Patents Assigned to Roche Diagnostics GmbH
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Patent number: 7008799Abstract: The invention concerns an analytical test element for the determination of an analyte in a liquid containing an inert carrier, a detection element and a channel capable of capillary liquid transport which has a sample application opening at one end and a vent opening at the other end of the channel capable of capillary liquid transport, wherein the channel capable of capillary liquid transport is formed at least partially by the carrier and the detection element and extends in the direction of capillary transport from the sample application opening at least to the edge of the detection test element that is nearest to the vent opening and wherein a notch is located in one of the surfaces forming the channel capable of capillary liquid transport at the edge of the test element forming the sample application opening so that one side of the edge of the test element forming the sample application opening is at least partially discontinuous and the surface opposite to the notch is exposed.Type: GrantFiled: December 4, 1998Date of Patent: March 7, 2006Assignee: Roche Diagnostics GmbHInventors: Volker Zimmer, Wolfgang Schwöbel, Ronald Mönch, Wilhelm Leichner
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Patent number: 6991913Abstract: A procedure is described for the determination of triglyceride contained in low density lipoprotein with the measures that triglyceride-containing lipoprotein is reacted with a non-ionic surface-active agent which is synthesized from a block copolymer of propylene oxide and ethylene oxide, and that a triglyceride determination method is carried out. The procedure is particularly suitable for the in-vitro diagnosis of vascular disorders, in particular in the detection of coronary heart disease.Type: GrantFiled: June 16, 2000Date of Patent: January 31, 2006Assignee: Roche Diagnostics GmbHInventors: Heinrich Wieland, Matthias Nauck
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Patent number: 6986754Abstract: A needleless hypodermic injection system for injecting a liquid medication, which system comprises a disposable cartridge which contains a medication and which includes a propellant and an igniter, and a reusable application device which comprises a pressure chamber for receiving the medication cartridge, actuation means including an ignition system and means for ensuring reliability and safety of the system. The reusable application device comprises: (a) a housing including a fist housing section and a second housing section which are adapted to be assembled together by a screwing operation, the first housing section comprising a front part having an injection outlet and a chamber adapted to receive a the cartridge contains the medication to be injected and also contains a propellant and an igniter, and (b) means for selectively activating said igniter of said cartridge when predetermined conditions are fulfilled.Type: GrantFiled: March 19, 2002Date of Patent: January 17, 2006Assignee: Roche Diagnostics GmbHInventors: Hans-Peter Haar, George Bevan Kirby Meacham, Konrad Joseph Popp, Otto Bruntrup, Ulrich Josef Riemensperger, Guenter Franz Ihle, Bruno Robert Thös, Hans List, Dirk Bandau, Horst Engelhardt, Christian Gliewe
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Publication number: 20050281714Abstract: System for processing samples, in particular samples containing nucleic acids comprising a multichamber arrangement the chambers of which are used to receive liquids and it also concerns a pipetting device for removing liquids from the chambers and/or dispensing liquid into the chambers, wherein the system has a contamination protection which can move relative to the multichamber arrangement and which prevents contamination of an adjacent second chamber with liquid from the first chamber during a pipetting operation in the first chamber, by preventing discharge of fluid droplets from the first chamber into the second chamber by at least partially covering the first chamber.Type: ApplicationFiled: July 25, 2005Publication date: December 22, 2005Applicant: Roche Diagnostic GmBHInventors: Frank Schubert, Udo Eichenlaub, Armin Tgetgel
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Patent number: 6925393Abstract: A system for the extrapolation of a glucose concentration has a data input device for entering administered insulin doses and their times of administration, a data input device for entering the carbohydrates consumed or to be consumed, a unit for determining an actual glucose concentration at a point in time (ta) in a patient's bodily fluid, a memory unit, and an evaluation unit for evaluation of the data stored in the memory unit, and for the extrapolation of a glucose concentration at a point in time tp, whereby tp is after ta The extrapolation includes determining the portion (Iwirk) of insulin doses that become effective between ta and tp; determining the portion of consumed carbohydrate units KHwirk, that become effective between ta and tp; and determining an extrapolated glucose concentration Gp at the point in time tp with consideration for Iwirk and KHwirk.Type: GrantFiled: November 13, 2000Date of Patent: August 2, 2005Assignee: Roche Diagnostics GmbHInventors: Brit Kalatz, Udo Hoss
