Patents Assigned to Research
  • Simultaneous multi-slice MRSI using density weighted concentric ring acquisition
    Patent number: 11828822
    Abstract: A method of performing magnetic resonance spectroscopic imaging (MRSI) measures neurochemical profiles over larger regions non-invasively. The method includes transmitting a multi-slice excitation pulse through tissue, the multi-slice excitation pulse configured to generate multi-slice MRSI signals. The method also includes performing density weighted concentric ring acquisition on the multi-slice MRSI signals. The method further includes receiving the generated multi-slice MRSI signals in a plurality of sensors disposed in various locations around the tissue. Imaging data is reconstructed based on the acquired imaging signals. A representation of the data is displayed.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: November 28, 2023
    Assignee: Purdue Research Foundation
    Inventors: Uzay Emir, Mark Chiew
  • Antimicrobial peptide ID13, preparation method and use thereof
    Patent number: 11827677
    Abstract: The present invention provides an antimicrobial peptide ID13 (with a sequence set forth in SEQ ID NO. 1), a preparation method and use thereof. The antimicrobial peptide ID3 is successfully expressed in Pichia pastoris using genetic engineering technology. The antimicrobial peptide ID13 of the present invention has an excellent bactericidal activity against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus suis, and has a low hemolytic activity against mouse red blood cells and a low murine macrophage cytotoxicity.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: November 28, 2023
    Assignee: Feed Research Institute, Chinese Academy of Agricultural Sciences
    Inventors: Jianhua Wang, Bing Li, Da Teng, Ruoyu Mao, Xiumin Wang, Ya Hao, Na Yang
  • Modular multiplication circuit and corresponding modular multiplication method
    Patent number: 11829731
    Abstract: A modular multiplication circuit includes a main operation circuit, a look-up table, and an addition unit. The main operation circuit updates a sum value and a carry value according to 2iA corresponding to a first operation value A and m bits of a second operation value B currently under operation, m is a positive integer, i is from 0 to m?1. The look-up table records values related to a modulus, and selects one of the values as a look-up table output value according to the sum value. The addition unit updates the sum value and the carry value according to the look-up table output value and outputs the updated sum value and the updated carry value to the main operation circuit. The modular multiplication circuit updates the sum value and the carry value in a recursive manner by using m different bits of the second operation value B.
    Type: Grant
    Filed: December 27, 2021
    Date of Patent: November 28, 2023
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Chia-Hsiang Yang, Liang-Hsin Lin, Yu-Ling Kang, Li-Chi Su
  • Proline-based neuropeptide FF receptor modulators
    Patent number: 11826350
    Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.
    Type: Grant
    Filed: October 2, 2022
    Date of Patent: November 28, 2023
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Yanan Zhang, Thuy Nguyen
  • Air conditioning system and control method therefor
    Patent number: 11828507
    Abstract: The present application discloses an air conditioning system and a control method therefore. An intermediate heat exchanger can include a first heat exchange portion and a second heat exchange portion, a first end of the first heat exchange portion is in communication with an inlet of a compressor, a second end of the first heat exchange portion is communicable with an outlet of a second heat exchanger and/or a second end of the first heat exchanger, a first end of the second heat exchange portion is communicable with a first end of the first heat exchanger, and a second end of the second heat exchange portion is communicable with an inlet of the second heat exchanger and/or an outlet of the compressor. In the refrigeration mode, the first branch can have an adjustable amount of flow.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: November 28, 2023
    Assignee: HANGZHOU SANHUA RESEARCH INSTITUTE CO., LTD.
    Inventors: Qiaofeng Liu, Junqi Dong, Shiwei Jia
  • Nano-ligand for promoting cell adhesion and differentiation of stem cells and method of promoting cell adhesion and differentiation of stem cells by using the same
    Patent number: 11828719
    Abstract: The present invention relates to a nano-ligand for promoting cell adhesion and differentiation of stem cells and a method of promoting cell adhesion and differentiation of stem cells by using the nano-ligand, and the method of promoting cell adhesion and differentiation of stem cells according to the present invention may temporally and spatially, and reversibly control nano-ligand sliding by applying a magnetic field to a substrate including the nano-ligands, and efficiently control stem cell adhesion and differentiation ex vivo or in vivo through the magnetic-field based on spatiotemporal control.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: November 28, 2023
    Assignee: Korea University Research and Business Foundation
    Inventors: Hee-Min Kang, Chandra Khatua, Gun-Hyu Bae, Hyo-Jun Choi, Sun-Hong Min
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 11827891
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: November 28, 2023
    Assignee: VTT TECHNICAL RESEARCH CENTRE OF FINLAND LTD
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • Pharmaceutical intermediates and methods for preparing the same
    Patent number: 11827643
