Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an oxycodone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.
Type:
Application
Filed:
September 8, 2020
Publication date:
April 1, 2021
Applicant:
RHODES TECHNOLOGIES
Inventors:
Stuart James GEBBIE, Joshua R. GIGUERE, Keith MCCARTHY, Lonn S. RIDER
Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Abstract: This invention relates to novel opioid derivatives of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R3, R4 and Z are as defined herein in the disclosure. The invention also relates to the use of such compounds for the treatment or prevention of, for example, pain.
Type:
Application
Filed:
February 22, 2019
Publication date:
March 4, 2021
Applicant:
RHODES TECHNOLOGIES
Inventors:
Ping CHANG, Raymond GLOWAKY, Michael David ROGERS
Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.
Type:
Application
Filed:
October 29, 2020
Publication date:
February 18, 2021
Applicant:
Rhodes Technologies
Inventors:
C. Frederick M. HUNTLEY, Erik Wayne KATAISTO, Helge Alfred REISCH, Archana SHARMA
Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.
Type:
Grant
Filed:
June 19, 2019
Date of Patent:
December 29, 2020
Assignee:
Rhodes Technologies
Inventors:
C. Frederick Huntley, Erik Wayne Kataisto, Helge Alfred Reisch, Archana Sharma
Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.
Type:
Grant
Filed:
July 31, 2019
Date of Patent:
November 24, 2020
Assignee:
RHODES TECHNOLOGIES
Inventors:
Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.
Type:
Grant
Filed:
June 19, 2019
Date of Patent:
November 17, 2020
Assignee:
Rhodes Technologies
Inventors:
C. Frederick M. Huntley, Erik Wayne Kataisto, Helge Alfred Reisch, Archana Sharma
Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.
Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.
Abstract: The disclosure relates to processes for reducing the amount of a compound of formula (I) or a salt or a solvate thereof present in a composition comprising compounds of formulae (I) and (II) or a salt or a solvate thereof.
Type:
Application
Filed:
September 20, 2019
Publication date:
July 16, 2020
Applicant:
Rhodes Technologies
Inventors:
Keith Edward MCCARTHY, Helge Alfred REISCH, Christopher SPROUT
Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.
Type:
Application
Filed:
July 31, 2019
Publication date:
June 25, 2020
Applicant:
RHODES TECHNOLOGIES
Inventors:
Joshua Robert GIGUERE, Keith Edward MCCARTHY, Marcel SCHLEUSNER
Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.
Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.
Type:
Application
Filed:
April 17, 2019
Publication date:
December 5, 2019
Applicant:
RHODES TECHNOLOGIES
Inventors:
Stuart James Gebbie, Joshua R. Giguere, Keith McCarthy, Lonn S. Rider
Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.
Type:
Application
Filed:
June 19, 2019
Publication date:
October 17, 2019
Applicant:
Rhodes Technologies
Inventors:
C. Frederick M. HUNTLEY, Erik Wayne KATAISTO, Helge Alfred REISCH, Archana SHARMA
Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an oxycodone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.
Type:
Application
Filed:
February 8, 2019
Publication date:
October 10, 2019
Applicant:
RHODES TECHNOLOGIES
Inventors:
Stuart James GEBBIE, Joshua R. Giguere, Keith McCarthy, Lonn S. Rider
Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.
Type:
Application
Filed:
June 19, 2019
Publication date:
October 3, 2019
Applicant:
Rhodes Technologies
Inventors:
C. Frederick M. HUNTLEY, Erik Wayne KATAISTO, Helge Alfred REISCH, Archana SHARMA
Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.
Type:
Grant
Filed:
March 30, 2018
Date of Patent:
October 1, 2019
Assignee:
RHODES TECHNOLOGIES
Inventors:
Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner