Patents Assigned to Rhone-Poulenc Sante
  • Patent number: 5089405
    Abstract: S Enantiomers of 2-arylpropionic acids are made by enantioselective hydrolysis of the corresponding racemic 2-arylpropionamides in the presence of a microorganism, or of an enzyme derived therefrom, able selectively to hydrolyze racemic .alpha.-phenylpropionamide to S .alpha.-phenylpropionic acid. The S Enantiomers obtained may be incorporated into antiinflammatory, analgesic and antipyretic compositions.
    Type: Grant
    Filed: July 26, 1989
    Date of Patent: February 18, 1992
    Assignee: Rhone-Poulenc Sante
    Inventors: Edith Cerbelaud, Dominique Petre
  • Patent number: 5089527
    Abstract: The invention provides a stabilized aqueous solution of a water soluble pentamidine salt comprising an acetate buffer, and having a total acetate concentration of 0.01-0.06M, and a pH of 4.0-5.0 at room temperature.
    Type: Grant
    Filed: February 12, 1990
    Date of Patent: February 18, 1992
    Assignee: Rhone-Poulenc Sante
    Inventor: John D. Lord
  • Patent number: 5086051
    Abstract: New derivatives of formula (I) in which R.sub.1 =H, halogen, alkyl, alkyloxy, CF.sub.3, NH.sub.2, alkylamino, dialkylamino, OH, CH, phenyl or phenoxy, Ar=phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl, thienyl, thieno[2,3-b]thienyl or thieno[3,2-b]thienyl (these groups optionally substituted with halogen, alkyl, alkyloxy, CF.sub.3, NH.sub.2, alkylamino, dialkylamino, OH or CN), p=0, 1 or 2, andA--either Z=valency bond and R.sub.2 =HB--or Z=valency bond and R.sub.2 =pyridyl, quinuclidinyl, 3-pyrrolidinyl, 3- or 4-piperidyl (these groups optionally being substituted with alkyl, hydroxyalkyl, phenyl or phenylalkyl)C--or Z=alkylene radical (1 to 4C) and R.sub.2 =2-, 3- or 4-pyridyl, 3-quinuclidinyl, 2- or 3-pyrrolidinyl, 2-, 3- or 4-piperidyl (optionally substituted with alkyl, hydroxyalkyl, phenyl or phenylalkyl) or R.sub.2 =CON(R.sub.3)(R.sub.4) wherea) either R.sub.3 and R.sub.4 form a piperazine optionally substituted with alkyl, hydroxyalkyl, pyridyl, phenyl or phenylalkyl,b) or R.sub.
    Type: Grant
    Filed: March 14, 1990
    Date of Patent: February 4, 1992
    Assignee: Rhone-Poulenc Sante
    Inventors: Claude James, Daniel Lave, Francoise Soler
  • Patent number: 5077052
    Abstract: Novel organosoluble derivatives of chitosan, useful in coating biologically active feedstuff additives intended for ruminants, to provide coatings which are stable at a pH greater than 5 and which release the biologically active substance at a pH below 3.5, consist of a random chain of units represented by the formulae: ##STR1## in which: R.sub.1 represents an alkylcarbonyl radical (2 to 4 carbon atoms), R.sub.2 represents an alkyl radical (2 to 21 carbon atoms) or an optionally substituted phenyl radical, and R.sub.3 and R.sub.4 represent a hydrogen atom or alkylcarbonyl radicals (2 to 4 carbon atoms).
    Type: Grant
    Filed: November 29, 1989
    Date of Patent: December 31, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Christine Franzoni, Christian Gagnieu, Hugues Porte
  • Patent number: 5068238
    Abstract: Compounds of formula: ##STR1## R.sub.1 represents a polyfluoroalkoxy radical, R.sub.2 represents an alkylthioalkyl, alkylsulphinylalkyl or alkylsulphonylalkyl radical, andR.sub.3 represents an alkyl radical,as well as the salts of these compounds with an inorganic or organic acid, processes for preparing them and medicinal products containing them.
