Abstract: In a method for making a flexible material, a sheet of graphene oxide-composite paper is subjected to an environment having a relative humidity above a predetermined threshold for a predetermined amount of time. At least one expansion cut is cut in the sheet of graphene oxide-composite paper. A flexible conductive material includes a sheet of graphene oxide-composite paper defining at least one cut passing therethrough and formed it a kirigami structure. A region of the sheet of graphene oxide-composite paper includes reduced graphene oxide.
Abstract: The present invention provides a method of detecting senescent cells or diagnosing cellular senescence in a subject wherein the level of one or more selected miRNAs is quantified in a sample from said subject.
Type:
Grant
Filed:
June 26, 2018
Date of Patent:
November 14, 2023
Assignees:
BUCK INSTITUTE FOR RESEARCH ON AGING, UNIVERSITÄT FÜR BODENKULTUR WIEN
Inventors:
Johannes Grillari, Matthias Hackl, Judith Campisi, Abhijit Kale
Abstract: The present disclosure provides antibody sequences found in antibodies that bind to human CD25, in particular an anti CD25-a-672 antibody which do not block the binding of CD25 to IL-2 or IL-2 signalling. The claimed antibody binds to the epitopes: PHATFKAMA YKEGTM (42-56) and YQCVQGYRALH (150-160) on CD25. Antibodies and antigen-binding portions thereof including such sequences can be used in pharmaceutical compositions and methods of treatment, in particular for treating cancer.
Type:
Grant
Filed:
March 13, 2019
Date of Patent:
November 14, 2023
Assignees:
Tusk Therapeutics Ltd., Cancer Research Technology Limited
Inventors:
Anne Goubier, Beatriz Goyenechea Corzo, Josephine Salimu, Kevin Moulder, Pascal Merchiers, Mark Brown, James Geoghegan, Bianka Prinz, Sergio Quezada
Abstract: Provided is a method of producing a long bagworm silk thread, the method comprising a spinning process of making a bagworm having its nest hang its legs on a rail and continuously spin a silk thread along the rail, wherein the rail has a width smaller than the maximum width between the left and right legs when the bagworm used spreads out its legs and wherein the rail is such that the bagworm can hang its legs on the rail, and a collection process of collecting a long silk thread from the rail after the spinning process.
Type:
Grant
Filed:
June 29, 2017
Date of Patent:
November 14, 2023
Assignee:
NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION
Abstract: The present disclosure discloses a method for plasma modification of sodium super ionic conductor type solid electrolyte, which comprises: dielectric barrier discharge plasma modification of sodium super ionic conductor solid electrolyte particles to obtain activated sodium super ionic conductor solid electrolyte particles; weigh the polymer and the activated sodium super ionic conductor solid electrolyte particles in a predetermined proportion, dissolve the polymer and the activated sodium super ionic conductor solid electrolyte particles in an organic solvent to obtain a mixed solution, then pour the mixed solution into a preset mold, and then dry it to remove the organic solvent and form a composite solid electrolyte film. The composite solid electrolyte film is taken out of the mold and rolled to obtain the composite solid electrolyte film after rolling treatment.
Type:
Grant
Filed:
November 24, 2022
Date of Patent:
November 14, 2023
Assignees:
KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY, JIANGSU FENGCHI CARBON-BASED NEW MATERIALS RESEARCH INSTITUTE CO., LTD.
Inventors:
Feng Liang, Minjie Hou, Da Zhang, Tao Zhang, Sunzu Xiang, Wenlong Jiang, Baoqiang Xu, Bin Yang
Abstract: A reactive torque automatic balancing device for a screw drilling tool includes an upper joint (1); a core cylinder (9) having an inner chamber in communication with the screw drilling tool (305) located downstream, so that drilling fluid from the inner chamber of the upper joint (1) flows to the screw drilling tool (305) through the inner chamber of the core cylinder (9) to allow the screw drilling tool to perform drilling; a lower joint (16) fixedly arranged at a lower end of the core cylinder (9); and an automatic balancing assembly, which is arranged between an outer wall of the core cylinder (9) and an inner wall of the upper joint (1), and driven by hydraulic pressure generated by a part of the drilling fluid flowing through the inner chamber of the upper joint (1).
Type:
Grant
Filed:
April 15, 2020
Date of Patent:
November 14, 2023
Assignees:
CHINA PETROLEUM & CHEMICAL CORPORATION, SINOPEC RESEARCH INSTITUTE OF PETROLEUM ENGINEERING
Abstract: Provided is an oxidizing composition, in which a liquid medium is substantially inert in the presence of an oxidizing electrophile contained in the liquid medium. The composition comprises (a) an oxidizing electrophile comprising a main group element in oxidized form and at least one conjugate anion of an oxygen acid; (b) a non-oxidizable liquid selected from a fluorinated hydrocarbon, a sulfone, a deactivated arene, a deactivated aliphatic, a deactivated heteroarene, a deactivated heteroaliphatic, and a combination thereof; and (c) optionally one or more salt additives. Further provided are a method of using the oxidizing composition to oxidize a substrate and a method of generating and/or regenerating an oxidizing electrophile comprising a main group element.
