Abstract: The present invention relates to a method for guiding a user in interaction with an insulin pump comprising providing in response to a user interaction at least one of (i) a first acoustic signal comprising at least five descending halftones, wherein the duration of each tone is independently selected from a range of from 0.025 s to 5 s; (ii) a second acoustic signal comprising at least five ascending halftones, wherein the duration of each tone is independently selected from a range of from 0.025 s to 5 s; (iii) a third acoustic signal comprising at least seven ascending halftones, wherein the duration of each tone is independently selected from a range of from 0.025 s to 5 s; (iv) a fourth acoustic signal comprising at least two alternating tritones, wherein the duration of each tone is independently selected from a range of from 0.025 s to 5 s; (v) a fifth acoustic signal of four tones with a duration of from 0.025 s to 0.

Abstract: A diagnostic tape unit and a process for producing it are provided, in which disposable, test units are applied to a rollable transport tape which is wound onto an unwinding spool and is connected to a take-up spool such that the test units can be successively made available to a user by winding on the transport tape. One or both of the leading end and trailing end of the transport tape is connected to their corresponding spools by means of an auxiliary tape.

Abstract: The invention concerns a reservoir (1) for storing a liquid medicament. The reservoir (1) comprises a flexible container (10) which includes one folding layer (12), wherein the folding layer (12) includes a seam (13) which provides for a sealing of the flexible container (1). The reservoir comprises a rigid part (20) which is connected to the flexible container (10) and which includes a support (25) extending into the flexible container (10) and which includes one or more ports (21, 22) providing fluidic access to the flexible container (10). The reservoir comprises a porous hydrophilic membrane (26) which is connected to the support (25) of the rigid part (20). The invention further concerns a method for producing of a reservoir (1).

Abstract: The invention relates to a drug delivery system for a patient comprising an insulin delivery device (100), a user interface (101), a controller comprising instructions and a user definable threshold criterion (114; 116) of a residual availability of a drug provided in a reservoir (102) of the drug delivery system, wherein executing of the instructions by the controller (110) causes the controller (110) to control the drug delivery system to determine the amount of the drug that is currently available to the patient and compare the determined amount with the threshold criterion (114; 116), in response to the comparison, in case the determined amount is lower than or equal to the threshold criterion (114; 116), providing a signal to the patient via the user interface (101). The drug is insulin.

Abstract: The concentration of glucose in a blood sample is determined by methods utilizing test strips having a sample receiving cavity having a volume from about 0.3 ?l to less than 1 ?l and determining the glucose concentration within a time period from about 3.5 seconds to about 8 seconds.

Abstract: A medical applicator and a manipulation unit for use in connection with specific variants of the medical applicator are disclosed. In general, the medical applicator has an insertion needle (108; 308) configured for puncturing a part of a human or animal body (B), a sensor assembly (110; 310) configured to be at least partially inserted into a human or animal body (B) when the body is punctured by said insertion needle (108; 308) and a lifting means (102; 301, 302) for lifting up a surface adjacent portion of the human or animal body (B) towards the insertion needle (108; 308).

Abstract: Methods of cross-linking polypeptide molecules are provided, where such methods include combining a cross-linking agent and polypeptide molecules in a solution under conditions suitable for a cross-linking reaction to occur. Also provided are preparations of cross-linked polypeptide molecules, where the polypeptide molecules are cross-linked by essentially unbranched cross-linking groups of at least 40 contiguous atoms. Further provided are test chemistry matrices and methods of making the same, where the matrices include a redox cofactor, an agent capable of eliciting a change in at least one measurable property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and a preparation of cross-linked polypeptide molecules as described herein. Test elements and methods of using the same to diagnose diseases such as diabetes also are provided, where the test elements include a test chemistry matrix as described herein.

Abstract: Systems, methods and apparatuses for delivering therapeutic fluid to the body of a patient are disclosed. The apparatus includes a dispensing unit having a driving mechanism, a pumping mechanism, a reservoir containing therapeutic fluid, and an outlet port. The driving mechanism causes the pumping mechanism to positively displace therapeutic fluid within the reservoir for delivery of therapeutic fluid to the body of the patient via the outlet port.

Abstract: This disclosure concerns a carrier system for a medical device worn on the body comprising a flexible carrier plaster which has a flat carrier layer and an adhesive coating thereon consisting of a pressure sensitive adhesive which adheres on the skin of a body part, and further comprising a platform which is positioned on the upper side of the carrier layer for mounting the device, wherein the platform has a bottom joining area which is joined to the upper side of the carrier layer by means of a structural adhesive which is applied as a bead along predefined adherend tracks.

Abstract: Electrode systems are disclosed for measuring the concentration of an analyte under in-vivo conditions, where such systems include a counter electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.

Abstract: Analytes in a liquid sample are determined by methods utilizing sample volumes from about 0.3 ?l to less than 1 ?l and test times from about 3.5 to about 6 seconds after detection of the sample. The methods are preferably performed using small test strips including a sample receiving chamber filled with the sample by capillary action.