    Type: Grant
    Filed: June 29, 1990
    Date of Patent: November 26, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Patrick Jimonet, Conception Nemecek
  • Patent number: 5068214
    Abstract: This invention relates to a process for preparation of a platinum-cobalt bi-metallic catalyst having an alloy structure.
    Type: Grant
    Filed: August 28, 1990
    Date of Patent: November 26, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Georges Cordier, Pierre Fouilloux, Jean-Michel Grosselin
  • Patent number: 5064843
    Abstract: This invention relates to a thioformamide derivative of the formula I ##STR1## wherein: R and R.sup.1 each independently represent an alkyl group;A represents either:(1) a phenyl group which is optionally substituted; or(2) a heteroaromatic group (e.g. pyrid-3-yl, quinolin-3-yl); andY represents:an ethylene or methylene group or a direct bond.These compounds may be formulated as pharmaceutical preparations and have utility for the treatment of disorders associated with smooth muscle contraction.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: November 12, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Terance W. Hart, Bernard Y. J. Vacher, Brian W. Sharp
  • Patent number: 5049574
    Abstract: 5-Trifluoromethoxy-2-benzimidazolamine and its salts with an inorganic or organic acid, its preparation and medicinal products containing it.
    Type: Grant
    Filed: February 16, 1990
    Date of Patent: September 17, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Francois Audiau, Christian Renault
  • Patent number: 5049669
    Abstract: Phenothiazine derivatives of general formula (I), in which R is a linear or branched (1 to 6 C) alkyl radical and R.sub.1 and R.sub.2, which may be identical or different, are linear or branched (1 to 4 C) alkyl radicals or form, with the nitrogen atom to which they are attached, a 4- to 7-membered heterocycle, their isomeric forms and mixtures thereof as well as their addition salts with acids, possess analgesic and diuretic activity.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: September 17, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Claude Garret, Claude Guyon, Bernard Plau, Gerard Taurand
  • Patent number: 5036075
    Abstract: This invention relates to a compound of the formula: ##STR1## in which R.sub.1 representsa 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position.a 1-piperazinyl radical substituted in the 4-position.a piperidino radical substituted in the 4-positioneither:R.sub.2 and R.sub.3, which are identical, represent a hydrogen or halogen atom and R.sub.4 represents a hydrogen atom orR.sub.2 and R.sub.4 represent a hydrogen atom and R.sub.3 represents a halogen atom or an acetylamino radical orR.sub.2 and R.sub.3 represent a hydrogen atom and R.sub.4 represents a halogen atom and R.sub.5 represents a --CH.dbd. group.or R.sub.2, R.sub.3 and R.sub.4 represent a hydrogen atom and R.sub.5 represents a nitrogen atom.R.sub.
