Patents Assigned to Roche Molecular System, Inc.
  • Non-replicative transduction particles and transduction particle-based reporter systems
    Patent number: 11008602
    Abstract: Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The non-replicative transduction particles can be constructed from viruses and use viral transduction and replication systems. The reporter nucleic acid molecules include a reporter gene, such as a reporter molecule or selectable marker, for detecting target genes or cells. Methods and systems are provided for detection of cells and target nucleic acid molecules using the non-replicative transduction particles as reporter molecules.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: May 18, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Slav Dugenny, Ellen H Fiss, Marc Rehfuss
  • Compositions and methods for detection of drug resistant
    Patent number: 11008626
    Abstract: Methods for the rapid detection of the presence or absence of Mycobacterium tuberculosis (MTB) resistant to rifampicin (MTB-RIF) and/or MTB resistant to isoniazid (MTB-INH) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the genes for rpoB, inhA, and katG, along with kits are provided that are designed for the detection of MTB-RIF and/or MTB-INH.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: May 18, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jenny A. Johnson, Rochak Mehta, Andy Yuen
  • Catalysts for reversing formaldehyde adducts and crosslinks
    Patent number: 10995104
    Abstract: Catalysts act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting catalysts to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: May 4, 2021
    Assignee: Roche Molecular System, Inc.
    Inventor: Alexander Nierth
  • Magnetic nanoparticles for nucleic acid purification
    Patent number: 10988758
    Abstract: The present invention relates to monodisperse silanized ferrimagnetic iron oxide particles, a method for producing the same and a method for independent generic binding of nucleic acid molecules to the particles.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: April 27, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jens Christian Bolle, Thomas Walter, Peter Wenzig
  • Bead emulsion nucleic acid amplification
    Patent number: 10982274
    Abstract: Disclosed are methods for nucleic acid amplification wherein nucleic acid templates, beads, and amplification reaction solution are emulsified and the nucleic acid templates are amplified to provide clonal copies of the nucleic acid templates attached to the beads. Also disclosed are kits and apparatuses for performing the methods of the invention.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: April 20, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jan Berka, Yi-Ju Chen, John H. Leamon, Steven Lefkowitz, Kenton L. Lohman, Vinod B. Makhijani, Jonathan M. Rothberg, Gary J. Sarkis, Maithreyan Srinivasan, Michael P. Weiner
  • Microfluidic device and method for manufacturing the same
    Patent number: 10967370
    Abstract: The present disclosure provides a microfluidic device (1) comprising at least one flow channel (21) connecting an inlet opening (22) with an outlet opening (23), and an array of wells (24) in fluid communication with the flow channel (21), wherein the flow channel (21) comprises an inlet portion (211) at the inlet opening (22), an outlet portion (212) at the outlet opening (23), and a middle portion (213) between the inlet portion (211) and the outlet portion (212), wherein at least the middle portion (213) comprises the array of wells (24) and is provided with a hydrophilic surface, and the flow channel (21) further comprises a transition area (214) provided at least between the middle portion (213) and the outlet portion (212), which transition area (214) is constituted by providing a hydrophobic surface. Furthermore, a method for manufacturing such a microfluidic device is also provided.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: April 6, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Alexander Meier, Chris Steinert, Michael Zeder
  • Informatics platform for integrated clinical care
    Patent number: 10963821
    Abstract: An informatics platform provides an architecture to integrate information from relevant patient information systems.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: March 30, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Michael Barnes, Stephen Burnell, William Evans, Weng Chi Lou, Mark M. Morita, Oluwatosin Oyeniran, Joseph Perez-Rogers, Joachim Schmid
  • Polymerase variants
    Patent number: 10961520
    Abstract: Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363, S365Q, S366, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 and combinations thereof.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: March 30, 2021
    Assignees: Roche Molecular Systems, Inc., Roche Sequencing Solutions, Inc.
