Patents Assigned to Research
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Patent number: 11422065Abstract: A bumper for a mobile platform of a guided test platform includes a first end, a second end residing opposite the first end, a first surface extending between the first and second ends, and a second surface extending between the first and second ends and residing opposite the first surface. The bumper defines a ramp structure extending between the bumper first end and the bumper second end. The ramp structure is structured to guide a wheel of a vehicle in a direction away from the first surface as the wheel moves along the second surface in a direction from the bumper first end toward the bumper second end.Type: GrantFiled: July 16, 2019Date of Patent: August 23, 2022Assignee: Toyota Research Institute, Inc.Inventors: Matthew Amacker, Joseph Taylor, Gregory J. Klein, Jonathan Yao, Andrew Custer
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Patent number: 11421005Abstract: The invention provides chimeric antigen receptor(s) (CAR(s)) that comprise a fusion protein of CTX or any functional variant thereof or a CTX-like peptide or any functional variant thereof as the extracellular antigen recognition moiety of the CAR. CAR(s) comprising CTX, a CTX-like peptide or functional variants of the foregoing are collectively referred to herein as “CTX-CAR(s).” Such CTX-CAR(s) may further comprise additional moieties or domains in the extracellular domain, a transmembrane domain and at least one intracellular! signaling domain. Such CTX-CAR(s) may be expressed in a host cell, such as, but not limited to, an immune effector cell. The present invention also provides methods of treatment (such as, for example, methods for treating cancer) by providing to the patient in need thereof immune effector cells that are engineered to express a CTX-CAR described herein.Type: GrantFiled: December 9, 2017Date of Patent: August 23, 2022Assignee: The UAB Research FoundationInventors: Lawrence S. Lamb, Jr., Antonio Di Stasi, G. Yancey Gillespie, Larisa Pereboeva
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Patent number: 11419933Abstract: The present invention provides novel and stable pharmaceutical compositions comprising bispecific single chain antibody constructs, cyclodextrins and a buffer.Type: GrantFiled: January 25, 2017Date of Patent: August 23, 2022Assignees: AMGEN INC., AMGEN RESEARCH (MUNICH) GMBHInventors: Sekhar Kanapuram, Ramil Latypov, Balakumar Thangaraj, Cornelius Pompe
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Patent number: 11422363Abstract: The present invention is intended to provide an adaptive optics system and an optical device that allow correction of wavefront phase aberration with higher accuracy than before and have a wider correction range than the conventional ones, regardless of the distance between the observation target and the fluctuation layer, and the size of the observation target. An adaptive optics system includes: a wavefront phase modulator that makes aberration correction to incident light and emits the corrected light; and an imaging-conjugated position adjustment mechanism that adjusts freely within a specimen the position of a surface imaging-conjugated with a fluctuation correction surface formed by the wavefront phase modulator. The imaging-conjugated position adjustment mechanism adjusts the fluctuation correction surface to be imaging-conjugated with a fluctuation layer existing in the specimen.Type: GrantFiled: February 22, 2019Date of Patent: August 23, 2022Assignee: INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCESInventors: Masayuki Hattori, Yosuke Tamada, Takashi Murata, Yasuhiro Kamei, Mitsuyasu Hasebe, Yutaka Hayano, Shin Oya
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Patent number: 11424525Abstract: A ring resonator based T-shaped duplexer for use in communication systems, the T-shaped duplexer comprising a T-shaped microstrip duplexer body having a first rectangular-shaped body section and a second rectangular-shaped body section that extends from the first-rectangular shaped section in a perpendicular position relative to the first rectangular-shaped section, three connection ports including a first connection port disposed at an open end of the second rectangular-shaped body section, a second connection port disposed at one end of the first rectangular-shaped body section, and a third connection port disposed at another end of the first rectangular-shaped body section, and two bandpass filters, each bandpass filter comprising a ring resonator structure having a circular shape, an outer edge of the ring resonator structure being connected to the first rectangular-shaped body section of the T-shaped microstrip duplexer body, wherein each of the two bandpass filters creates an Electromagnetically InducedType: GrantFiled: March 11, 2021Date of Patent: August 23, 2022Assignee: WI-LAN RESEARCH INC.Inventors: Muhammad Rashad Ramzan, Muhammad Omar, Kenneth Stanwood
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Patent number: 11420338Abstract: Embodiments are directed to an assistive robot system. The assistive robot system includes a lifting mechanism, a movable arm assembly coupled to the lifting mechanism, a container tilting arm assembly, a processing device communicatively coupled to the lifting mechanism and the movable arm assembly, and a non-transitory, processor-readable storage medium in communication with the processing device. The non-transitory, processor-readable storage medium causes the processing device to transmit a command to the lifting mechanism to cause the lifting mechanism to move the movable arm assembly such that the container tilting arm assembly makes contact with a container and transmits one or more signals to the movable arm assembly to cause the movable arm assembly to extend in a system longitudinal direction such that the container within the movable arm assembly is pivoted against the container tilting assembly to tilt the container within the movable arm assembly.Type: GrantFiled: September 4, 2019Date of Patent: August 23, 2022Assignee: TOYOTA RESEARCH INSTITUTE, INC.Inventors: Joseph Bondaryk, James D. C. Lent, Aimee S. Goncalves, Paul W. Baim, Christopher Gidwell, Toffee Albina