    Type: Grant
    Filed: November 6, 1990
    Date of Patent: July 30, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Marie-Therese Comte, Claude Gueremy, Jean-Luc Malleron, Serge Mignani, Jean-Francois Peyronel, Alain Truchon
  • Patent number: 5034329
    Abstract: Optically active 2-arylalkanoic acids are made by enantioselective hydrolysis of the corresponding racemic amides in the presence of a microorganism, or of an enzyme derived therefrom, able selectively to hydrolyse racemic .alpha.-phenylpropionamide to S .alpha.-phenylpropionic acid.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: July 23, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Edith Cerbelaud, Dominique Petre
  • Patent number: 5026846
    Abstract: Diaryl sulphides and diaryl selenides of formula:Ar--X--Arwhere X=S or Se and Ar=aryl are made by the action of sulphur and sulphur dioxide or selenium and selenium dioxide on a compound of formula:Ar--HThe process is especially useful for the preparation of phenothiazines of formula ##STR1## in which X=S or Se and Z and Z.sub.1, which may be identical or different, are each hydrogen, halogen, alkyl or alkoxy.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: June 25, 1991
    Assignee: Rhone-Poulenc Sante
    Inventor: Jean-Pierre Duchesne
  • Patent number: 5026717
    Abstract: Compounds of formula: ##STR1## and their salts, in which R.sub.1 represents polyfluoroalkoxy, and R.sub.2 represents alkyl, alkenyl (3-6 C), [cycloalkyl (3-6 C)]-alkyl, carbamoylalkyl, dialkylcarbamoylalkyl, acylaminoalkyl, phenylthioalkyl, hydroxyalkyl, cyanoalkyl, sulphamoylethyl, N-alkylsulphamoylethyl, pyridylthioalkyl, pyridiylalkylthioalkyl, pyridylsulphinylalkyl, alkynyl (3-6 C), phenylsulphinylalkyl, halophenylthioalkyl, (2,2,2-trifluoroethylthio)alkyl, 2-dialkylaminopropyl, pyrimidinylsulphinylalkyl, pyridylalkylsulphinylalkyl, halophenylsulphinylalkyl or (2,2,2-trifluoroethylsulphinyl)alkyl are useful in the treatment of medical conditions associated with the effects of glutamate.
    Type: Grant
    Filed: June 26, 1990
    Date of Patent: June 25, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Francois Audiau, Claude Gueremy, Patrick Jimonet, Serge Mignani
  • Patent number: 5025013
    Abstract: New benzopyran derivatives of general formula (I) in which:R.sub.1 represents a hydrogen or halogen atom or a hydroxy, alkyloxy, nitro, amino, alkylsulphonamido or acylamino radical,R represents(1) radical ##STR1## R.sub.2 and R.sub.3, which may be identical or different, being H, halogen, OH, alkyl, alkyloxy, NH.sub.2, alkylsulphonamido or NO.sub.2, or(2) a radical ##STR2## n being 0 or 1, R.sub.4 being H, alkyl or optionally substituted phenyl and Q is acyl, alkylsulphonyl or ##STR3## Y being --CO-- or --SO.sub.2 -- and Z being a single bond, --CH.sub.2 -- or --NH--, or(3) a radical ##STR4## n being 0 or 1, m being 0 or 2, X being C or N (if n=0), W being a bond or --NH-- and AR being pyridyl, indolyl, quinolyl, 2-alkylquinolyl or phenyl optionally substituted with R.sub.2 and R.sub.3, provided that n=0 when X equals N, or(4) a radical of general formula: ##STR5## R.sub.
    Type: Grant
    Filed: January 16, 1990
    Date of Patent: June 18, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Michel Barreau, Jean-Claude Hardy, Jean-Paul Martin, Christian Renault
  • Patent number: 5023361
    Abstract: Hydroxyalkylating agents of formula: ##STR1## in which R denotes alkyl, n is 2 or 3, R.sub.1 denotes hydrogen or alkyl and R.sub.2 denotes alkyl an unsubstituted or substituted phenyl or ##STR2## are useful inter alia for the preparation of 1-(hydroxyalkyl)imidazoles. They are made by reaction of a sulphonic acid or dimethyl sulphate with a corresponding decarboxylate ester.
    Type: Grant
    Filed: February 27, 1990
    Date of Patent: June 11, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Viviane Massonneau, Michel Mulhauser, Albert Buforn
  • Patent number: 5021420
    Abstract: This invention relates to a compound ##STR1## in which R.sub.1 representsa 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or an alkyl, hydroxy or alkoxy radical, (c) a 3-indolyl radical, (d) a 3-indolyl radical substituted on the nitrogen atom by an alkyl or alkylcarbonyl radical and/or in the 5-position by a halogen atom or (e) a 3-(5-hydroxyindolyl) radical.a 1-piperazinyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by an alkoxy, alkyl, hydroxy, nitro or amino radical or a halogen atom, (c) a 1,2-benzisothiazol-3-yl radical, (d) a 1,2-benzisoxazol-3-yl radical or (e) a 2-pyridyl radical.
