Patents Assigned to Roche Diagnostics GmbH
  • Patent number: 7008799
    Abstract: The invention concerns an analytical test element for the determination of an analyte in a liquid containing an inert carrier, a detection element and a channel capable of capillary liquid transport which has a sample application opening at one end and a vent opening at the other end of the channel capable of capillary liquid transport, wherein the channel capable of capillary liquid transport is formed at least partially by the carrier and the detection element and extends in the direction of capillary transport from the sample application opening at least to the edge of the detection test element that is nearest to the vent opening and wherein a notch is located in one of the surfaces forming the channel capable of capillary liquid transport at the edge of the test element forming the sample application opening so that one side of the edge of the test element forming the sample application opening is at least partially discontinuous and the surface opposite to the notch is exposed.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: March 7, 2006
    Assignee: Roche Diagnostics GmbH
    Inventors: Volker Zimmer, Wolfgang Schwöbel, Ronald Mönch, Wilhelm Leichner
  • Patent number: 6991913
    Abstract: A procedure is described for the determination of triglyceride contained in low density lipoprotein with the measures that triglyceride-containing lipoprotein is reacted with a non-ionic surface-active agent which is synthesized from a block copolymer of propylene oxide and ethylene oxide, and that a triglyceride determination method is carried out. The procedure is particularly suitable for the in-vitro diagnosis of vascular disorders, in particular in the detection of coronary heart disease.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: January 31, 2006
    Assignee: Roche Diagnostics GmbH
    Inventors: Heinrich Wieland, Matthias Nauck
  • Patent number: 6986754
    Abstract: A needleless hypodermic injection system for injecting a liquid medication, which system comprises a disposable cartridge which contains a medication and which includes a propellant and an igniter, and a reusable application device which comprises a pressure chamber for receiving the medication cartridge, actuation means including an ignition system and means for ensuring reliability and safety of the system. The reusable application device comprises: (a) a housing including a fist housing section and a second housing section which are adapted to be assembled together by a screwing operation, the first housing section comprising a front part having an injection outlet and a chamber adapted to receive a the cartridge contains the medication to be injected and also contains a propellant and an igniter, and (b) means for selectively activating said igniter of said cartridge when predetermined conditions are fulfilled.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: January 17, 2006
    Assignee: Roche Diagnostics GmbH
    Inventors: Hans-Peter Haar, George Bevan Kirby Meacham, Konrad Joseph Popp, Otto Bruntrup, Ulrich Josef Riemensperger, Guenter Franz Ihle, Bruno Robert Thös, Hans List, Dirk Bandau, Horst Engelhardt, Christian Gliewe
  • Publication number: 20050281714
    Abstract: System for processing samples, in particular samples containing nucleic acids comprising a multichamber arrangement the chambers of which are used to receive liquids and it also concerns a pipetting device for removing liquids from the chambers and/or dispensing liquid into the chambers, wherein the system has a contamination protection which can move relative to the multichamber arrangement and which prevents contamination of an adjacent second chamber with liquid from the first chamber during a pipetting operation in the first chamber, by preventing discharge of fluid droplets from the first chamber into the second chamber by at least partially covering the first chamber.
    Type: Application
    Filed: July 25, 2005
    Publication date: December 22, 2005
    Applicant: Roche Diagnostic GmBH
    Inventors: Frank Schubert, Udo Eichenlaub, Armin Tgetgel
  • Patent number: 6925393
    Abstract: A system for the extrapolation of a glucose concentration has a data input device for entering administered insulin doses and their times of administration, a data input device for entering the carbohydrates consumed or to be consumed, a unit for determining an actual glucose concentration at a point in time (ta) in a patient's bodily fluid, a memory unit, and an evaluation unit for evaluation of the data stored in the memory unit, and for the extrapolation of a glucose concentration at a point in time tp, whereby tp is after ta The extrapolation includes determining the portion (Iwirk) of insulin doses that become effective between ta and tp; determining the portion of consumed carbohydrate units KHwirk, that become effective between ta and tp; and determining an extrapolated glucose concentration Gp at the point in time tp with consideration for Iwirk and KHwirk.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: August 2, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Brit Kalatz, Udo Hoss
  • Patent number: 6921513
    Abstract: System for processing samples, in particular samples containing nucleic acids comprising a multichamber arrangement the chambers of which are used to receive liquids and it also concerns a pipetting device for removing liquids from the chambers and/or dispensing liquid into the chambers, wherein the system has a contamination protection which can move relative to the multichamber arrangement and which prevents contamination of an adjacent second chamber with liquid from the first chamber during a pipetting operation in the first chamber, by preventing discharge of fluid droplets from the first chamber into the second chamber by at least partially covering the first chamber.
