Abstract: Disclosed is an antibody that selectively binds CD47 on tumor cells. Also disclosed is a method for treating cancer in a subject, comprising administering to the subject an effective amount of the antibody disclosed.
Abstract: The present invention relates to a method for inducing differentiation of bone marrow cells into myeloid-derived suppressor cells (MDSCs) by treating the bone marrow cells with a toll-like receptor agonist (TLR agonist) or type I interferon, or for inducing dendritic cells from the MDSCs.
Type:
Grant
Filed:
September 28, 2018
Date of Patent:
November 7, 2023
Assignees:
Industry-Academic Cooperation Foundation, Yonsei University, Research & Business Foundation Sungkyunkwan University
Inventors:
Sung Jae Shin, Woo Sik Kim, Hong Min Kim, Kee Woong Kwon, Joo Heon Yoon, Won Jung Koh
Abstract: A method for providing a sub-population of stem cell or plurality of stem cells by determining or modulating GSTT1 expression level or genotype is disclosed together with uses of the stem cells.
Type:
Grant
Filed:
May 15, 2020
Date of Patent:
November 7, 2023
Assignee:
Agency for Science, Technology and Research
Inventors:
Lawrence Stanton, Padmapriya Sathiyanathan, Simon Cool, Victor Nurcombe, Rebekah M. Samsonraj
Abstract: The present invention discloses monodisperse protein-dendron conjugates that self-assemble to generation-dependent supramolecular protein assemblies of different size and surface charges. The invention further provides a process for synthesis of protein-dendron conjugates containing hydrophobic dendron of different generations.
Type:
Grant
Filed:
December 8, 2018
Date of Patent:
November 7, 2023
Assignee:
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH
Abstract: Systems, methods, and other embodiments described herein relate to improving controls in a device according to risk. In one embodiment, a method includes, in response to receiving sensor data about a surrounding environment of the device, identifying objects from the sensor data that are present in the surrounding environment. The method includes generating a control sequence for controlling the device according to a risk-sensitivity parameter to navigate toward a destination while considering risk associated with encountering the objects defined by the risk-sensitivity parameter. The method includes controlling the device according to the control sequence.
Type:
Grant
Filed:
December 31, 2020
Date of Patent:
November 7, 2023
Assignees:
Toyota Research Institute, Inc., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors:
Haruki Nishimura, Boris Ivanovic, Adrien David Gaidon, Marco Pavone, Mac Schwager
Abstract: Systems and methods are disclosed to downscale the resolution of a coarse-resolution soil moisture data. Coarse-resolution soil moisture data may include data cells that each represent a geographic region having at least one dimension greater than or equal to 1 km. A plurality of fine-resolution supplemental soil moisture data may be received that includes at least one of soil data, vegetation data, topography data, and climate data. The fine-resolution supplemental soil moisture data comprising data cells that each represent a geographic region having at least one dimension less than or equal to 100 meters. The coarse-resolution soil moisture data may be downscaled to fine-resolution soil moisture data using the plurality of fine-resolution supplemental soil moisture data, the fine-resolution soil moisture data comprising data cells that each represent a geographic region having at least one dimension less than 100 meters.
Type:
Grant
Filed:
May 5, 2021
Date of Patent:
November 7, 2023
Assignee:
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Abstract: The present invention relates to a novel cannabinoid oral pharmaceutical dosage form, based on a Type IV or Type IV-like formulation, as classified using the Lipid Formulation Classification System. The formulation is contained in a container. By Type IV-like, it is meant that the formulation comprises no oil, for example no triglycerides or mixed glycerides.
Abstract: A novel silicoaluminophosphate molecular sieve has a schematic chemical composition, expressed on a molar basis, of mSiO2·Al2O3·nP2O5, in which m represents the molar ratio of SiO2 to Al2O3 and is in a range of about 0.005-0.15, and n represents the molar ratio of P2O5 to Al2O3 and is in a range of about 0.7-1.1. The silicoaluminophosphate molecular sieve has a unique X-ray diffraction pattern, and can be used as an adsorbent, a catalyst or a catalyst carrier.