    Abstract: A pharmaceutical intermediate including a first indole moiety which is associated with an optionally carboxylated hexahydroazepino moiety, an optionally carboxylated azonane moiety, or a second, optionally carboxylated indole moiety, having an alkyl, allyl, phenylallyl, cinnamyl, alkenyl, and/or alkyl-alkenyl substituent pendant from a nitrogen atom of the same.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: November 28, 2023
    Assignee: Obiter Research, LLC
    Inventor: William Allen Boulanger
  • Nanostructure, a biosensor including the nanostructure, and a screening method
    Patent number: 11827920
    Abstract: Disclosed are a nanostructure including a nanoparticle, and a first compound including a probe and bound to the surface of the nanoparticle, a second compound including a DNA sequence encoding the probe and bound to the surface of the nanoparticle, and optionally substituted or unsubstituted polyalkylene glycol bound to the surface of the nanoparticle, wherein when the nanostructure does not include substituted or unsubstituted polyalkylene glycol bound to the surface of the nanoparticle, a ratio ((n1+n2)/w) of the sum of the number of moles (n1) of the first compound and the number of moles (n2) of the second compound relative to the weight (w) of the nanostructure is about 1.2 nmol/g to about 85 ?mol/g on average, a biosensor including the nanostructure, and a method of screening a biological material using the nanostructure or the biosensor.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: November 28, 2023
    Assignee: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION
    Inventors: Hyun-Suk Lim, Kang Ju Lee
  • MUSCLE-DRIVEN ENDOPROSTHESIS SYSTEMS AND METHODS FOR USING SAME
    Publication number: 20230372124
    Abstract: A muscle-driven endoprosthesis system may include a bone extension, an intramedullary stem extending form a first end of the bone extension, a joint at a second end of the bone extension, a moveable portion coupled to the hinge, and synthetic tendons coupled to the moveable portion. The bone extension, intramedullary stem, hinge, and movable portion are sized and shaped to fit within a skin of a patient.
    Type: Application
    Filed: May 16, 2023
    Publication date: November 23, 2023
    Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Dustin Lee Crouch, David Edgar Anderson, Stacy Stephenson
  • SOFT TISSUE CUTTING DEVICE AND METHODS OF USE
    Publication number: 20230371974
    Abstract: Some embodiments provide a soft tissue device, such as a transverse carpal ligament cutting device having one or more balloons that are deflated when the device is in an inactive position and are inflated when the device is in an active position. Other embodiments provide a soft tissue cutting method, such as a method of cutting a transverse carpal ligament that uses a soft tissue cutting device.
    Type: Application
    Filed: July 25, 2023
    Publication date: November 23, 2023
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: DARRYL E. BARNES, JAY SMITH
  • ENHANCED IMAGES
    Publication number: 20230377095
    Abstract: Examples of methods for image enhancement are described. In some examples, a method includes segmenting an image into an object region and a background region. In some examples, the image has a first resolution. In some examples, the method includes generating, using a first machine learning model, an enhanced object region with a second resolution that is greater than the first resolution. In some examples, the first machine learning model has been trained based on object landmarks. In some examples, the method includes generating, using a second machine learning model, an enhanced background region with a third resolution that is greater than the first resolution. In some examples, the method includes combining the enhanced object region and the enhanced background region to produce an enhanced image.
    Type: Application
    Filed: October 16, 2020
    Publication date: November 23, 2023
    Applicants: Hewlett-Packard Development Company, L.P., Purdue Research Foundation
    Inventors: Xiaoyu Xiang, Tianqi Guo, Qian Lin, Jan Philip Allebach
  • OPTOELECTRONIC DEVICE
    Publication number: 20230375680
    Abstract: This disclosure relates to a time-of-flight sensor including, on a same base substrate, a light emitter configured to emit light into an image scene, a reference sensor configured to detect light emitted by the light emitter, and a signal reception sensor array separated from the light emitter by an optical barrier. The optical barrier is configured to prevent light emitted by the light emitter from directly reaching the signal reception sensor array, with the signal reception sensor array being configured to detect light reflected by the image scene. The reference sensor and the signal reception sensor array are based on semiconductor nanoparticles.
    Type: Application
    Filed: May 10, 2023
    Publication date: November 23, 2023
    Applicants: STMicroelectronics (Research & Development) Limited, STMicroelectronics (Grenoble 2) SAS
    Inventors: Neale DUTTON, Jonathan STECKEL
  • SYSTEMS AND METHODS FOR NEURAL IMPLICIT SCENE REPRESENTATION WITH DENSE, UNCERTAINTY-AWARE MONOCULAR DEPTH CONSTRAINTS
    Publication number: 20230377180
    Abstract: In accordance with one embodiment of the present disclosure, a method includes receiving a set of images, each image depicting a view of a scene, generating sparse depth data from each image of the set of images, training a monocular depth estimation model with the sparse depth data, generating, with the trained monocular depth estimation model, depth data and uncertainty data for each image, training a NeRF model with the set of images, wherein the training is constrained by the depth data and uncertainty data, and rendering, with the trained NeRF model, a new image having a new view of the scene.
    Type: Application
    Filed: May 18, 2022
    Publication date: November 23, 2023
    Applicant: Toyota Research Institute Inc.
