Patents Assigned to Rhone-Poulenc Sante
  • Process for preparing 1-alkyl-5-nitroimidazoles
    Patent number: 4925949
    Abstract: Process for preparing 1-alkyl-5-nitroimidazoles of formula: ##STR1## which comprises reacting an alkyl sulphate with an imidazole derivative of general formula: ##STR2## in an organic solvent, and then hydrolyzing or alcoholyzing the product obtained. In the formulae (I) and (II), R denotes hydrogen, unsubstituted or substituted alkyl, aryl or cycloalkyl. In the formula (I), R.sub.1 denotes alkyl. In the formula (II), X denotes a group which can be removed by hydrolysis or alcoholysis.
    Type: Grant
    Filed: January 13, 1989
    Date of Patent: May 15, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Viviane Massonneau, Michel Mulhauser, Claude Bonnamas, Noel Rouy
  • Process for preparing 1-hydroxyalkyl-2-methyl-5-nitroimidazoles
    Patent number: 4925951
    Abstract: Process for preparing 1-(hydroxyalkyl)nitroimidazoles of formula: ##STR1## which comprises reacting a sulphite or diacetate of an alkylenediol of formula:HO-(CH.sub.2).sub.n -OH (II)in the presence of a strong acid (sulphuric acid) with an imidazole derivative of formula: ##STR2## followed by hydrolizing or alcoholizing the product obtained. In the formulae (I) and (III), R denotes hydrogen or hydrocarbon. In the formulae (I) and (II), n is 2 or 3. In the formula (III), X denotes hydrogen or a radical which can be removed by hydrolysis or alcoholysis.
    Type: Grant
    Filed: January 13, 1989
    Date of Patent: May 15, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Viviane Massonneau, Michel Mulhauser, Albert Buforn
  • Process for preparing 1-hydroxyalkyl-5-nitroimidazoles
    Patent number: 4925952
    Abstract: Process for preparing 1-(hydroxyalkyl)nitroimidazoles of formula: ##STR1## which comprises reacting an alkylene sulphate of formula: ##STR2## with an imidazole derivative of formula: ##STR3## followed by hydrolyzing or alcoholyzing the product obtained. In the formulae (I) and (II), n is 2 or 3; in the formulae (I) and (III), R denotes hydrogen or hydrocarbon radical; and in the formula (III), X denotes hydrogen or a radical that can be removed by hydrolysis or alcoholysis.
    Type: Grant
    Filed: January 13, 1989
    Date of Patent: May 15, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Viviane Massonneau, Michel Mulhauser, Albert Buforn, Bernadette Mandard-Cazin
  • Process for the preparation of cyclic sulphates
    Patent number: 4924007
    Abstract: Cyclic sulphates of formula ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6, which are identical or different, each denote hydrogen, halogen, alkyl, alkoxy, aryloxy or alkoxycarbonyl and n is 0 or 1, are prepared by rapid reaction, at a temperature of 150.degree. to 250.degree. C.
    Type: Grant
    Filed: May 15, 1989
    Date of Patent: May 8, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Viviane Massonneau, Michel Mulhauser
  • Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III
    Patent number: 4924012
    Abstract: Process for preparing derivatives of baccatine III and of 10-deacetylbaccatine III, of general formula (I), in which R is hydrogen or acetyl, by condensation of an acid of general formula (II) with a derivative of baccatine III or of 10-deacetylbaccatine III of general formula (III), R.sub.1, R.sub.2 and R.sub.3 denoting hydroxy-protecting groups, followed by the replacement of the protecting groups by hydrogen.
    Type: Grant
    Filed: April 3, 1989
    Date of Patent: May 8, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Michel Colin, Daniel Guenard, Francoise Gueritte-Voegelein, Pierre Potier
  • Apparatus for feeding syringes into a cartoning machine with slots
    Patent number: 4913278
    Abstract: Apparatus for feeding syringes into a cartoning machine in which the syringes slide down the feed section 10 of a guide 1 to a substantially horizontal central section 12. Rotatable adjacent this central section is a feed worm 2, the threads of which are of decreasing depth. As the syringes are fed forwardly toward a discharge section 14, the plungers of the syringes are forced to a fully inserted position by the decreasing depth of the thread.