Type:
Grant
Filed:
May 25, 2018
Date of Patent:
November 14, 2023
Assignees:
University of Florida Research Foundation, Incorporated, Hyconix, Inc.
Inventors:
Roy A. Periana, Brian G. Hashiguchi, Michael M. Konnick
Abstract: The present invention relates to a homopolymer, copolymer, block copolymer, and statistical copolymer comprising plural polyol monomeric units. The polyol monomeric units being acrylated and acylated or acetalized. The acrylated and acylated or acetalized polyol monomeric units have an average degree of acrylation which is 1 or more, but less than the number of the hydroxyl groups of the polyol and have an average degree of acylation or acetalization which is 1 or more, but less than the number of the hydroxyl groups of the polyol. The present invention also relates to a method of making the homopolymers, copolymers, block copolymers, and statistical copolymers, and using them in various applications, such as asphalt rubber modifiers, adhesives, or an additive in a fracking fluid for oil fracking.
Type:
Grant
Filed:
December 17, 2021
Date of Patent:
November 14, 2023
Assignee:
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Inventors:
Eric W. Cochran, Nacu Hernandez, Michael Forrester, Shailja Goyal, Austin Hohmann
Abstract: In the present invention, in classifying modulation types of a plurality of modulation signals by using a classifier (an artificial neural network model based on machine learning), the classifier may classify the modulation types of the modulation signals by using pieces of I/Q data, sampled with one sampling frequency, as input data, and thus, may quickly classify the modulation signals.
Type:
Grant
Filed:
March 31, 2022
Date of Patent:
November 14, 2023
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Byung Chan Kim, Kang Hee Kim, Haeng Sook Ro, Gwang Moon Park, Soo Ho Sohn, Ki Cheol Tae
Abstract: Acoustically mediated pulsed radiation sources, phased arrays incorporating the radiation sources, and methods of using the radiation sources and phased arrays to generate electromagnetic radiation via magnetic dipole emission are provided. The radiation sources are based on a superlattice heterostructure that supports in-phase magnetic dipole emission from a series of magnetic insulator layers disposed along the length of the heterostructure.
Abstract: A method of synthesizing a clay-polyacrylate composite. An aqueous solution including clay is mixed with at least one organosilane coupling agent including an acrylate moiety to form a silanized-clay suspension. The silanized-clay suspension is contacted with a first acrylate monomer and a second acrylate monomer in an inert environment, where the first acrylate monomer and the second acrylate monomer have different solubility. A polymerization initiator is added to the silanized-clay suspension before or during the contacting of the silanized-clay suspension with the first acrylate monomer and the second acrylate monomer in the inert environment to form the clay-polyacrylate composite including the first and second acrylate monomer, where the first acrylate monomer is a hydrophilic acrylate monomer including a hydroxyl (—OH) group and the second acrylate monomer is a hydrophobic acrylate monomer which repels water.
Type:
Grant
Filed:
February 27, 2023
Date of Patent:
November 14, 2023
Assignee:
Agency for Science, Technology and Research
Inventors:
Xu Li, Yu Zhang, Ming Yan Tan, Siew Yee Wong, Xi Kui Zhang
Abstract: The present invention relates to methods for improvement in lower urinary tract function in an individual with neurogenic urological dysfunction through epidural stimulation of the spinal cord. In certain embodiments, the methods comprise applying a pattern of epidural electrical stimulation to the spinal cord of an individual with impaired lower urinary tract under stimulation parameters sufficient to improve the storage of fluid in the bladder, sensations of fullness and/or emptying, detrusor over-activity, high detrusor pressure, voiding the bladder, transitioning from a storage state to a voiding state, and decreasing detrusor-external urethral sphincter dyssynergia. In certain embodiments, additional patterns of epidural electrical stimulation may be applied simultaneously, such as to maintain a normotensive cardiovascular state of the individual.
Type:
Grant
Filed:
April 4, 2020
Date of Patent:
November 14, 2023
Assignee:
University of Louisville Research Foundation, Inc.
Inventors:
Charles S. Hubscher, Susan J. Harkema, April N. Herrity, Yangsheng Chen, Claudia Angeli
Abstract: Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.
Type:
Grant
Filed:
December 12, 2022
Date of Patent:
November 14, 2023
Assignee:
University of Iowa Research Foundation
Inventors:
Elise Lin Cheng, C. Allan Guymon, Marian R. Hansen, Braden Leigh
Abstract: Photoresist layers of semiconductor components including electric fields. The photoresist layer may include a body including a first portion disposed directly over a conductive layer of the semiconductor component. The body may also include a second portion integrally formed with and positioned over the first portion. The second portion may include a surface formed opposite the first portion. Additionally, the second portion may include a plurality of charged-particles implanted therein, where the plurality of charged-particles generating an electric field may extend through the first portion and the second portion of the body.
