Abstract: Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.

Abstract: A method of preparing a fuel cell electrode catalyst by preparing a platinum-carbon core-shell composite, which has a platinum nanoparticle core and a graphene carbon shell, using a simultaneous evaporation process, a method for preparing a fuel cell electrode comprising the catalyst prepared thereby, and a fuel cell comprising the same. A fuel cell comprising an electrode catalyst consisting of the core-shell composite prepared by simultaneously evaporating the platinum precursor and the organic precursor can have high performance and high durability, because the platinum particles are not agglomerated or detached and corroded even under severe conditions, including high-temperature, long use term, acidic and alkaline conditions.

Abstract: A method for visualizing on a display unit of an operator terminal a transmission flow in a system. The method includes: retrieving a starting point and an end point of the transmission flow; generating a picture wherein a geometrical line from the starting point to the end point graphically represents the transmission flow and wherein a direction of the transmission flow is graphically represented by a continuously increased opacity of the geometrical line between the starting point and the end point of the transmission flow; and outputting the picture on the display unit.

Abstract: A method for retrodicting source-rock quality and/or paleoenvironmental conditions are disclosed. A first set of system variables associated with source-rock quality is selected (705). A second set of system variables directly or indirectly causally related to the first set of variables is also selected (710). Data for variables selected to be known quantities are estimated or obtained (720). A network with nodes including both sets of variables is formed (715). The network has directional links connecting interdependent nodes (715). The directional links preferably honor known causality relations. A Bayesian network algorithm is used with the data to solve the network for the unknown variables and their associated uncertainties (725). The variables selected to be unknowns can be input nodes (paleoenvironmental conditions), intermediate nodes, output nodes (source rock quality), or any combination thereof.

Abstract: A system for accepting a mail matter is provided, which includes an image processing unit recognizing a mailing address; a weight measurement unit measuring a weight of the mail matter; a mailing address information input unit; a postage information storage unit; a postage settlement unit; an interface unit for selecting mailing addresses of an addresser and an addressee; a labeler printing the mailing addresses of the addresser and the addressee and a registered barcode on a label and attaching the label to the mail matter; a discharger discharging the mail matter; and an integrated control unit settling the postage through the postage settlement unit, attaching the selected mailing addresses of the addresser and the addressee and the registered barcode to the mail matter through the labeler, and discharging the mail matter through the discharger.

Abstract: The present disclosure is directed at an electrode and methods for forming such electrode for a battery wherein the electrode comprises silicon clathrate. The silicon clathrate may include silicon clathrate Si46 containing an arrangement of 20-atom and 24-atom cages fused together through 5 atom pentagonal rings and/or silicon clathrate Si34 containing an arrangement of 20-atom and 28-atom cages fused together through 5 atom pentagonal rings. The silicon clathrate may be present as particles having a largest linear dimension in the range of 0.1 ?m to 100.0 ?m.

Abstract: The present disclosure relates to an ionization chamber with a built-in temperature sensor, which is especially adapted for devices, such as X-ray units, gamma irradiators and linear accelerators, whichever is used for performing radiation dose output measurement accordingly. In an embodiment, the ionization chamber comprises: a cavity, an inner electrode, a chamber wall, an outer electrode, a guard electrode and a calibrated temperature sensor for detecting real-time temperature inside the cavity of ionization chamber to be used in the correction process of radiation dose measurement signals. With the aforesaid device, not only the accuracy of measurement can be improved effectively, but also the time consumed in a radiation dose measurement period can be reduced greatly since it will no longer bear the disadvantage that the radiation dose measurement has to wait until the temperatures inside and outside the cavity of ionization chamber had reached a thermal equilibrium before the measurement.

Abstract: The present invention relates to flavanoid compounds of general formula (X1) wherein: R1 is selected from a group consisting of morpholinyl, N-methyl piperizinyl, piperidinyl and N,N?-dimethylamino groups, and n ranges from 3 to 6, and process for preparation thereof. The present invention relates to the demonstration of anti Helicobacter pylori activity and gastric antisecretory activity of semisynthetically designed flavonoid compounds, to be used for the prevention and treatment of gastroduodenal disorders in general and peptic ulcer diseases in particular. The present invention also relates to a hetero-dimeric bi-functional molecule that can be used as monotherapy substituting/replacing/overcoming currently used triple/quadruple therapy, thereby implicating/anticipating/envisaging its commercial applicability.

Abstract: The purpose of the present invention is to provide an FAD-conjugated glucose dehydrogenase that is hard to be inhibited by the inhibitors such as 1,10-phenanthroline. The present invention relates to a modified glucose dehydrogenase (GLD), comprising an amino acid sequence of a wild-type FAD-conjugated glucose dehydrogenase (GLD) represented by SEQ ID NO: 1 having a substitution of at least one amino acid residue selected from the group consisting of amino acid residues at positions 298, 338, 340, 341, 343, 352, 354, 424, 426, 431 and 432, wherein the modified GLD has a reduced susceptibility to an inhibitor, as compared with the wild-type GLD, especially to said modified GLD, which has 40% or more of a relative activity when determined in a system wherein the inhibitor coexists at a final concentration of 1 mM based on an enzymatic activity when determined in a system wherein the inhibitor does not coexist.

