Patents Assigned to Rhone-Poulenc Rorer S.A.
  • Ureidoacetamide derivatives, their preparation and the medicaments containing them
    Patent number: 5663204
    Abstract: This invention relates to compounds of formula (I), in which R denotes a hydrogen atom or a methoxy radical. The invention also concerns the salts of said compounds, their racemic forms, their enantiomers, the preparation of said derivatives and drugs containing same.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: September 2, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Marie-Christine Dubroeucq, Claude Guyon
  • Application of carbamazepine and oxcarbazepine in the treatment of Parkinson's disease and parkinsonian syndromes
    Patent number: 5658900
    Abstract: This invention relates to an application of an anticonvulsant selected from carbamazepine and oxcarbazepine or the pharmaceutically acceptable salts of said compounds in the preparation of drugs for the treatment of Parkinson's disease and parkinsonian syndromes.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 19, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Alain Boireau, Fran.cedilla.oise Bordier, Adam Doble, Pierre Dubedat, Erik Louvel, Mireille Meunier, Jean-Marie Miquet, Jean-Marie Stutzmann
  • Application of riluzole for promoting restoration following radiation
    Patent number: 5656647
    Abstract: This invention relates to an application of riluzole or its pharmaceutically acceptable salts in the preparation of drugs having radiorestoring properties.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 12, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jeremy Pratt, Jean-Marie Stutzmann
  • Peptides having GDP exchange factor activity, nucleic acid sequences coding for these peptides, preparation and use
    Patent number: 5656595
    Abstract: The present invention relates to peptides capable of modulating the levels of GDP exchange on p21-GDP complexes, the nucleic acid sequences coding for said peptides, preparation thereof and pharmaceutical compositions containing them.
    Type: Grant
    Filed: October 19, 1994
    Date of Patent: August 12, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Fabien Schweighoffer, Bruno Tocque
  • Taxoids, their preparation and the pharmaceutical compositions which contain them
    Patent number: 5654449
    Abstract: This invention relates to a process for preparing taxoid derivatives of formulae II and XI: ##STR1## in which Ar represents an aryl radical; R.sub.1 represents a benzoyl radical or a radical R.sub.2 --O--CO-- in which R.sub.2 represents an unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl, or saturated or unsaturated heterocyclic radical; R.sub.3 represents an unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, saturated or unsaturated heterocyclic, or aryl radial, but not a phenyl radical; R.sub.4 represents a hydrogen atom and R.sub.5 represents a hydroxyl-protecting group or R.sub.4 and R.sub.5 together form a heterocyclic group; G.sub.1 represents a hydroxyl-protecting group; and G.sub.
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: August 5, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Herve Bouchard, Jean-Dominique Bourzat, Alain Commercon, Jean-Pierre Pulicani
  • Polypeptides having NMDA receptor activity, nucleic acids encoding those polypeptides and applications
    Patent number: 5648259
    Abstract: The present invention concerns novel polypeptides having NMDA receptor activity and genetic material permitting their expression. It also concerns a method for demonstrating and isolating ligands and/or modulators of the activity of these polypeptides and their utilization as drugs.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: July 15, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jacques Mallet, Tania Smirnova
  • Yeast promoter and use thereof
    Patent number: 5646012
    Abstract: The present invention concerns DNA sequences from the K. lactis PGK gene having transcriptional promoter activity, to expression vectors comprising these sequences and to their use for the production of proteins.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 8, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Reinhard Fleer, Alain Fournier, Jean-Francois Mayaux, Patrice Yeh
  • Process for the preparation of N-carbonylarylimines useful in the synthesis of therapeutically active taxoids
    Patent number: 5637753
    Abstract: A process for the preparation of N-carbonylarylimine of the general formula I: ##STR1## in which Ar represent an aryl radical and R represent a phenyl or t-butoxy radical, by desulphonating the compound of the general formula II. ##STR2## The compounds of formula II are novel when R is t-butoxy.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: June 10, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Didier Bernard, Patrick Leon
  • Purified form of streptogramins, its preparation and pharmaceutical compositions containing it
    Patent number: 5637565
    Abstract: This invention relates to a purified form of streptogramins, consisting of a combination of one or more group B components of streptogramins, of general formula: ##STR1## in which A.sub.1 is a radical of general formula: ##STR2## for which R' is H or OH and Y is H, a methylamino radical or a dimethylamino radical, R is an ethyl radical or, when R' is H, R can also represent --CH.sub.3, and R.sub.1 and R.sub.2 are H, or alternatively A.sub.1 is a radical of formula: ##STR3## R is an isobutyl radical, and R.sub.1 is OH and R.sub.2 is --CH.sub.3, and one or more group A minority components of streptogramins, of general formula: ##STR4## in which R" is H or a methyl or ethyl radical, in the state of cocrystallizate, of a coprecipitate or of a physical mixture of the powders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 10, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Pascal Anger, Bertrand Bonnavaud, Alain Callet, Patrick Lefevre
  • Pyrrolidine and thiazolidine derivatives, their preparation and drugs containing same