    Type: Grant
    Filed: July 6, 1989
    Date of Patent: June 4, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Marie-Iherese Comte, Claude Gueremy, Jean-Luc Malleron, Serge Mignani, Jean-Francois Peyronel, Alain Truchon
  • Patent number: 5017576
    Abstract: Quinoline derivatives of formula: ##STR1## in which either R.sub.1 denotes trifluoromethyl, R.sub.2 and R.sub.3 form, together with the nitrogen atom to which they are attached, morpholino and R.sub.4 denotes a 4-methylphenyl, 4-chlorophenyl, 2-, 3- or 4-fluorophenyl, 4-methoxyphenyl, 4-methyl-3-fluorophenyl, 2,4-difluorophenyl or 4-aminophenyl,or R.sub.1 denotes trifluoromethyl, R.sub.2 and R.sub.3 form, together with the nitrogen atom to which they are attached, thiomorpholino, or R.sub.2 denotes methyl and R.sub.3 denotes 2-methoxyethyl and R.sub.4 denotes 4-methylphenyl,or R.sub.1 denotes chlorine fluorine, or methoxy, R.sub.2 and R.sub.3 form, together with the nitrogen atom to which they are attached, morpholino, and R.sub.4 denotes 4-methylphenyl, are useful as anxiolytics, hypnotics, anticonvulsants and antiepileptics.
    Type: Grant
    Filed: September 11, 1989
    Date of Patent: May 21, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Marie-Christine Dubroeucq, Jean-Marc Paris, Christian Renault
  • Patent number: 5013855
    Abstract: A process for the preparation of an aromatic ether of general formula: ##STR1## by the action of 3-chloro-1,2-propanediol sulfate on a phenol of general formula:Ar--OHin the presence of an inorganic base.Use of a product obtained according to the process for the preparation of adrenergic .beta.-blockers.
    Type: Grant
    Filed: May 22, 1990
    Date of Patent: May 7, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Bernard Botannet, Isidore Le Fur, Viviane Massonneau, Michel Mulhauser
  • Patent number: 5008280
    Abstract: Compounds of the formula: ##STR1## in which - R.sub.1 denotes a polyfluoroalkoxy or polyfluoroalkyl radical, and - R.sub.2 denoteseither a chain --CH.sub.2 --(CH(R.sub.4)).sub.n --R.sub.3, in which R.sub.3 denotes a dialkylamino, piperidino, 1-pyrrolidinyl, mercapto, acylthio, alkylthio, alkylsulphinyl or alkylsulphonyl radical, R.sub.4 denotes a hydrogen atom or an alkyl radical and n is equal to 0 or 1,or a residue of formula: ##STR2## the said alkyl and alkoxy radicals and portions containing 1 to 4 carbon atoms each in a straight or branched chain and said the acyl portions containing 2 to 4 carbon atoms each, and the salts of these compounds, are useful in the treatment of diseases in which glutamate is implicated.
    Type: Grant
    Filed: December 13, 1989
    Date of Patent: April 16, 1991
    Assignee: Rhone-Poulenc Sante
    Inventors: Claude Gueremy, Patrick Jimonet, Serge Mignani
  • Patent number: 5006546
    Abstract: The invention provides: (2S,4R,6S)-6-[(4,5-diphenylimidazol-2-yl)thiomethyl]-4-hydroxy-2-methoxy-3 ,4,5,6-tetrahydro-2H-pyran and (2R,4R,6S)-6-[(4,5-diphenylimidazol-2-yl)thiomethyl]-4-hydroxy-2-methoxy-3 ,4,5,6-tetrahydro-2H-pyran or a mixture thereof; the compounds are anti-atherosclerotic agents.
    Type: Grant
    Filed: March 26, 1990
    Date of Patent: April 9, 1991
    Assignee: Rhone-Poulenc Sante
    Inventor: Edward C. J. Coffee