Patents Assigned to Research
  • METHODS AND PRODUCTS FOR BIASING CELLULAR DEVELOPMENT
    Publication number: 20150056704
    Abstract: Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.
    Type: Application
    Filed: August 19, 2013
    Publication date: February 26, 2015
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Angel Alvarez, Amelia Marutle
  • ANTI-METASTATIC AGENTS PREDICATED UPON POLYAMINE MACROCYCLIC CONJUGATES
    Publication number: 20150057361
    Abstract: Disclosed herein are novel motuporamine compounds that act as anti-metastatic agents with low toxicity and high anti-migration activity. The non-toxic, anti-metastatic agents may be given to patients with potential or actual metastatic cancers, such as pancreatic cancers, alone in combination with known and/or new therapies to help block the growth and spread of tumor(s).
    Type: Application
    Filed: March 13, 2013
    Publication date: February 26, 2015
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Otto Phanstiel, IV, Aaron Muth
  • Transcranial stimulation
    Patent number: 8965514
    Abstract: A method includes coupling electrodes to a patient's head and identifying whether any of the electrodes form a functional set, such that a desired therapeutic effect is achieved when the two or more electrodes deliver a total amount of current to the patient regardless of what portion of the total amount of current each respective electrode carries. One or more constant current sources are provided, each having a supply and return terminal, which supply and return equal amounts of current at any given time. The constant current source(s) are coupled to the electrodes in such a manner that each supply terminal and each return terminal is coupled to no more than the electrodes of a single one of the functional sets, if any, or to a single one of the electrodes not included in one of the functional sets.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: February 24, 2015
    Assignee: Research Foundation of the City University of New York
    Inventors: Marom Bikson, Abhishek Datta, Varun Bansal, Lucas C. Parra, Xiang Zhou
  • Method and system of drying a microelectronic topography
    Patent number: 8961701
    Abstract: Drying a microelectronic topography. At least some of the illustrative embodiments are methods that include placing a microelectronic topography inside a process chamber, providing a non-aqueous liquid to the process chamber until at least 90% of the volume of the process chamber contains the non-aqueous liquid, pressurizing the process chamber by way of a fluid different than the non-aqueous liquid, ceasing activity with respect to the process chamber until the non-aqueous liquid and fluid form a mixture that is substantially homogenous, venting the process chamber while simultaneously providing the fluid to the process chamber, and venting the process chamber in a manner which prevents formation of liquid in the process chamber.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: February 24, 2015
    Assignee: Lam Research Corporation
    Inventors: Mark I. Wagner, James P. DeYoung
  • Therapy and method for intratumorally introducing cytotoxic T lymphocyte and/or NKT cell with anti-TNF and/or anti-IL-10
    Patent number: 8961957
    Abstract: The invention relates to therapy and methods of applying the therapy to cancer patients. The invention includes introducing intratumorally cytotoxic T lymphocyte and/or NKT cells, and prior to, coincident with, or following introducing intratumorally the cytotoxic T lymphocyte and/or NKT cells, introducing intratumorally anti-TNF and/or anti-IL-10 to the patient. The cytotoxic T lymphocyte and/or NKT cells can be induced by the intratumoral introduction of immature dendritic cells to the patient. This therapy of the invention can be effective to regress, reduce or eliminate tumor cells in tumor tissue of the patients in the absence of radiation therapy.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: February 24, 2015
    Assignee: Hasumi International Research Foundation
    Inventor: Kenichiro Hasumi
  • Identification of inhibitors of a bacterial stress response
    Patent number: 8962550
    Abstract: A system, a composition, a method and a kit for identifying anti-bacterial agents are provided. The invention described herein is useful in identifying inhibitors of any bacterial stress response. Moreover, the invention can be applied to any sRNA and its target, any transcription factor and its target, and any transcription factor/sRNA pair (i.e., a transcription factor that regulates a sRNA). In particular, the present invention provides a system, a composition, a method and a kit for the identification of cyclic peptides that block the ?E pathway in Escherichia coli.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: February 24, 2015
