Patents Assigned to Roche Molecular Systems, Inc.
  • Method for validating a resource for a lab task schedule of a laboratory device
    Patent number: 10867262
    Abstract: A method and a laboratory device for validating a resource for a lab task schedule of a laboratory device, the lab task schedule including at least one lab task, the method including the steps of: identifying a resource upon being loaded onto the laboratory device; retrieving resource validity data (RVD) corresponding to the identified resource; retrieving an expected lab task completion time (CT) corresponding to each lab task of the lab task schedule; validating of the resource validity data (RVD) against the expected lab task completion time (CT) corresponding to one or more lab task(s) of the lab task schedule; and generating a resource validation signal indicative of a result of the validation of the resource validity data (RVD).
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: December 15, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Raymond Minder
  • HAV detection
    Patent number: 10865454
    Abstract: Methods for detecting HAV in a biological sample are provided, comprising amplifying a target nucleic acid comprising the sequence of HAV in a reaction mixture. The reaction mixture comprises a biological sample which may contain the target nucleic acid and set of oligonucleotides. The invention also provides kits for the detection of HAV.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: December 15, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Hermann Leying, Ning Lu, Nick Newton, Andreas Wolfelschneider, Karen Young, Dirk Zimmermann
  • Devices, systems, and methods for extracting a material from a material sample
    Patent number: 10866170
    Abstract: Devices, systems, and associated methods for selectively extracting a material from a sample are provided. In one aspect, for example, a method for selectively extracting biological material from a biological sample can include identifying a region of biological material to be extracted from a biological sample disposed on a substantially planar surface, applying an extraction tool to the region of biological material to disrupt biological material from the biological sample, and dispensing a liquid at the region of biological material. The method can also include aspirating the liquid and the disrupted biological material from the biological sample.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: December 15, 2020
    Assignee: Roche Molecular Systems, Inc
    Inventors: Nils B. Adey, Katherine B. Geiersbach, Mark Herrmann, Robert J. Parry
  • Pol6 polymerase variants
    Patent number: 10851353
    Abstract: The present disclosure provides variant Pol6 polymerase polypeptides, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: December 1, 2020
    Assignees: Roche Sequencing Solutions, Inc., Roche Molecular Systems, Inc.
    Inventors: Evan Amato, Cleoma Arnold, Aruna Ayer, Mara Boenitz-Dulat, Barbara Eckert, Ilya Lederman, Colin McGaw, Preethi Sarvabhowman, Charles Wayan Schwab, Shawn Suko, Eileen Thai, Bigna Woersdoerfer, David Wunderlich
  • Method to correct signal light intensities measured by a detector of a detection unit in a laboratory instrument
    Patent number: 10856391
    Abstract: A method to correct signal light intensities measured by a detector of a detection unit in a laboratory instrument is presented. The detection unit comprises a light source, a sample plane comprising a sample holder configured to hold at least one sample vessel comprising a test sample to be illuminated, a reference light sensor, and the detector. Based on a basic light intensity of a newly manufactured light source and an initial light intensity measured by the reference light sensor the sensitivity of the reference light sensor can be determined. And signal light intensities measured by the detector can be corrected based on the determined sensitivity and subsequently measured reference light intensities of the reference light sensor in order to generate comparable test results.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: December 1, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Patrick Waser, Florian Betschart
  • Polymerase variants
    Patent number: 10829747
    Abstract: The present disclosure provides variant Pol6 polymerase polypeptides, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: November 10, 2020
    Assignees: Roche Sequencing Solutions, Inc., Roche Molecular Systems, Inc.
    Inventors: Aruna Ayer, Cleoma Arnold, Charles Schwab, Preethi Sarvabhowman, Eileen Thai, Ilya Lederman, Colin McGaw, Evan Amato, Barbara Eckert, Shawn Suko, Mara Boenitz-Dulat, Bigna Woersdoerfer, David Wunderlich
  • Sequence-specific detection and phenotype determination
    Patent number: 10822664
    Abstract: Disclosed herein are materials and methods for achieving sequence-specific organism detection and/or phenotype(s) using sequence-specific oligonucleotides. Also disclosed are related kits, cultures, and cells for detecting and/or phenotyping microorganisms in a sequence-specific manner.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: November 3, 2020
    Assignee: Roche Molecular Systems Inc.
