Patents Assigned to Rhone-Poulenc
  • Patent number: 6146663
    Abstract: This invention relates to stabilized nanoparticles which may be filtered under sterile conditions, comprising at least one hydrophobic, water-insoluble and non-water-dispersible polymer or copolymer (and optionally an active principle) which is emulsified in an aqueous solution or suspension comprising a phospholipid and a bile salt.
    Type: Grant
    Filed: September 9, 1997
    Date of Patent: November 14, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Marie-Christine Bissery, Michel Laborie, Joel Vacus, Thierry Verrecchia
  • Patent number: 6147184
    Abstract: Novel onium borates of an element of Groups 15 to 17 of the Periodic Table, or borates of an organometallic complex of an element of Groups 4 to 10 of the Periodic Table, well suited for the photochemical/electron beam cationic initiation of polymerization/crosslinking, the anionic borate moiety of which having the formula:[BX.sub.a R.sub.b ].sup.-in which a and b are integers ranging from 0 to 4 and a+b=4; the symbols X are each a halogen atom when a ranges up to 3 and an OH functional group when a ranges up to 2; and the symbols R, which may be identical or different, are each a phenyl radical substituted by at least one element or electron-withdrawing substituent or by at least two halogen atoms, or an aryl radical containing at least two aromatic ring members, or such aryl radical bearing at least one electron-withdrawing substituent.
    Type: Grant
    Filed: May 6, 1997
    Date of Patent: November 14, 2000
    Assignee: Rhone-Poulenc Chimie
    Inventors: Frederic Castellanos, Jacques Cavezzan, Jean-Pierre Fouassier, Christian Priou
  • Patent number: 6143530
    Abstract: Double-stranded DNA molecules characterised in that they are circular and in that they essentially include one or more genes of interest.
    Type: Grant
    Filed: August 19, 1997
    Date of Patent: November 7, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Joel Crouzet, Daniel Scherman, Beatrice Cameron, Pierre Wils, Anne-Marie Darquet
  • Patent number: 6143518
    Abstract: Expression plasmids comprising a nucleic acid sequence of interest controlled by a T7 bacteriophage promoter and a stabilizing region comprising all or part of the par region of the RP4 plasmid or a derivative thereof. The invention also concerns the use of said plasmids in the production of recombinant products.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: November 7, 2000
    Assignee: Rhone-Poulenc Rorer SA
    Inventors: Beatrice Cameron, Joel Crouzet
  • Patent number: 6143508
    Abstract: Devices, processes and compositions are provided for effective separation of cells from a mixture of cells, where depletion or positive selection may be employed to provide a cellular population of interest. Of particular utility is the separation of cells from peripheral blood mononuclear cells, where members of the lymphoid or myeloid lineages may be isolated and used for research, diagnosis or therapy. Also of interest are cellular separation from bone marrow, tumor suspensions or lymphoid tissue suspensions, where cells can be isolated and used for a variety of purposes. The separated cells may be homogeneous, free of exogenous biologicals, viable, capable of replication and exhibit their full complement of biological activities. Multiple phenotypes can be captured simultaneously. Captured cells can be specifically activated with cytokines and antigens to provide cells which are MHC restricted and have antigen-specific effector functions.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 7, 2000
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventor: Thomas B. Okarma
  • Patent number: 6140528
    Abstract: The invention relates to intermediates to herbicidal compounds of formulae (Ia), (Ib) or (Ic): ##STR1##
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: October 31, 2000
    Assignee: Rhone-Poulenc Agriculture Ltd
    Inventor: David William Hawkins
  • Patent number: 6140112
    Abstract: The present invention pertains to the use of compounds affecting the activity of transcription factors for the preparation of a pharmaceutical composition for the treatment of neurodegenerative diseases.
    Type: Grant
    Filed: April 25, 1996
    Date of Patent: October 31, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jacques Mallet, Frederic Revah, Jean-Jacques Robert
  • Patent number: 6136867
    Abstract: The invention relates to aqueous suspensions of precipitated silica and of aluminum sulphate which have a pH lower than 4 and a solids content of between 10 and 50% by weight and which, after a period at rest of 48 hours, are in the form of a gel. The gel is reversible under low shear. The invention also relates to processes for the preparation of these suspensions and to their uses, especially in the field of cement mixes, mortars and concretes.