Type:
Grant
Filed:
September 19, 2019
Date of Patent:
November 7, 2023
Assignees:
CHINA PETROLEUM & CHEMICAL CORPORATION, SHANGHAI RESEARCH INSTITUTE OF PETROCHEMICAL TECHNOLOGY SINOPEC
Abstract: A method to treat a patient with a Clostridium difficile infection comprising administering a therapeutically effective amount of diiodohydroxyquinoline, with or without one or more anti-infective agents.
Abstract: A flexible thermoelectric structure is provided, which includes a porous thermoelectric pattern having a first surface and a second surface opposite to the first surface, and a polymer film covering the first surface of the porous thermoelectric pattern. The polymer film fills pores of the porous thermoelectric pattern. The polymer film has a first surface and a second surface opposite to the first surface. The second surface of the polymer film is coplanar with the second surface of the porous thermoelectric pattern.
Type:
Grant
Filed:
April 30, 2020
Date of Patent:
November 7, 2023
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: Methods and devices are provided for the identification and/or quantification of microbes. In particular, the methods comprise: (a) extracting DNA from a microbial sample; (b) performing 16S ribosomal RNA gene-targeted sequencing to obtain DNA sequences; and (c) analyzing the DNA sequences to identify the species of the one or more microbes.
Type:
Grant
Filed:
July 20, 2020
Date of Patent:
November 7, 2023
Assignee:
ZYMO RESEARCH CORPORATION
Inventors:
Ryan Kemp, Mike Weinstein, Shuiquan Tang
Abstract: A method of casting an article includes forming a melt comprising copper, introducing manganese into the melt to produce a copper-manganese alloy, and casting the copper-manganese alloy in a mold to form the article. The carbon and oxygen contents of the copper-manganese alloy are controlled in order to control the formation of graphite, manganese carbide, and/or manganese oxide particles within the article. Copper-manganese alloys containing carbon are also provided, as well as articles made therefrom in cast or wrought form.
Type:
Grant
Filed:
April 28, 2021
Date of Patent:
November 7, 2023
Assignee:
Purdue Research Foundation
Inventors:
Kevin Paul Trumble, Kevin Joseph Chaput
Abstract: The present invention describes compositions and method for improving outcomes after injury to the central nervous system wherein complement signaling is activated. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a therapeutic agent comprising a targeted inhibitor molecule comprising a targeting portion and an inhibitor portion, wherein the molecule inhibits complement, and wherein therapeutic agent is administered in combination with rehabilitation therapy or thrombolytic agent.
Type:
Grant
Filed:
May 14, 2021
Date of Patent:
November 7, 2023
Assignees:
MUSC Foundation For Research Development, United States Government as Represented by the Department of Veteran Affairs
Inventors:
Stephen Tomlinson, DeAnna Adkins, Ali Alawieh
Abstract: Systems and methods of model or prediction algorithm selection are provided. An autonomous control system may include a perception component that, based on environmental inputs regarding an object(s), a vehicle's operating characteristics, etc., outputs a current state of the vehicle's surrounding environment. This in turn, is used as input to a prediction component comprising a plurality of prediction algorithms. The prediction component outputs a set of predictions regarding the trajectory of the object(s). Accordingly, for each object, a set of trajectories at specific timesteps may be generated by the different prediction algorithms which are input to a planner component. These trajectories may then be analyzed, compared, or otherwise processed to determine which trajectory regarding the object is most accurate. The prediction algorithm or model that produced the most accurate predicted trajectory may then be used for subsequent predictions/timesteps.
Type:
Grant
Filed:
July 28, 2020
Date of Patent:
November 7, 2023
Assignee:
TOYOTA RESEARCH INSTITUTE, INC.
Inventors:
Blake Warren Wulfe, Guy Rosman, Noah J. Epstein, Luke D. Fletcher
Abstract: A semiconductor chip includes: an epitaxial film made of gallium nitride; a semiconductor element disposed in the epitaxial film; a chip formation substrate including the epitaxial film and having a first surface, a second surface opposite to the first surface, and a side surface connecting the first surface and the second surface; and a convex and a concavity on the side surface.
