Abstract: A system and method for acquiring medical images of a subject includes performing two-dimensional (2D) scan of a subject using a medical imaging system to acquire 2D data from at least two view angles and generating a three-dimensional (3D) model of the subject from the 2D data. The method also includes extracting desired images of the subject from the 3D model. The desired images are at view angles different from the at least two view angles. The method further includes prescribing an imaging study of the subject using the desired images of the subject to control at least one of a signal-to-noise ratio of data acquired using the imaging study or a dose of ionizing radiation delivered to the subject during the imaging study. The method also includes performing the imaging study using the medical imaging system to acquire imaging data from the subject and reconstructing images of the subject from the imaging data.

Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo.

Abstract: The present invention provides novel and stable pharmaceutical compositions comprising bispecific single chain antibody constructs, cyclodextrins and a buffer.

Abstract: Embodiments of the invention provide systems and methods of generating a complete and accurate geometrically optimized environment. Stereo pair images depicting an environment are selected from a plurality of images to generate a Digital Surface Model (DSM). Characteristics of objects in the environment are determined and identified. The geometry of the objects may be determined and fit with polygons and textured facades. By determining the objects, the geometry, and the material from original satellite imagery and from a DSM created from the matching stereo pair point clouds, a complete and accurate geometrically optimized environment is created.

Abstract: The present invention provides novel compounds of Formula (I?) and (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for killing a microorganism (e.g., bacteria, fungi, viruses, protozoa, or multicellular parasites), the prevention and/or treatment of infectious diseases (e.g., infections by microorganisms, bacterial infection, cystic fibrosis infection, foreign body infection, urinary tract infection (UTI), or infections leading to biofilms), controlling and/or eradicating biofilms (e.g., bacterial biofilms), preventing biofilm formation, sterilizing a surface, and/or eradicating persister cells (e.g., in a subject in need thereof or in a subject involving a biofilm).

Abstract: Methods, systems, and computer readable media for controlling ventricular assist devices are disclosed. In some embodiments, the method includes receiving at least one reference pump speed differential associated with a pump of a ventricular assist device; determining a filtered pump speed differential associated with the pump of a ventricular assist device; and adjusting, using a feedback based controller algorithm, current to the pump based on the at least one reference pump speed differential and the filtered pump speed differential.

Abstract: The present invention relates to new transporter polypeptides, and genes encoding therefor, which can be used to confer upon a plant resistance to one or more biotrophic fungal pathogens.

Abstract: Provided herein is a fuel injector capable of providing fuel into a jet engine operating at hypersonic speeds. Embodiments may include a system for fuel injection for an engine traveling at supersonic speeds. The system may include a fuel injection strut extending between opposing walls of an inlet to the engine, and a porous surface extending across at least a portion of the fuel injection strut. The fuel may be introduced into the inlet of the engine through the porous surface of the fuel injection strut. The porous surface of the fuel injection strut may extend along a fuel injecting portion of the fuel injection strut spaced a predefined distance from the opposing walls of the inlet. The porous portion of the fuel injection strut may include a porosity of about 100 pores per square inch or lower porosities as dictated by the specific design considerations.

Abstract: A method of estimating a state of health of a battery, the method being performed by a computing apparatus, the method including: preparing a trained artificial neural network; generating input data by measuring at least one parameter of a battery; acquiring a plurality of output values each corresponding to a plurality of classes by inputting the input data into the trained artificial neural network; and generating a state of health estimation value of the battery using a plurality of preset health state sections each corresponding to the plurality of classes and the plurality of output values each corresponding to the plurality of classes.

Abstract: A patient monitoring system comprises a plurality of sensors and an analysis computing entity. The sensors comprise a visual sensor and a wearable sensor. The visual sensor is configured to capture images of a patient and provide the images of the patient such that the analysis computing entity receives the images. The wearable sensor is configured to capture wearable data. The wearable data comprises (a) biometric data of the patient and/or (b) movement data of the patient. The wearable sensor is configured to provide the wearable data such that the analysis computing entity receives the wearable data. The analysis computing entity is configured to receive the images of the patient and the wearable data, analyze at least one of the images of the patient and the wearable data to determine objective patient data, and update a patient record based on the objective patient data.

Abstract: Disclosed herein are a decoding method and apparatus and an encoding method and apparatus that perform inter-prediction using a motion vector predictor. For a candidate block in a col picture, a scaled motion vector is generated based on a motion vector of the candidate block. When the scaled motion vector indicates a target block, a motion vector predictor of the target block is generated based on the motion vector of the candidate block. The motion vector predictor is used to derive the motion vector of the target block in a specific inter-prediction mode such as a merge mode and an AMVP mode.

Abstract: The invention relates to a ventilation flow rate regulator (1) for a pressurized vehicle tank (4), which comprises a plunger (10) adapted to be mounted in a ventilation line (7). The plunger (10) has at least one peripheral orifice (111) and at least one non-central internal orifice (112) which is closer to an axis of symmetry (A) of the plunger (10 than the peripheral orifice (111). The non-central internal orifice (112) has a section perpendicular to the axis of symmetry (A) which is smaller than any section of the peripheral orifice (111) perpendicular to the axis of symmetry (A).

