Patents Assigned to Rijksuniversiteit
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Patent number: 9322000Abstract: The present invention relates to a nucleic acid molecule, which encodes a polypeptide having alcohol dehydrogenase activity, in particular methanol dehydrogenase activity, comprising having a nucleotide sequence selected from the group consisting of: (i) a nucleotide sequence as set forth in any one of SEQ ID NOs: 1 (mdh2-MGA3), 3 (mdh3-MGA3), or 5 (mdh2-PB1); (ii) a nucleotide sequence having at least 90% sequence identity, more particularly at least 91, 92, 93, 94, 95, 96, 97, 98 or 99% sequence identity, with a nucleotide sequence as set forth in any one of SEQ ID NOs: 1, 3 or 5; (iii) a nucleotide sequence which is degenerate with any one of the nucleotide sequences of SEQ ID NOs: 1, 3 or 5; (iv) a nucleotide sequence which is a part of the nucleotide sequence of any one of SEQ ID NOs: 1, 3 or 5, or of a nucleotide sequence which is degenerate with a sequence of SEQ ID NOs: 1, 3 or 5; (v) a nucleotide sequence encoding all or part of a polypeptide whose amino acid sequence is set forth in any one of SEQ IType: GrantFiled: January 25, 2013Date of Patent: April 26, 2016Assignees: SINTEF TTO AS, ETH ZURICH, RIJKSUNIVERSITEIT GRONINGENInventors: Trygve Brautaset, Tonje Marita Bjerkan Heggeset, Anne Krog, Wilhelmus Johannes Quax, Mark Jan Jacobus Bernhard Sibbald, Julia Vorholt, Jonas Müller, Patrick Kiefer, Eva Potthoff, Volker F Wendisch, Lennart Lessmeier, Stéphanie Heux, Jean-Charles Portais
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Publication number: 20160000838Abstract: The present invention relates to medicine, particularly immunology and gastroenterology. Specifically, it relates to probiotic bacteria and extracts thereof for therapeutic use for the treatment of inflammatory disorders such as inflammatory bowel disease. Provided is a composition comprising as active ingredient Faecalibacterium prausnitzii strain HTF-F (DSM 26943) or an extract thereof comprising extracellular polymeric matrix (EPM), and an acceptable carrier, diluent or excipient. Also provided is an anti-inflammatory composition comprising EPM extracted from F. prausnitzii strain HTF-F, and a method for preparing the same.Type: ApplicationFiled: March 5, 2014Publication date: January 7, 2016Applicants: RIJKSUNIVERSITEIT GRONINGEN, THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN, WAGENINGEN UNIVERSITEIT, ACADEMISCH ZIEKENHUIS GRONINGENInventors: Hermanus Josef Martinus HARMSEN, Muhammad Tanweer KHAN, Jeremy WELLS, Oriana ROSSI, Harry James FLINT, Sylvia Helen DUNCAN
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Patent number: 9060881Abstract: A lower leg prosthesis, for an amputee who has at least one leg having a leg stump, has a distal end and a proximal end. The distal end is connectable to an artificial foot. The proximal end is connectable to the leg stump via a stump socket. A use condition of the lower leg prosthesis includes the distal end being connected to the artificial foot and the proximal end being connected to the leg stump via the stump socket.Type: GrantFiled: December 12, 2011Date of Patent: June 23, 2015Assignees: RIJKSUNIVERSITEIT GRONINGEN, ACADEMISCH ZIEKENHUIS GRONINGENInventor: Egbert Otten
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Publication number: 20150164930Abstract: The present invention relates to the use of an arginase inhibitor for the preparation of a medicament for the prophylactic maintenance therapy of an asthmatic or allergic patient by preventing obstruction of upper and lower airways, in particular allergen-induced bronchial obstruction and/or airway hyperresponsiveness. The patients are either asthmatic or have allergic rhinitis. Preferably, the arginase inhibitor is 2(S)-amino-6-boronohexanoic acid (ABH).Type: ApplicationFiled: December 5, 2014Publication date: June 18, 2015Applicant: RIJKSUNIVERSITEIT GRONINGENInventors: Hermanus Meurs, Johan Zaagsma, Harm Maarsingh, Michel Van Duin