    Inventors: Aruna Ayer, Cleoma Renetta Arnold, Arkadiusz Bibillo, Mara Boenitz-Dulat, Barbara Eckert, Ilya Lederman, Colin Alexander McGaw, Charles Wayan Schwab, Tyler O'Brien Shultz, Shawn Suko, Eileen Thai, Bigna Woersdoerfer, David Daniel Wunderlich
  • Compositions and methods for detection of trichomonas vaginalis
    Patent number: 10934597
    Abstract: Methods for the rapid detection of the presence or absence of Trichomonas vaginalis (TV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target TV gene, along with kits are provided that are designed for the detection of TV.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: March 2, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jody Harris, Shi-Da Y. Lu, Kalyani Mangipudi, Jingtao Sun
  • Modified sample processing device
    Patent number: 10906035
    Abstract: A sample processing tubule is provided including, from a proximate to a distal end, an opening through which a sample is introducible, at least three segments, and an extraction port operatively connected to a distal segment of the at least three segments. The extraction port enables extraction of a reaction mixture in the distal segment of the tubule without piercing the tubule or one or more seals separating each of the segments in the tubule.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: February 2, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Thomas Drechsler
  • Compositions and methods for detection of herpes simplex virus 1 and 2
    Patent number: 10889869
    Abstract: Methods for the rapid detection of the presence or absence of Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the genes for HSV-1 viral DNA polymerase B (HSV-1 Pol) and HSV-1 thymidine kinase C (HSV-1 TK), and also target the genes for HSV-2 thymidine kinase C (HSV-2 TK) and HSV-2 glycoprotein B (HSV-2 gB), along with kits are provided that are designed for the detection of HSV-1 and/or HSV-2.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: January 12, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Xiaoning Wu, Karen Young
  • Instrument and method for automatically heat-sealing a microplate
    Patent number: 10884006
    Abstract: A heating device for heating a thermally fixable sealing cover disposed over the microplate adjacent the wells, a cooling device for actively cooling the microplate and a controller set up to control activity of the heating and cooling devices in a manner to heat the sealing cover so as to thermally fix it to the microplate and to actively cool the microplate so as to keep a temperature of the samples below a predefined temperature when heating the sealing cover. It further relates to a method for automatically sealing a microplate in which the thermally fusible sealing cover is disposed over the microplate, the sealing cover is heated to thermally fix it to the microplate and the microplate is actively cooled in a manner that a temperature of the liquid reaction mixtures is kept below a predefined temperature when heating the sealing cover.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: January 5, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Daniel Bommer, Thomas Schlaubitz, Pius Studer
  • Systems and methods for meso-dissection
    Patent number: 10871425
    Abstract: The subject disclosure presents systems and methods for improved meso-dissection of biological specimens and tissue slides including importing one or more reference slides with annotations, using inter-marker registration algorithms to automatically map the annotations to an image of a milling slide, and dissecting the annotated tissue from the selected regions in the milling slide for analysis, while concurrently tracking the data and analysis using unique identifiers such as bar codes.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: December 22, 2020
    Assignee: ROCHE MOLECULAR SYSTEMS INC.
    Inventors: Michael Barnes, Christophe Chefd'hotel, Srinivas Chukka, Mohammad Qadri
  • Method for validating a resource for a lab task schedule of a laboratory device
    Patent number: 10867262
    Abstract: A method and a laboratory device for validating a resource for a lab task schedule of a laboratory device, the lab task schedule including at least one lab task, the method including the steps of: identifying a resource upon being loaded onto the laboratory device; retrieving resource validity data (RVD) corresponding to the identified resource; retrieving an expected lab task completion time (CT) corresponding to each lab task of the lab task schedule; validating of the resource validity data (RVD) against the expected lab task completion time (CT) corresponding to one or more lab task(s) of the lab task schedule; and generating a resource validation signal indicative of a result of the validation of the resource validity data (RVD).