    Inventor: Diego Ariel Rey
  • Sensor for detecting a state of a fluid within a microfluidic plate, system for controlling a preparation of a sample including a fluid and method for detecting a state of a fluid within a microfluidic plate
    Patent number: 10809219
    Abstract: A sensor (100) for detecting a state of a fluid within a microfluidic plate (120) is disclosed. The sensor (100) comprises at least a first planar electrode (102) and a second planar electrode (104) arranged parallel to one another so as to form an electric capacitor (106). The first planar electrode (102) and the second planar electrode (104) are configured to generate an electric field (114) within the fluid, wherein the sensor (100) is configured to detect the state of the fluid by means of a capacitance of the electric capacitor (106). Further, a system (116) for controlling a preparation of a sample including a fluid is disclosed. Furthermore, a method for detecting a state of a fluid within a microfluidic plate (120) is disclosed.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: October 20, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Claudio Cherubini, Michal Dobrzynski, Paul Federer, Thomas Kern, Lukas Schneider
  • Reversibly protected nucleotide reagents with high thermal stability
    Patent number: 10793901
    Abstract: The present invention provides for stable nucleotide reagents used for nucleic acid amplification by PCR and RT-PCR (Reverse Transcriptase-PCR) that comprises modified nucleoside polyphosphates. The present invention also provides for methods for using the modified nucleoside polyphosphates for detecting the presence or absence of a target nucleic acid sequence in a sample in an amplification reaction.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: October 6, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Amar Gupta
  • Compositions and methods for detection of BK virus
    Patent number: 10793923
    Abstract: Methods for the rapid detection of the presence or absence of BK virus in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting BK virus and kits are provided that are designed for the detection of BK virus.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: October 6, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Rochak Mehta, Jingtao Sun
  • Cell surface marker depletion in a sample processing device
    Patent number: 10774393
    Abstract: The disclosure provides methods, devices, and kits for conducting a quantitative analysis of a whole blood sample. Various modifications to the disclosed methods, devices, and kits are described.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: September 15, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jinshuang Lu, Beiyang Ma, Nancy Schoenbrunner, Fangnian Wang
  • Method for reducing quantification errors caused by reaction volume deviations in digital polymerase chain reaction
    Patent number: 10767218
    Abstract: The present disclosure relates to a method for reducing quantification errors caused by reaction volume deviations in digital polymerase chain reaction (dPCR) and to a method for determining the amount or concentration of a nucleic acid of interest in a sample with dPCR.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: September 8, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Alan Furlan
  • Display screen or portion thereof with graphical user interface for oncology progress for multidisciplinary cancer treatment planning
    Patent number: D900835
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 3, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen Burnell, Oluwatosin Oyeniran, Amelia E. Schladow, Weng Chi Lou
  • Display screen or portion thereof with graphical user interface for interactive guidelines for multidisciplinary cancer treatment planning
    Patent number: D900836
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 3, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen Burnell, Oluwatosin Oyeniran, Mark M. Morita, Amelia E. Schladow, Weng Chi Lou
  • Display screen or portion thereof with graphical user interface for literature search information for multidisciplinary cancer treatment planning
    Patent number: D900837
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 3, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen Burnell, Joachim Schmid, Oluwatosin Oyeniran, Mark M. Morita, Amelia E. Schladow, Weng Chi Lou
  • Display screen or portion thereof with graphical user interface for similar patient information for multidisciplinary cancer treatment planning
    Patent number: D901521
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 10, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen Burnell, Joachim Schmid, Oluwatosin Oyeniran, Mark M. Morita, Amelia E. Schladow, Weng Chi Lou
  • Display screen or portion thereof with graphical user interface for timeline information for multidisciplinary cancer treatment planning
    Patent number: D902226
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 17, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen Burnell, Joachim Schmid, Vikram Mohan, Michael Barnes, William Evans, Oluwatosin Oyeniran, Leia Garrote-Gallego, Mark M. Morita, Michael Pan, Alex Kalogrides, Chandana Pandrangi, Rita Isabel da Silva Reis, João Paulo Alves Mendes, Margaret Ann Peterson, Namita Deshpande, Amelia E. Schladow, Weng Chi Lou, Dominik Seeger, Dania Maria Afonso, Eduardo Ferrão Ulrich
  • Display screen or portion thereof with graphical user interface for patient information for multidisciplinary cancer treatment planning
    Patent number: D902227
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 17, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen Burnell, Joachim Schmid, Vikram Mohan, Michael Barnes, William Evans, Oluwatosin Oyeniran, Leia Garrote-Gallego, Mark M. Morita, Michael Pan, Alex Kalogrides, Chandana Pandrangi, Rita Isabel da Silva Reis, João Paulo Alves Mendes, Margaret Ann Peterson, Namita Deshpande, Amelia E. Schladow, Weng Chi Lou, Dominik Seeger, Dania Maria Afonso, Eduardo Ferrão Ulrich
  • Display screen or portion thereof with graphical user interface for clinical information for multidisciplinary cancer treatment planning
    Patent number: D902228
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 17, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen Burnell, Joachim Schmid, Vikram Mohan, Michael Barnes, William Evans, Oluwatosin Oyeniran, Leia Garrote-Gallego, Mark M. Morita, Michael Pan, Alex Kalogrides, Chandana Pandrangi, Rita Isabel da Silva Reis, João Paulo Alves Mendes, Margaret Ann Peterson, Namita Deshpande, Amelia E. Schladow, Weng Chi Lou, Dominik Seeger, Dania Maria Afonso, Eduardo Ferrão Ulrich
  • Biological slide tray
    Patent number: D902432
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: November 17, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Jag Pankhania