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Publication number: 20150152076Abstract: The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula (formula I) wherein R1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C-atoms; and X is selected from the group consisting of moieties X1, X2, X3, X4, X5 and X6. Exemplary uses include the prevention or therapeutic treatment of a HSF1-mediated disease.Type: ApplicationFiled: April 19, 2013Publication date: June 4, 2015Applicants: NYKEN HOLDING B.V., ACADEMISCH ZIEKENHUIS GRONINGEN, RIJKSUNIVERSITEIT GRONINGENInventors: Bianca Johanna Josephina Maria Brundel, Hermannus Steen, André Heeres, Johannes Paulus Gerardus Seerden
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Publication number: 20150098908Abstract: The invention relates to the field of medicine. In particular, it relates to recombinant cationic polypeptides and their use as biolubricant. Provided is a biolubricant substance comprising the amino acid sequence[(GKGVP)9]n, wherein n is ?5.Type: ApplicationFiled: October 4, 2013Publication date: April 9, 2015Applicants: ACADEMISCH ZIEKENHUIS GRONINGEN, RIJKSUNIVERSITEIT GRONINGENInventors: PRASHANT KUMAR SHARMA, ANDREAS HERRMANN, ANKE KOLBE, DEEPAK HALENAHALLY VEEREGOWDA
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Patent number: 8944063Abstract: A tracheostoma valve (1) comprises a main air passage structure provided with a main valve arrangement. The tracheostoma valve is switchable in response to a spurt of inhalation air from a breathing condition into a speaking condition, while the tracheostoma valve is switchable in response to a spurt of exhalation air from said speaking condition into said breathing condition. The main valve arrangement comprises an at least partly flexible bistable wall portion which has a circumferential bordering edge. At least part of the bordering edge forms a hinging means around which the bistable wall portion is hingeable between a first stable position in which an orifice of the main air passage structure is being blocked, and a second stable position in which said orifice is released.Type: GrantFiled: March 31, 2010Date of Patent: February 3, 2015Assignees: Academisch Ziekenhuis Groningen, Rijksuniversiteit GroningenInventors: Eduard Berend van der Houwen, Gijsbertus Jacobus Verkerke, Bernandus Franciscus Augustinus Maria van der Laan
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Publication number: 20140348773Abstract: The present invention relates to methods for providing polymeric composites with bone forming, such as with osteogenic and/or osteoinductive and/or osteoconductive, properties. The present invention further relates to polymeric composites provided by the present method and the use of thereof for bone implants, or grafts, specifically the use thereof for orbital floor reconstruction. Specifically, the present invention relates to methods for providing a composite with bone forming properties, the method comprises the steps of: a) providing a liquid, or liquefied, polymeric composition of homopolymers or copolymers of 1,3-trimethylene carbonate (TMC); b) adding to said liquid, or liquefied, polymeric composition one or more agents with osteogenic and/or osteoinductive and/or osteoconductive properties thereby providing a dispersion of said agents in said liquid or liquefied polymeric composition; and c) crosslinking the product obtained, thereby providing a composite with bone forming properties.Type: ApplicationFiled: October 26, 2011Publication date: November 27, 2014Applicants: UNIVERSITEIT TWENTE, ACADEMISCH ZIEKENHUIS GRONINGEN, RIJKSUNIVERSITEIT GRONINGENInventors: Dirk Wybe Grijpma, Rudolf Robert Maria Bos, Anne Cornelis Van Leeuwen
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Publication number: 20140243280Abstract: The invention relates to drug development and synthetic chemistry, in particular to the manufacture of biologically active compounds based on naturally occurring molecules. It also relates to novel biologically active compounds, for example aminoglycoside antibiotics, in a substantially pure regioisomeric form.Type: ApplicationFiled: June 14, 2012Publication date: August 28, 2014Applicant: Rijksuniversiteit GroningenInventors: Andreas Herrmann, Andreas Alexander Bastian, Alessio Marcozzi
