Abstract: Methods and compositions for reducing the risk of cardiovascular, cerebrovascular, or renovascular adverse events are provided. Generally, the methods include administering to a subject taking an NSAID a therapeutically effective amount of a misoprostol compound. The methods can also include administering to a subject in need thereof a therapeutically effective amount of an NSAID and therapeutically effective amount of a misoprostol compound.

Abstract: The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

Abstract: A heterocyclic derivative represented by formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, which has an inhibitory effect on the activation of STAT3 protein, and is useful for the prevention or treatment of diseases associated with the activation of STAT3 protein.

Abstract: A key unit that locks and unlocks a target by transmitting a signal to a locking and unlocking device, includes: a substrate on which a power supply circuit and a reception circuit that receives a request signal transmitted in a first frequency band from the locking and unlocking device via a reception antenna are mounted; and a housing configured to accommodate the substrate. Among parts associated with the power supply circuit, a part having the highest height from a substrate surface is mounted on a first surface of the substrate. The reception antenna is mounted on a second surface. When the substrate is accommodated in the housing, a distance from a substrate surface of the second surface to an inner surface of the housing is shorter than a distance from the substrate surface of the first surface to the inner surface of the housing.

Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.

Abstract: A dual-shaft push-moving varying speed device includes a drive unit; an input shaft, having at least an odd-numbered input gear and at least an even-numbered input gear is coupled with the drive unit; an output shaft, having an end thereof penetrate through the input shaft and the drive unit, and the another end thereof possesses an output gear; a transmission shaft, including at least an odd-numbered output gear, at least an even-numbered output gear, and a transmission gear where the odd-numbered output gear is meshed with the corresponding odd-numbered input gear while the even-numbered output gear is meshed with the corresponding even-numbered input gear, and the transmission gear is meshed with the output gear; and at least a push-moving fork, being furnished between the odd-numbered input gear and the even-numbered input gear, selectively pushes the odd-numbered input gear and the even-numbered input gear to move.

Abstract: A nanosatellite with an illumination element, and an arrangement of nanosatellites in low earth orbit (LEO) arranged to controllably apply their illumination to be visible on the ground. The nanosatellites may be coordinated to provide illumination events visible on the ground at particular locations and particular times.

Abstract: A perpendicularly magnetized spin-orbit magnetic device including a heavy metal layer, a magnetic tunnel junction, a first antiferromagnetic layer, a first block layer and a first stray field applying layer is provided. The magnetic tunnel junction is disposed on the heavy metal layer. The first block layer is disposed between the magnetic tunnel junction and the first antiferromagnetic layer. The first stray field applying layer is disposed between the first antiferromagnetic layer and the first block layer. The first stray field applying layer provides a stray magnetic field parallel to a film plane. The first antiferromagnetic layer contacts the first stray field applying layer to define the direction of the magnetic moment in the first stray field applying layer.

Abstract: A carbon-sulfur composite including a carbon aggregate and sulfur, a method for preparing the same, and a positive electrode and a lithium-sulfur battery including the same.

Abstract: Provided herein are compositions of virus like particles (VLPs) of poliovirus (PV) that have one or more stabilizing mutations that confer a higher degree of thermostability to the N-antigenic form of the VLPs. These VLPs are non-infectious, and thus safer for use in vaccine development and administration to clinical subjects.

Abstract: A key unit includes: a first communication module; a second communication module; an authentication unit configured to perform authentication using authentication information when an operation request including the authentication information has been received via the first communication module; and a control unit configured to perform locking and unlocking with a key in response to the operation request when the authentication using the authentication information has succeeded and to transmit a control signal for performing an operation other than the locking and unlocking with the key to the control device via the second communication module after the authentication.

Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.

Abstract: A method of operating a network coordinator for a spatial reuse scheme includes receiving a reservation request for a time period for a data communication of a target transmitter/receiver pair that uses a directional antenna, searching for a time period reserved in advance for another transmitter/receiver pair, from a Channel Time Allocation Period (CTAP) that is a contention-free access period for the data communication, and reserving a time period for the target transmitter/receiver pair in the CTAP, so that the time period reserved for the target transmitter/receiver pair overlaps the time period reserved in advance for the other transmitter/receiver pair.

Abstract: A system and a method for imaging a surface defect on an object are provided. The system includes an actuator, a sensor assembly connected to the actuator, and a processor configured to control the actuator and the sensor assembly. The sensor assembly includes at least one sensor configured to capture at least one image of the object. The processor is configured to control the actuator and the sensor assembly to identify the actuator and the sensor assembly, a region of a region of interest associated with the surface defect using an using an image of the object and to repeatedly identify at least one subsequent region of interest associated with the surface defect using at least a preceding region of interest such that the surface defect is identified according to a predetermined criterion.

Abstract: In a first aspect, a system for analysing a fluid sample is provided, comprises: a container configured to receive the fluid sample; a first light source optically coupled to the container and configured to project a first light having a first wavelength; a second light source optically coupled to the container and configured to project a second light having a second wavelength different from the first wavelength; one or more photo-sensors optically coupled to the container and configured to analyse the fluid sample in response to a first scattered light generated in response to projecting the fluid sample with the first light source and a second scattered light generated in response to projecting the fluid sample with the second light source. In a preferred embodiment, the nutritious compositions (such as the concentration of fats and protein) of milk samples are identified based on the scattering of the first and second light source by the milk sample.

Abstract: The disclosure relates to the field of fusion proteins. In some aspects, the invention to artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes and uses thereof. In some aspects, the disclosures relates to compounds produced by artificial cytochrome P450 enzymes.

Abstract: The present invention provides a pharmaceutical composition for inhibiting the metastasis of cancer, comprising, as an active ingredient, an antibody that specifically binds to an epidermal growth factor receptor, and a method for inhibiting the metastasis of cancer using the composition. The composition or the method is effective in inhibiting the invasion of various gastric cancer cell lines induced by EGFR ligands. Therefore, the pharmaceutical composition can be usefully used for inhibiting the metastasis of cancer.

Abstract: The present invention relates to a method and an apparatus for processing a signal, which are used to effectively reproduce an audio signal, and more particularly, to a method for generating a filter for an audio signal, which are used for implementing a filtering for input audio signals with a low computational complexity and a parameterization apparatus therefor.

Abstract: An onboard device includes a storage unit configured to store a control program for controlling the onboard device and a communication unit configured to perform data communication with a mobile terminal. The communication unit performs data communication of a rewriting program with the mobile terminal when the communication unit has received a rewriting notification signal indicating rewriting of the control program stored from the mobile terminal and the vehicle is in a chargeable state in which the battery is able to be charged by the power generator. The communication unit does not perform data communication of the rewriting program with the mobile terminal when the vehicle is not in the chargeable state.

Abstract: The present discloser relates to an infrared device using intra-band electron transition of non-stoichiometric quantum dots and, more specifically, to non-stoichiometric quantum dot nanoparticles and an infrared device comprising the nanoparticles, in which the nanoparticles comprise quantum dot cores and nonthiol ligands bonded to the core and emits infrared rays from electron transition between discrete energy levels in the band. The infrared device has an effect of emitting infrared rays, particularly, mid-infrared rays or far-infrared rays, by using the electron transition between discrete energy levels in the band of quantum dots in which the proportion of a metal is higher than that of a chalcogen. In addition, the quantum dots are prepared by containing nonthiol ligands, and thus, compared with a conventional thiol ligand, ligand substitution is very easy while the n-type doping of quantum dots is maintained.