Abstract: This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their synthetic precursors, R-isomers, and non-hydroxylated and/or non-chiral propanamides, and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: The present disclosure relates to a chromium-aluminum binary alloy with excellent corrosion resistance and a method of producing the same, and more particularly to a chromium-aluminum binary alloy with excellent corrosion resistance. The chromium-aluminum binary alloy may be easily produced and has ductility, thus being highly applicable as a coating material for a material requiring high-temperature corrosion resistance and wear resistance.

Abstract: The present invention relates to a time-resolved fluorescent immunochromatographic assay rapid test kit for quantitative determination of the level of type I pyrethroid, which has the advantages of simple operation, rapid detection, and with high accuracy. The kit has a quantitative detection limit of 9.12 ng/mL for a type I pyrethroid sample. When the kit is applied to the detection of an actual sample of type I pyrethroid and by comparing the detection result obtained by HPLC, the kit has a coefficient of correlation of 0.986 (R2). Hence, the kit is applicable to the detection by using the actual samples of type I pyrethroid.

Abstract: This invention is directed to selective androgen receptor degrader (SARD) compounds pharmaceutical compositions and uses thereof in treating early prostate cancer, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: A catalytic cracking process includes the following steps: i) subjecting a heavy feedstock oil to flail catalytic cracking; ii) separating the catalytic cracking reaction product obtained from step i) to obtain a catalytic cracking gasoline and a catalytic cracking light cycle oil; iii) splitting the catalytic cracking gasoline to obtain a light gasoline fraction, a medium gasoline fraction and a heavy gasoline fraction; iv) subjecting the catalytic cracking light cycle oil to hydrogenation to obtain a hydrogenated light cycle oil); v) mixing a portion of the light gasoline fraction with at least a portion of the hydrogenated light cycle oil to obtain a mixed fraction; vi) subjecting the mixed fraction to catalytic cracking; and vii) subjecting a portion of the medium gasoline fraction to flail catalytic cracking. The process is capable of producing more catalytic cracking gasoline, reducing the olefin content of the catalytic cracking gasoline, and increasing its octane number.

Abstract: An upper plasma-exclusion-zone ring for a bevel etcher is provided that is configured to etch a bevel edge of a substrate. The upper plasma-exclusion-zone ring includes a ring-shaped body and a radially-inner stepped surface. The ring-shaped body of the upper plasma-exclusion-zone ring defines an upper surface, a lower surface, a radially inner surface, and a radially outer surface. The radially-inner stepped surface of the upper plasma-exclusion-zone ring extends inwardly into the ring-shaped body between the radially inner surface of the ring-shaped body and the lower surface of the ring-shaped body. The ring-shaped body is made of a material selected from a group consisting of aluminum oxide, aluminum nitride, silicon, silicon carbide, silicon nitride, and yttria.

Abstract: Example embodiments provide real time quality monitoring of a magnetic resonance imaging (MRI) scan. Data associated with an MRI scan of a particular patient is received. The data is sequential MRI data associated with various times. A rate of change of the sequential data is determined with reference to the various times. It is determined whether the rate of change of the sequential data meets a first configurable threshold. It is determined whether the rate of change of the sequential data meets a second configurable threshold. The sequential data is classified based on whether the rate of change of the sequential data meets the first and second configurable thresholds.

Abstract: A semiconductor device includes a gate electrode extending in a first direction on a substrate, a first active pattern extending in a second direction intersecting the first direction on the substrate to penetrate the gate electrode, the first active pattern including germanium, an epitaxial pattern on a side wall of the gate electrode, a first semiconductor oxide layer between the first active pattern and the gate electrode, and including a first semiconductor material, and a second semiconductor oxide layer between the gate electrode and the epitaxial pattern, and including a second semiconductor material. A concentration of germanium of the first semiconductor material may be less than a concentration of germanium of the first active pattern, and the concentration of germanium of the first semiconductor material may be different from a concentration of germanium of the second semiconductor material.

Abstract: Methods and systems for imaging precision ellipsometry of a sample are provided. The method includes shining a source of linearly polarised light on a surface of the sample wherein light reflected off the surface of the sample has elliptic polarisation. The method further includes converting polarisation of the light reflected off the surface of the sample into linear polarisation suitable for a polarisation modulator by a retarder and oscillating a polarisation modulator to measure the polarisation rotation of the polarised light passing through the retarder. In addition, the method includes synchronising acquisition of images of the light from the retarder with oscillations of the polarisation modulator to acquire first array images during positive half-periods of oscillations of the polarisation modulator and to acquire second array images during negative half-periods of the oscillations of the polarisation modulator.