    Patent number: 5637602
    Abstract: This invention relates to a compound of formula (I), their salts, the preparation thereof and drugs containing same. The compounds of formula (I) have interesting pharmacological properties. Said compounds have a high affinity for chloecystokinin (CCK) and gastrin receptors and are therefore useful in the treatment and prevention of CCK and gastrin-related disorders affecting the nervous system and gastrointestinal tract.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 10, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Marc Capet, Marie-Christine Dubroeucq, Franco Manfre, Jean-Paul Martin
  • Process for preparing taxane derivatives
    Patent number: 5637723
    Abstract: Method of preparing taxane derivatives of general formula (I) by esterification of protected baccatine III or 10-deacetyl-baccatine III by means of an acid of general formula (VII), deprotection of the side chain and elimination of the hydroxy function protection groupings. In general formulae (I) and (VII): Ar stands for aryl, R is hydrogen or acetyl, R.sub.1 is benzoyl or R.sub.2 --O--CO-- in which R.sub.2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl, and R.sub.3 is hydrogen, alkoxy, optionally substituted aryl.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: June 10, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Alain Commercon, Eric Didier, Elie Fouque
  • Method for producing recombinant proteins and host cells used therein
    Patent number: 5633146
    Abstract: Novel genetically engineered yeast strains of genus Kluyveromyces lactis, their preparation, and the use thereof for producing recombinant proteins, are described.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: May 27, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Reinhard Fleer, Alain Fournier, Patrice Yeh
  • Thiazolidine derivatives, preparation thereof and drugs containing samem
    Patent number: 5633270
    Abstract: Derivatives of formula (I), their salts, the preparation of said derivatives and drugs containing same. The compounds of formula (I) have interesting pharmacological properties.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 27, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Marie-Christine Dubroeucq, Franco Manfre
  • Perhydroisoindole derivatives, preparation thereof and pharmaceutical compositions containing same
    Patent number: 5631279
    Abstract: This invention relates to perhydroisoindole derivatives of 08/448,402 formula (I), wherein radicals R are phenyl radicals optionally 2-or 3-substituted by a halogen atom or a methyl radical; R.sub.1 is optionally substituted phenyl, cyclohexadienyl, naphthyl, indenyl or optionally substituted heterocyclyl; R.sub.2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, acyloxy, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino; and R.sub.3 is optionally 2-substituted phenyl; optionally salts thereof where applicable; and preparation thereof. Said derivatives are particularly useful as neurokinin A antagonists.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 20, 1997
    Assignee: Rhone-Poulenc Rorer, S.A.
    Inventors: Andre Crespo, Veronique Fardin, Jean-Marc Guillaume, Jean-Luc Malleron, Jean-Francois Peyronel
  • Derivatives of 2-azabicyclo[2.2.1]heptane, their preparation and their application
    Patent number: 5631383
    Abstract: Novel derivatives of 1R- or 1S-2-azabicyclo[2.2.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 20, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Denis Largeau, Patrick Leon
  • K. lactis pyruvate-decarboxylase promoter and use thereof
    Patent number: 5631143
    Abstract: The present invention concerns DNA sequences comprising all or part of the K. lactis promoter gene PDC1 or a derivative thereof, and having transcriptional promoter activity. The invention also relates to the use of the sequences for the expression of recombinant genes.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: May 20, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Sandrine Menart, Monique Bolotin
  • Use of lamotrigine for treating AIDS-related neural disorders
    Patent number: 5629312
    Abstract: The use of lamotrigine or pharmaceutically acceptable salts thereof for treating AIDS-related neuronal disorders is disclosed.
    Type: Grant
    Filed: September 1, 1995
    Date of Patent: May 13, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Anne Bousseau, Adam Doble, Erik Louvel
  • Yeast promoter and its use
    Patent number: 5627046
    Abstract: DNA sequences comprising all or part of the ADH4 gene promoter of K. lactis or a derivative of the latter, and having transcriptional promoter activity. The invention also concerns the use of said sequences for the expression of recombined genes.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: May 6, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Claudio Falcone, Reinhard Fleer, Michele Saliola
  • K. lactis RP28 ribosomal protein gene promoter and use thereof
    Patent number: 5627049
    Abstract: The present invention concerns DNA sequences comprising all or part of the K.lactis RP28 ribosomal protein promoter gene or a derivative thereof, and having transcriptional promoter activity. The invention also relates to the use of said sequences for the expression of recombinant genes.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: May 6, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Sandrine Menart, Monique Bolotin
  • N-acyl pyrrolidines and drugs for the treatment or prevention of cholecystokinin and gastrin-related disorders
    Patent number: 5624939
    Abstract: Compounds of formula I ##STR1## wherein the substituents are as defined herein, are disclosed as treatments for disorders linked to CCK and gastrin. Processes for preparing the compounds are also taught.
    Type: Grant
    Filed: June 28, 1995
    Date of Patent: April 29, 1997
    Assignee: Rhone-Poulenc Rorer, S.A.
    Inventors: Marc Capet, Marie-Christine Dubroeucq