Type:
Grant
Filed:
April 13, 2021
Date of Patent:
November 7, 2023
Assignees:
DENSO CORPORATION, HAMAMATSU PHOTONICS K.K., National University Corporation Tokai National Higher Education and Research System
Inventors:
Masatake Nagaya, Kazukuni Hara, Daisuke Kawaguchi, Toshiki Yui, Chiaki Sasaoka, Jun Kojima, Shoichi Onda
Abstract: A method of depositing a multiphase material. The method includes providing a Continuous Multifunctional Composite (CMC) phase containing at least one continuous element in a polymeric matrix, passing the CMC phase through a feeding system containing a cutting system, producing a predetermined length of the CMC phase, providing a flow a molten polymer such that the molten polymer and the CMC phase are merged into a continuous co-extrusion nozzle so as to produce a co-extruded multiphase material, and depositing the co-extruded multiphase material onto a surface. An apparatus for depositing a multiphase material. The apparatus contains a co-extrusion nozzle, a means to introduce a CMC phase and a molten polymer into the co-extrusion nozzle, such that the molten polymer and the CMC phase are co-extruded and deposited on a surface. An article containing a CMC phase containing continuous elements embedded in a polymer resin forming a multiphase structure.
Type:
Grant
Filed:
January 2, 2022
Date of Patent:
November 7, 2023
Assignee:
Purdue Research Foundation
Inventors:
Eduardo Barocio, Jorge A. Ramirez, Miguel Angel Ramirez, Bastian Brenken, Robert Byron Pipes
Abstract: The present invention relates to a method for treating the surface of a wafer with multiple liquids, comprising rotating the surface of the wafer and discharging different liquid streams onto the rotating surface in a sequence from separate outlets, wherein the discharge of liquid streams which are contiguous in the sequence overlaps during a transition phase, and wherein during the transition phase the liquid streams merge after exiting said outlets to form a merged liquid stream before impacting the rotating surface. The invention also provides a liquid dispensing device incorporating a housing holding two or more liquid delivery tubes, wherein the tubes' outlets are inwardly angled towards one another, such that in use liquid streams delivered from the outlets of the two or more liquid delivery tubes merge to form a merged liquid stream.
Type:
Grant
Filed:
September 16, 2019
Date of Patent:
November 7, 2023
Assignee:
LAM RESEARCH AG
Inventors:
Christoph Semmelrock, Ulrich Tschinderle, Reinhard Sellmer, Walter Esterl
Abstract: A measuring equipment, applied to carry a workpiece to be measured, includes a main base and a positioning device. The main base includes a measuring center axis. The positioning device includes at least two positioning elements. Each of the at least two positioning elements is disposed movably on the main base, and each of the at least two positioning elements is moved with respect to the measuring center axis. An identical distance is there from each of the at least two positioning elements to the measuring center axis. Each of the at least two positioning elements is used for the workpiece to contact and to be positioned to the measuring center axis.
Type:
Grant
Filed:
July 7, 2021
Date of Patent:
November 7, 2023
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: A system a method for controlling an operation of HVAC system is provided. The system comprises at least one processor; and memory having instructions stored thereon that, when executed by the at least one processor, cause the system to receive data indicative of the operation of the HVAC system and optimize a cost function to reduce a difference between a full thermal state of the conditioned environment simulated from the received data based on a physical model of airflow including a partial differential equation (PDE) and a thermal state of the conditioned environment reconstructed by an observer using a reduced order model (ROM) of airflow including an ordinary differential equation (ODE) from values of the full thermal state at a set of locations, wherein optimization of the cost function is a multivariable optimization of a structure of the observer and a structure of the ODE.
Type:
Grant
Filed:
March 26, 2021
Date of Patent:
November 7, 2023
Assignee:
Mitsubishi Electric Research Laboratories Inc.
Abstract: A system and method for converting a radio frequency (RF) to a direct current (DC) signal by generating acoustic phonons from the received RF signal utilizing a piezoelectric material. The acoustic phonons of the RF signal interact with the electrons of a semiconductive material to generate a DC signal that is proportional to the power of the RF signal. The DC signal can be used to power devices or can be interpreted as a measure of a local RF frequency spectrum.
Type:
Grant
Filed:
May 5, 2023
Date of Patent:
November 7, 2023
Assignee:
University of Central Florida Research Foundation, Inc.