Abstract: A magnetic microparticle drug carrier comprising mesoporous iron oxide is described. The drug carrier has an average diameter in a range of 0.5-1.2 ?m, a BET surface area ranging from 50-300 m2/g, and a pore volume ranging from 0.15-0.65 cm3/g. The drug carrier is made using a hard mesoporous silica template which is completely removed from the deposited iron oxide. The drug carrier may be loaded with high amounts of hydrophilic anticancer chemotherapeutic drugs and/or hydrophobic hormonal anticancer drugs, and released in a pH-controlled manner inside cancerous cells. Compared to free drugs, the drug microparticle carrier displays enhanced drug accumulation inside tumor tissues, deeply penetrates into a tumor region and kills the tumor cells inside. The designed carriers described here entrap and release different kinds of anticancer drugs in a controlled manner for synergistic combinatorial chemo/hormonal cancer therapy.

Abstract: Provided is a bio-signal detection and stimulation device. The bio-signal detection and stimulation device includes a flexible substrate, a stimulation part on the flexible substrate, and a detection electrode part on the flexible substrate. The stimulation part and the detection electrode part vertically overlap each other, the stimulation part includes an organic light emitting diode (OLED), the stimulation part emits an optical signal, and the detection electrode part detects a bio-signal.

Abstract: A method for controlling an ego agent includes periodically receiving policy information comprising a spatial environment observation and a current state of the ego agent. The method also includes selecting, for each received policy information, a low-level policy from a number of low-level policies. The low-level policy may be selected based on a high-level policy. The method further includes controlling an action of the ego agent based on the selected low-level policy.

Abstract: An enriched population of connective tissue cells that are capable of anchorage-independent growth are provided. Compositions comprising those cells, as well as methods of producing those cells are also provided.

Abstract: The invention generally relates to engineered prephenate dehydrogenases and arogenate dehydrogenases and methods of using the same. More specifically, the invention relates in part to compositions including engineered prephenate dehydrogenases (PDH) polypeptides and engineered arogenate dehydrogenase (ADH) polypeptides with altered substrate preferences and tyrosine sensitivities and methods of using the same.

Abstract: Embodiments of the present disclosure describe an efficient O(n log n) method that implements the Inverse Chirp Z-Transform (ICZT). This transform is the inverse of the well-known forward Chirp Z-Transform (CZT), which generalizes the fast Fourier transform (FFT) by allowing the sampling points to fall on a logarithmic spiral contour instead of the unit circle. Thus, the ICZT can be viewed as a generalization of the inverse fast Fourier transform (IFFT).

Abstract: Systems and processes for dehydrogenating one or more alkanes using electrically heated dehydrogenation reactors. The source of electric energy or power can be a power grid, solar panel, windmill, hydropower, nuclear power, fuel cell, gas turbines, steam turbines, portable generator or the like. The systems and processes provided herein result in a simpler dehydrogenation process which is particularly beneficial at a small scale and at remote locations, including the well site.

Abstract: A matrix resin composition for fiber reinforced composite materials is described. The resin is thermosetting and achieves a glass transition temperature of at least 177° C. (Tg), obtained by curing under anaerobic conditions at room temperature. The matrix resin will streamline composite fabrication processes by eliminating the need for heating during the cure process. The implications of this development are significant in terms of the ease of use and elimination of procedural steps. While the resin system was developed specifically for vacuum bagging, it is expected to be viable for other composite fabrication methods including resin transfer molding (RTM) and vacuum-assisted resin transfer molding (VARTM). The resin system is viable for use with carbon fiber reinforcements to fabricate laminates at least 0.20 inches thick. The resulting laminates have low porosity and mechanical properties equivalent to those prepared with common epoxy matrix resins.

Abstract: A method can apply permutation procedures to mediation and moderation tests of multiple hypotheses, while controlling the rate of false positives. The techniques presented here through a platform-independent tool can be applied to a variety of datasets in diverse and interdisciplinary fields, such as biology and medicine, where integration of multi-scale data is utilized to unmask disease diagnosis, prognosis, susceptibility/resilience, treatment optimization, and biopharmaceutical development for any brain-based, psychological, or medical illness. This platform allows for study of human illness where animal models are proving inadequate.

Abstract: The present disclosure provides inhibitors of bunyavirus of the formula: wherein the variables are defined herein.