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Publication number: 20140005799Abstract: A lower leg prosthesis, for an amputee who has at least one leg having a leg stump, has a distal end and a proximal end. The distal end is connectable to an artificial foot. The proximal end is connectable to the leg stump via a stump socket. A use condition of the lower leg prosthesis includes the distal end being connected to the artificial foot and the proximal end being connected to the leg stump via the stump socket.Type: ApplicationFiled: December 12, 2011Publication date: January 2, 2014Applicant: Rijksuniversiteit GroningenInventor: Egbert Otten
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Publication number: 20130196931Abstract: The invention provides a use of a substance that is capable of enhancing the amount and/or activity of DnaJB8, or a functional part, derivative and/or analogue thereof, for counteracting protein aggregation.Type: ApplicationFiled: April 14, 2008Publication date: August 1, 2013Applicants: Rijksuniversiteit Groningen, Academisch Ziekenhuis GroningenInventors: Harm Harmannus Kampinga, Maria Alexandra Rujano Maldonado, Jurre Hageman
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Patent number: 8481996Abstract: The present invention relates to a photodiode, comprising a photo-active layer which layer comprises at least one electron donating material, and at least one fullerene derivative as an electron accepting material. The present invention further relates to a method for making such a photo diode, to a photo-active layer and to a fullerene derivative.Type: GrantFiled: September 22, 2010Date of Patent: July 9, 2013Assignee: Rijksuniversiteit GroningenInventors: Jan Cornelis Hummelen, René Albert Johan Janssen, Joop Knol, Martinus Maria Wienk, Johannes Martinus Kroon, Wilhelmus Johannus Hermanus Verhees
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Publication number: 20120090621Abstract: A tracheostoma valve (1) comprises a main air passage structure provided with a main valve arrangement. The tracheostoma valve is switchable in response to a spurt of inhalation air from a breathing condition into a speaking condition, while the tracheostoma valve is switchable in response to a spurt of exhalation air from said speaking condition into said breathing condition. The main valve arrangement comprises an at least partly flexible bistable wall portion which has a circumferential bordering edge. At least part of the bordering edge forms a hinging means around which the bistable wall portion is hingeable between a first stable position in which an orifice of the main air passage structure is being blocked, and a second stable position in which said orifice is released.Type: ApplicationFiled: March 31, 2010Publication date: April 19, 2012Applicant: Rijksuniversiteit GroningenInventors: Eduard Berend van der Houwen, Gijsbertus Jacobus Verkerke, Bernandus Franciscus Augustinus Maria van der Laan
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Publication number: 20120058977Abstract: A pharmaceutical composition for the treatment of a disease caused by a bacterium that belongs to the group of nocardioform actinomycetes, said composition comprising an effective amount of a compound selected from compound I, (+)-compound II, (?)-compound II, compound III, or mixtures thereof.Type: ApplicationFiled: February 23, 2010Publication date: March 8, 2012Applicant: Rijksuniversiteit GroningenInventors: Robert Van Der Geize, Lubbert Dijkhuizen, Martin Ostendorf, Peter Van Der Meijden
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Patent number: 8120084Abstract: Described is a modulatable injection barrier and a semiconductor element comprising same. More particularly, the invention relates to a two-terminal, non-volatile programmable resistor. Such a resistor can be applied in non-volatile memory devices, and as an active switch e.g. in displays. The device comprises, in between electrode layers, a storage layer comprising a blend of a ferro-electric material and a semiconductor material. Preferably both materials in the blend are polymers.Type: GrantFiled: May 22, 2008Date of Patent: February 21, 2012Assignee: Rijksuniversiteit GroningenInventors: Paulus Wilhelmus Maria Blom, Bert de Boer, Kamal Asadi