Abstract: This invention discloses caps and closures produced by injection molding with a bimodal high density polyethylene (HDPE) resin comprising a low molecular weight, high density polyethylene fraction substantially free of comonomer and a high molecular weight, low density polyethylene fraction, having a molecular weight distribution of at least 3.5, preferably greater than 4.0, prepared in two reactors connected in series in the presence of a metallocene-containing catalyst system, wherein the metallocene comprises a bisindenyl or a bis-tetrahydrogenated-indenyl component.

Abstract: This invention is directed to perylene-diimide aromatic dianion compounds, process of preparation and uses thereof. The perylene-diimide aromatic dianion compounds of this invention are stable in aqueous solution and can be used for photofunctional and electron transfer systems in aqueous phase. This invention is also directed to supramolecular polymers derived from perylene-diimide compounds and to uses thereof.

Abstract: The invention provides a method for improving image quality. Through applying variation value during operation of iterated algorithm, this invention can reduce blur phenomenon caused by partial volume effects and improve image accuracy. In an embodiment, by applying the algorithm utilized in the method for improving image quality, this invention further provides an imaging system to detect the distribution of the object, thereby obtaining a clear restored image corresponding to the radiation source.

Abstract: The present invention relates to a method for preparation of an ultraviolet (UV)-curable inorganic-organic hybrid resin containing about or less than 4% volatiles and less than 30% organic residues. The UV-curable inorganic-organic hybrid resin obtained according to this method can be UV-cured within a markedly very short time and enables, upon curing, the formation of a transparent shrink-and crack-free glass-like product having high optical quality, high thermal stability and good bonding properties. In view of these properties, this hybrid resin can be used in various applications such as electro-optic, microelectronic, stereolithography and biophotonic applications.

Abstract: A method of alleviating a symptom of relapsing-remitting multiple sclerosis in a human patient suffering from relapsing-remitting multiple sclerosis or a patient who has experienced a first clinical episode and is determined to be at high risk of developing clinically definite multiple sclerosis comprising administering to the human patient three subcutaneous injections of a therapeutically effective dose of glatiramer acetate over a period of seven days with at least one day between every subcutaneous injection so as to thereby alleviate the symptom of the patient.

Abstract: The present invention deals with a process for the preparation of multifunctional additive for aqueous lubricants. These I multifunctional additive for aqueous lubricant comprises of co-polymer having vinyl group containing polyhydric alcohol along with monomer selected from aqueous soluble acrylate co-monomer in different mole fraction for addition polymerization to facilitate the sequencing of monomer in polymer chain. Thus the polymeric molecule has been designed for improving tribological properties i.e. low wear, low friction and EP property of aqueous lubricants.

Abstract: Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.

Abstract: Hand pointing has been an intuitive gesture for human interaction with computers. A hand pointing estimation system is provided, based on two regular cameras, which includes hand region detection, hand finger estimation, two views' feature detection, and 3D pointing direction estimation. The technique may employ a polar coordinate system to represent the hand region, and tests show a good result in terms of the robustness to hand orientation variation. To estimate the pointing direction, Active Appearance Models are employed to detect and track, e.g., 14 feature points along the hand contour from a top view and a side view. Combining two views of the hand features, the 3D pointing direction is estimated.

Abstract: A method for preparing hydro/organo gelators from disaccharide sugars by biocatalysis and their use in enzyme-triggered drug delivery. Controlled delivery of an anti-inflammatory, chemopreventive drug is achieved by an enzyme-triggered drug release mechanism via degradation of encapsulated hydrogels. The hydro- and organo-gelators are synthesized in high yields from renewable resources by using a regioselective enzyme catalysis and a known chemopreventive and anti-inflammatory drug, curcumin, is encapsulated in the gel matrix and released by enzyme triggered delivery. The release of the drug occurs at the physiological temperature and control of the drug release rate is achieved by manipulating the enzyme concentration and temperature. The by-products formed after the gel degradation clearly demonstrated the site specificity of degradation of the gelator by enzyme catalysis.

Abstract: Provided are processes for the oxidative cleavage of a double bond in an unsaturated carboxylic acid. The process includes contacting the unsaturated carboxylic acid with a mild oxidizing agent and agitating the unsaturated carboxylic acid and the mild oxidizing agent for a time sufficient to cleave a double bond of the unsaturated carboxylic acid and produce a product comprising an aldehyde. The process is typically carried out in a mill, such as a ball, hammer, attrition, or jet mill.

Abstract: Disclosed embodiments include a method of paging one of a plurality of mobile subscribers in a wireless communication network. The method includes receiving, at a base station, an idle mode request from the one mobile subscriber and sending an idle mode notification to a control device, after receiving the idle mode request from the one mobile subscriber. The method also includes receiving a paging request from the control device and sending a paging advertisement intended for the one mobile subscriber, after receiving the paging request from the control device.