Abstract: RNA virus vectors comprising a gene encoding the DNA-dependent activator of interferon-regulatory factors (DAI) protein, and optionally further comprising a gene encoding the receptor-interacting serine/threonine-protein kinase 3 (RIPK3) may be used therapeutically to induce cell death, as well as an inflammatory immune response, against tumors and virally-infected cells.

Abstract: Bispecific aptamers having a first end that specifically binds to a first tumor specific marker, tumor antigen, or viral protein and a second end that specifically binds to a second tumor specific marker, tumor antigen, or viral protein are provide. The bispecific aptamers can be used to treat cancer or virally infected cells. Generally, the bispecific aptamers bind to two surface proteins, preferably different proteins, on the same cell. In a preferred embodiment the bispecific aptamers bind to two different tumor markers, tumor antigens, tumor specific proteins and combinations thereof.

Abstract: A signal sensing module includes a substrate, a sensing electrode, a piezoresistive material layer and a sensing circuit. The substrate has a surface. The sensing electrode is disposed on the substrate and is exposed from the surface. The piezoresistive material layer is formed on the surface and covers the sensing electrode. The piezoresistive material layer has a resistance value. The sensing circuit is disposed in the substrate and adapted to sense a change of resistance value when a pressure wave passes through the piezoresistive material layer.

Abstract: The invention provides mass spectrometry methods, compositions and systems which enable a unique platform for analyte quantitation accessing very high degrees of multiplexing and accurate quantification, particularly well-suited for a range of quantitative analysis for proteomics applications. Embodiments of the present methods and systems combine isotopic coding agents characterized by very small differences in molecular mass with mass spectrometry methods providing large resolving power to provide relative or absolute analyte quantification in a large number of samples.

Abstract: The present disclosure provides antibodies that specifically bind to human OX40 receptor (OX40) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human OX40 and modulate OX40 activity, e.g., enhance, activate, or induce OX40 activity, or reduce, deactivate, or inhibit OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., enhances, activates, or induces OX40 activity. Also provided are methods for treating autoimmune or inflammatory diseases or disorders, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., reduces, deactivates, or inhibits OX40 activity.

Abstract: A medical implant device (100) is disclosed that can protect and shield an implant (101) as the implant (101) moves through body tissue. The medical implant device (100) can comprise a main body portion (110) having a payload opening (111) to receive a payload (i.e., an implant). The medical implant device (100) can also comprise a tapered nose portion (120) at a front end (103a) of the medical implant device (100) extending from the main body portion (110) and configured to penetrate body tissue. In addition, the medical implant device (100) can comprise a payload coupling interface (130) configured to couple the implant (101) to the main body portion (110).

Abstract: A gas treatment method includes an absorption step in which a gas to be treated containing an acidic compound, such as carbon dioxide, is brought into contact, in an absorber, with a treatment liquid that absorbs the acidic compound; and a regeneration step in which the treatment liquid, having the acidic compound absorbed therein, is sent to a regenerator, and the treatment liquid is then heated to separate the acidic compound from the treatment liquid. In the regeneration step, a gas almost insoluble to the treatment liquid, such as hydrogen gas, is brought into contact with the treatment liquid.

Abstract: A method for estimating quantitative precipitation by combining observation data of a weather radar and rain gauges includes: acquiring original accumulated data of rain gauges and original accumulated precipitation data of a weather radar to obtain rain gauge-weather radar data G/R pairs matched in the same grid; calculating an observation error of the original accumulated precipitation data of the weather radar through the G/R pairs, and detecting abnormal data to generate an initial correction factor field; determining whether a distance correlation exists between the initial correction factor field and the observation error, and if yes, adjusting the initial correction factor field, and correcting the original accumulated precipitation data of the weather radar through the adjusted correction factor field to obtain corrected accumulated precipitation data of the weather radar; and if not, obtaining the corrected accumulated precipitation data of the weather radar directly through a mean field bias (MFB) f

Abstract: Described herein are methods of identifying a plurality of polynucleotides, as well as detecting presence, absence, or abundance of a plurality of taxa in a sample. Also provided are systems for performing methods of the disclosure.

Abstract: Provided is a ternary or quaternary semiconductor nanoparticle that enables the band-edge emission and a less toxic composition. A semiconductor nanoparticle is provided that contains Ag, In, and S and has an average particle size of 50 nm or less, wherein the ratio of the number of atoms of Ag to the total number of atoms of Ag and In is 0.320 or more and 0.385 or less, the ratio of the number of atoms of S to the total number of atoms of Ag and In is 1.20 or more and 1.45 or less. The semiconductor nanoparticle is adapted to emit photoluminescence having a photoluminescence lifetime of 200 ns or less upon being irradiated with light having a wavelength in a range of 350 nm to 500 nm.

