Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.
Type:
Grant
Filed:
March 9, 2016
Date of Patent:
September 10, 2019
Assignee:
RHODES TECHNOLOGIES
Inventors:
C. Frederick M. Huntley, Erik Wayne Kataisto, Helge Alfred Reisch, Archana Sharma
Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Type:
Grant
Filed:
January 30, 2019
Date of Patent:
September 10, 2019
Assignees:
PURDUE PHARMA L.P., THE P.F. LABORATORIES, INC., PURDUE PHARMACEUTICALS L.P., RHODES TECHNOLOGIES
Inventors:
Robert Chapman, Lonn S. Rider, Qi Hong, Donald Kyle, Robert Kupper
Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.
Type:
Grant
Filed:
July 15, 2013
Date of Patent:
June 11, 2019
Assignee:
RHODES TECHNOLOGIES
Inventors:
Stuart James Gebbie, Joshua R. Giguere, Keith McCarthy, Lonn S. Rider
Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.
Type:
Grant
Filed:
February 12, 2018
Date of Patent:
May 7, 2019
Assignee:
Rhodes Technologies
Inventors:
C. Frederick M. Huntley, Erik Wayne Kataisto, Helge Alfred Reisch, Archana Sharma
Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Type:
Grant
Filed:
September 29, 2017
Date of Patent:
April 16, 2019
Assignees:
PURDUE PHARMA L.P., THE P.F. LABORATORIES, INC., PURDUE PHARMACEUTICALS L.P., RHODES TECHNOLOGIES
Inventors:
Robert Chapman, Lonn S. Rider, Qi Hong, Donald Kyle, Robert Kupper
Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.
Type:
Application
Filed:
March 30, 2018
Publication date:
April 11, 2019
Applicant:
RHODES TECHNOLOGIES
Inventors:
Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an oxycodone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.
Type:
Grant
Filed:
September 11, 2017
Date of Patent:
February 12, 2019
Assignee:
RHODES TECHNOLOGIES
Inventors:
Stuart James Gebbie, Joshua R. Giguere, Keith McCarthy, Lonn S. Rider
Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.
Type:
Grant
Filed:
April 3, 2018
Date of Patent:
January 29, 2019
Assignee:
RHODES TECHNOLOGIES
Inventors:
Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.
Type:
Application
Filed:
April 3, 2018
Publication date:
November 15, 2018
Applicant:
RHODES TECHNOLOGIES
Inventors:
Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an oxycodone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.
Type:
Application
Filed:
September 11, 2017
Publication date:
April 26, 2018
Applicant:
RHODES TECHNOLOGIES
Inventors:
Stuart James GEBBIE, Joshua R. Giguere, Keith McCarthy, Lonn S. Rider
Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.
Type:
Grant
Filed:
January 15, 2015
Date of Patent:
April 10, 2018
Assignee:
RHODES TECHNOLOGIES
Inventors:
Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.
Type:
Grant
Filed:
January 15, 2015
Date of Patent:
April 3, 2018
Assignee:
RHODES TECHNOLOGIES
Inventors:
Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.
Type:
Grant
Filed:
March 1, 2017
Date of Patent:
March 27, 2018
Assignee:
Rhodes Technologies
Inventors:
C. Frederick M. Huntley, Erik Wayne Kataisto, Helge Alfred Reisch, Archana Sharma
Abstract: The application is directed to a process for increasing the proportion of 7?-epimer in an 7?/7?-epimer mixture of a 7-substituted 6?,14?-ethenomorphinan or a 7-substituted 6?,14?-ethanomorphinan, and specifically of compounds of Formula (I), wherein G, R2-R4, and are defined as set forth in the specification. The application is also directed to a process for purifying the 7?-epimer from an 7?/7?-epimer mixture of a 7-substituted 6?,14?-ethenomorphinan or a 7-substituted 6?,14?-ethanomorphinan. The application is also directed to a process for preparing 7?-substituted compounds of Formula Vb wherein G and R2-R5 are defined as set forth in the specification.
Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Type:
Grant
Filed:
March 2, 2016
Date of Patent:
October 3, 2017
Assignees:
PURDUE PHARMA L.P., THE P.F. LABORATORIES, INC., PURDUE PHARMACEUTICALS L.P., RHODES TECHNOLOGIES
Inventors:
Robert Chapman, Lonn S. Rider, Qi Hong, Donald Kyle, Robert Kupper
Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.
Type:
Application
Filed:
January 15, 2015
Publication date:
September 7, 2017
Applicant:
RHODES TECHNOLOGIES
Inventors:
Joshua Robert GIGUERE, Keith Edward MCCARTHY, Marcel SCHLEUSNER
Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
Type:
Grant
Filed:
August 14, 2015
Date of Patent:
May 23, 2017
Assignee:
Rhodes Technologies
Inventors:
Joshua Robert Giguere, Keith Edward McCarthy, Helge Alfred Reisch, Sergio Sandoval, Jake Larry Stymiest
Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
Type:
Grant
Filed:
August 14, 2015
Date of Patent:
April 18, 2017
Assignee:
Rhodes Technologies
Inventors:
Joshua Robert Giguere, Keith Edward McCarthy, Helge Alfred Reisch, Sergio Sandoval, Jake Larry Stymiest
Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
Type:
Grant
Filed:
August 4, 2015
Date of Patent:
March 14, 2017
Assignee:
Rhodes Technologies
Inventors:
Joshua Robert Giguere, Keith Edward McCarthy, Helge Alfred Reisch, Sergio Sandoval, Jake Larry Stymiest
Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.
Type:
Application
Filed:
January 15, 2015
Publication date:
January 26, 2017
Applicant:
RHODES TECHNOLOGIES
Inventors:
Joshua Robert GIGUERE, Keith Edward MCCARTHY, Marcel SCHLEUSNER