    Type: Grant
    Filed: December 6, 1988
    Date of Patent: April 3, 1990
    Assignee: Rhone-Poulenc Sante Propharm
    Inventor: Emmanuel Bourgeois
  • Derivatives of phenothiazine and the compositions which contain them
    Patent number: 4912105
    Abstract: Phenothiazine derivatives of formula ##STR1## in which R represents --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which may be identical or different, are alkyl, hydroxyalkyl or acetyloxyalkyl radicals, or form, together with the nitrogen atom to which they are attached, a heterocycle containing 4 to 7 members which may be substituted by 1 or 2 alkyl, hydroxyalkyl or acetyloxyalkyl radicals, or R represents --N.sup.+ R.sub.1 R.sub.2 R.sub.3 in which R.sub.1 and R.sub.2 are as defined above and R.sub.3 is alkyl or phenylalkyl, their isomeric forms and their mixtures, and their salts, are useful in the field of antidiarrhetics.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: March 27, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Claude Garret, Claude Guyon, Bernard Plau, Gerard Taurand
  • Process for preparing N-methyl derivatives of lysergol and 10.alpha.-methoxylumilysergol
    Patent number: 4908449
    Abstract: A process for preparing 1-methyllysergol or 10.alpha.-methoxy-1-methyllumilysergol, which comprises adding a base, which is an alkali metal hydride or alcoholate, to a solution of lyergol or 10.alpha.-methoxylumilysergol in a polar aprotic solvent in such a way that the molecular ratio between the base and the lysergol or 10.alpha.-methoxylumilysergol remains less than 0.5:1, and then adding a methylating agent which is methyl iodide, methyl sulphate or trimethylsulphonium iodide.1-methyllysergol and 10.alpha.-methoxy-1-methyllysergol are useful intermediates in the synthesis of pharmacological compounds.
    Type: Grant
    Filed: March 27, 1989
    Date of Patent: March 13, 1990
    Assignee: Rhone-Poulenc Sante
    Inventor: Christian Gervais
  • Use of a compound for the treatment of sleep disorders and depression
    Patent number: 4906649
    Abstract: 2-amino-6-(trifluoromethoxy)benzothiazole may be used in the production of a sleep-regulating medicinal product, which is useful in the treatment of sleep disorders and in the treatment of depression.
    Type: Grant
    Filed: August 22, 1988
    Date of Patent: March 6, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Jean-Charles Blanchard, Pierre Laduron, Jean-Maris Stutzmann
  • Chlorinated .beta.-ketoesters
    Patent number: 4906414
    Abstract: New chlorinated .beta.-ketoesters of the formula: ##STR1## wherein R represents alkyl of 1 through 6 carbon atoms or alkenyl of 2 through 6 carbon atoms, and R.sub.1 represents alkyl of 1 through 4 carbon atoms, their preparation and their use for the preparation of ethylenic ketones of the formula: ##STR2## wherein R is as hereinbefore defined.
    Type: Grant
    Filed: January 25, 1989
    Date of Patent: March 6, 1990
    Assignee: Rhone-Poulenc Sante
    Inventor: Didier Morel
  • Process for the preparation of vitamin A
    Patent number: 4906795
    Abstract: Vitamin A containing practically no 2-cis or 6-cis isomer is prepared by hydrogenation of the aldehyde of vitamin A, optionally in the form of a complex with hydroquinone, in the presence of a ruthenium hydride catalyst.
    Type: Grant
    Filed: November 29, 1988
    Date of Patent: March 6, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Jean-Michel Grosselin, Claude Mercier
  • Process for the preparation of dextrorotatory 3-(3-pyridyl)-1H,3H-pyrrolo [1,2-c]-7-thiazolecarboxylic acid
    Patent number: 4906757
    Abstract: The acid of formula: ##STR1## is prepared by reaction of an ester of 2-chloroacrylic acid with an organic salt of 2R, 4R (or predominantly 2R, 4R) 3-formyl-2-(3-pyridyl)-4-thiazolidinecarboxylic acid in the presence of an acid chloride and of triethylamine and then saponifying the ester obtained.
    Type: Grant
    Filed: June 30, 1988
    Date of Patent: March 6, 1990
    Assignee: Rhone-Poulenc Sante
    Inventor: Gerard H. Rajoharison
  • Process for purifying styrene/vinylpyridine copolymer using supercritical carbon dioxide
    Patent number: 4902780
    Abstract: A basic copolymer of styrene with vinylpyridine is purified by extraction with supercritical carbon dioxide to remove residual monomers.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: February 20, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Paul Bourrain, Gerard Collas, Jean-Francois Rostaing, Francois Sagi
  • Process for the preparation of a 6-halo-3-methyl-1-trialkylsilyloxy-1,3,5-hexatriene
    Patent number: 4900858
    Abstract: 6-halo-3-methyl-1-trialkylsilyloxy-1,3,5-hexatriene, useful as an intermediate in the preparation of terpene compounds, is prepared by reaction of a 6-halohexadienal with a halo-silane in the presence of a tertiary amine.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: February 13, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Lucette Duhamel, Pierre Duhamel, Jean-Pierre Lecouve
  • Pyrrole derivatives and pharmaceutical compositions which contain them as hypnotics and anticonvulsants
    Patent number: 4898871
    Abstract: Pyrrole derivatives of formula ##STR1## in which A forms with the pyrrole ring an isoindoline, 6,7-dihydro-5H-pyrrolo-[3,4-b]pyrazine, 2,3,6,7-tetrahydro-5H-[1,4]-oxathiino-[2,3-c]pyrrole or 2,3,6,7-tetrahydro-5H-[1,4]dithiino-[2,3-c]pyrrole ring-system, Y+0, S or NH, Het=naphthyridinyl or quinolyl which are unsubstituted or substituted with halogen, (1 to 4 C) alkyl, (1 to 4 C) alkyloxy, (1 to 4 C) alkylthio, CN or CF.sub.3 and R=(3 to 10 C) alkenyl or alkyl which is unsubstituted or substituted with alkyloxy, alkylthio, cycloalkyl, alkylcarbonyl, cycloalkylcarbonyl or cycloalkylcarbamoyl in which the cycloalkyl portions contain 3 to 6 C, NH.sub.
