteInventors: Tatsuo Morita, Robert J. Markunas
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Patent number: 5496953Abstract: Novel compounds show high affinity for specific cocaine receptors in the brain, particularly dopamine transporter sites, and have the formula ##STR1## Wherein Y=CONRR.sub.2, R.sub.1 =hydrogen, C.sub.1-5 alkyl,X=H, C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.1-4 alkoxy, C.sub.1-6 alkynyl, halogen, amino, acylamido,R and R.sup.2 may be saturated or unsaturated substituents of 1-6 carbon atoms, aromatic, or combine to form pyrrolidinyl, morpholinyl or piperidinyl moieties, andZ=H, I, Br, Cl, F, CN, CF.sub.3 NO.sub.2, N.sub.3, OR.sub.1, CO.sub.2 NH.sub.2, CO.sub.2 R.sub.1, C.sub.1-6 alkyl, NR.sub.4 R.sub.5, NHCOF.sub.5, NHCO.sub.2 R.sub.6,wherein R.sub.4 -R.sub.6 are each C.sub.1-6 alkyl.Type: GrantFiled: December 10, 1993Date of Patent: March 5, 1996Assignee: Research Triangle InstituteInventors: Michael J. Kuhar, Frank I. Carroll, Joh W. Boja, Anita H. Lewin, Philip Abraham
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Patent number: 5496830Abstract: Camptothecin compounds are effective inhibitors of hemoflagellate growth and are useful in treating leishmaniasis and trypanosomiasis in livestock, other domestic animals and humans.Type: GrantFiled: September 14, 1994Date of Patent: March 5, 1996Assignees: Johns Hopkins University, Research Triangle InstituteInventors: Theresa A. Shapiro, Annette L. Bodley, Monroe E. Wall, Mansukh C. Wani
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Patent number: 5480686Abstract: A chemical vapor deposition (CVD) process and apparatus for the growth of diamond films using vapor mixtures of selected compounds having desired moieties, specifically precursors that provide carbon and etchant species that remove graphite. The process involves two steps. In the first step, feedstock gas enters a conversion zone. In the second step, by-products from the conversion zone proceed to an atomization zone where diamond is produced. In a preferred embodiment a feedstock gas phase mixture including at least 20% water which provides the etchant species is reacted with an alcohol which provides the requisite carbon precursor at low temperature (55.degree.-1100.degree. C.) and low pressure (0.1 to 100 Torr), preferably in the presence of an organic acid (acetic acid) which contributes etchant species reactant. In the reaction process, the feedstock gas mixture is converted to H.sub.2, CO, C.sub.2 H.sub.2, no O.sub.2, with some residual water. Oxygen formerly on the water is transferred to CO.Type: GrantFiled: November 12, 1993Date of Patent: January 2, 1996Assignee: Research Triangle InstituteInventors: Ronald A. Rudder, George C. Hudson, Robert C. Hendry, Robert J. Markunas, Michael J. Mantini
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Patent number: 5472550Abstract: An apparatus for processing a substrate surface in a process chamber wherein during chemical or physical altering of the substrate surface a laser beam is projected inside the processing chamber and along a trajectory which does not contact the substrate surface in order to capture particles by means of the photophoretic effect, particles which would otherwise impinge upon and contaminate the substrate surface.Type: GrantFiled: June 13, 1994Date of Patent: December 5, 1995Assignee: Research Triangle InstituteInventor: Ravindran Periasamy
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Patent number: 5439513Abstract: A device for controlling the motion of particles suspended in a gas stream is provided, including a pipe, through which at least a fraction of the gas stream flows, a source of AC voltage, a source of DC voltage, and a plurality of electrode sets positioned within the pipe in series, generating an inhomogeneous electric field to cause the particles suspended in the gas stream to concentrate into a narrow axial region in the center of the pipe. Each electrode set includes a first pair of opposed hyperboloidally shaped electrodes connected to the AC voltage source and a second pair of opposed hyperboloidally shaped electrodes connected to the DC voltage. The first and second pairs of opposed electrodes are positioned at spaced apart intervals around the circumference of the pipe to define an opening through which at least a fraction of the gas stream flows. The electrode sets are positioned within the pipe in series such that the gas stream flows through the openings defined by each successive electrode set.Type: GrantFiled: May 31, 1994Date of Patent: August 8, 1995Assignee: Research Triangle InstituteInventors: Ravindran Periasamy, David S. Ensor, Robert P. Donovan
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Patent number: 5436243Abstract: Potentiating agents inhibit the development of multidrug resistance, reduce drug-resistance in drug-resistant tumors, or sensitize tumors to antineoplastic drugs, thereby potentiating the effect of antineoplastic agents. The potentiating agents are aminoanthraquinones, preferably 1,4-bis(N-substituted) amino anthraquinones, and pharmaceutically acceptable salts thereof.Type: GrantFiled: November 17, 1993Date of Patent: July 25, 1995Assignees: Research Triangle Institute Duke University, Pharmaceuticals CorporationInventors: Clifford W. Sachs, Robert L. Fine, Lawrence M Ballas, R. Ivy Carroll, Robert Bell
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Patent number: 5418018Abstract: A chemical vapor deposition (CVD) technique (process and apparatus) for the growth of diamond films using vapor mixtures of selected compounds having desired moieties, specifically precursors that provide carbon and etchant species that remove graphite disclosed. The selected compounds are reacted in a plasma created by a confined rf discharge to produce diamond films on a diamond or a non-diamond substrate. In a preferred embodiment a gas phase mixture including at least 20% water which provides the etchant species is reacted with an alcohol which provides the requisite carbon precursor at low temperature (300.degree.-650.degree. C.) and low pressure (0.1 to 10 Torr), preferably in the presence of an organic acid (acetic acid) which contributes etchant species reactant. In the preferred embodiment the volumetric mixtures have typically been 40-80% water and 60-20% alcohol. The gaseous mixture of H.sub.2 O and alcohol is dissociated to produce H, OH, and carbon radicals.Type: GrantFiled: May 14, 1993Date of Patent: May 23, 1995Assignee: Research Triangle InstituteInventors: Ronald A. Rudder, George C. Hudson, Robert C. Hendry, Robert J. Markunas
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Patent number: 5413779Abstract: 3.beta.-[4-iodophenyl]-tropan-2.beta.-carboxylic acid methyl ester tartrate is a high affinity binding ligand for cocaine receptors in mammalian brains. It and its congeners may be employed for imaging and other brain scanning techniques that allow the determination of the presence of cocaine receptors, such as dopamine and serotonin transporters and the like.Type: GrantFiled: March 23, 1993Date of Patent: May 9, 1995Assignees: Research Triangle Institute, The United States of America represented by the Secretary of Health and Human ServicesInventors: Michael J. Kuhar, Frank I. Carroll, John W. Boja, Anita H. Lewin, Philip Abraham