Abstract: A method for reducing effluent buildup in a pumping exhaust system of a substrate processing system includes, during a substrate treatment process, arranging a substrate on a substrate support in a processing chamber; supplying one or more process gases to the processing chamber; supplying an inert dilution gas at a first flow rate to the pumping exhaust system; performing the substrate treatment process on the substrate in the processing chamber; evacuating reactants from the processing chamber using the pumping exhaust system. The method includes, after the substrate treatment process, supplying cleaning plasma including cleaning gas in the processing chamber during a cleaning process; and supplying the inert dilution gas at a second flow rate that is less than the first flow rate to the pumping exhaust system during the cleaning process.

Abstract: The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.

Abstract: Various embodiments may relate to a radiant cooler. The radiant cooler may include a chamber. The radiant cooler may also include a vacuum pump connected to the chamber. The radiant cooler may further include an infrared absorber arranged within the chamber. A wall of the chamber may be configured to allow at least a portion of infrared light to pass through. The vacuum pump may be configured to generate a vacuum in the chamber. The infrared absorber may include a fluid, i.e. a liquid, configured to evaporate into the vacuum upon receiving thermal energy from at least the portion of infrared light.

Abstract: It discloses to a device and a method for controlling pollutants in metal mine water resources cycling utilization. The device includes a multi-stage inflow constructed wetland (3), in which one or more layers of the filler are laid, and water distribution pipes (4) are buried at different height levels in the filler layers for multi-stage inflow, so that the received basin water is allowed to flow through each layer of the filler to degrade or remove the pollutants. In the multi-stage inflow constructed wetland, the types of fillers, dosage ratio, particle size and filling height of fillers in each layer are specifically selected. Therefore, heavy metal adsorption, suspended matter filtration, organic matter degradation, dephosphorization and denitrification can be effectively realized in the multi-stage inflow constructed wetland.

Abstract: A method of increasing terpenoid production in a host cell that produces one or more terpenoids, comprising: a) providing a host cell that produces one or more terpenoids, said host cell comprising a vector comprising a polynucleotide sequence encoding a terpene synthase enzyme; b) modifying the vector to: i. introduce an inducible promoter operably linked to the polynucleotide sequence encoding the terpene synthase enzyme; and ii. introduce a polynucleotide sequence encoding a ribosomal binding site (RBS) that increases translation initiation rate of the terpenoid compared to a wild type ribosomal binding site; c) determining the dosage of an inducer capable of inducing the inducible promoter; d) culturing the host cell in a culture medium in the presence of the inducer at the dosage determined from step c); and e) isolating the terpenoid from the culture medium.

Abstract: Disclosed are novel methods for the therapeutic treatment of cancer and angiogenesis. The enzyme Ape1/Ref-1, via its redox function, enhances the DNA binding activity of transcription factors that are associated with the progression of cancer. The present disclosure describes the use of agents to selectively inhibit the redox function of Ape1/Ref-1 and thereby reduce tumor cell growth, survival, migration and metastasis. In addition, Ape1/Ref-1 inhibitory activity is shown to augment the therapeutic effects of other therapeutics and protect normal cells against toxicity. Further, Ape1/Ref-1 inhibition is shown to decrease angiogenesis, for use in the treatment of cancer as well other pathologic conditions of which altered angiogenesis is a component.

Abstract: Methods for making metastable lead-free piezoelectric materials are presented herein.

Abstract: Nanostructured carbide chemical compound is used to convert carbide to carbon. A method comprising: providing at least one carbide chemical compound and reducing a metal cation with use of the carbide chemical compound to form elemental carbon, wherein the carbide chemical compound is nanostructured. The nanostructured carbide chemical compound can be in the form of a nanoparticle, a nanowire, a nanotube, a nanofilm, a nanoline. The reactant can be a metal salt. Electrochemical reaction, or reaction in the melt or in solution, can be used to form the carbon. The nanostructured carbide chemical compound can be an electrode.

Abstract: A method for synchronous control of a gantry mechanism with online inertia matching is applicable to a machine tool equipped with a gantry mechanism. The gantry mechanism includes two rails, a crossbeam and a saddle, in which the saddle is disposed on the crossbeam, and the crossbeam is disposed by crossing the two rails. Each of the two rails is furnished with a driving apparatus for synchronously driving the crossbeam, and the driving apparatus includes a drive motor and a lead screw. This method includes the steps of: obtaining gantry-mechanism information; detecting position information of the saddle on the crossbeam; evaluating the position information and the gantry-mechanism information to derive load-inertia variety information; and, evaluating the load-inertia variety information to adjust torque-output information of the drive motor corresponding to the respective driving apparatus.

Abstract: Provided is a method and apparatus that may control a configuration and operation of a network including a base station to support a multicast and broadcast multimedia service in a cellular system and may control an operation of a terminal and the like, and thus, may effectively provide a multimedia service in the cellular system.