Abstract: Methods of using the small molecule STAT3 inhibitor LLL 12B in the treatment of cancer, such as triple-negative breast cancer (TNBC) and pancreatic cancer, either alone or in combination with additional therapeutic agents, such as PARP inhibitors and CDK inhibitors, are provided.

Abstract: Methods are disclosed for treating inflammatory disease states in a mammalian patient (e.g., human) by applying noninvasive focused ultrasound stimulation to the celiac-superior mesenteric ganglion complex of the patient.

Abstract: Disclosed herein is an apparatus and method for managing a giant model. The apparatus includes memory in which at least one program is recorded and a processor for executing the program. The program may perform lightweighting a first model into a second model in consideration of hardware resources, generating partitioning information of the first model based on a result of analysis of the second model, and performing training or inference for the first model based on the generated partitioning information.

Abstract: Disclosed herein is a method for memory management in a memory disaggregation environment. The method includes generating virtual memory based on multiple first memory devices, determining whether a condition for allocation acceleration is satisfied by the first memory devices, and allocating a memory page to the first memory devices based on whether the condition for allocation acceleration is satisfied.

Abstract: Provided is a sensor module and a manufacturing method of the same. The sensor module includes a substrate having a first region, a second region, and a third region, an insulation layer provided on the substrate, a temperature sensor layer provided in the insulation layer of the first region, a gas sensor layer provided in an upper portion of and inside the insulation layer of the second region adjacent to the temperature sensor layer, and being thicker than the temperature sensor layer, and a sensor module provided on the insulation layer of the third region adjacent to the gas sensor layer, and including a humidity sensor layer thinner than the gas sensor layer.

Abstract: A method of a near-real time controller may comprise: receiving, from a non-real time controller, information on an offline-trained artificial intelligence/machine learning (AI/ML) model; obtaining, from a base station, first data for beam management inference based on the offline-trained AI/ML model; performing beam management inference based on the offline-trained AI/ML model using the first data; and providing a control and policy according to a result of performing the beam management inference to the base station.

Abstract: Provides a flexible copper clad laminate, which includes a polyimide substrate; a nickel-copper alloy layer; and a copper layer. The nickel-copper alloy layer is formed on at least one side of the polyimide substrate by electroless plating and comprises at least nickel, copper and phosphorus. A content of the copper is more than 30 wt % of the nickel-copper alloy layer, a content of the phosphorus is less than 5 wt % of the nickel-copper alloy layer, and a corrosion potential of the nickel-copper alloy layer in a 0.02 vol % sulfuric acid solution is greater than ?20 mV. The copper layer is formed on a side of the nickel-copper alloy layer away from the polyimide substrate and combined with the nickel-copper alloy layer to form a metal conductive layer. In addition, the aforementioned flexible copper clad laminate has electrochemical corrosion resistance and sufficient peel strength, facilitating the production of flexible printed circuit boards.

Abstract: The following disclosure relates to a method of detecting an anomaly in log data and includes obtaining first log data by collecting log data from a database and processing the log data in a time axis through a log data manager, reconstructing the first log data into second log data through a transformer, calculating an anomaly score of each time point through the transformer based on a difference between the first log data and the second log data, and detecting an anomaly for each time point through an anomaly detector based on the anomaly score.

Abstract: Methods and compositions for treating multiple sclerosis using dendritic cell anti-ASGPR antibodies fused to myelin basic protein or myelin oligodendrocyte glycoprotein are provided.

Abstract: The present disclosure relates to a photoresist composition including a tin-oxo cluster, an oxidizing agent, and a polar organic solvent in which when irradiated with ultraviolet, bonds constituting the cluster are broken to form cross-linking between the clusters

Abstract: An operation method of a terminal in a communication system may comprise: receiving downlink control information (DCI) for scheduling uplink transmission from a base station; identifying a communication node initiating a channel occupancy time associated with the uplink transmission based on a channel access parameter included in the DCI; and performing the uplink transmission scheduled by the DCI within the channel occupancy time initiated by the communication node, wherein the communication node is the terminal or the base station.