Abstract: A laparoscopic surgery support system can include a plurality of ports configured to receive a trocar therethrough and a plurality of arms connecting the plurality of ports together and configured to allow fixation of a relative position of the plurality of ports. For example, the plurality of ports can include three or more ports.

Abstract: A method includes capturing a two-dimensional (2D) image of an environment adjacent to an ego vehicle, the environment includes at least a dynamic object and a static object. The method also includes generating, via a depth estimation network, a depth map of the environment based on the 2D image, an accuracy of a depth estimate for the dynamic object in the depth map is greater than an accuracy of a depth estimate for the static object in the depth map. The method further includes generating a three-dimensional (3D) estimate of the environment based on the depth map and identifying a location of the dynamic object in the 3D estimate. The method additionally includes controlling an action of the ego vehicle based on the identified location.

Abstract: A method for monocular depth/pose estimation in a camera agnostic network is described. The method includes training a monocular depth model and a monocular pose model to learn monocular depth estimation and monocular pose estimation based on a target image and context images from monocular video captured by the camera agnostic network. The method also includes lifting 3D points from image pixels of the target image according to the context images. The method further includes projecting the lifted 3D points onto an image plane according to a predicted ray vector based on the monocular depth model, the monocular pose model, and a camera center of the camera agnostic network. The method also includes predicting a warped target image from a predicted depth map of the monocular depth model, a ray surface of the predicted ray vector, and a projection of the lifted 3D points according to the camera agnostic network.

Abstract: Volumetric muscle loss (VML) injuries characterized by critical loss of skeletal muscle tissues result in severe functional impairment. Current treatments involving use of muscle grafts are limited by tissue availability and donor site morbidity. The present application relates to methods and composition matters for skeletal muscle healing and regeneration for a patient with volumetric muscle loss using a glycosaminoglycan-based hydrogel, wherein said hydrogel for skeletal muscle regeneration comprises functionalized hyaluronic acid (HA), functionalized chondroitin sulfate (CS) and poly(ethylene glycol) diacrylate (PEGDA), wherein said HA and said CS are cross-linked by said PEGDA.

Abstract: Disclosed herein are an apparatus and method for evaluating a human motion using a mobile robot. The method may include identifying the exercise motion of a user by analyzing an image of the entire body of the user captured using a camera installed in the mobile robot, evaluating the pose of the user by comparing the standard pose of the identified exercise motion with images of the entire body of the user captured by the camera of the mobile robot from two or more target locations, and comprehensively evaluating the exercise motion of the user based on the pose evaluation information of the user from each of the two or more target locations.

Abstract: Systems and methods for scenario marker infrastructure are disclosed. In one embodiment, a method comprises receiving driving scenario data, extracting simulated sensor data from the driving scenario data, extracting scenario markers from the driving scenario data, inputting the simulated sensor data into autonomous driving software, receiving driving instructions output by the driving software, updating a driving status of the autonomous vehicle based on the driving instructions output by the autonomous driving software, creating a simulation log comprising the simulated sensor data and the driving instructions, and inserting the scenario markers into the simulation log.

Abstract: The present disclosure relates to a group of peptide compounds and their use in identifying molecules that stimulate proteasome or immunoproteasome are disclosed herein. Composition matters and methods of uses are within the scope of this disclosure.

Abstract: Provided herein are methods and compositions for expressing Otoferlin, e.g., utilizing adeno-associated viral (AAV) particles. Further provided herein are compositions of AAV particles comprising one or more polynucleotides encoding Otoferlin are codon optimized for expression in human cells. Such methods and compositions may be useful for treatment of diseases and disorders such as Deafness, Autosomal Recessive 9 (DFNB9). Also provided are kits comprising such compositions.

Abstract: The present invention relates to a method for fabrication of a three-dimensional lung organoid comprising human stem cell-derived alveolar macrophages. Specifically, a lung organoid is fabricated by co-culturing cells not expressing the definitive endoderm marker CRCX4 according to a fabrication method of the present disclosure. The lung organoid comprises type 1 and type 2 alveolar epithelial cells as well as alveolar macrophages and realizes infectious or inflammatory responses unlike conventional lung organoids that contain no immune cells and as such, can be advantageously used in studying mechanisms of related lung diseases, excavating biomarkers, developing therapeutic agents, and so on.

Abstract: A composition that includes procyanidins for use in the prevention or treatment of endothelial inflammation and/or endothelial systemic dysfunction triggered by Corona virus disease 2019 (COVID-19) including for use in treating symptomatic post-COVID-19 subjects recovering from COVID-19.