Abstract: The floating-type contamination measurement apparatus according to embodiments of the present invention can provide a body part; a buoyancy providing part, which is received to the body part and provides buoyancy to the body part; and a measurement part, which is received to the body part and measures the level of contamination in a closed space.

Abstract: Systems and methods for quantitatively optimizing the design of prosthetic sockets are disclosed herein. An example method may involve receiving data indicating a first prosthetic socket design for a first patient and data associated with the first patient. The example method may also involve receiving data indicating a structure of an second prosthetic socket design for a second patient and data associated with the second patient. The example method may also involve determining, based on the data associated with the first patient, the data indicating the structure of the optimized prosthetic socket for the second patient, and the data associated with the second patient, an third prosthetic socket design for the first patient. The example method may also involve providing, based on the third prosthetic socket design for the first patient, an output indicating an area of the first prosthetic socket design to add or remove material.

Abstract: This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding VSV polypeptides, methods for making vesicular stomatitis viruses, and methods for using vesicular stomatitis viruses to treat cancer are provided.

Abstract: Compositions comprising nanoparticles are described herein. At least a portion of the nanoparticles comprises a lipid and/or polymer which is water-insoluble, and an agent incorporated in the lipid and/or polymer. The nanoparticles are optionally associated with a surface of water-soluble particles which comprise a water-soluble compound. The polymer is optionally a polyanhydride. Further described herein are processes for preparing such compositions, comprising contacting a solution comprising the lipid and/or polymer dissolved in a non-aqueous solvent with an anti-solvent (in which the lipid and/or polymer and agent are insoluble) which is miscible with the non-aqueous solvent. Further described herein are uses of the compositions for nasal administration, and devices configured for nasal administration of the composition upon atomization.

Abstract: Systems and methods for tuning a digital screen to provide high quality data are provided. Methods include determining a target level of participant data quality associated with accurate completion of an online survey, determining a participant screening threshold based on the target level of participant data quality, and adjusting a survey screen based on the participant screening threshold. Methods may achieve high data quality without sacrificing participant diversity. Methods may also include transmitting the survey screen to a computing device associated with a participant, and receiving a response of the participant to the survey screen on the computing device. When the response fails to achieve a predetermined threshold response, methods may include rejecting the participant from the survey.

Abstract: A wastewater treatment system may use recycle water to apply an anaerobic ammonium oxidation (ANAMMOX) process to a water treatment process (mainstream treatment process) and to stably supply nitrite required for an ANAMMOX. By applying the ANAMMOX process, nitrogen and phosphorus may be simultaneously treated in the water treatment process, and recycle water may be used as a source of nitrite for ANAMMOX, thereby reducing wastewater treatment costs and pollutant loading.

Abstract: This document features methods of evaluating mammals by assessing expression of B7-H1 in a body fluid.

Abstract: Fatty acids, and methods for the production thereof, are provided. Transgenic organisms, microbes, plants, seeds, and cells useful in the production of fatty acids, along with related expression vectors, phages, plasmids, nucleic acids, and enzymes, are also provided. Methods for the production of fatty acids such as docosadienoic acid and docosatrienoic acid, involving the use of winter aconite (Eranthis hyemalis) EhELO1 elongase, are described in detail.

Abstract: The present disclosure is directed to a diode including a first doped structure, doped with a first type of material and forming at least part of an isolation structure for the diode; at least one contact structure located within the first doped structure, the at least one contact structure forming one of the cathode or anode of the diode; a second doped structure, doped with a second type of material, and forming at least one depletion region or PN junction with the first doped structure; at least one second contact structure located within the second doped structure, the at least one second contact structure forming the other of the anode or the cathode of the diode; at least one further contact structure, doped with the first type of material, the at least one further contact structure forming at least one further depletion region or further PN junction, such that the at least one further depletion region is configured to steer charge from the at least one depletion region and thus decrease the sensitivity

Abstract: A well plate for measuring an analyte in a sample is disclosed. The well plate includes at least a first, a second, and a third electrode. The first electrode has a higher sensitivity to a first analyte than the second and third electrodes. The second electrode has a higher sensitivity to a second analyte than the first and third electrodes.

Abstract: A method for indexing network camera data across heterogeneous web page structures is disclosed, which includes receiving a list of predetermined file formats, generating a list of IP network camera IP addresses, sending requests to each of the IP addresses, including transmitting a HTTP request to each IP address in the list, based on a response or lack thereof determine if an IP address is i) a network camera thereby adding the IP address to a list of network cameras, ii) a website thereby adding the IP address to a list of websites to be further investigated, or iii) an address void of network camera information thereby skipping the IP address, and crawling the IP addresses that have been determined to be websites using a web crawler identifying IP addresses of network cameras and resource path associated therewith and adding the same to the list of network cameras.