Abstract: This disclosure relates to compositions for use in treatment of Alzheimer's Disease, and/or a ocular and retinal degenerative disease, such as age related macular degeneration. The described compositions include effective amounts of LLMe, the hydrobromide form thereof, or functional derivatives thereof. Methods of treatment of a retinal degenerative disease of Alzheimer's Disease using the described compositions are also provided.

Abstract: Disclosed are molecules for treating non-del(5q) MDS that mimic allelic deficiency in del5q MDS to sensitize the malignant clones of patient without del(5q). The disclosed molecule contains an inhibitor of Cdc25C, an inhibitor of PP2Ac?, or a combination thereof, and a toll like receptor-9 (TLR9) targeting ligand. The molecule can also contain lenalidomide, or an analogue or derivative thereof. Also disclosed is a composition comprising the disclosed molecule in a pharmaceutically acceptable carrier. Also disclosed is a method for treating non-del(5q) meylodysplastic syndrome (MDS) in a subject by administering to the subject a therapeutically effective amount of the disclosed pharmaceutical composition.

Abstract: Methods and systems to improve printed electrical components and for integration in circuits are disclosed. Passive components, e.g., capacitors, resistors and inductors, can be printed directly into a solid ceramic block using additive manufacturing. A grounded conductive plane or a conductive cage may be placed between adjacent electrical components, or around each component, to minimize unwanted parasitic effects in the circuits, such as, e.g., parasitic capacitance or parasitic inductance. Resistors may be printed in non-traditional shapes, for example, S-shape, smooth S-shape, U-shape, V-shape, Z-shape, zigzag-shape, and any other acceptable alternative configurations. The flexibility in shapes and sizes of the printed resistors allows optimal space usage of the ceramic block. The present invention also discloses an electrical component comprising combined predetermined values of capacitance, resistance and inductance.

Abstract: A method is provided for recommending a desired func sequence schedule to a user. The method includes obtaining at least one user intention inputted by the user; creating a func sequence including a plurality of funcs for fulfilling the user intention; and determining user preference on scheduling of the plurality of funcs in the func sequence. The method also includes determining a dependency relationship among the plurality of funcs in the func sequence; and determining scheduling constraints to the scheduling of the plurality of funcs in the func sequence. The method further includes, based on the user preference, the dependency relationship, and the scheduling constraints, performing an optimization process to determine a desired schedule for the plurality of funcs in the func sequence to fulfill the user intention; and recommending the func sequence with the desired schedule to the user.

Abstract: An operation method of a transmitting apparatus in a multi-connection based mobile communication system includes generating combined data by combining data and an extended information element (IE), when the data received from a serving gate way (SGW) or a core network is determined to be transmitted to a receiving apparatus; transmitting the combined data to the receiving apparatus; and receiving, from the receiving apparatus, feedback information indicating whether or not the receiving apparatus normally receives the combined data.

Abstract: Methods of and apparatuses for processing substrates having carbon-containing material using atomic layer etch and selective deposition are provided. Methods involve exposing a carbon-containing material on a substrate to an oxidant and igniting a first plasma to modify a surface of the substrate and exposing the modified surface to a second plasma at a bias power to remove the modified surface. Methods also involve selectively depositing a second carbon-containing material onto the substrate using a precursor having a chemical formula of CxHy, where x and y are integers greater than or equal to 1. ALE and selective deposition may be performed without breaking vacuum.

Abstract: The invention relates to a compound of Formula (I): Formula (I), or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.

Abstract: We describe the use of comparative structural analysis and structure-guided molecular design to develop potent and selective inhibitors (10d and (S)-17b) of matrix metalloproteinase 13 (MMP-13). We applied a three-step process, starting with a comparative analysis of the X-ray crystallographic structure of compound 5 in complex with MMP-13 with published structures of known MMP-13 inhibitor complexes followed by molecular design and synthesis of potent, but non-selective zinc-chelating MMP inhibitors (e.g., 10a and 10b). After demonstrating that the pharmacophores of the chelating inhibitors (S)-10a, (R)-10a, and 10b were binding within the MMP-13 active site, the Zn2+ chelating unit was replaced with non-chelating polar residues that bridged over the Zn2+ binding site and reach into a solvent accessible area.

Abstract: Provided are a system and method for providing a microservice-based device control interface. The system for providing a microservice-based device control interface includes a Docker registry server in which resources required for providing a device control interface are located and a gateway which receives and installs resources and provides a device control interface using a Docker-based microservice structure.