Abstract: A biosensor for detecting nitrotoluenes. Two P. putida host populations (H-I and H-II) are engineered. H-1 undergoes fluorescence when a nitrotoluene is detected but it is also engineered to metabolize nitrotoluenes to toluene as its sole nitrogen-source. H-I is 1-ACC Deaminase inactive and is further engineered to efflux toluene and provide toluene to adjacent H-II. In H-II, ACC is the N-source and metabolizes toluene as the sole carbon and energy source available. The H-II cells are engineered to not be able to use medium fructose. The H-II population has a promoter/GFP construct with a promoter sensitive to toluene and thus they fluoresce from that first nitrotoluene metabolite i.e. toluene, produced by the H-I cells. This is achieved by making H-II cells mutants unable to transport and phosphorylate fructose i.e. PTSFRU gene knock-out.

Abstract: A field condition-based experimental apparatus for an ecological indicator of vegetation includes a plurality of isolation units arranged at intervals and an auxiliary mechanism detachably connected to the isolation unit. The isolation units include a plurality of isolation boxes arranged at intervals and respectively having a hollow structure, and a support frame respectively disposed at four corners of the isolation box. The auxiliary mechanism is detachably connected to the support frame. A soil layer is disposed in the isolation box. The experimental apparatus has a reliable structure and is easy to use. An appropriate number of isolation units are buried under field conditions based on experimental needs. Auxiliary mechanisms of different structures are mounted based on experimental conditions. This implements reliable detection of an ecological indicator of vegetation under the field conditions and effectively improves authenticity and reliability of detection results.

Abstract: Systems, devices, and methods disclosed herein can generally include electrical contacts for high voltage, high current, and/or fast acting electromechanical switches and methods for manufacturing the same. The electrical contacts can be optimized for high voltage blocking capabilities with minimal gap spacing in the open state and low electrical resistance when in contact in the closed state. Electrical contacts can have a geometry to produce a low peak electric field between the contacts when in the open state, have a high contact surface area when in the closed state, and a low mass. The geometry of the contacts can be based on geometries traditionally utilized for uniform field electrodes.

Abstract: The present invention relates to the use of cannabidiol (CBD) in combination with an agonist of 5-HT2B receptors. Such a combination provides protection against the adverse effects caused by agonists of 5-HT2B receptors. The invention further relates to the use of CBD in combination5 with an amphetamine or amphetamine derivative in the treatment of epilepsy. In one embodiment the CBD is used in combination with the amphetamine derivative fenfluramine to produce a significant reduction in seizures. Preferably the CBD used is in the form of a highly purified extract of cannabis such that the CBD is present at greater than 98% of the total extract (w/w) and the other components of the extract are characterised. In particular the cannabinoid10 tetrahydrocannabinol (THC) has been substantially removed, to a level of not more than 0.15% (w/w) and the propyl analogue of CBD, cannabidivarin, (CBDV) is present in amounts of up to 1%. Alternatively, the CBD may be a synthetically produced CBD.

Abstract: Provided are sentence embedding method and apparatus based on subword embedding and skip-thoughts. To integrate skip-thought sentence embedding learning methodology with a subword embedding technique, a skip-thought sentence embedding learning method based on subword embedding and methodology for simultaneously learning subword embedding learning and skip-thought sentence embedding learning, that is, multitask learning methodology, are provided as methodology for applying intra-sentence contextual information to subword embedding in the case of subword embedding learning. This makes it possible to apply a sentence embedding approach to agglutinative languages such as Korean in a bag-of-words form. Also, skip-thought sentence embedding learning methodology is integrated with a subword embedding technique such that intra-sentence contextual information can be used in the case of subword embedding learning.

Abstract: A drug containing, as an active ingredient, a compound represented by ALK inhibitors such as brigatinib, AP26113-analog, and AZD3463 has been found to be effective against a non-small cell lung cancer having a point mutation at C797S in EGFR which has acquired a resistance to chemotherapy agents. Further, the drug used in combination with an anti-EGFR antibody demonstrates a notable suppression effect on the tumor growth. The drug has a potential to be a therapeutic agent effective against a non-small cell lung cancer which is resistant to gefitinib, a first generation therapeutic agent and osimertinib, a third generation therapeutic agent.

Abstract: There is provided a nucleic acid molecule comprising a nucleotide sequence encoding a Factor VIII protein, wherein a B domain portion of the Factor VIII protein is encoded by a nucleotide sequence between 90 and 111 nucleotides in length and has an amino acid sequence that is at least 85% identical to SEQ ID NO: 4 which comprises six asparagine residues. Also provided is a Factor VIII protein, a vector comprising the above nucleic acid molecule, a host cell, a transgenic animal, a method of treating Haemophilia for example, Haemophilia A, and a method for the preparation of a parvoviral gene delivery vector.