Abstract: The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.

Abstract: The invention concerns a liquid transfer device for an analysis apparatus with a liquid transfer cannula (5) and a capacitive liquid level detector to detect the immersion of the liquid transfer cannula (5) in an analysis liquid contained in a vessel. To reliably check if the liquid transfer cannula (5) is submerged in the analysis liquid or immersed for example in foam it is proposed additionally that resistance is measured by a measurement section (16) in the liquid transfer cannula (5).

Abstract: The subject matter of the invention are new xanthene derivatives of the formula I, wherein R1,R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and X, Y, are as defined herein. The compounds according to the invention provide molecules that are—due to their spectral properties (absorption maxima in the range of approx. 650 nm and above as well as emission maxima above 670 nm)—very suitable for the use as dyes and in particular as fluorescence dyes. The compounds of the formula I according to the invention are used for the production of fluorescence conjugates, for their application in immunoassays, for DNA analytics, for in-vivo diagnostics or as a laser dye.

Abstract: The invention concerns a method for stabilizing the content of glycated protein in a sample on a matrix material, which is characterized in that the matrix material is impregnated with boric acid buffer with a pH which is larger or equal to 10.5 or a transition metal salt as well as an appropriate matrix material, an element for collecting, transporting and storing sample material to be analyzed with such a matrix material and a system containing such an element and a sealable covering.

Abstract: The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.

Abstract: A system for producing multiple diagnostic test elements has a support (1) with an analytical region (3) to which diagnostic test spots (8) are applied, one or several stop edges (11-13) for each direction in space for positioning the support, a first holding unit (10I) into which the support is inserted and positioned by means of the one or more stop edges, a first printing head (20I) arranged above the holding unit (10) for applying drops of a first liquid to the analytical region of the support (1), a first positioning unit which laterally displaces and positions the first holding unit, a second holding unit (10II) into which the support is inserted and positioned by means of the one or more stop edges, a second printing head (20II) arranged above the second holding unit for applying drops of a second liquid to the analytical region of the support (1), a second positioning unit which laterally displaces and positions the second holding unit, a transport unit (41) and a control unit.

Abstract: Preparations of particles having a glass surface, wherein more than 75% by weight of these particles have a particle size between 0.5 &mgr;m and 15 &mgr;m and a glass surface which contains between 2 and 6 mole % zinc oxide, have proven to be particularly advantageous in processes for the purification of nucleic acids. This in particular results in an increased nucleic acid yield.

Abstract: The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.

Abstract: The present invention concerns processes for the production of dry, partially amorphous products containing biologically active and in particular therapeutically active material which are macroscopically homogeneous substance mixtures, the substance mixtures being selected from at least one substance of each of the groups

Abstract: A flat-shaped functional overlay for at least one region of a flat-shaped flexible object which does not form a fold when the sandwich composed of the flexible object and overlay is bent towards the side on which the overlay is located is described. The overlay is composed of one or several flat-shaped overlays which are attached to the flexible object in such a way that a part of their surface can move freely relative to the surface of the object covered by this part in the direction of curvature produced when the object is bent. In addition diagnostic test strips are described which have such an overlay.

Abstract: The invention concerns a magazine for storing test elements (1) with one or several test zones (3) which are attached adjacent to one another on a rectangular support, wherein the magazine has at least one pair of guide grooves (18a, b) located opposite to one another into which the test elements are inserted in such a way that they lie directly adjacent to one another and the edges of adjacent supports abut one another. A further subject matter of the invention is a system which comprises a slide (14, 31) in addition to the magazine according to the invention which is used to push a layer of test elements along the guide grooves towards the opposite end of the layer to remove test elements from the magazine.

Abstract: Sample carrier for IR spectroscopy which has a sample application zone as well as at least one groove-shaped channel into which liquid is drawn from the sample application zone as a result of capillary forces. A method for IR spectroscopy using a sample carrier according to the invention and a system for IR spectroscopy using the sample carrier according to the invention.

