Abstract: Various examples are provided related to hydrogen plasma treatment of hafnium oxide. In one example, a method includes depositing a monolayer of a precursor on a first oxide monolayer; forming a second oxide monolayer by applying an oxygen (O2) plasma to the monolayer of the precursor; and creating oxygen vacancies in the second oxide monolayer by applying a hydrogen (H2) plasma to the second oxide monolayer. In another example, a device includes a hafnium oxide (HfO2) based ferroelectric thin film on a first side of a substrate and an electrode layer disposed on the HfO2 based ferroelectric thin film opposite the substrate. The HfO2 film includes a plurality of oxide monolayers including at least one HfO2 monolayer, each of the plurality of oxide monolayers having oxygen vacancies distributed throughout that oxide monolayer.

Abstract: A memory device for in-memory computation includes data channels, a memory cell array, a maximum accumulated weight generating array, a minimum accumulated weight generating array, a reference generator and a comparator. The data channels are selectively enabled according to data input. The memory cell array generates an accumulated data weight value according to the quantity of enabled data channels, a first resistance and a second resistance. The maximum accumulated weight generating array generates a maximum accumulated weight value according to the quantity of enabled data channels and the first resistance. The minimum accumulated weight generating array generates a minimum accumulated weight value according to the quantity of enabled data channels and the second resistance. The reference generator generates reference value(s) according to the maximum and minimum accumulated weight values.

Abstract: System, methods, and other embodiments described herein relate to predicting effects of a stimulus on a particle or other material structure. In one embodiment, a method includes receiving a segmented image of a particle that identifies at least semantics of the particle and associated characteristics according to subregions of the particle. The method includes analyzing, using a stimulus model, the segmented image to predict changes in the particle associated with applying the stimulus to the particle. Analyzing the segmented image includes generating a predicted image identifying characteristics, semantics and other properties of the particle according to the changes. The method includes providing the predicted image as an electronic output.

Abstract: Disclosed herein are immunoglobulin fusion proteins comprising an insulin therapeutic peptide and an immunoglobulin region that targets the insulin therapeutic peptide to the liver of an individual in need thereof. Further disclosed herein are compositions comprising the immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject, for example, diabetes and diabetes related conditions.

Abstract: The present disclosure provides methods of preventing or treating renal ischemia-reperfusion injury in a mammalian subject and methods for chronic treatment of ARVD, including administering an effective amount of an aromatic-cationic peptide to a subject in need thereof. The methods include administering aromatic-cationic peptides to prevent or treat renal injury during the treatment of renal artery stenosis. The methods include administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.

Abstract: An arrangement of acoustic transducers for a flow meter. The flow meter is for measuring the rate at which fluid is flowing. The arrangement includes a respective transducer set for each edge of a notional regular polygon. The transducer sets are associated with a tubular cavity for carrying the fluid. Each of the transducer sets respectively includes two acoustic transducers oriented to define an acoustic path lying in a measurement plane of the respective set, and another two acoustic transducers oriented to define another acoustic path lying in the measurement plane of the respective set. The transducers sets are positioned so that, in a cross-section normal to the tubular cavity, the measurement plane of each respective transducer set is coincident with a respective edge of the notional regular polygon.

Abstract: A mobile platform is provided for a guided soft target. The mobile platform includes a platform base, and a drive unit that is configured to move the platform base along a ground surface. A projector assembly is provided, configured for projecting light patterns for visual display on an exterior of the guided soft target. The projector assembly may include a hardened housing defining at least one opening for projecting the light patterns. In certain aspects, the projector assembly is coupled to an outer surface of the platform base. In other aspects, the projector assembly may be built into, or is retractable into, an interior the platform base. The projector assembly may include a control module that is configured to be remotely controllable.

Abstract: Embodiments of the invention provide systems and methods of generating a complete and accurate geometrically optimized environment. Stereo pair images depicting an environment are selected from a plurality of images to generate a Digital Surface Model (DSM). Characteristics of objects in the environment are determined and identified. The geometry of the objects may be determined and fit with polygons and textured facades. By determining the objects, the geometry, and the material from original satellite imagery and from a DSM created from the matching stereo pair point clouds, a complete and accurate geometrically optimized environment is created.

Abstract: Methods, systems, and computer readable media for controlling ventricular assist devices are disclosed. In some embodiments, the method includes receiving at least one reference pump speed differential associated with a pump of a ventricular assist device; determining a filtered pump speed differential associated with the pump of a ventricular assist device; and adjusting, using a feedback based controller algorithm, current to the pump based on the at least one reference pump speed differential and the filtered pump speed differential.

