Patents Assigned to Rhone-Poulenc Rorer S.A.
  • Optically active hydroquinine (amino-3 phenyl)-1 ethanesulfonate, preparation and use thereof
    Patent number: 5625066
    Abstract: This invention relates to an optically active hydroquinine (amino-3 phenyl)-1 ethanesulfonate (form A), preparation thereof and its use as an intermediate in the preparation of cholecystokinine and gastrin antagonists.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: April 29, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventor: Claude Guyon
  • Use of riluzole for the treatment of neuro-aids
    Patent number: 5624945
    Abstract: The invention relates to the application of riluzole or the pharmaceutically acceptable salts of this compound in the treatment of neuro-AIDS.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: April 29, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Anne Bousseau, Adam Doble, Erik Louvel
  • Perhydroisoindole derivatives as substance P antagonists
    Patent number: 5624950
    Abstract: Perhydroisoindole derivatives of formula I, wherein the substituents are as defined in the specification, are particularly suitable as substance P antagonists. Several processes for preparing the compounds are also taught.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: April 29, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Daniel Achard, Serge Grisoni, Evelyne James-Surcouf, Jean-Luc Malleron, Anne Morgat, Jean-Fran.cedilla.ois Peyronel, Jean-Fran.cedilla.ois Sabuco, Michel Tabart
  • Process for the preparation of a 6-fluoro-2-halo-quinoline
    Patent number: 5624933
    Abstract: Method of preparation of 6-fluoro-2-halogen quinoline of general formula (I) wherein R is a hydrogen atom or an alkyl radical and Hal and Hal' are identical or different halogen atoms. The invention is characterized in that a halogenating agent is made to act on hydroxy-1 quinoline of general formula (II) wherein Hal is defined as above and R.sub.1 is defined as R excepting a hydrogen atom, the acid function being optionally released if a 6-fluoro-2-halogen quinoline is to be obtained for which R is a hydrogen atom.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 29, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Herve Garcia, Roland Jacquot, Patrick Leon
  • Process for the preparation of taxane derivatives
    Patent number: 5621121
    Abstract: This invention relates to a method of preparing taxane derivatives of formula (I) by esterification of protected baccatin III or 10-deacetylbaccatin III by means of an acid of formula (VII), elimination of protection groupings and acylation of the amine function of the side chain. The products of formula (I) have remarkable antitumor and antileukemia properties. In formulae (I) and (VII): Ar stands for aryl, R is hydrogen or acetyl, R.sub.1 is a benzoyl radical or an R.sub.2 --O--CO-- radical in which R.sub.2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl, R.sub.3 is a trihalomethyl radical or phenyl substituted by a trihalomethyl radical, R.sub.4 is a hydrogen atom or is the same as R.sub.1.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: April 15, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Alain Commercon, Eric Didier, Elie Fouque
  • Method of preparing taxane derivatives
    Patent number: 5616739
    Abstract: This invention relates to a method of preparing taxane derivatives of general formula (I) by esterification of protected baccatine III or 10-deacetylbaccatine III by means of an acid of general formula (VII), elimination of protection groupings of the ester obtained, and acylation of the amine function of the side chain. In formulae (I) and (VII): Ar stands for aryl, R is hydrogen or acetyl, R.sub.1 is benzoyl or R.sub.2 --CO--O-- in which R.sub.2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl, R.sub.3 and R.sub.4 may be the same or different and represent hydrogen, alkyl, alkenyl, aralkyl, aryl or alkoxy, and R.sub.5 is an alkyl radical substituted by one or more chlorine atoms (2,2,2-trichloroethyl, (2-trichloromethylisopropyl).
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: April 1, 1997
    Assignee: Rhone-Poulenc Rorer, S.A.
    Inventors: Jean-Manuel Mas, Viviane Massonneau
  • K. lactis transaldolase gene promoter and use thereof
    Patent number: 5616474
    Abstract: The present invention relates to DNA sequences comprising all or part of the K. lactis TAL1 gene promoter or of a derivative thereof and having a transcriptional promoter activity. It also relates to the use of these sequences for expression of recombinant genes.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: April 1, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Monique Bolotin, Sandrine Menart
  • Human serun albumin, preparation and use
    Patent number: 5612196
    Abstract: The present invention relates to a preparation of serum-human albumin having a colorimetry index lower than 0.2 resulting from the expression, in a eukaryotic or prokaryotic host, of an exogenous DNA sequence.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: March 18, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: J er ome Becquart, Reinhard Fleer, G erard Jung
  • Pyrrolidine and thiazolidine derivatives, their preparation and medicaments containing them
    Patent number: 5610144
    Abstract: This invention relates to compositions of formula: ##STR1## and their salts, their preparation and the medicaments containing them.