    Assignee: The Penn State Research Foundation
    Inventors: Sarah Ellen Ades, Kenneth Charles Keiler
  • Process and apparatus for manufacturing grease
    Patent number: 8962542
    Abstract: A process and corresponding apparatus and system for use in preparing soaps from fatty acid containing oil compositions, and in turn, for preparing greases by the use of such soaps in combination with one or more base oils.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: February 24, 2015
    Assignee: University of Northern Iowa Research Foundation
    Inventors: Lou A. T. Honary, Wesley E. James
  • Diffusion sources from liquid precursors
    Patent number: 8962459
    Abstract: A method selectively diffuses dopants into a substrate wafer. The method comprises blanket depositing a doped liquid precursor including dopants on a surface of the substrate wafer to create a doped film on the surface of the substrate wafer, selectively forming a diffusion source in the doped film to selectively diffuse the dopants into the substrate wafer, and heating the doped film on the substrate wafer, wherein said heating the doped film diffuses the dopants from the doped film into the substrate wafer.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: February 24, 2015
    Assignee: Piquant Research LLC
    Inventor: Daniel Inns
  • Modular hand-held electronic device charging and monitoring system
    Patent number: 8963498
    Abstract: This specification relates to a charging, securing and monitoring system for hand-held electronic devices such as cell phones, BlackBerry's, PDA's, cameras, or the like and the components therefore. More particularly the teachings herein include a coaxial cable construction that permits securing and charging of said hand-held devices which are on display at a typical retailer. Further the cable may be accumulated on a unique recoiler assembly at one end of the coaxial cable and engages a unique holding device proximate the other end thereof.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: February 24, 2015
    Assignee: RTF Research and Technologies Inc.
    Inventor: Joel Ferguson
  • Detection of buried explosives
    Patent number: 8963071
    Abstract: A system and method are described for capturing and analyzing gamma rays from neutron excitation of a region in 3-space being analyzed for explosives. A processor analyzes the results, determining whether underground explosives are present in a particular region of the ground. In one embodiment, one gamma ray energy band is used to infer an amount of silicon in the region, while another indicates the combined amount of silicon and nitrogen. The concentration of nitrogen in the region is inferred and used to trigger an “explosive found” or a “no explosive found” signal. In other embodiments, the system or method uses inferences about other elemental constituents of the ground being examined, sometimes taking as input analyzes from prior scans, and providing output indicating the likelihood of the presence of explosives in the region.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: February 24, 2015
    Assignee: Purdue Research Foundation
    Inventor: David S. Koltick
  • Transporting and managing liquefied natural gas
    Patent number: 8959931
    Abstract: The present application is directed to methods and systems for transporting or importing LNG via vessels. Under the present techniques, SRTs, which are equipped with regasification equipment, LNG offloading equipment (e.g. marinized mechanical loading arms), LNG storage tanks, and equipment to transfer natural gas to an import terminal are utilized as temporary interchangeable FSRUs (TIFs). Two or more TIFs in conjunction with transport vessels (e.g. LNGCs) are utilized to transfer LNG between an export terminal and an import terminal. A first of the TIFs is utilized at an import terminal to offload LNG from LNGCs, while the second of the TIFs is utilized as a LNGC, carrying LNG between the export terminal and import terminal. The first of the TIFs may be replaced by the second of the TIFs to maintain operations for the import terminal.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: February 24, 2015
    Assignee: ExxonMobil Upstream Research Company
    Inventors: William S. Mathews, Mark E. Ehrhardt
  • Intelligent low noise design
    Patent number: 8965727
    Abstract: An automated phase noise test measurement system includes a software controlled phase shifter to maintain quadrature so that a carrier may be removed from a signal provided by UUT. In this fashion, the UUT's phase noise may be measured. Based upon the UUT's measured phase noise, controllable variable(s) within the UUT are tuned so as to minimize the measured phase noise.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: February 24, 2015
    Assignee: OmniPhase Research Laboratories, Inc.