Abstract: A method for marking adventitious sounds is provided. The method includes: receiving a lung sound signal generated by a sensor from a chest cavity sound signal; capturing a lung sound signal segment from the lung sound signal every sampling time interval; converting the lung sound signal segments into spectrograms; inputting the spectrograms into a recognition model to determine whether the spectrograms include adventitious sounds; obtaining time points of occurrence corresponding to the adventitious sounds according to abnormal spectrograms including the adventitious sounds, and the number of occurrences of the adventitious sounds corresponding to the time points; and marking an adventitious sound signal segment having the highest probability of occurrence of the adventitious sound in the lung sound signal according to the time points and the number of occurrences.

Abstract: A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.

Abstract: A single volume soft sensor capable of sensing real-time continuous contact and stretching. A low-cost and an easy method to fabricate such piezoresistive elastomer-based soft sensors for instant interactions is also provided. An electrical impedance tomography (EIT) technique is employed to estimate changes of resistance distribution on the sensor caused by fingertip contact. To compensate for the rebound elasticity of the elastomer and achieve real-time contact sensing, an adaptive baseline update for EIT is utilized. The baseline updates are triggered by fingertip contact and movement detections.

Abstract: Disclosed are a system for and a method of manufacturing a three-dimensional (3D) structure. The method may include injecting a fluid with a first pressure toward a surface of a first output layer to form a softening layer in the first output layer, injecting the fluid with a second pressure toward the softening layer to form an uneven structure in the softening layer, the second pressure being higher than the first pressure, and forming a second output layer on the softening layer with the uneven structure.

Abstract: The invention relates to an ELABELA polypeptide or nucleic acid for use in the treatment, alleviation or prophylaxis of pre-eclampsia in an individual. In another aspect of the invention, there is provided a method of diagnosing or detecting the susceptibility of an individual to pre-eclampsia, wherein the method comprises detecting modulation, preferably down-regulation of expression, amount or activity of ELABELA.

Abstract: The present disclosure generally relates to layer-wise agglomerated controlled release granular urea composition and methods of making and using the layer-wise agglomerated controlled release granular urea composition. In a particular composition, the water-soluble plant nutrient comprises urea, the binding material for the core comprises corn starch, the hydrogel for the coating layer comprises corn starch hydrogel, the core has a thickness of 2.5-3.5 mm and a closed porosity of 0.05-3%, and the coating layer has a thickness of 1.35-1.5 mm and a closed porosity of 0.1-5%.

Abstract: Compositions and methods for producing modified AAV Cap genes and combinatorial libraries of chimeric AAV vectors and virions in an AAV serotype 3 background. Selecting for modified AAV3 virions displaying cell- or tissue-specific tropisms differing from WT AAV3. Using the synthetic combinatorial AAV3 capsid libraries for introducing into a selected target host cells one or more nucleic acid molecules useful in diagnostic and/or therapeutic gene-therapy regimens.

Abstract: The present invention relates to a current sensor which measures alternating electromagnetic wave and a current breaker using the same, and the current sensor for alternating current is characterized in that it includes a sensor part arranged at a separation distance from the power wire through which alternating current is flowing; and a means of detecting alternating current by measuring the electromagnetic wave generated across the above sensor part by the electromotive force induced by the alternating current flowing through the above power wire, and in that the above means of detecting alternating current includes an amplifier.

Abstract: Provided are an optical waveform shaping apparatus and an optical waveform shaping method. According to an embodiment, the optical waveform shaping apparatus includes a multiplexer/demultiplexer(D/MUX) unit demultiplexing an optical signal in which optical signals of a plurality of wavelengths are multiplexed, a micro lens system refracting the demultiplexed optical signal into a collimated beam of light, and a wavelength level controller unit shaping a waveform of the optical signal. The wavelength level controller unit includes a 2D LCoS for adjusting and reflecting an amplitude or a phase value of the demultiplexed optical signal to have a distribution that is desired for each cell, and a controller for controlling the distribution.

Abstract: Embodiments relate to reconfigurable unmanned vehicles (100). Such vehicles (100) comprise a fuselage (102) presenting a bay (118) for receiving a plurality of components (120-128), each of the plurality of components (120-128) relating to a respective entity for at least one of flight control or operation of the unmanned vehicle (100). The bay (118) comprising a bus to support communications between at least two of the plurality of components (120-128), the plurality of components (120-128) comprising a controller to determine a configuration or presence of one or more than one component of the plurality of components (120-128) when coupled to the bus.

Abstract: Methods using idelalisib to treat proliferative vitreoretinopathy and intraocular pathological angiogenesis (e.g., proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and wet age-related macular degeneration (AMD)).