Abstract: Disclosed is a method of controlling the operation of a fuel cell triple cogeneration system configured to supply power and cooling heat to a data center, the method including detecting change in a power load or a cooling heat load of the data center and adjusting electrical energy and cooling capacity of the fuel cell triple cogeneration system.

Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of tumors, containing a novel pyrazolopyrimidine compound or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered in combination with other anticancer agents, and thus can be effectively used as a composition for preventing or treating cancer.

Abstract: An HME unit for use in a breathing circuit is provided and includes an HME chamber that contains an HME member. The HME unit also includes an inner core for reception in the HME chamber. The inner core having at least one first opening formed therein and at least one second opening formed therein and spaced from the at least one first opening with an intermediate area being located between the at least one first opening and the at least one second opening. The HME member is disposed about the intermediate area of the inner core. The HME unit also includes a movable valve that has a valve member disposed within an interior bore of the inner core and being movable between a fully open position and a fully closed position that causes incoming breathing gas to flow across the HME member.

Abstract: A confocal microscope system includes a light source configured to form a light beam, a scanning unit, and an objective lens. The scanning unit is in the form of a mechanically driven scanning unit with a controllable scanning trajectory, and is configured to direct the light beam through the scanning trajectory. The objective lens defines a pupil plane and a focal plane. The light beam is directed from the scanning unit to the objective lens. The confocal microscope system is configured for multi-color line-scanning confocal microscopy, and implements multi-color fluorescence imaging without laser excitation crosstalk.

Abstract: A paramagnetic stainless steel part including a core surrounded by a surface including at least a first zone and at least a second zone, the core and the second zone having a hardness HV1 of between 500 and 900, and a microstructure formed by a sigma phase at a mass percentage of between 40 and 80% and an austenitic phase at a mass percentage of between 20 and 60%, the part wherein the first zone is enriched in Ni relative to the core and the second zone, in that the first zone forms a layer entirely made up of an austenitic phase, the layer being referred to as the austenitic layer, and wherein the austenitic layer has a hardness of less than 400 HV1. Another aspect of the disclosure relates to the method for manufacturing this part.

Abstract: Disclosed herein are compositions and methods for treating diseases characterized by expanded microsatellite repeats by impeding or inhibiting transcription of expanded microsatellite repeats.

Abstract: A method of manufacturing a current collector of an energy storage device includes the following. A substrate is provided. A modified layer is formed on the substrate using a microwave plasma chemical vapor deposition process. The modified layer includes nanographene and has a thickness of 1 nm to 500 nm. In the microwave plasma chemical vapor deposition process, a microwave frequency is 300 MHz to 300 GHz, a microwave power is 500 W to 75000 W, a temperature is 25° C. to 600° C., and a deposition time is less than 30 minutes. The microwave plasma chemical vapor deposition process includes the following. Inert gas or stable gas is passed in. Hydrocarbon gas and hydrogen are passed in. Microwaves are applied to generate plasma. The hydrocarbon gas and the hydrogen are ionized. Nanographene is formed on the substrate.

Abstract: A machining and positioning system for aerospace irregular parts and a discrete intelligent production line therefor are provided, which relates to the field of aerospace irregular part machining. In view of the problem that complex repeated positioning and poor positioning stability is required during the transportation and processing of aerospace irregular parts, a self-positioning device, a clamping device, and a support device are used to form a follow-up clamping and positioning system for the irregular part casing, reducing complex repeated positioning. The support block of the support device can fit to the inner wall of the casing, collect the support force using piezoelectric plates, and feedback and adjust the thrust of the support block based on the magnitude of the cutting radial force, maintaining stable support of the support block for the casing and meeting production needs.

Abstract: An electronic device for managing a network device by using a digital twin and an operating method thereof are provided. The electronic device includes a processor and a memory configured to store instructions, wherein the instructions, when executed by the processor, cause the electronic device to obtain traffic information of a network device, generate digital twins respectively corresponding to the network device and the traffic information, synchronize current traffic information of the network device with the digital twins corresponding to the traffic information, and train a model that is configured to predict an abnormal situation of the network device, based on the synchronized digital twins.