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: December 15, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Raymond Minder
  • HAV detection
    Patent number: 10865454
    Abstract: Methods for detecting HAV in a biological sample are provided, comprising amplifying a target nucleic acid comprising the sequence of HAV in a reaction mixture. The reaction mixture comprises a biological sample which may contain the target nucleic acid and set of oligonucleotides. The invention also provides kits for the detection of HAV.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: December 15, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Hermann Leying, Ning Lu, Nick Newton, Andreas Wolfelschneider, Karen Young, Dirk Zimmermann
  • Devices, systems, and methods for extracting a material from a material sample
    Patent number: 10866170
    Abstract: Devices, systems, and associated methods for selectively extracting a material from a sample are provided. In one aspect, for example, a method for selectively extracting biological material from a biological sample can include identifying a region of biological material to be extracted from a biological sample disposed on a substantially planar surface, applying an extraction tool to the region of biological material to disrupt biological material from the biological sample, and dispensing a liquid at the region of biological material. The method can also include aspirating the liquid and the disrupted biological material from the biological sample.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: December 15, 2020
    Assignee: Roche Molecular Systems, Inc
    Inventors: Nils B. Adey, Katherine B. Geiersbach, Mark Herrmann, Robert J. Parry
  • Pol6 polymerase variants
    Patent number: 10851353
    Abstract: The present disclosure provides variant Pol6 polymerase polypeptides, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: December 1, 2020
    Assignees: Roche Sequencing Solutions, Inc., Roche Molecular Systems, Inc.
    Inventors: Evan Amato, Cleoma Arnold, Aruna Ayer, Mara Boenitz-Dulat, Barbara Eckert, Ilya Lederman, Colin McGaw, Preethi Sarvabhowman, Charles Wayan Schwab, Shawn Suko, Eileen Thai, Bigna Woersdoerfer, David Wunderlich
  • Method to correct signal light intensities measured by a detector of a detection unit in a laboratory instrument
    Patent number: 10856391
    Abstract: A method to correct signal light intensities measured by a detector of a detection unit in a laboratory instrument is presented. The detection unit comprises a light source, a sample plane comprising a sample holder configured to hold at least one sample vessel comprising a test sample to be illuminated, a reference light sensor, and the detector. Based on a basic light intensity of a newly manufactured light source and an initial light intensity measured by the reference light sensor the sensitivity of the reference light sensor can be determined. And signal light intensities measured by the detector can be corrected based on the determined sensitivity and subsequently measured reference light intensities of the reference light sensor in order to generate comparable test results.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: December 1, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Patrick Waser, Florian Betschart
  • Display screen or portion thereof with graphical user interface for timeline information for multidisciplinary cancer treatment planning
    Patent number: D902226
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 17, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen Burnell, Joachim Schmid, Vikram Mohan, Michael Barnes, William Evans, Oluwatosin Oyeniran, Leia Garrote-Gallego, Mark M. Morita, Michael Pan, Alex Kalogrides, Chandana Pandrangi, Rita Isabel da Silva Reis, João Paulo Alves Mendes, Margaret Ann Peterson, Namita Deshpande, Amelia E. Schladow, Weng Chi Lou, Dominik Seeger, Dania Maria Afonso, Eduardo Ferrão Ulrich
  • Display screen or portion thereof with graphical user interface for patient information for multidisciplinary cancer treatment planning
    Patent number: D902227
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 17, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen Burnell, Joachim Schmid, Vikram Mohan, Michael Barnes, William Evans, Oluwatosin Oyeniran, Leia Garrote-Gallego, Mark M. Morita, Michael Pan, Alex Kalogrides, Chandana Pandrangi, Rita Isabel da Silva Reis, João Paulo Alves Mendes, Margaret Ann Peterson, Namita Deshpande, Amelia E. Schladow, Weng Chi Lou, Dominik Seeger, Dania Maria Afonso, Eduardo Ferrão Ulrich