    Inventors: Rares Ambrus, Sergey Zakharov, Vitor C. Guizilini, Adrien Gaidon
  • DEVICE FOR SWITCHING OPTICAL SIGNAL
    Publication number: 20230375896
    Abstract: Proposed is a device for switching an optical signal, the device including a first waveguide constituting an input port and a first output port; and a second waveguide constituting a second output port, wherein the first waveguide is formed of a first material, wherein the second waveguide is formed of the first material and contains a second material, wherein a gap between the first and second waveguides has a first value in a first section, a gap therebetween has a value increasing from the first value to a second value in a second section, and a gap therebetween has a third value in a third section, wherein at least one portion of the first section and at least one portion of the second section overlap in the one section, and wherein a grating structure applies to the first and second waveguides in at least one portion of the first section.
    Type: Application
    Filed: May 18, 2023
    Publication date: November 23, 2023
    Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Jae Gyu PARK, Sung Hoon HONG, Soo Jung KIM
  • ULTRAVIOLET LASER APPARATUS AND ELECTRONIC DEVICE MANUFACTURING METHOD
    Publication number: 20230378713
    Abstract: An ultraviolet laser apparatus includes an oscillation-stage laser, an amplifier that amplifies the pulse laser light, and an optical isolator. The optical isolator includes a first Faraday rotator that rotates the polarization direction of the pulse laser light output from the oscillation-stage laser by a first angle in a first rotation direction, a first polarizer so disposed to transmit the pulse laser light that exits out of the first Faraday rotator at normalized transmittance greater than or equal to 0.9, a second Faraday rotator that rotates the polarization direction of the pulse laser light passing through the first polarizer by a second angle in the opposite direction to the first rotation direction, and a second polarizer so disposed to transmit the pulse laser light that exits out of the second Faraday rotator at the normalized transmittance greater than or equal to 0.9.
    Type: Application
    Filed: August 1, 2023
    Publication date: November 23, 2023
    Applicants: Gigaphoton Inc., Inter-University Research Institute Corporation, National Institutes of Natural Sciences
    Inventors: Yuki TAMARU, Taisuke MIURA, Ryo YASUHARA
  • SELF-ASSEMBLING URICASE FUSION PEPTIDES
    Publication number: 20230374471
    Abstract: Provided herein are charge complementary peptides coupled to a cargo polypeptide (e.g., a uricase protein) (e.g., uricase) that are capable of self-assembling under stimulating conditions. The charge complementary peptides can be capable of forming supramolecular structures. Also provided herein are methods of using the charge complementary peptides provided herein (e.g., to treat gout).
    Type: Application
    Filed: October 13, 2021
    Publication date: November 23, 2023
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Gregory Allan Hudalla, Benjamin G. Keselowsky, Madeline Jeanne Fuchs, Dillon T. Seroski
  • SYSTEM AND METHOD FOR POWER-EFFICIENT MULTIPLEXING FOR HIGH RESOLUTION TIME-OF-FLIGHT POSITRON EMISSION TOMOGRAPHY MODULES WITH INTERCRYSTAL LIGHT SHARING
    Publication number: 20230375731
    Abstract: A multiplexing scheme for both energy and timing information is provided for a particle detection system having an optical sensor array with multiple optical sensors. Each optical sensor is associated with multiple scintillator modules. The system has a segmented prismatoid light guide comprising multiple prismatoid segments. Each segment is associated with multiple optical sensors, where the optical sensors are adjacent. One end each scintillator module is in contact with its associated optical sensor and the other is in contact with its associated segment. Multiple optical sensors may be connected to an energy readout channel, respectively, such that optical sensors associated with the same segments are not connected to the same energy readout channel. Each energy readout channel has at least two timestamps associated therewith.
    Type: Application
    Filed: October 7, 2021
    Publication date: November 23, 2023
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Andrew LABELLA, Amirhossein GOLDAN, Eric PETERSEN, Wei ZHAO
  • RADIOLABELED LIGANDS FOR TARGETED PET/SPECT IMAGING AND METHODS OF THEIR USE
    Publication number: 20230372551
    Abstract: The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject.
    Type: Application
    Filed: September 21, 2021
    Publication date: November 23, 2023
    Applicants: MEMORIAL SLOAN-KETTERING CANCER CENTER, MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES, SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES, PHLIP, INC.
    Inventors: Jason S. LEWIS, Yana K. RESHETNYAK, Lukas M. CARTER, David BAUER
  • BENTHONIC ANIMAL ISOLATION FRAME AND METHOD FOR STUDYING AQUATIC ECOSYSTEM BY USING SAME
    Publication number: 20230371478
    Abstract: A benthonic animal isolation frame and a method for studying an aquatic ecosystem by using the same is provided. The benthonic animal isolation frame includes side surfaces and a bottom surface of the isolation frame as hollow structures. Joints of the side surfaces and the bottom surface are provided with clamping grooves. The bottom surface is provided with a filter membrane; and the filter membrane is fixed on the bottom surface through the clamping grooves. The benthonic animal isolation frame can be used for easily studying the influence of the benthonic animal and excrement thereof on a water body ecological system.
    Type: Application
    Filed: May 17, 2023
    Publication date: November 23, 2023
    Applicant: FRESHWATER FISHERIES RESEARCH CENTER,CAFS
    Inventors: Yiran HOU, Jian ZHU, Bing LI, Rui JIA, Wei SUN