Patents Assigned to Ribozyme Pharmaceutical
  • Method for screening nucleic acid catalysts
    Patent number: 6280936
    Abstract: Nucleic acid catalysts, method of screening for variants of nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences are described.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: August 28, 2001
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Alex Burgin, Leonid Beigelman, Laurent Bellon
  • Process for the synthesis of N,N-Dioleyl-N,N-Dimethylammonium Chloride
    Patent number: 6268534
    Abstract: A novel process for the synthesis of N,N-dioleyl-N,N-dimethylammonium chloride (DODAC) is described.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: July 31, 2001
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventor: Jasenka Matulic-Adamic
  • Method and reagent for inhibiting influenza virus replication
    Patent number: 6258585
    Abstract: An enzymatic RNA molecule which specifically cleaves an influenza virus RNA.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: July 10, 2001
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventor: Kenneth G. Draper
  • Nucleic acid catalysts comprising L-nucleotide analogs
    Patent number: 6251666
    Abstract: A nucleic acid catalyst comprising at least one L-nucleotide substitution.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: June 26, 2001
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventor: Leonid Beigelman
  • Nucleoside analogs
    Patent number: 6248878
    Abstract: Novel nucleoside analogs, such as 3-(&bgr;-D-Ribofuranosyl)-2-fluoropyridine, 3-(&bgr;-D-Ribofuranosyl)-pyridin-2-one, 3-(&bgr;-D-Ribofuranosyl)-pyridin-2-(4-nitrophenylethyl)-one, 3-(&agr;-D-Ribofuranosyl)-2-fluoropyridine, 5-(&bgr;-D-Ribofuranosyl)-2-bromopyridine, 5-(&agr;-D-Ribofuranosyl)-2-bromopyridine, 5-(&bgr;-D-Ribofuranosyl)-pyridin-2-one, 5-(&agr;-D-Ribofuranosyl)-pyridin-2-one, 5-(&bgr;-D-Ribofuranosyl)-2-aminopyridine, 5-(&bgr;-D-Ribofuranosyl)-pyridin-2-(4-nitrophenylethyl)-one, and 5-(&agr;-D-Ribofuranosyl)-2-aminopyridine; process for their synthesis and incorporation into polynucleotides.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: June 19, 2001
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Jasenka Matulic-Adamic, Leonid Beigelman, Alexander Karpeisky
  • 2'-O-alkylthioalkyl and 2'-c-alkylthioalkyl-containing nucleic acids
    Patent number: 6239272
    Abstract: A compound having the formula: wherein, R1 represents 2′-O-R3-thio-R3 and/or 2′-C-R3-thio-R3, wherein R3 is a compound independently selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide and ester, X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group.
    Type: Grant
    Filed: June 17, 1998
    Date of Patent: May 29, 2001
    Assignee: Ribozyme Pharmaceutical
    Inventors: Leonid Beigelman, Alex Karpeisky
  • Nucleic acid based inhibition of CD40
    Patent number: 6194150
    Abstract: Nucleic acid molecule which blocks synthesis and/or expression of an mRNA encoding B7-1, B7-2, B7-3 and/or CD40.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: February 27, 2001
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Dan T. Stinchcomb, Thale Jarvis, James McSwiggen
  • Method for target site selection and discovery
    Patent number: 6183959
    Abstract: Nucleic acid catalysts, method of screening/selection for nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences involved in a biological process are described.
    Type: Grant
    Filed: July 8, 1998
    Date of Patent: February 6, 2001
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventor: James D. Thompson
  • Deprotection of RNA
    Patent number: 6162909
    Abstract: Method for one-pot deprotection of RNA molecules.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: December 19, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Laurent Bellon, Christopher T. Workman
  • 2'-O-amino-containing nucleoside analogs and polynucleotides
    Patent number: 6159951
    Abstract: Novel nucleoside or nucleotide analogs comprising 2'-O-amino residues, processes for their synthesis and incorporation into polynucleotides.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: December 12, 2000
    Assignee: Ribozyme Pharmaceuticals Inc.
    Inventors: Alexander Karpeisky, Leonid Beigelman
  • Method and reagent for inhibiting human immunodeficiency virus replication
    Patent number: 6159692
    Abstract: An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: December 12, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Kenneth G. Draper, Bharat Chowrira, James McSwiggen, Dan T. Stinchcomb, James D. Thompson
  • RNA polymerase III-based expression of therapeutic RNAs
    Patent number: 6146886
    Abstract: A transcribed non-naturally occuring RNA molecule comprising a desired RNA molecule, wherein the 3' region of the RNA is able to base-pair with at least 8 bases at the 5' terminus of the same RNA molecule.
    Type: Grant
    Filed: August 7, 1995
    Date of Patent: November 14, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventor: James D. Thompson
  • Nucleozymes
    Patent number: 6140491
    Abstract: Nucleozymes containing ribonucleotides and deoxyribonucleotides or nucleic acid analogues are described herein. The nucleozymes have catalytic activity and are significantly more resistant to degradation than their all-RNA ribozyme counterparts. Also described are methods for preparing the nucleozymes along with methods of using nucleozymes, e.g., as therapeutic agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 31, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Rich, Robert J. Cedergren, Jean-Pierre Perreault, Jing-Hua Yang
  • Method and reagent for inhibiting hepatitis C virus replication
    Patent number: 6132966
    Abstract: An enzymatic RNA molecule which specifically cleaves RNA of a hepatitis C virus.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: October 17, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventor: Kenneth G. Draper
  • Ribozyme treatment of diseases or conditions related to levels of intercellular adhesion molecule-1 (ICAM-1)
    Patent number: 6132967
    Abstract: Enzymatic RNA molecules which cleave ICAM-1 mRNA.
    Type: Grant
    Filed: May 1, 1998
    Date of Patent: October 17, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Susan Grimm, Dan T. Stinchcomb, James McSwiggen, Sean Sullivan, Kenneth G. Draper
  • Nucleic acid catalysts with endonuclease activity
    Patent number: 6127173
    Abstract: Nucleic acid molecules with new motifs having catalytic activity, methods of synthesis, and use thereof are also described.
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: October 3, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Fritz Eckstein, Paul A. Heaton, Narendra K. Vaish
  • Nucleoside triphosphates and their incorporation into oligonucleotides
    Patent number: 6127535
    Abstract: Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: October 3, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler
  • Non-nucleotide containing enzymatic nucleic acid
    Patent number: 6117657
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: September 12, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • Enzymatic nucleic acids that cleave C-fos
    Patent number: 6103890
    Abstract: Enzymatic nucleic acid molecules which cleave c-fos RNA.
    Type: Grant
    Filed: December 24, 1997
    Date of Patent: August 15, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Thale Jarvis, James A. McSwiggen, Dan T. Stinchcomb
  • Amido and peptido modified enzymatic nucleic acid molecules
    Patent number: 6093555
    Abstract: Oligonucleotide comprising a nucleotide base having the formula: ##STR1## wherein B is a nucleotide base or hydrogen; R.sub.1, R.sub.2 and R.sub.3 independently is selected from the group consisting of hydrogen, an alkyl group containing between 2 and 10 carbon atoms inclusive, an amine, an amino acid, and a peptide containing between 2 and 5 amino acids inclusive; and the zigzag lines are independently hydrogen or a bond.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: July 25, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Lech Dudycz, Jasenka Matulic-Adamic, Leonid Beigelman