Abstract: A three-dimensional human body scanning device includes: a carrier module, moving around a to-be-measured person; a bracket module, installed above the carrier module, where the bracket module includes a plurality of stretchable brackets connected in an enveloping and storage manner, and other brackets are accommodated and assembled inside a sleeve; and a fixed module, installed on the sleeve, where the fixed module is used to hold the scanning device, and drives the scanning device through up-and-down stretch of the bracket module and movement of a slider element to scan a human body.

Abstract: The present invention relates to the use of cannabidiol (CBD) in combination with an agonist of 5-HT2B receptors. Such a combination provides protection against the adverse effects caused by agonists of 5-HT2B receptors. The invention further relates to the use of CBD in combination5 with an amphetamine or amphetamine derivative in the treatment of epilepsy. In one embodiment the CBD is used in combination with the amphetamine derivative fenfluramine to produce a significant reduction in seizures. Preferably the CBD used is in the form of a highly purified extract of cannabis such that the CBD is present at greater than 98% of the total extract (w/w) and the other components of the extract are characterised. In particular the cannabinoid10 tetrahydrocannabinol (THC) has been substantially removed, to a level of not more than 0.15% (w/w) and the propyl analogue of CBD, cannabidivarin, (CBDV) is present in amounts of up to 1%. Alternatively, the CBD may be a synthetically produced CBD.

Abstract: A multi-chip package and a manufacturing method thereof are provided. The multi-chip package includes: an interposer including a dielectric body, a plurality of semiconductor bodies separated by the dielectric body, a through via penetrating through the dielectric body, and a wiring structure located in each of the plurality of semiconductor bodies; a plurality of semiconductor chips located side by side on a first surface of the interposer and electrically connected to the wiring structure; an encapsulant located on the first surface of the interposer and encapsulating at least a portion of the plurality of semiconductor chips; and a redistribution circuit structure located on a second surface of the interposer opposite to the first surface of the interposer and electrically connected to the plurality of semiconductor chips through the through via.

Abstract: Plant scanning vehicles (10) including, but not limited to, plant scanning vehicles for use in field-based phenotyping. There is a central body (16); three or more legs (15) extending from the central body (16) to support a wheel (13) on each leg (15); wherein the three or more legs (15) are mounted to the central body (16) rotatably about a respective vertical axis (95) to allow adjustment of a track width W of the vehicle by rotating the legs wherein the legs are mechanically coupled to transmit rotation between the legs about their respective vertical axes and the central body (16) or the three or more legs (13) are configured to support a sensor (47) to scan plants.

Abstract: An electrosurgical device (10) operable to deliver microwave energy to cause targeted tissue ablation is provided. The electrosurgical device (10) comprises an antenna (26), a reflector (30), and a dielectric material (34) disposed therebetween. The selection of the dielectric material (30) and the relative positioning of the antenna (26) and the reflector (30) provide impedance matching between the antenna (26) and a transmission line (12) so as to minimize heating along the length of the device (10) during use.

Abstract: The disclosure discloses a method, apparatus and system for detecting multi-mode electromagnetic acoustic and magnetic flux leakage and a sensor. The method comprises: S102, receiving an operation instruction for detecting an object to be detected, the operation instruction is used for controlling a detection sensor to enter into any one or more of working modes as follows: magnetic flux leakage detection, ultrasonic bulk wave detection, ultrasonic guided wave detection and surface wave detection; S104, controlling the detection sensor to output a corresponding detection signal according to the operation instruction; and S106, detecting the object to be detected on the basis of the detection signal. The technical solution achieves a purpose of using one sensor to realize various detection modes, such as magnetic flux leakage and electromagnetic acoustic modes, reduces complexity and cost of a detection system, and improves detection efficiency.

Abstract: Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.

Abstract: The invention provides chimeric antigen receptor(s) (CAR(s)) that comprise a fusion protein of CTX or any functional variant thereof or a CTX-like peptide or any functional variant thereof as the extracellular antigen recognition moiety of the CAR. CAR(s) comprising CTX, a CTX-like peptide or functional variants of the foregoing are collectively referred to herein as “CTX-CAR(s).” Such CTX-CAR(s) may further comprise additional moieties or domains in the extracellular domain, a transmembrane domain and at least one intracellular! signaling domain. Such CTX-CAR(s) may be expressed in a host cell, such as, but not limited to, an immune effector cell. The present invention also provides methods of treatment (such as, for example, methods for treating cancer) by providing to the patient in need thereof immune effector cells that are engineered to express a CTX-CAR described herein.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: A phase plate for high precision wavelength extraction can include a planar substrate which has a point spread function engineered profile formed of a tessellation of regions. The point spread function engineered profile transforms a point spread function of a light source to form a wavelength dependent geometric pattern. The geometric pattern can also preserve spatial location information of the light source. Such a phase plate permits extracting three-dimensional position and the wavelength of a point emitter.

Abstract: Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.