Abstract: Methods and devices involving using a bolus calculator to account for an uncertainty of a carbohydrate estimate to reduce a risk of hypoglycemia and/or a risk of hyperglycemia. More specifically, methods and devices using an algorithm executed by a processor of the bolus calculator and using a carbohydrate estimate and a measure defining the uncertainty of the carbohydrate estimate to determine the probability of hypoglycemia and/or hyperglycemia if the carbohydrate estimate is an overestimate or an underestimate, and subsequently providing recommendations and alerts to a user.

Abstract: The invention concerns a device (1) for generating protocol data for an injection pen (2). The device (1) comprises a motion sensing unit (13) including one or more of a gyroscope and an accelerometer in order to generate one or more of a gyro signal and an acceleration signal. The device comprises a signal processing unit (14) which implements an analyser which is configured to analyse one or more of the gyro signal and the acceleration signal and to generate protocol data reflecting an adjusted dosage of a medicament. Optionally, the analyser is configured to generate protocol data reflecting delivery of the adjusted dosage of the medicament.

Abstract: A first disclosed connector part (110) for establishing a fluid connection with a second connector part comprises a valve (111) with a valve seat (112), the valve seat comprising a valve chamber (116), and a circular opening with a circumferential sealing lip (114); a valve member (113), the valve member being provided in the valve chamber, and being able to sealingly close the circular opening of the valve seat when being pushed against the circular opening; and a resilient element (115) that subjects the valve member to a bias force pushing the valve member against the circular opening of the valve seat. The valve member further comprises a circumferential wall around the circular opening, located on the side of the circular opening opposite to the valve chamber.

Abstract: The present invention pertains to the field of manufacture of diagnostic test elements. Specifically, the invention relates to a diagnostic test element for determining an analyte comprised in a body fluid sample, said test element comprising at least one test field with at least one detection layer and at least one separation layer, wherein said at least one separation layer comprises dispersed SiO2 in an amount of about 1.0 to 1.6 g/m2. The invention also relates to a coating composition being capable of forming a separation layer on a diagnostic test element of the present invention described above. Moreover, provided is a method for the manufacture of the diagnostic test element as well as the use of the diagnostic test element for determining the amount of an analyte, preferably, glucose, in a sample of a subject.

Abstract: Embodiments of a testing method for diabetics to optimize their administered insulin dosage comprise collecting sampling sets of biomarker data, each sampling set comprising a sufficient plurality of non-adverse sampling instances and each sampling instance comprising an acceptable biomarker reading at a single point in time recorded upon compliance with adherence criteria, determining a biomarker sampling parameter from each sampling set, comparing the biomarker sampling parameter to a target biomarker range, calculating an insulin adjustment parameter associated with the biomarker sampling parameter if the biomarker sampling parameter falls outside the target biomarker range, adjusting the insulin dosage by the insulin adjustment parameter if the biomarker sampling parameter falls outside the target biomarker range and the insulin dosage does not exceed maximum dosage, and exiting the testing method if the adjusted insulin dosage is optimized.

Abstract: A medical device (110) for detecting at least one analyte in a body fluid, a method of using a medical device (110) and a method for assembling a medical device are disclosed.

Abstract: A device for the dosed dispensing of a medium (e.g., therapeutic and/or diagnostic agent) for an insulin pump is proposed. The device comprises a transporting and transferring container, a measuring element, and an adjusting element for influencing a dispensing of the medium by way of a connection to an interior space. The transporting and transferring container has a reservoir for receiving the medium. The reservoir is closed by a displaceable element. The displaceable element is movably mounted in relation to the reservoir. A relative positioning of the displaceable element in relation to the reservoir determines the interior space of the reservoir available for receiving the medium. The measuring element senses the relative positioning of the displaceable element in relation to the reservoir. The measuring element and the adjusting element interact so that the dispensing of the medium is influenced by the relative positioning sensed by the measuring element.

Abstract: A puncturing system has a carrier tape carrying multiple lancets, a device housing comprising a conveying facility for moving the lancets into a usage position consecutively by moving the carrier tape in a conveying direction, a puncturing drive for accelerating one of the lancets that is positioned in the usage position in a puncturing motion, an opening in the device housing for touching against a body part in which a puncture is to be made by the puncturing motion of one of the lancets, an actuation facility for driving the conveying facility, and an unlockable interlock comprising a stop that blocks further transport of the carrier tape as soon as one of the lancets has reached the usage position.

Abstract: A method is disclosed for determining analyte concentration that includes applying a first electrical potential excitation pulse to a body fluid sample in an analyte sensor, and a first current response of the body fluid sample to the first pulse is measured. A second excitation pulse is applied to the body fluid sample in the analyte sensor, and a second current response of the body fluid sample to the second pulse is measured. An analyte level in the body fluid sample is determined by compensating for sources of error based on the first current response to the first pulse.