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Patent number: 11421236Abstract: A biosensor for detecting nitrotoluenes. Two P. putida host populations (H-I and H-II) are engineered. H-1 undergoes fluorescence when a nitrotoluene is detected but it is also engineered to metabolize nitrotoluenes to toluene as its sole nitrogen-source. H-I is 1-ACC Deaminase inactive and is further engineered to efflux toluene and provide toluene to adjacent H-II. In H-II, ACC is the N-source and metabolizes toluene as the sole carbon and energy source available. The H-II cells are engineered to not be able to use medium fructose. The H-II population has a promoter/GFP construct with a promoter sensitive to toluene and thus they fluoresce from that first nitrotoluene metabolite i.e. toluene, produced by the H-I cells. This is achieved by making H-II cells mutants unable to transport and phosphorylate fructose i.e. PTSFRU gene knock-out.Type: GrantFiled: April 17, 2020Date of Patent: August 23, 2022Assignee: Research Foundation of the City University of New YorkInventors: Chang-Hui Shen, Robert Corin
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Patent number: 11420922Abstract: The present disclosure relates to inhibitors of herpesvirus nucleic acid metabolism and inhibitors of Hepatitis B virus. Also provided are methods of treatment using these agents.Type: GrantFiled: June 10, 2016Date of Patent: August 23, 2022Assignees: Saint Louis University, Research Foundation of the City University of New YorkInventors: John Edwin Tavis, Lynda Anne Morrison, Ryan P. Murelli
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Patent number: 11420971Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.Type: GrantFiled: August 6, 2018Date of Patent: August 23, 2022Assignee: Heidelberg Pharma Research GmbHInventors: Werner Simon, Susanne Werner-Simon, Christian Lutz, Christoph Müller, Torsten Hechler, Michael Kulke
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Patent number: 11419902Abstract: The invention provides a composition comprising a bacterial strain of the genus Megasphaera, for use in stimulating the immune system in subject.Type: GrantFiled: September 4, 2020Date of Patent: August 23, 2022Assignee: 4D Pharma Research LimitedInventors: Imke Elisabeth Mulder, Parthena Fotiadou, Amy Beth Holt, Suaad Ahmed, Anna Ettorre, Samantha Yuille, Ted Dinan, John Cryan
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Patent number: 11419876Abstract: Methods for preventing feedlot bovine respiratory diseases employing mirtazapine as pre-shipment treatments are disclosed. Compositions are further disclosed. Beneficially, the methods and compositions provide safe and cost-effective management of a costly disease.Type: GrantFiled: August 10, 2020Date of Patent: August 23, 2022Assignee: Iowa State University Research Foundation, Inc.Inventors: Steven Alan Carlson, Tim Day
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Patent number: 11422090Abstract: A phase plate for high precision wavelength extraction can include a planar substrate which has a point spread function engineered profile formed of a tessellation of regions. The point spread function engineered profile transforms a point spread function of a light source to form a wavelength dependent geometric pattern. The geometric pattern can also preserve spatial location information of the light source. Such a phase plate permits extracting three-dimensional position and the wavelength of a point emitter.Type: GrantFiled: October 4, 2019Date of Patent: August 23, 2022Assignee: University of Utah Research FoundationInventors: Jason Martineau, Jordan Gerton, Erik Jorgensen, Tim Allen
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Patent number: 11420994Abstract: Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.Type: GrantFiled: November 15, 2017Date of Patent: August 23, 2022Assignee: Georgia State University Research Foundation, Inc.Inventors: Binghe Wang, Xingyue Ji, Zhixiang Pan
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Patent number: 11419954Abstract: Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.Type: GrantFiled: September 9, 2020Date of Patent: August 23, 2022Assignee: Georgia State University Research Foundation, Inc.Inventors: Jenny Jie Yang, Fan Pu, Shenghui Xue, Jingjuan Qiao, Shanshan Tan, Mani Salarian
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Patent number: 11420155Abstract: A process for sweetening a syngas stream, the process comprising the steps of: providing a syngas stream to a nonselective amine absorption unit, the sour syngas stream comprising syngas, carbon dioxide, and hydrogen sulfide; separating the syngas stream in the nonselective amine absorption unit to obtain an overhead syngas stream and an acid gas stream; introducing the acid gas stream to a membrane separation unit, the acid gas stream comprising hydrogen sulfide and carbon dioxide; separating the acid gas stream in the membrane separation unit to produce a retentate stream and a permeate stream, wherein the retentate stream comprises hydrogen sulfide, wherein the permeate stream comprises carbon dioxide; introducing the retentate stream to a sulfur recovery unit; processing the retentate stream in the sulfur recovery unit to produce a sulfur stream and a tail gas stream, wherein the sulfur stream comprises liquid sulfur.Type: GrantFiled: May 18, 2020Date of Patent: August 23, 2022Assignees: SAUDI ARABIAN OIL COMPANY and, MEMBRANE TECHNOLOGY AND RESEARCHInventors: Milind M. Vaidya, Sebastien A. Duval, Feras Hamad, Richard Baker, Tim Merkel, Kaaeid Lokhandwala, Ivy Huang, Ahmad A. Bahamdan, Faisal D. Al-Otaibi