Type:
Grant
Filed:
January 11, 2021
Date of Patent:
November 14, 2023
Assignee:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Abstract: A method for fabricating structures includes on a substrate includes providing the substrate having a substrate surface, and generating nanostructures or microstructures on the substrate surface at least in part by exposing the substrate surface to thermal particles from a thermal particle source while irradiating the substrate surface with an ion beam. The generated nanostructures or microstructures have a smaller surface area than the area of incidence of the ion beam or a beam generated by the thermal particle source. The method also includes obtaining a measurement of a characteristic of the substrate surface and adjusting at least one of the thermal particle source and the ion beam based on the measurement.
Type:
Grant
Filed:
October 20, 2020
Date of Patent:
November 14, 2023
Assignee:
Purdue Research Foundation
Inventors:
Jean Paul Allain, Osman J. El-Atwani, Juan Jose Pavon Palacio
Abstract: The present disclosure provides a system for perceiving an operating state of a large power transformer based on vibro-acoustic integration, including a perception layer, a network layer, and a diagnostic layer, where the perception layer is used for monitoring, in real time, a state parameter for a coupling vibration signal and an acoustic signal of each of a transformer core, a winding, a clamp and a housing, a state parameter of each of a vibration signal and an acoustic signal during a gear position change of an on-load tap changer (OLTC), and preliminarily diagnosing and analyzing monitored data. The system can monitor the operating state of the OLTC online for a long time, flexibly configure the sensor channel and the sensor type according to different application requirements, automatically acquire and identify the gear position change, and correctly identify and process a gear position corresponding to the monitoring signal.
Type:
Grant
Filed:
October 8, 2021
Date of Patent:
November 14, 2023
Assignees:
STATE GRID XINJIANG CO., LTD. ELECTRIC POWER RESEARCH INSTITUTE, Nanjing Unitech Electric Power Co., Ltd., State Grid Corporation of China
Inventors:
Yi You, Ling Zhang, Kaike Wang, Cheng He, Puzhi Zhao, Ronggang Gao, Jianping Zhao, Xinxin Wang, Xianfu Liu
Abstract: A piston press system and a test method using the same are used for predicting the roll service life of high-pressure grinding rolls. The method is based on the same comminution mechanism of inter-particle layers compression as the heavy equipment high-pressure grinding rolls to simulate the grinding process of the studded high-pressure grinding roll, realizing that the coverage area of studs accounts for 16% to 20% of the compression surface by disposing tungsten carbide upper studs and lower studs, better restoring the simulation process and effectively realizing the roll service life prediction of the heavy equipment high-pressure roller mill with a small quantity of materials.
Type:
Grant
Filed:
November 28, 2022
Date of Patent:
November 14, 2023
Assignees:
Northeastern University, Liaoning Wuhuan Special Materials And Intelligent Equipment Industry Technology Research Institute Co. Ltd.
Abstract: Systems and methods for analyzing samples, such as tissue samples, and measuring the emissions when these samples are exposed to light are disclosed. Embodiments include illuminating multiple target locations on a sample with laser light, which may first be manipulated by a scanner, and receiving decaying emissions from the target location. At least some embodiments include the emissions traveling backwards along a substantial portion of the laser light pathway and being received by a detector. Additional embodiments include converting the received emissions into streak lines of position versus time, converting the streak lines to plots of signal strength versus time, and curve fitting the plots to determine representative decay times. In some embodiments, the decay times are presented as plots of position on the surface of the sample versus emission strength, which may be color coded. Some embodiment dwell on each target location for multiple scans of the laser.
Abstract: The present application provides a method for testing the coverage effect of a VHF communication base station, including: a server sending preset test parameter information to a mobile station, sending a first start test instruction to the mobile station and at least one base station, and receiving first audio data and first location information sent by the at least one base station, and second audio data and second location information sent by the mobile station. By using the mobile stations to send or receive audio data at different distances to a temporary VHF communication base station, it is possible to accurately determine a coverage distance of the temporary VHF communication base station and a transmission effect of the audio data at different communication distances.
Type:
Grant
Filed:
April 29, 2021
Date of Patent:
November 14, 2023
Assignee:
Transport Planning and Research Institute Ministry of Transport
Abstract: The present invention relates to N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-fluorophenyl)-2-((4-ethylpiperazin-1-yl)methyl)quinoline-6-carboxamide, or a pharmaceutically acceptable salt or solvate thereof, wherein at least one hydrogen atom has been substituted with a deuterium atom. Other aspects include pharmaceutical compositions comprising said compounds and medical uses and methods of treatment using said compounds.
Type:
Grant
Filed:
October 6, 2017
Date of Patent:
November 14, 2023
Assignee:
CANCER RESEARCH TECHNOLOGY LIMITED
Inventors:
Keith Jones, Matthew D. Cheeseman, A. Elisa Pasqua, Michael J. Tucker