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Publication number: 20110237508Abstract: The present invention relates to the field of preventive and therapeutic medicine, in particular to peptide formulations. Provided is a pH-buffered aqueous formulation comprising oxytocin, vasopressin or an analogue thereof and at least one non-toxic source of divalent metal ions in a concentration of at least 2 mM, and the use of the formulation for the manufacture of a medicament for therapeutic and/or prophylactic treatments. Also provided is a method for treating or preventing haemorrhage in a subject in need thereof, comprising administering to said subject an effective dosage amount of an oxytocin formulation according to the invention. Further provided is a method for treating or preventing diabetes insipidus or vasodilatory shock in a subject in need thereof, comprising administering to said subject an effective dosage amount of a vasopressin formulation according to the invention.Type: ApplicationFiled: September 9, 2009Publication date: September 29, 2011Applicant: RIJKSUNIVERSITEIT GRONINGENInventors: Jean-Pierre Amorij, Christina Avanti, Henderik Willem Frijlink, Wouter Leonardus Joseph Hinrichs
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Publication number: 20110200552Abstract: The present invention relates to novel cytokines, which have a modified selectivity/specificity for their cognate receptors. In particular, the invention relates to a variant TRAIL protein, which has superior selectivity for the death receptor 4 (TRAIL-RI) over the death receptor 5 (TRAIL-R2). In addition, the invention relates to a variant TRAIL protein which exhibits superior selectivity for the death receptor 4 (TRAIL-R1) over the decoy receptors DcR1 (TRAIL-R3) and DcR2 (TRAIL-R4).Type: ApplicationFiled: November 21, 2008Publication date: August 18, 2011Applicants: RIJKSUNIVERSITEIT GRONINGEN, NATIONAL UNIVERSITY OF IRELAND, GALWAY, TRISKEL THERAPEUTICS B.V, Fundacio Privada Centre De Regulacio Genomica (CRG), Institucio Catalana De Recerca I Estudis Avancats (ICREA)Inventors: Carlos Ricardo Rodrigues Dos Reis, Wilhelmus Johannes Quax, Afshin Samali, Eva Szegezdi, Robbert Hans Cool, Albert Martinus Van Der Sloot, Luis Serrano, Vicente Tur
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Publication number: 20110165265Abstract: The present invention relates to the use of a mutant TRAIL protein to treat various cancers in mammals. The invention provides a variant TRAIL protein, which has superior selectivity for the death receptor 5, for treating a mammal diagnosed with cancer.Type: ApplicationFiled: December 17, 2008Publication date: July 7, 2011Applicants: FUNDACIÓ GENÒMICA (CRG), INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANCATS, NATIONAL UNIVERSITY OF IRELAND, GALWAY, ACADEMISCH ZIEKENHUIS GRONINGEN, RIJKSUNIVERSITEIT GRONINGENInventor: Afshin Samali
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Patent number: 7906797Abstract: The present invention relates to a photodiode including a photo-active layer, which layer includes at least one electron donating material, and at least one fullerene derivative as an electron accepting material. The present invention further relates to a method for making such a photodiode, to a photo-active layer and to a fullerene derivative.Type: GrantFiled: August 17, 2005Date of Patent: March 15, 2011Assignee: Rijksuniversiteit GroningenInventors: Jan Cornelis Hummelen, René Albert Johan Janssen, Joop Knol, Martinus Maria Wienk, Johannes Martinus Kroon, Wilhelmus Johannus Hermanus Verhees
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Publication number: 20110033909Abstract: The invention provides means and methods for efficiently cloning nucleic acid sequences of interest in micro-organisms that are less amenable to conventional nucleic acid manipulations, as compared to, for instance, E.coli. The present invention enables high-throughput cloning (and, preferably, expressing) of a nucleic acid of interest in a first kind of micro-organism, while an initial (preferably high throughput) cloning of the nucleic acid of interest is done in a second kind of micro-organism.Type: ApplicationFiled: May 30, 2008Publication date: February 10, 2011Applicant: RIJKSUNIVERSITEIT GRONINGENInventors: Eric Robin Geertsma, Berend Poolman