    Type: Grant
    Filed: November 30, 1987
    Date of Patent: February 6, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Jean-Dominique Bourzat, Marc Capet, Claude Cotrel, Richard Labaudiniere, Philippe Pitchen, Gerard Roussel
  • Alkadiene derivatives, their preparation, and pharmaceutical compositions containing them
    Patent number: 4886835
    Abstract: Substituted alkadienes of the formula: ##STR1## in which R.sub.1 is hydroxy or acetoxy, R.sub.2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, andR.sub.3 is alkylthio or alkoxy and R.sub.4 is naphthoyl or optionally substituted benzoyl,or R.sub.3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R.sub.4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio,or R.sub.3 and R.sub.4 form, with the carbon atom to which they are attached, a ring-system of formula: ##STR2## in which R.sub.5 is hydrogen or alkoxy and X is methylene or S inhibit 5-lipoxygenase and are useful, for example, as anti-inflammatories.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: December 12, 1989
    Assignee: Rhone-Poulenc Sante
    Inventors: Jean-Luc Malleron, Gerard Ponsinet, Gerard Roussel
  • Use of a compound for the treatment of schizophrenia
    Patent number: 4882345
    Abstract: 2-amino-6-(trifluoromethoxy)benzothiazole or a pharmaceutically accpetable salt thereof is useful for the treatment of schizophrenia, particularly the negative forms thereof.
    Type: Grant
    Filed: August 22, 1988
    Date of Patent: November 21, 1989
    Assignee: Rhone-Poulenc Sante
    Inventors: Claude Gueremy, Francoise Maillard, Bruno Musch
  • Compositions for coating feedstuff additives for ruminants and feedstuff additives thus coated
    Patent number: 4877621
    Abstract: A composition for coating a biologically active substance, which is stable in a medium with a pH greater than or equal to 5 and which enables the active substance to be released in a medium with a pH less than or equal to 3.5, consisting of a basic amino copolymer (preferably vinyl-pyridine/styrene copolymer) and a hydrophobic substance with a melting point greater than 60.degree. C. (preferably stearic acid), the hydrophobic substance content being between 50 and 90% of the total mass of the coating, and granules comprising a nucleous containing the biologically active substance, coated with this composition.
    Type: Grant
    Filed: September 2, 1987
    Date of Patent: October 31, 1989
    Assignee: Rhone-Poulenc Sante
    Inventors: Pierre Ardaillon, Pierre Autant, Paul Bourrain, Andre Cartillier
  • Compositions for coating feeding stuff additives intended for ruminants and feeding stuff additives thus coated
    Patent number: 4876097
    Abstract: A composition for coating a biologically active substance which is stable in a medium in which the pH is greater than or equal to 5 and which permits the release of the active substance in a medium in which the pH is less than or equal to 3.5, comprises a film-forming, water-insoluble binder which possesses controlled hydrophilicity and is optionally slightly sensitive to pH variations, and a substance which is sensitive to pH variations (e.g. an inorganic filler, simple aminated substance, basic polymer or copolymer, chitosan). Pellets for feeding to ruminants consist of a core containing the biologically active substance, e.g. methionine or lysine, coated with this substance.
    Type: Grant
    Filed: September 2, 1987
    Date of Patent: October 24, 1989
    Assignee: Rhone-Poulenc Sante
    Inventors: Pierre Autant, Andre Cartillier, Raymond Pigeon
  • 1,3,5-nonatriene derivatives, their preparation and their use
    Patent number: 4876370
    Abstract: 1,3,5-Nonatriene derivatives of formula: ##STR1## in which R.sub.1 and R.sub.2, together with the carbon atom to which they are linked, form a carbonyl group, or each of R.sub.1 and R.sub.2 denotes alkoxy or R.sub.1 and R.sub.2 together form an alkylenedioxy radical, which may be made by reaction of a butadiene derivative of formula: ##STR2## in which R is alkyl or phenyl, with a butanal ketoacetal of 10 formula: ##STR3## followed by reaction of the product with a halomethyltriphenylphosphonium halide, are useful intermediates e.g. for the production of phytol.
    Type: Grant
    Filed: September 19, 1988
    Date of Patent: October 24, 1989
    Assignee: Rhone-Poulenc Sante
    Inventors: Lucette Duhamel, Pierre Duhamel