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: March 11, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Marc Capet, Claude Cotrel, Claude Guyon, Michel Joannic, Franco Manfre, G erard Roussel, Marie-Christine Dubroeuco, Michel Cheve, Gilles Dutruc-Rosset
  • Process for the preparation of .beta.-phenylisoserine and its analogues
    Patent number: 5608102
    Abstract: This invention relates to a method for preparing .beta.-phenylisoserine and analogues thereof having general formula (I) ##STR1## from an aromatic aldehyde and an .alpha.-methylarylamine-S, and through a lactam of general formula (II) as described herein. The acids of general formula (I) (R.dbd.H) may be used to prepare taxane derivatives having remarkable antitumoral and antileukaemic activity.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: March 4, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Dominique Bourzat, Alain Commer.cedilla.on
  • Acid anhydrides, their preparation and their use
    Patent number: 5606068
    Abstract: This invention relates to novel anhydrides of general formula (I), ##STR1## wherein Ar is an aryl radical, and either R.sub.1 is C.sub.6 H.sub.5 --CO or (CH.sub.3).sub.3 C--O--CO, R.sub.2 is a hydrogen atom and R.sub.3 is a hydroxy function protective grouping, or R.sub.1 is (CH.sub.3).sub.3 C--O--CO and R.sub.2 together form a saturated 5 or 6-membered heterocyclic ring; preparation thereof; and uses thereof for preparing taxane derivatives having general formula (III), ##STR2## wherein R=H, acetyl; R.sub.1 is C.sub.6 --H.sub.5 --CO or (CH.sub.3).sub.3 C--O--CO), and having antitumoral properties.
    Type: Grant
    Filed: February 9, 1996
    Date of Patent: February 25, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventor: Jean-Manuel Mas
  • Process for the preparation of taxane derivatives, new derivatives thus obtained and the compositions which contain them
    Patent number: 5606083
    Abstract: This invention relates to a method for the preparation of taxane derivatives having the formula (I) and pharmaceutical compositions which contain the derivatives thus obtained. In formula (I), R is hydrogen or acetyl, R.sub.1 is benzoyl or R.sub.2 --O--CO wherein R.sub.2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl and Het is a 5-membered optionally substituted aromatic heterocycle (thiophene, tiazole, furan, pyrrole, imidazole, oxazole, isoxazole, pyrazole). The products of formula (I) have remarkable antitumor and antileukemia properties.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: February 25, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Herve Bouchard, Jean-Dominique Bourzat, Alain Commercon
  • Liquid compositions based on derivatives of 1,4 substituted piperidine
    Patent number: 5602148
    Abstract: The present invention concerns aqueous pharmaceutical compositions based on 1,4-substituted derivatives of piperidine characterized in that the composition contains a solubilizing agent and does not contain a surfactant. The solubilizing agent for the active principle is polyethylene glycol.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: February 11, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Marc Bobee, Anne Coutel
  • Taxoid intermediates
    Patent number: 5599942
    Abstract: Taxoids having a 1,3-oxazole containing moiety at the 13-position of the taxane nucleus.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 4, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Herv e Bouchard, Jean-Dominique Bourzat, Alain Commercon
  • Process for the enzymatic preparation of macrolactone
    Patent number: 5591614
    Abstract: This invention concerns a process for enzymatically preparing a compound of formula (1) ##STR1## from the compound of formula (2) ##STR2## by way of a microorganism or an acellular preparation derived from this microorganism. The microorganism and acellular preparation oxidizes the 2-3 bond of the macrolactones' D-proline into dehydroproline.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: January 7, 1997
    Assignee: Rhone-Poulenc Rorer, S.A.
    Inventors: Francis Blanche, Denis Thibaut
  • Process for preparing taxoids
    Patent number: 5587493
    Abstract: The invention relates to a process for preparing taxoids of formula I herein that includes the steps of esterifying a baccatin III derivative of the formula VI herein, acylating the compound obtained, and optionally removing a protecting group to give the desired taxoid product.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 24, 1996
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Herv e Bouchard, Jean-Dominique Bourzat, Alain Commercon
  • Baccatin III derivatives
    Patent number: 5580997
    Abstract: New Baccatin III derivatives are disclosed for use in making taxoid compounds having formula (I) illustrated herein that exhibit antitumor activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 3, 1996
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Herv e Bouchard, Jean-Dominique Bourzat, Alain Commercon
  • Process for preparing taxoids
    Patent number: 5580998
    Abstract: The invention relates to a process for preparing taxoids of formula I herein that includes comprising the steps of esterifying a baccatin III derivative of the formula VI herein, treating the compound obtained in acidic medium, and optionally removing a protecting group to give the desired taxoid product.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 3, 1996
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Herv e Bouchard, Jean-Dominique Bourzat, Alain Commercon
  • Process for the preparation of Baccatin III and 10-deacetylbaccatin III derivatives
    Patent number: 5578739
    Abstract: This invention relates to process for the preparation of a taxane derivative of general formula (I): ##STR1## and use of the product obtained for the preparation of taxane derivatives of general formula (II): ##STR2## In the general formula (I), R.sub.1 is an acetyl radical or a protective grouping G.sub.1 is a protective grouping and R is a t-butoxy or phenyl radical. In the general formula (II), R is a t-butoxy or phenyl radical and R'.sub.1 is a hydrogen atom or an acetyl radical.
    Type: Grant
    Filed: July 6, 1995
    Date of Patent: November 26, 1996
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventor: Augustin Hittinger
  • Process for preparing taxoids
    Patent number: 5576450
    Abstract: The invention relates to a process for preparing taxoids of formula I herein that includes the steps of esterifying a baccatin III derivative of the formula VI herein, treating the compound obtained in acidic medium, and optionally removing a protecting group to give the desired taxoid product.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 19, 1996
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Herv e Bouchard, Jean-Dominique Bourzat, Alain Commer.cedilla.on