    Type: Grant
    Filed: December 16, 2000
    Date of Patent: July 26, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Frank Ulrich Schubert, Udo Eichenlaub, Armin Tgetgel
  • Patent number: 6919444
    Abstract: Preparations of particles having a glass surface, wherein more than 75% by weight of these particles have a particle size between 0.5 ?m and 15 ?m and a glass surface which contains between 2 and 6 mole % zinc oxide, have proven to be particularly advantageous in processes for the purification of nucleic acids. This in particular results in an increased nucleic acid yield.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: July 19, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Herbert Harttig, Michael Riedling, Martin Mennig, Helmut Schmidt
  • Patent number: 6919175
    Abstract: A procedure for the release and isolation of nucleic acids from biological compartments of a sample always uses an instrument that can hold one or more sample processsing vessels, maintain the sample processing vessels at a constant temperature, shake the sample processing vessels and separate magnetic particles by means of magnetic force. This system greatly simplifies the isolation of nucleic acids.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: July 19, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Gerhard Bienhaus, Ulrich Schubert, Uwe Kolb, Burkhard Stolz, Manfred Pasch
  • Patent number: 6916616
    Abstract: The invention concerns stable aqueous solutions containing one or several nucleoside triphosphates wherein the respective solution has a pH value of more than 7.5 and contains no additional substances with a stabilizing effect. The nucleoside triphosphate solutions are used in particular for DNA synthesizing reactions such as e.g. RT-PCR, cycle sequencing, random priming and nick translation. One of the most important applications of such solutions containing deoxy-nucleoside triphosphates (d-NTP) is their use in the polymerase chain reaction (PCR).
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: July 12, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Hans-Georg Ihlenfeldt, Axel Schmidt, Klaus Muhlegger, Volker Leitenberger
  • Patent number: 6911553
    Abstract: The invention is directed to compounds of formula (I) wherein R1 alkyl, alkenyl or alkynyl having from 6 to 24 carbon atoms; n=0-12; X=oxygen or NH; and the physiologically safe salts, esters, optically active forms, racemates and derivatives thereof which can be metabolized in vivo to yield compounds of general formula (I), methods of preparing same, and drugs containing said compounds, for treating bone metabolic disorders.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: June 28, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Angelika Esswein, Lothar Kling
  • Patent number: 6908769
    Abstract: The present invention concerns new fluorescent dye systems especially for fluorescence resonance energy transfer determinations for example combined with the time-resolved measurement of the resulting fluorescence. The invention also concerns the use of these dyes to label biomolecules and for the homogeneous determination of interactions between biomolecules, for example for detecting an analyte.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: June 21, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Daniel Belik, Hans-Peter Josel, Rupert Herrmann, Bernard Koenig, Francis Mueller
  • Patent number: 6887427
    Abstract: The invention concerns a process for coating a metallic or semimetallic surface in which coating molecules containing reactive groups are bound covalently to the surface by irradiation with light and it also concerns a structured coated surface.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: May 3, 2005
    Assignee: Roche Diagnostics GmbH
    Inventor: Franz Effenberger
  • Patent number: 6881378
    Abstract: The invention concerns an analytical device containing at least two components in which at least two of the components are joined together with the aid of an adhesive, which is characterized in that the adhesive contains an adsorptive material. The invention additionally concerns the use of adhesives which contain adsorptive material to manufacture analytical devices.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: April 19, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Volker Zimmer, Hans-Peter Braun
  • Patent number: 6881559
    Abstract: The present invention relates to thermostable mutants of B-type DNA polymerases comprising a Y-GG/A amino acid motif between the N-terminal 3?-5?-exonuclease domain and the C-terminal polymerase domain whereas the tyrosine of the Y-GG/A amino acid motif is mutated and whereas these mutant DNA polymerases are suitable for PCR.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: April 19, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Harald Sobek, Bruno Frey, Garabed Antranikian, Kristina Boehike, Francesca Maria Pisani, Mosè Rossi
