Abstract: A hydrophilic intraocular lens (IOL) with high refractive index comprising at least one copolymer comprising: ((a) a first monomeric subunit comprising (i) a polymerized (meth)acrylate group and an aliphatic carbon moiety comprising at least two hydroxyl substituents or (ii) a polymerized (meth)acrylamide group, (b) a second monomeric subunit different from the first monomeric subunit comprising a polymerized (meth)acrylate group, at least one side group comprising (i) an aryloxy moiety comprising at least one halogen, and (ii) an aliphatic carbon moiety linking the aryloxy moiety with the polymerized (meth)acrylate group, wherein the aliphatic carbon moiety comprises optionally at least one hydroxyl substituent, (c) a third monomeric subunit different from the first and second monomeric subunits comprising a polymerized (meth)acrylate group and at least one alkoxyalkoxyalkyl side group.

Abstract: A key unit that locks and unlocks a target by transmitting a signal to a locking and unlocking device, includes: a substrate on which a power supply circuit and a reception circuit that receives a request signal transmitted in a first frequency band from the locking and unlocking device via a reception antenna are mounted; and a housing configured to accommodate the substrate. Among parts associated with the power supply circuit, a part having the highest height from a substrate surface is mounted on a first surface of the substrate. The reception antenna is mounted on a second surface. When the substrate is accommodated in the housing, a distance from a substrate surface of the second surface to an inner surface of the housing is shorter than a distance from the substrate surface of the first surface to the inner surface of the housing.

Abstract: A mechanical timepiece oscillator including, between a first element and a second inertial element, more than two distinct flexible strips returning the inertial element to a rest position in an oscillation plane, wherein the projections of these strips cross each other, at a point, through which passes the axis of pivoting of the second solid inertial element, and the height to thickness aspect ratio is less than 10 for each strip.

Abstract: A method for certified control of a self-driving ego vehicle is described. The method includes analyzing a safety situation of the self-driving ego vehicle to determine a proposed vehicle control action using a main controller of the self-driving ego vehicle. The method also includes presenting, by the main controller, the proposed vehicle control action to an interlock controller, including a certificate of the proposed vehicle control action. The method further includes checking a safety certification evidence from the certificate by the interlock controller using a predefined safety argument to verify the safety certification evidence of the certificate. The method also includes directing, by a low-level controller, the self-driving ego vehicle to perform a certified vehicle control action.

Abstract: An operation method of robot operating system and a robot control method are provided in this invention. The operation method of robot operating system includes steps of: monitoring an operating state of the Linux kernel through the security kernel when the security kernel and the Linux kernel of the robot operating system are both started; and hosting the Linux kernel through the security kernel when the Linux kernel runs abnormally or crashes. The technical scheme of the present invention is able to improve stability and safety of the robot operation.

Abstract: A quantum simulator includes a pseudo speckle pattern generator, a main vacuum chamber, an atomic gas supply unit, a light beam generator, a photodetector, and an atom number detector. The pseudo speckle pattern generator generates a pseudo speckle pattern in the inside of the main vacuum chamber by light allowed to enter the inside of the main vacuum chamber through the second window. The pseudo speckle pattern generator includes a controller, a light source, a beam expander, a spatial light modulator, and a lens. The controller sets a modulation distribution of the spatial light modulator based on a two-dimensional pseudo random number pattern.

Abstract: Embodiments provide a system and method for extracting configuration-related information for reasoning about the security and functionality of a composed system. During operation, the system determines, by a computing device, information sources associated with hardware and software components of a system, wherein the information sources include at least specification sheets, standard operating procedures, user manuals, and vulnerability databases. The system selects a set of categories of vulnerabilities in a vulnerability database, and ingests the information sources to obtain data in a normalized format. The system extracts, from the ingested information sources, configuration information, vulnerability information, dependency information, and functionality requirements to create a model for the system.

Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Abstract: The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoic acid derivative.

Abstract: Provided is a forming method of a metal layer suitable for a 3D printing process. The method includes the steps of (1) providing first metal particles on a substrate to form a first layer; (2) performing a first pre-heat treatment on the first layer; (3) applying an oxide-removing agent on selected first metal particles in the first layer to remove metal oxides; (4) providing second metal particles on the first layer to form a second layer; (5) performing a second pre-heat treatment on the second layer; (6) applying the oxide-removing agent on selected second metal particles in the second layer to remove metal oxides; repeating (1) to (6) until a latent part is formed; performing a first heat treatment on the first and second metal particles of the latent part to form a near shape; and performing a second heat treatment on the near shape to form a sintered body.