    Type: Grant
    Filed: April 3, 1996
    Date of Patent: October 24, 2000
    Assignee: Rhone-Poulenc Chimie
    Inventors: Laurent Frouin, Evelyne Prat
  • Patent number: 6136983
    Abstract: Pyrazole, pyrrole and imidazole derivatives having formula (I) or (II): ##STR1## wherein .dbd.X is .dbd.NR.sup.3, .dbd.O or an electron pair and Q comprises certain pyrazole, pyrrole and imidazole structures which, together with the remaining substituents, are defined in the description, are useful for controlling arthropod, nematodes, helminth or protozoan pests.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: October 24, 2000
    Assignee: Rhone-Poulenc Agrochimie
    Inventors: Patrick Doyle Lowder, David Treadway Manning, Jennifer Lantz Phillips, Michael Thomas Pilato, Tai-Teh Wu
  • Patent number: 6133432
    Abstract: A process for preparing a compound of the formula ##STR1## wherein R is C.sub.1 -C.sub.18 alkyl by reacting a compound of the formulaRO.sub.2 C--CH.sub.2 CN (II)with a cyanide salt and formaldehyde or source thereof. Compounds of formula (I) are useful intermediates to pesticidally active compounds.
    Type: Grant
    Filed: December 1, 1998
    Date of Patent: October 17, 2000
    Assignee: Rhone-Poulenc Agro
    Inventors: David William Hawkins, David Alan Roberts, John Harry Wilkinson, Jean-Louis Clavel
  • Patent number: 6127175
    Abstract: The invention relates to cells usable for the production of defective adenoviruses comprising, inserted into their genome, a portion of the region E4 of an adenovirus genome carrying the reading phase ORF6 under the control of a functional promoter.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: October 3, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Emmanuelle Vigne, Michel Perricaudet, Jean-Fran.cedilla.ois Dedieu, Cecile Orsini, Patrice Yeh, Martine Latta, Edouard Prost
  • Patent number: 6126941
    Abstract: A phospholipidic composition provides resistance against rancidity and the development of undesirable odors. The composition includes at least one phospholipid and a stabilizer. The stabilizer is ground parts and/or an extract of a grain. The composition is prepared by simple and reliable methods of production.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: October 3, 2000
    Assignee: Rhone-Poulenc Rorer GmbH & Co.
    Inventor: Miklos Ghyczy
  • Patent number: 6127550
    Abstract: This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: October 3, 2000
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Luc Grondard, Jean-Paul Casimir, Patrick Leon, Michael K. O'Brien, Matthew R. Powers, Daniel Robin
  • Patent number: 6127336
    Abstract: The present invention provides a peptide with antibacterial and antifungal properties, and compositions containing the peptide. Methods of making and using the antibacterial and antifungal peptide are also provided.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: October 3, 2000
    Assignee: Rhone-Poulenc Agro
    Inventors: Philippe Bulet, Charles Hetru, Jules Hoffmann, Laurence Sabatier
  • Patent number: 6124465
    Abstract: Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. ##STR1## In the formula (I), the following substituents are among the preferred: Ar represents a substituted or condensed phenyl radical or a polycyclic or heterocyclic aromatic radical, R represents a radical of general formula --(CH.sub.2).sub.m --X.sub.1 --(CH.sub.2).sub.n --Z in which X.sub.1 =single bond, O, S; m=0, 1; n=0, 1, 2; it being possible for the CH.sub.2 radicals to be substituted; Z represents carboxyl, COOR.sub.6 (R.sub.6 =alkyl), CON(R.sub.7)(R.sub.8) (R.sub.7 =hydrogen or alkyl and R.sub.8 =hydrogen, hydroxyl, arylsulphonyl, heterocyclyl, optionally substituted amino, optionally substituted alkyloxy or optionally substituted alkyl), PO(OR.sub.9).sub.2 (R.sub.9 =hydrogen or alkyl), an --NH--CO--T (T=hydrogen or optionally substituted alkyl) radical, or else--a ##STR2## radical, R.sub.1 and R.sub.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: September 26, 2000
    Assignee: Rhone-Poulenc S.A.