  • Patent number: 6880968
    Abstract: Test element analysis system (1) for the analytical investigation of a sample (8), in particular of a body liquid, of human beings or of animals, comprising test elements (3) with a test zone (7), to be brought in contact with the sample to be investigated for the purpose of performing an analysis, in order to measure a measurement quantity characteristic for the analysis, and an evaluation instrument (2) with a test element holder (5) for positioning a test element (3) in a measuring position in order to perform a measurement, and a measurement and evaluation electronics (15) for measuring the characteristic change and for determining a result of the analysis, based on the result of the measurement. In order to provide increased measuring accuracy by improved temperature compensation, it is proposed, in the scope of the invention, that the evaluation instrument (2) for the determination of the temperature prevailing in the test zone (7) of the test element (3) comprises an infrared detector (20).
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: April 19, 2005
    Assignee: Roche Diagnostics GmbH
    Inventor: Hans-Peter Haar
  • Patent number: 6875859
    Abstract: The invention concerns compounds of the general formula (I) in which the residues R1 to R7 have the meanings given in the application as well as methods for their preparation.
    Type: Grant
    Filed: March 11, 2002
    Date of Patent: April 5, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Klaus Mühlegger, Herbert Von Der Eltz
  • Patent number: 6870047
    Abstract: Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free class surface or having pores with a diameter offices than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 ?m. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: March 22, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Jörg Kleiber, Thomas Walter, Herbert Harttig, Christoph Lesniak, Martin Mennig, Michael Riedling, Helmut Schmidt
  • Patent number: 6852337
    Abstract: The invention relates to a process for the preparation of fast-dissolving pharmaceutical preparations from difficultly soluble active substances, wherein an aqueous suspension is made from the active substance and one or more water-soluble adjuvants and then the resulting aqueous suspension is processed, with removal of the water, by methods conventional per se, to form solid pharmaceutical preparations. The invention also relates to fast-dissolving pharmaceutical preparations of active substances having a dissolution rate of at least 70% after 30 minutes, prepared in accordance with the process of the invention.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: February 8, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Rolf-Dieter Gabel, Walter Preis, Alexander Wirl
  • Patent number: 6852500
    Abstract: The invention concerns a method and an arrangement for determining the concentration of glucose in a body fluid. In the microdialysis technology used for this purpose, perfusate containing glucose is transported in intermittent delivery pulses through a microdialysis probe (10) inserted into the body fluid and dialysate obtained in this process is passed to a measuring cell (16) to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the body fluid by means of a control device (18, 20) in accordance with a command variable derived from the measurement signals of the measuring cell (16). When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the body fluid.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: February 8, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Udo Hoss, Hans-Joerg Pfleiderer, Ralf Gessler, Hans-Ulrich Zieten, Rolf Fussgaenger
  • Publication number: 20050019789
    Abstract: A thermostable enzyme is provided which is derived from the microorganism Anaerocellum thermophilum. The enzyme has a molecular weight of 96 to 100 kDa, shows DNA polymerase activity and reverse transcriptase activity in the presence of magnesium ions. The enzyme may be native or recombinant, and may be used with selected primers and nucleoside triphosphates in a temperature cycling polymerase chain reaction on DNA or RNA as template with or without additional DNA polymerases as an enzyme mixture.
    Type: Application
    Filed: February 2, 2004
    Publication date: January 27, 2005
    Applicant: Roche Diagnostics GMBH
    Inventors: Waltraud Ankenbauer, Gudrun Schmitz-Agheguian, Elizaveta Bonch-Osmolovskaya, Vitaly Svetlichny, Ursula Markau, Bernhard Angerer, Astrid Reiser