Abstract: Embodiments provide a system and method for constructing a graph-based model for optimizing the security posture of a composed system. During operation, the system constructs a multi-layer graph for a system with a plurality of components, wherein the multi-layer graph comprises a configuration subgraph, a vulnerability subgraph, and a dependency subgraph. The system constructs the multi-layer graph by the following. The system generates nodes in the configuration subgraph, including: nodes in a first class which encode information associated with a configuration parameter for a respective component, wherein the encoded information includes a name, a default value, a range of values, and a data type; and nodes in a second class which encode value assignments for configuration parameters and relationships between configuration parameters. The system generates nodes in the vulnerability subgraph based on known vulnerabilities associated with a component, bad security practices, and best security practices.

Abstract: Disclosed are an intelligent bionic human body part model detection device and a method for manufacturing same. The device comprises: a bionic human body part model (1); and multiple optical fiber grating sensing units (5) which are integrated on an optical fibre and arranged at multiple pre-determined positions of the bionic human body part model (1). The device can improve the accuracy of the detection of pressure applied to the intelligent bionic human body part model.

Abstract: The present disclosure relates to an enzyme complex of arabinose isomerase, agarase and 3,6-anhydro galactosidase and a method for producing tagatose by degrading agar using the same. By using the enzyme complex according to the present disclosure, agar obtained from marine biomass can be degraded effectively and useful physiologically active substances such as tagatose can be obtained effectively therefrom.

Abstract: A method and system for removing ground clutter data from time series radar data are provided. The method comprises receiving the time series radar data, applying a clutter filter to the time series radar data to generate a filtered time series radar data, applying a discrete Fourier transform to the filtered time series radar data to generate a filtered frequency domain data, determining a filter bias for one or more filter biased frequency domain frequencies of the filtered frequency domain data based on a frequency response of the clutter filter, and correcting the filtered frequency domain data by adding the filter bias to the filtered frequency domain data at the one or more filter biased frequency domain frequencies to generate a filtered and bias corrected frequency domain data.

Abstract: In aspect, the disclosure includes a method of configuring a MIMO wideband receiver. The method would include estimating, on a SISO basis, a set of post-processing parameters for a plurality of receiver channels; receiving, by each of the plurality of receiver channels, a first test signal which is transmitted from a first transmitter channel on a MIMO basis; calculating a first set of crosstalk parameters in response to receiving the first test signal; receiving, by each of the plurality of receiver channels, a second test signal which is transmitted from a second transmitter channel on the MIMO basis; calculating a second set of crosstalk parameters in response to receiving second test signal; and calculating the set of post-processing parameters based on the first set of crosstalk parameters and the second set of crosstalk parameters by cancelling a crosstalk interference among plurality of receiver channels.

Abstract: Provided is a composition for the treatment of diarrheal disease, comprising a polyphenol-rich extract of a mixture of 80-20% by weight of blueberry or bilberry from Vaccinium cyanococcus spp., Vaccinium myrtillis spp., or both; and 20-80% by weight of sloe berry from Prunus spinosa spp. Other compositions, and methods of making and using the compositions for the treatment of diarrheal disease are disclosed.

Abstract: Provided is an apparatus and method for wideband short-range wireless communication using a directional antenna in a millimeter wave band, and the method for wideband short-range wireless communication according to an embodiment may determine a first time interval and a second time interval for a cooperated data frame transfer based on a packet transmission time at each transmission from a source node to a destination node, transmit a frame to a relay node through an antenna pattern directed towards the relay node at a start point of the first time interval, and transmit the frame to the destination node through an antenna pattern directed towards the destination node after a predetermined period of time from a start point of the second time interval.

Abstract: Provided is a polynucleotide, including a cis-regulatory element and a nucleotide sequence encoding a vestigial like 4 protein, wherein the cis-regulatory element includes an uncoupling protein 1 enhancer and an uncoupling protein 1 promoter. Also provided is a viral vector including said polynucleotide. Also provided is a method of transfecting a cell or a subject with said polynucleotide or said viral vector.

Abstract: Various methods and devices for spatial molecular analysis from tissue is provided. For example, a method of spatially mapping a tissue sample is provided with a microarray having a plurality of wells, wherein adjacent wells are separated by a shearing surface; overlaying said microarray with a tissue sample; applying a deformable substrate to an upper surface of said tissue sample; applying a force to the deformable substrate, thereby forcing underlying tissue sample into the plurality of wells; shearing the tissue sample along the shearing surface into a plurality of tissue sample islands, with each unique tissue sample island positioned in a unique well; and imaging or quantifying said plurality of tissue sample islands, thereby generating a spatial map of said tissue sample. The imaging and/or quantifying may use a nucleic acid amplification technique.

Abstract: The invention relates to a nucleic acid construct for bi-allelic conditional modification of a target gene and methods of use thereof.