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Patent number: 6921513Abstract: System for processing samples, in particular samples containing nucleic acids comprising a multichamber arrangement the chambers of which are used to receive liquids and it also concerns a pipetting device for removing liquids from the chambers and/or dispensing liquid into the chambers, wherein the system has a contamination protection which can move relative to the multichamber arrangement and which prevents contamination of an adjacent second chamber with liquid from the first chamber during a pipetting operation in the first chamber, by preventing discharge of fluid droplets from the first chamber into the second chamber by at least partially covering the first chamber.Type: GrantFiled: December 16, 2000Date of Patent: July 26, 2005Assignee: Roche Diagnostics GmbHInventors: Frank Ulrich Schubert, Udo Eichenlaub, Armin Tgetgel
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Patent number: 6919444Abstract: Preparations of particles having a glass surface, wherein more than 75% by weight of these particles have a particle size between 0.5 ?m and 15 ?m and a glass surface which contains between 2 and 6 mole % zinc oxide, have proven to be particularly advantageous in processes for the purification of nucleic acids. This in particular results in an increased nucleic acid yield.Type: GrantFiled: February 20, 2003Date of Patent: July 19, 2005Assignee: Roche Diagnostics GmbHInventors: Herbert Harttig, Michael Riedling, Martin Mennig, Helmut Schmidt
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Patent number: 6919175Abstract: A procedure for the release and isolation of nucleic acids from biological compartments of a sample always uses an instrument that can hold one or more sample processsing vessels, maintain the sample processing vessels at a constant temperature, shake the sample processing vessels and separate magnetic particles by means of magnetic force. This system greatly simplifies the isolation of nucleic acids.Type: GrantFiled: April 26, 2000Date of Patent: July 19, 2005Assignee: Roche Diagnostics GmbHInventors: Gerhard Bienhaus, Ulrich Schubert, Uwe Kolb, Burkhard Stolz, Manfred Pasch
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Patent number: 6916616Abstract: The invention concerns stable aqueous solutions containing one or several nucleoside triphosphates wherein the respective solution has a pH value of more than 7.5 and contains no additional substances with a stabilizing effect. The nucleoside triphosphate solutions are used in particular for DNA synthesizing reactions such as e.g. RT-PCR, cycle sequencing, random priming and nick translation. One of the most important applications of such solutions containing deoxy-nucleoside triphosphates (d-NTP) is their use in the polymerase chain reaction (PCR).Type: GrantFiled: December 19, 2001Date of Patent: July 12, 2005Assignee: Roche Diagnostics GmbHInventors: Hans-Georg Ihlenfeldt, Axel Schmidt, Klaus Muhlegger, Volker Leitenberger
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Patent number: 6911553Abstract: The invention is directed to compounds of formula (I) wherein R1 alkyl, alkenyl or alkynyl having from 6 to 24 carbon atoms; n=0-12; X=oxygen or NH; and the physiologically safe salts, esters, optically active forms, racemates and derivatives thereof which can be metabolized in vivo to yield compounds of general formula (I), methods of preparing same, and drugs containing said compounds, for treating bone metabolic disorders.Type: GrantFiled: September 29, 2000Date of Patent: June 28, 2005Assignee: Roche Diagnostics GmbHInventors: Angelika Esswein, Lothar Kling
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Patent number: 6908769Abstract: The present invention concerns new fluorescent dye systems especially for fluorescence resonance energy transfer determinations for example combined with the time-resolved measurement of the resulting fluorescence. The invention also concerns the use of these dyes to label biomolecules and for the homogeneous determination of interactions between biomolecules, for example for detecting an analyte.Type: GrantFiled: November 14, 2001Date of Patent: June 21, 2005Assignee: Roche Diagnostics GmbHInventors: Daniel Belik, Hans-Peter Josel, Rupert Herrmann, Bernard Koenig, Francis Mueller
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Patent number: 6887427Abstract: The invention concerns a process for coating a metallic or semimetallic surface in which coating molecules containing reactive groups are bound covalently to the surface by irradiation with light and it also concerns a structured coated surface.Type: GrantFiled: June 17, 2002Date of Patent: May 3, 2005Assignee: Roche Diagnostics GmbHInventor: Franz Effenberger
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Patent number: 6881378Abstract: The invention concerns an analytical device containing at least two components in which at least two of the components are joined together with the aid of an adhesive, which is characterized in that the adhesive contains an adsorptive material. The invention additionally concerns the use of adhesives which contain adsorptive material to manufacture analytical devices.Type: GrantFiled: March 17, 2000Date of Patent: April 19, 2005Assignee: Roche Diagnostics GmbHInventors: Volker Zimmer, Hans-Peter Braun