Abstract: Metal chelate-labelled peptide which has a maximum length of 50 amino acids and is coupled to at least one luminescent metal chelate at the amino terminus or/and at amino side groups, wherein the at least one luminescent metal chelate is present on the peptide at a predetermined position on the peptide.

Abstract: The present invention provides peptides as inhibitors of the binding of urokinase to the urokinase receptor. The peptides have the general structural formula (I): X1-[X2]n-X3-X4-K-Y-F-X5-X6-I-X7-W-[X8]m  (I) in which X1, X2, X3, X4, X5, X6, X7 and X8 each denote an aminocarboxylic acid, n and m are each independently 0 or 1, K denotes an aminocarboxylic acid with a lysine side chain, Y denotes an aminocarboxylic acid with a tyrosine side chain, F denotes an aminocarboxylic acid with a phenyl-alanine side chain, I denotes an aminocarboxylic acid with an isoleucine side chain, W denotes an aminocarboxylic acid with a tryptophan side chain, and the monomeric building blocks are linked by —CONR1— or —NR1CO— bonds where R1 in each case independently denotes hydrogen, methyl or ethyl, and pharmaceutically compatible salts and derivatives thereof.

Abstract: The present application relates to a diisopropyl-fluorophosphatase from Loligo vulgaris, and to the amino acid and nucleic acid sequences encoding the enzyme. Also provided are vectors which contain the DNA sequence according to the invention, and to cells transformed with the base sequence according to the invention. Finally, the present application also provides a method for the production of the diisopropyl-fluorophosphatase and various types of use and areas of employment of the diisopropyl-fluorophosphatase, in particular the decontamination of contaminated habitats, the production of medicinal products for treating or detoxifying humans and animals, the impregnation of clothing and the use in analyses.

Abstract: The invention concerns a process for coating a metallic or semimetallic surface in which coating molecules containing reactive groups are bound covalently to the surface by irradiation with light and it also concerns a structured coated surface.

Abstract: The present invention provides a method for synthesis polypeptides in a cell-free system by which products of synthesis are branched in a low molecular weight fraction and a fraction which contains high molecular weight components with the target polypeptide, the main part of the low molecular weight fraction is removed via at least one part of the second porous barrier, the ratio of the volume of the fractions of feed solution and expendable components to the volume of the fraction containing the target polypeptide is chosen, modes of supply of the feed solution and expendable components of the fraction are realized.

Abstract: The invention concerns an analytical element for determining the amount of an analyte in a liquid containing a sample application zone (1) and a detection zone (2) which are in liquid-transferring contact, the latter containing at least one enzyme and an indicator substance, the enzyme catalysing a reaction in which the analyte or a substance derived from the analyte participates and the indicator substance forming a signal when the analyte is present which signal correlates with the amount of analyte, and containing a liquid-permeable interference-reducing layer (3) in direct contact with the detection zone (2) arranged such that liquid does not reach the detection zone until it has passed through the interference-reducing layer, the interference-reducing layer containing at least one enzyme which participates in a reaction of the analyte to be determined or of a substance derived from the analyte, wherein the analyte or the substance derived from the analyte is converted enzymatically in the interference-re

Abstract: The invention addresses DNA-protein-complexes, proteins, DNA sequences and antibodies that are suitable for the detection of cells with an unlimited proliferation and tumor-formation potential. The invention further addresses methods for obtaining such proteins or DNA sequences and methods for identifying animal and human cells with with an unlimited proliferation and tumor-formation potential using such proteins, DNA sequences or antibodies.

Abstract: Methods are provided for quantifying the concentration of a nucleic acid in a nucleic acid sample. The methods include contacting the nucleic acid sample with an amplifying agent, amplifying at least one predetermined locus of the nucleic acid by subjecting the sample to a number of amplification, generating an amplification curve or array, calculating the first, second or n th order derivative of the amplification curve or array, determining a maximum, minimum, or zero value of the derivative, and using the maximum, minimum, or zero value to calculate the initial concentration of the nucleic acid in the nucleic acid sample.