Patents Assigned to Roche Molecular Systems, Inc.
  • MULTIMODAL MACHINE LEARNING BASED CLINICAL PREDICTOR
    Publication number: 20230029915
    Abstract: Methods and systems for performing a clinical prediction are provided. In one example, the method comprises: receiving first molecular data of a patient, the first molecular data including at least gene expressions of the patient; receiving first biopsy image data of the patient; processing, using a machine learning model, the first molecular data and the first biopsy image data to perform a clinical prediction of the patient's response to a treatment, wherein the machine learning model is generated or updated based on second molecular data including at least gene expressions and second biopsy image data of a plurality of patients; and generating an output of the clinical prediction.
    Type: Application
    Filed: August 16, 2022
    Publication date: February 2, 2023
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Antoaneta Petkova Vladimirova, Yogesh P. Pandit, Vishakha Sharma, Tod M. Klingler, Hari Singhal
  • Method to monitor and control the temperature of a sample holder of a laboratory instrument
    Patent number: 11517905
    Abstract: A method to monitor and control the temperature of a sample holder of a laboratory instrument during execution of a temperature profile on the sample holder is presented. The laboratory instrument comprises a sample holder with high temperature uniformity and at least three identical temperature sensors. The measured actual temperatures of the sample holder are processed in order to determine if the execution of the temperature profile should be continued or aborted. Furthermore, temperature sensors which measure actual temperatures that do not fulfil certain requirements are excluded from further monitoring and controlling the temperature of a sample holder.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: December 6, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Sven Ebert, Paul Federer, Pius Hermann, Stefan Vollenweider
  • INSTRUMENT FOR PROCESSING CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM
    Publication number: 20220381798
    Abstract: In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.
    Type: Application
    Filed: March 2, 2022
    Publication date: December 1, 2022
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Michael Thomas NGUYEN, Sean FORD, Nikolas James HANSEN
  • Multiplex PCR detection of ALK, RET, and ROS fusions
    Patent number: 11505830
    Abstract: Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: November 22, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Ann Begovich, Cindy Cheung, Javelin Chi, Grantland Hillman, Dwight Kuo, Michael Lee, Chitra Manohar, Xiaoju Max Ma, Ellen Ordinario, Jaya Rajamani, Huan Truong
  • SYSTEMS AND METHODS FOR ASSESSING ELECTRICAL CONNECTIVITY BETWEEN ELEMENTS OF ASSAY DEVICES
    Publication number: 20220365146
    Abstract: Disclosed are devices, systems and methods for assessing the integrity of electrical connections between elements of interfacing electronic devices. In some aspects, a system includes an analysis device having electronics that interface with an assay cartridge inserted into the analysis device, wherein the analysis device is configured to conduct a preflight test in which impedance values for each circuit between the assay cartridge and analysis device are rearranged and assessed to determine the electrical connection integrity of the assay cartridge to the analysis device prior to implementing the assay.
    Type: Application
    Filed: June 15, 2022
    Publication date: November 17, 2022
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Roger Harry Taylor, John B. Gorman, Tyler David Jensen
  • Module with collapsible fluid chamber and onboard fluid chamber compression element
    Patent number: 11498074
    Abstract: A module for processing fluids includes one or more collapsible fluid chambers supported on a substrate, a compression element supported on the substrate and configured to be movable with respect to the one or more chambers, and an actuating element coupled to the compression element and configured to effect movement of the compression element relative to the one or more fluid chambers to collapse each fluid chamber by compressing the fluid chamber between the compression element and the substrate as the compression element moves over the fluid chamber.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: November 15, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventor: David Walter Wright
  • MIXING BIOLOGICAL COMPONENTS WITHOUT FROTHING
    Publication number: 20220347637
    Abstract: A device for the mixing fluid media. The device is a bladeless mixer. The device comprises a hollow body with at least a single inlet opening in its bottom and at least a single outflow region in its side. The device is rotated at a speed at which the media due to centrifugal forces enters the device's hollow cavity via the inflow opening or unit. The media is discharged from the cavity through one or more outlet units or openings in the sides or in the top of the device. During mixing the media does not rise above the level of the undisturbed media.
    Type: Application
    Filed: April 4, 2022
    Publication date: November 3, 2022
    Applicant: Roche Molecular Systems, Inc.