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Patent number: 6881559Abstract: The present invention relates to thermostable mutants of B-type DNA polymerases comprising a Y-GG/A amino acid motif between the N-terminal 3?-5?-exonuclease domain and the C-terminal polymerase domain whereas the tyrosine of the Y-GG/A amino acid motif is mutated and whereas these mutant DNA polymerases are suitable for PCR.Type: GrantFiled: March 9, 2001Date of Patent: April 19, 2005Assignee: Roche Diagnostics GmbHInventors: Harald Sobek, Bruno Frey, Garabed Antranikian, Kristina Boehike, Francesca Maria Pisani, Mosè Rossi
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Patent number: 6880968Abstract: Test element analysis system (1) for the analytical investigation of a sample (8), in particular of a body liquid, of human beings or of animals, comprising test elements (3) with a test zone (7), to be brought in contact with the sample to be investigated for the purpose of performing an analysis, in order to measure a measurement quantity characteristic for the analysis, and an evaluation instrument (2) with a test element holder (5) for positioning a test element (3) in a measuring position in order to perform a measurement, and a measurement and evaluation electronics (15) for measuring the characteristic change and for determining a result of the analysis, based on the result of the measurement. In order to provide increased measuring accuracy by improved temperature compensation, it is proposed, in the scope of the invention, that the evaluation instrument (2) for the determination of the temperature prevailing in the test zone (7) of the test element (3) comprises an infrared detector (20).Type: GrantFiled: October 26, 2000Date of Patent: April 19, 2005Assignee: Roche Diagnostics GmbHInventor: Hans-Peter Haar
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Patent number: 6875859Abstract: The invention concerns compounds of the general formula (I) in which the residues R1 to R7 have the meanings given in the application as well as methods for their preparation.Type: GrantFiled: March 11, 2002Date of Patent: April 5, 2005Assignee: Roche Diagnostics GmbHInventors: Klaus Mühlegger, Herbert Von Der Eltz
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Patent number: 6870047Abstract: Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free class surface or having pores with a diameter offices than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 ?m. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3.Type: GrantFiled: January 10, 2001Date of Patent: March 22, 2005Assignee: Roche Diagnostics GmbHInventors: Jörg Kleiber, Thomas Walter, Herbert Harttig, Christoph Lesniak, Martin Mennig, Michael Riedling, Helmut Schmidt
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Patent number: 6852337Abstract: The invention relates to a process for the preparation of fast-dissolving pharmaceutical preparations from difficultly soluble active substances, wherein an aqueous suspension is made from the active substance and one or more water-soluble adjuvants and then the resulting aqueous suspension is processed, with removal of the water, by methods conventional per se, to form solid pharmaceutical preparations. The invention also relates to fast-dissolving pharmaceutical preparations of active substances having a dissolution rate of at least 70% after 30 minutes, prepared in accordance with the process of the invention.Type: GrantFiled: October 22, 2002Date of Patent: February 8, 2005Assignee: Roche Diagnostics GmbHInventors: Rolf-Dieter Gabel, Walter Preis, Alexander Wirl
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Patent number: 6852500Abstract: The invention concerns a method and an arrangement for determining the concentration of glucose in a body fluid. In the microdialysis technology used for this purpose, perfusate containing glucose is transported in intermittent delivery pulses through a microdialysis probe (10) inserted into the body fluid and dialysate obtained in this process is passed to a measuring cell (16) to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the body fluid by means of a control device (18, 20) in accordance with a command variable derived from the measurement signals of the measuring cell (16). When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the body fluid.Type: GrantFiled: July 20, 2000Date of Patent: February 8, 2005Assignee: Roche Diagnostics GmbHInventors: Udo Hoss, Hans-Joerg Pfleiderer, Ralf Gessler, Hans-Ulrich Zieten, Rolf Fussgaenger
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Publication number: 20050019789Abstract: A thermostable enzyme is provided which is derived from the microorganism Anaerocellum thermophilum. The enzyme has a molecular weight of 96 to 100 kDa, shows DNA polymerase activity and reverse transcriptase activity in the presence of magnesium ions. The enzyme may be native or recombinant, and may be used with selected primers and nucleoside triphosphates in a temperature cycling polymerase chain reaction on DNA or RNA as template with or without additional DNA polymerases as an enzyme mixture.Type: ApplicationFiled: February 2, 2004Publication date: January 27, 2005Applicant: Roche Diagnostics GMBHInventors: Waltraud Ankenbauer, Gudrun Schmitz-Agheguian, Elizaveta Bonch-Osmolovskaya, Vitaly Svetlichny, Ursula Markau, Bernhard Angerer, Astrid Reiser