    Inventors: Jean-Dominique Bourzat, Alain Commer.cedilla.on, Norbert Dereu, Patrick Mailliet, Fabienne Sounigo-Thompson, Jean-Paul Martin, Marc Capet, Michel Cheve
  • Patent number: 6124416
    Abstract: An aqueous emulsion comprising at least one (co)polymer is provided. The (co)polymer is derived from a monomer having formula (1):(R.sub.1 R.sub.2 C.dbd.CR.sub.3 --CO--L--).sub.q A(--NCOblock).sub.p(1)wherein R.sub.1, R.sub.2, and R.sub.3, which are the same or different, represent a hydrogen or a group selected from hydrocarbon chains comprising 1 to 12 carbon atoms, halogens, and electron-withdrawing functional groups; L, which is the same or different, represents a divalent hydrocarbon radical comprising 2 to 12 carbon atoms; A represents an organic backbone which has n free valencies, n is a number between 2 and 7, and is equal to p+q; NCOblock represents a protected isocyanate functional group; p is a number between 1 and 6; and q is a number between 1 and 6.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: September 26, 2000
    Assignee: Rhone-Poulenc Chimie
    Inventors: Michel Desbois, Roland Reeb, Joel Richard, Fran.cedilla.oise Truchet
  • Patent number: 6124339
    Abstract: The invention relates to novel arylpyrazoles of the formula (I): ##STR1## wherein R.sub.1, R.sub.3, R.sub.7, R.sub.14, R.sub.15, R.sub.16, and R.sub.17 are as defined in the description, and to their use as pesticides.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: September 26, 2000
    Assignee: Rhone-Poulenc Inc.
    Inventors: Jamin Huang, Patrick Doyle Lowder, Nicholas Charles Ray, David W. Hawkins
  • Patent number: 6124343
    Abstract: This invention is directed to compounds of formula I ##STR1## wherein R.sup.1 is CN, CH.sub.2 CN, CH.dbd.CHCN, CHO, or CH.dbd.CHCO.sub.2 H;R.sup.2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio wherein each of the aryl and heteroaryl moieties is optionally substituted;R.sup.3 is halogen;R.sup.4 is optionally substituted aryl or optionally substituted heteroaryl;R.sup.5 is carboxy or an acid isostere;X is oxygen or sulphur; andn is zero or 1; or an N-oxide thereof, prodrug thereof solvate thereof, or pharmaceutically acceptable salt thereof, which compounds have endothelin antagonist activity. The invention is also directed to methods for preparing the compounds of formula I and their pharmaceutical use.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: September 26, 2000
    Assignee: Rhone-Poulenc Rorer Limited
    Inventors: Christopher Smith, Barry Porter, Roger Walsh, Tahir Majid, Clive McCarthy, Neil Harris, Peter Astles, Iain McLay, Andrew Morley, Andrew Bridge, Andrew Van Sickle, Frank Halley, Alan Roach, Martyn Foster
  • Patent number: 6124235
    Abstract: An accelerator system for the cold crosslinking of polymers which harden on exposure to moisture by hydrolysis/condensation, comprising: (C) x parts by weight of a catalyst for crosslinking the said polymers by polycondensation, x ranging from 0.01 to 10; (E) Y parts by weight of a solid inorganic compound containing an amount y of water in the form of water of hydration and/or water adsorbed by capillary condensation, this amount y ranging from 0.5 to 40 parts by weight, and which can represent up to 70% of the weight of the said solid inorganic compound; (F) z parts by weight of fillers, z ranging from 0 to 50; (D) 100-(x+Y+z) parts by weight of a diluent or of a solvent of the said catalyst (C), the diluent or solvent having a dynamic viscosity at 25.degree. C. of the order of 50 to 200,000 mPa.s; the respective amounts of the four constituents (C), (E), (F) and (D) being such that the system obtained exists in the form of a manipulable paste.
    Type: Grant
    Filed: July 3, 1997
    Date of Patent: September 26, 2000
    Assignee: Rhone-Poulenc Chimie
    Inventors: Michel Letoffe, Jean-Marc Pujol
  • Patent number: H1900
    Abstract: A method of destroying insect eggs and a method of protecting crops from the insects resulting from the eggs wherein a compound of formula (I) is applied to the eggs
    Type: Grant
    Filed: September 2, 1998
    Date of Patent: October 3, 2000
    Assignee: Rhone-Poulenc Ag Company Inc.
    Inventor: Keith A. Holmes