    Inventor: Eugene Rzyski
  • Active voltage droop control-type pulse power generator
    Patent number: 8964419
    Abstract: An active voltage drop control-type pulse power generator includes power stages, a power inverter, a power loop, a control inverter, a control loop, and a compensation unit. The power stages include power cells connected in series. Each power cell includes a switch and a capacitor connected in series, a driver for driving the switch, a bypass diode connected to both ends of the switch, and a rectifying diode connected to both ends of the capacitor. The power inverter charges the capacitor via the power loop and the rectifying diode inside each power cell. The control inverter provides a control signal for the switch via the control loop and the driver inside each power cell. The compensation unit is connected to one of the power cells and generates a compensation voltage for compensating for a voltage drop at a load according to a voltage detected in real-time from the power cell.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: February 24, 2015
    Assignee: Korea Electrotechnology Research Institute
    Inventors: Hong Je Ryoo, Sung Roc Jang, Geun Hie Rim, Jong Soo Kim
  • Solute-enhanced production of gamma-valerolactone (GVL) from aqueous solutions of levulinic acid
    Patent number: 8962867
    Abstract: A method to produce levulinic acid (LA) and gamma-valerolactone (GVL) from biomass-derived cellulose or lignocellulose by selective extraction of LA using GVL and optionally converting the LA so isolated into GVL, with no purifications steps required to yield the GVL.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: February 24, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James A. Dumesic, Stephanie G. Wettstein, David Martin Alonso, Elif Ispir Gurbuz
  • Methods and compositions for alphavirus replicons
    Patent number: 8961995
    Abstract: The present invention provides alphavirus replicons and methods of their use in producing heterologous protein.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: February 24, 2015
    Assignee: UAB Research Foundation
    Inventors: Ilya Frolov, Elena Frolova
  • Silicon-based suspending antenna with photonic bandgap structure
    Patent number: 8963779
    Abstract: The disclosure provides a silicon-based suspending antenna with photonic bandgap structure, which includes a silicon substrate, an electrode layer, a spacing part and an F-shaped structure. The silicon substrate has a first side surface and a second side surface oppositing to the first surface. The electrode layer has a flat part, a first base and at least one second base, in which one side of the flat part has a notch, the first base, the second base and the notch are separately disposed on the second side surface and essentially parallel to the longitudinal edge of the second side surface, the first base has a main body and an extension, and the extension extends from the main body and into the notch. The F-shaped structure has a longitudinal part disposed on the spacing part and is parallel to the second side surface.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: February 24, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: I-Yu Huang, Chian-Hao Sun, Kuo-Yi Hsu
  • Fibroblast growth factor mutants having improved functional half-life and methods of their use
    Patent number: 8962557
    Abstract: Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: February 24, 2015
    Assignee: Florida State University Research Foundation
    Inventors: Michael Blaber, Jihun Lee
  • Technical or decorative piece associating a transparent material and a silicon based amorphous material and method of manufacturing the same
    Patent number: 8964513
    Abstract: A transparent substrate (10) made of a transparent material resistant to temperatures higher than 500° C., such as sapphire, includes recesses (13, 14) in at least one of its faces (11, 12) and/or a groove (15) machined into its thickness, that are covered with opaque, translucent or transparent enamel depositions (23 to 30) that may or may not be colored, depending upon the pigments used in the enamel composition. The invention is applicable to a dial of a timepiece.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: February 24, 2015
    Assignee: The Swatch Group Research and Development Ltd
    Inventors: Gilles Derriey, Christian Verdon, Stewes Bourban, Giancarlo Poli
  • Method of deriving mesenchymal stem cells from ES cells using FGF2
    Patent number: 8962318
    Abstract: We disclose a method comprising: (a) providing an embryonic stem (ES) cell; and (b) establishing a progenitor cell line from the embryonic stem cell; in which the progenitor cell line is selected based on its ability to self-renew. Preferably, the method selects against somatic cells based on their inability to self-renew. Preferably, the progenitor cell line is derived or established in the absence of co-culture, preferably in the absence of feeder cells, which preferably selects against embryonic stem cells. Optionally, the method comprises (d) deriving a differentiated cell from the progenitor cell line.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: February 24, 2015
    Assignee: Agency for Science, Technology and Research
    Inventors: Sai Kiang Lim, Elias Lye
  • Treating cardiovascular tissue
    Patent number: 8962320
    Abstract: This document provides methods and materials for treating cardiovascular tissue. For example, stem cells, compositions containing stem cells, methods for obtaining stem cells, compositions for generating stem cells expressing particular markers, and methods for repairing cardiovascular tissue are provided.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: February 24, 2015
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Andre Terzic, Atta Behfar