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Patent number: 11424757Abstract: A successive approximation register analog-to-digital converter (SAR ADC) with calibration function and a calibration method thereof are provided. The SAR ADC has at least one capacitor digital-to-analog converter (CDAC), having Nd capacitors corresponding to Nd bits; and a controller. The calibration method includes: coupling the capacitors of an i-th to an (Nd?1)-th bit to a first reference voltage, and generating a first digital code based an operation of the capacitors of an (i?1)-th bit to a 0-th bit; coupling the capacitors of an (i+1)-th bit to the (Nd?1)-th bit to the first reference voltage, coupling the capacitor of the i-th bit to a second reference voltage, and generating a second digital code based on the operation of the capacitors of the (i?1)-th bit to the 0-th bit; generating a capacitor weight of the capacitor of the i-th bit; and calibrating the SAR ADC based on the capacitor weight.Type: GrantFiled: December 24, 2020Date of Patent: August 23, 2022Assignee: Industrial Technology Research InstituteInventors: Yung-Hui Chung, Qi-Feng Zeng
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Patent number: 11425552Abstract: A method of establishing a connection for direct communication between terminals, performed in a terminal, may comprise transmitting a sensing signal or a sidelink discovery signal; transmitting sidelink discovery information; receiving a response to the sidelink discovery signal or the sidelink discovery information from a peer terminal; determining a cast type for the peer terminal, and establishing a PCS-radio resource control (RRC) connection with the peer terminal when the cast type is determined to be a unicast scheme or groupcast scheme; and performing direct communication with the peer terminal.Type: GrantFiled: August 7, 2020Date of Patent: August 23, 2022Assignee: Electronics and Telecommunications Research InstituteInventor: Jae Heung Kim
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Patent number: 11424775Abstract: Disclosed are a human body communication receiver and an operating method thereof, which may effectively remove low frequency noise. The human body communication receiver according to the present disclosure includes a receiving electrode, a virtual electrode, a filter circuit that is connected between the receiving electrode and the virtual electrode, and removes low frequency noise from a signal received through the receiving electrode to generate a high frequency signal, a low frequency reconstruction circuit that is connected to a rear end of the filter circuit and reconstructs a low frequency baseband signal by rectifying the high frequency signal, and an amplifying circuit that is connected to a rear end of the low frequency reconstruction circuit, and amplifies the low frequency baseband signal.Type: GrantFiled: April 22, 2021Date of Patent: August 23, 2022Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Kwang Il Oh, Tae Wook Kang, Sung Eun Kim, Hyuk Kim, Hyung-Il Park, Kyung Jin Byun, Jae-Jin Lee, In Gi Lim
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Patent number: 11421628Abstract: Provided herein is a fuel injector capable of providing fuel into a jet engine operating at hypersonic speeds. Embodiments may include a system for fuel injection for an engine traveling at supersonic speeds. The system may include a fuel injection strut extending between opposing walls of an inlet to the engine, and a porous surface extending across at least a portion of the fuel injection strut. The fuel may be introduced into the inlet of the engine through the porous surface of the fuel injection strut. The porous surface of the fuel injection strut may extend along a fuel injecting portion of the fuel injection strut spaced a predefined distance from the opposing walls of the inlet. The porous portion of the fuel injection strut may include a porosity of about 100 pores per square inch or lower porosities as dictated by the specific design considerations.Type: GrantFiled: September 4, 2019Date of Patent: August 23, 2022Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATEDInventor: Corin Segal
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Patent number: 11425580Abstract: Wireless offloading provides tools to a service provider to encourage or direct a subscriber to offload from a first network, e.g., a cellular network, to a second network, e.g., a Wi-Fi network. The cellular service provider can use network data to determine wireless offloading priorities for cellular subscribers on an individual or group basis. The cellular service provider may use wireless network data it has and/or wireless network data it learns about networks from the wireless devices (which may obtain Wi-Fi network data from beacon frames of Wi-Fi networks or active scanning and which may report to the cellular service provider). Each wireless device can be given scanning assignments to ensure that the reporting task is shared among subscribers or adjusted to fill in gaps in data. With the network data, the cellular service provider is capable of generating useful prioritized network lists for wireless devices, either individually or as a group.Type: GrantFiled: September 28, 2020Date of Patent: August 23, 2022Assignee: HEADWATER RESEARCH LLCInventors: Gregory G. Raleigh, Alireza Raissinia, James Lavine