    Inventor: Mohammad Sotoudeh
  • Multimodal machine learning based clinical predictor
    Patent number: 11462325
    Abstract: Methods and systems for performing a clinical prediction are provided. In one example, the method comprises: receiving first molecular data of a patient, the first molecular data including at least gene expressions of the patient; receiving first biopsy image data of the patient; processing, using a machine learning model, the first molecular data and the first biopsy image data to perform a clinical prediction of the patient's response to a treatment, wherein the machine learning model is generated or updated based on second molecular data including at least gene expressions and second biopsy image data of a plurality of patients; and generating an output of the clinical prediction.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: October 4, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Antoaneta Petkova Vladimirova, Yogesh P. Pandit, Vishakha Sharma, Tod M. Klingler, Hari Singhal
  • Noninvasive detection of fetal aneuploidy in egg donor pregnancies
    Patent number: 11441185
    Abstract: The present invention provides assay systems and methods for determining the percent fetal contribution of cell-free DNA in a maternal sample from a pregnant female with an egg donor pregnancy. Further provided, are assay systems and methods for determining a statistical likelihood of the presence or absence of a fetal aneuploidy in a maternal sample using a determined percent fetal cell-free DNA in the sample.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: September 13, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Arnold Oliphant, Eric Wang, Craig Struble
  • Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi
    Patent number: 11441167
    Abstract: The present invention relates to compositions and methods for the use of polymerase chain reaction (PCR) as a reporter assay for rapid and simultaneous bacterial identification and phenotype testing for antimicrobial susceptibility (AST). The current invention uses a strategy that has shown the ability for multiplexing and for handling polymicrobial samples for antimicrobial susceptibility testing.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: September 13, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Kyle C. Cady, Brett Hanson, Paulino Abdon, Ryan Chan, Patrick Lin, Rochak Mehta, Troy Rabang
  • Methods and compositions for nucleic acid detection
    Patent number: 11421268
    Abstract: Methods, compositions, reaction mixtures, kits, and/or systems for producing a complementary sequence to a region in a target polynucleotide in a sample are provided. In some aspects, the methods, compositions, reaction mixtures, kits, and/or systems comprise subjecting the sample to a nucleic acid amplification reaction in a reaction mixture under conditions to yield the complete sequence to the region of the target polynucleotide. In some aspects, the complementary sequence produced is amplified.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: August 23, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Mikael Kubista, Robert Sjöback
  • Set of oligonucleotide probes as well as methods and uses thereto
    Patent number: 11421266
    Abstract: The present disclosure relates to a set of at least 100 single-stranded oligonucleotide probes directed against (or complementary to) portions of a genomic target sequence of interest. The present disclosure also relates to a method of detecting a genomic target sequence of interest using the set of oligonucleotide probes and a method of generating the set of oligonucleotide probes. Further, the present disclosure relates to a kit comprising the set of oligonucleotide probes and at least one further component.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: August 23, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Frank Bergmann, Walter Eberle, Thomas Fischer, Herbert von der Eltz
  • Processes for calculating phased fetal genomic sequences
    Patent number: 11404142
    Abstract: The present invention provides processes for calculating phased genomic sequences of the fetal genome using fetal DNA obtained from a maternal sample. The processes and systems of the present invention utilize novel technological and computational approaches to detect fetal genomic sequences and determine the phased heritable genomic sequences. The invention could be used, e.g., to identify in utero deleterious mutations carried by the parents and inherited by a fetus within a particular heritable genomic region.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: August 2, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: John Stuelpnagel, Craig Struble, Eric Wang
  • Display screen portion with a graphical user interface activity card
    Patent number: D962957
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: September 6, 2022
    Assignees: Hoffmann-La Roche Inc., Roche Molecular Systems, Inc.
    Inventors: Jorge Cancela Gonzalez, Geraint Iwan Davies, Jean-Philippe Guy Roger Guyon, Christin Rene Kreml, Tommy Park
  • Display screen or portion thereof with animated graphical user interface for symptom tracking of covid-19
    Patent number: D969838
    Type: Grant
    Filed: May 3, 2020
    Date of Patent: November 15, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Matteus Pan, Shilpa Shenoy, Brigitta Monz, Brian Lee, Guillaume Bousquet, Niro Wijesekera, Huy Nam Doan, Alessandro Barbato, Joseph Rogers
  • Display screen or portion thereof with graphical user interface for selecting a report with an abstraction tool
    Patent number: D974390
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: January 3, 2023
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Cindy K. Barnard, Sambasivarao Byrapuneni, Diwakar Chapagain, Archana P. Dorge, Catherine M. Jeu, Rengaraja Kesavan, Kaushal D. Parekh, Raman Ramanathan, David M. Schlossman, Vishakha Sharma
  • Display screen or portion thereof with graphical user interface for publishing a report with an abstraction tool
    Patent number: D974391
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: January 3, 2023
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Cindy K. Barnard, Sambasivarao Byrapuneni, Diwakar Chapagain, Archana P. Dorge, Catherine M. Jeu, Rengaraja Kesavan, Kaushal D. Parekh, Raman Ramanathan, David M. Schlossman, Vishakha Sharma
  • Display screen or portion thereof with graphical user interface for manually abstracting text with an abstraction tool
    Patent number: D974392
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: January 3, 2023
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Cindy K. Barnard, Sambasivarao Byrapuneni, Diwakar Chapagain, Archana P. Dorge, Catherine M. Jeu, Rengaraja Kesavan, Kaushal D. Parekh, Raman Ramanathan, David M. Schlossman, Vishakha Sharma
  • Display screen or portion thereof with graphical user interface for selecting text with an abstraction tool
    Patent number: D974393
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: January 3, 2023
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Cindy K. Barnard, Sambasivarao Byrapuneni, Diwakar Chapagain, Archana P. Dorge, Catherine M. Jeu, Rengaraja Kesavan, Kaushal D. Parekh, Raman Ramanathan, David M. Schlossman, Vishakha Sharma
  • Display screen or portion thereof with graphical user interface for modifying a report with an abstraction tool
    Patent number: D975120
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: January 10, 2023
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Cindy K. Barnard, Sambasivarao Byrapuneni, Diwakar Chapagain, Archana P. Dorge, Catherine M. Jeu, Rengaraja Kesavan, Kaushal D. Parekh, Raman Ramanathan, David M. Schlossman, Vishakha Sharma