Abstract: An instrument tray is configured for use with surgical and/or other invasive or non-invasive medical procedures, such as in operating rooms or ICU rooms within a hospital, for example. The tray facilitates a safe transfer of instruments between a procedural team and performing the procedure. In an embodiment the surgical tray may be attached directly to the patient and/or patient's drapes so that the tray may rest upon the patient.
Type:
Grant
Filed:
March 23, 2020
Date of Patent:
January 10, 2023
Assignee:
Connected Rock, Inc.
Inventors:
Samuel Baradarian, Stephen Anthony Tunnell
Abstract: A method for generating a rebounding motion between a person and a surface includes the steps of providing a rebounding device, positioning the rear member against the surface and the front member adjacent to an upper body of the person and the surface, and applying pressure to the rebounding device through the upper body. The rebounding device includes front and rear members having front and rear widths spanning right front and rear side edges and left front and rear side edges and first and second spring mechanisms positioned between the front and rear members. The first and second spring mechanisms are positioned between the right front side edge of the front member and the right rear side edge of the rear member and between the left front side edge of the front member and the left rear side edge of the rear member, respectively.
Abstract: Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGF? and/or LTBP3-TGF?. The application also provides methods of use of these inhibitors for, for example, inhibiting TGF? activation, and treating subjects suffering from TGF?-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGF? inhibitor for a subject in need thereof are also provided.
Type:
Grant
Filed:
November 19, 2021
Date of Patent:
June 21, 2022
Assignee:
Scholar Rock, Inc.
Inventors:
Thomas Schurpf, Justin W. Jackson, George Coricor, Abhishek Datta, Stefan Wawersik, Christopher Littlefield, Adam Fogel, Caitlin Stein, Julia McCreary, Matthew Salotto, Frederick Streich, Jr.
Abstract: Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGF? and/or LTBP3-TGF?. The application also provides methods of use of these inhibitors for, for example, inhibiting TGF? activation, and treating subjects suffering from TGF?-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGF? inhibitor for a subject in need thereof are also provided.
Type:
Grant
Filed:
August 19, 2020
Date of Patent:
January 4, 2022
Assignee:
Scholar Rock, Inc.
Inventors:
Thomas Schurpf, Justin W. Jackson, George Coricor, Abhishek Datta, Stefan Wawersik, Christopher Littlefield, Adam Fogel, Caitlin Stein, Julia McCreary, Matthew Salotto, Frederick Streich, Jr.
Abstract: The present invention relates to antibodies, or antigen-binding fragments thereof, that specifically bind proMyostatin and/or latent Myostatin, and methods and uses thereof for treating metabolic diseases.
Type:
Grant
Filed:
January 5, 2018
Date of Patent:
October 26, 2021
Assignee:
Scholar Rock, Inc.
Inventors:
Adriana Donovan, Stefan Wawersik, Yung Chyung, Micah Webster
Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.
Type:
Grant
Filed:
July 11, 2019
Date of Patent:
September 28, 2021
Assignee:
Scholar Rock, Inc.
Inventors:
Abhishek Datta, Allan Capili, Thomas Schurpf, Constance Martin, Kevin B. Dagbay, Christopher Chapron, Stefan Wawersik, Christopher Littlefield, Gregory J. Carven, Alan Buckler, Susan Lin, Justin W. Jackson, Caitlin Stein, Matthew Salotto, Andrew Avery, Anthony Cooper
Abstract: A method for generating a rebounding motion between a person and a stationary surface comprising the steps of providing a rebounding device that includes a front member, a rear member, and a spring mechanism positioned between the front member and the rear member for allowing the front member and rear member to move toward and away from one another. The method further includes the steps of positioning the rear member against the stationary surface and the front member adjacent to an upper body of the person and the stationary surface, and applying pressure to the rebounding device through the upper body such that the upper body moves toward from the stationary surface while a lower body of the person remains in place.
Abstract: A flow diversion sub for a down-the-hole drill comprising a housing assembly that includes a housing body, a cap extending from the housing body, and a drive shaft having an upper central blind hole and a lower central blind hole spaced from the upper central blind hole, wherein the drive shaft is received within the housing assembly. In operation, one of the housing assembly and drive shaft moves between a first position and a second position relative to the other of the housing assembly and drive shaft. In the first position the upper central blind hole is in fluid communication with the lower central blind hole, and in the second position the upper central blind hole is blocked from being in fluid communication with the lower central blind hole.
Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
Type:
Grant
Filed:
December 4, 2018
Date of Patent:
April 20, 2021
Assignee:
Scholar Rock, Inc.
Inventors:
Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
Abstract: The present disclosure relates to the treatment of muscle conditions, such as SMA, with the use of an agent that inhibits myostatin signaling. The disclosure includes combination therapies that include a myostatin inhibitor and a neuronal corrector.
Abstract: An instrument tray is configured for use with surgical and/or other invasive or non-invasive medical procedures, such as in operating rooms or ICU rooms within a hospital, for example. The tray facilitates a safe transfer of instruments between a procedural team and performing the procedure. In an embodiment the surgical tray may be attached directly to the patient and/or patient's drapes so that the tray may rest upon the patient.
Type:
Application
Filed:
March 23, 2020
Publication date:
July 9, 2020
Applicant:
Connected Rock, Inc.
Inventors:
Samuel BARADARIAN, Stephen Anthony TUNNELL
Abstract: A down-the-hole drill hammer is provided that includes a housing, a drill bit proximate a distal end of the housing, and a roller bearing assembly. The roller bearing assembly circumscribes the drill bit. The roller bearing assembly includes a race and a plurality of rollers. The plurality of rollers are operatively engaged with the race.
Abstract: An instrument tray is configured for use with surgical and/or other invasive or non-invasive medical procedures, such as in operating rooms or ICU rooms within a hospital, for example. The tray facilitates a safe transfer of instruments between a procedural team and performing the procedure. In an embodiment the surgical tray may be attached directly to the patient and/or patient's drapes so that the tray may rest upon the patient.
Type:
Grant
Filed:
March 30, 2011
Date of Patent:
March 24, 2020
Assignee:
Connected Rock, Inc.
Inventors:
Samuel Baradarian, Stephen Anthony Tunnell
Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
Type:
Grant
Filed:
January 12, 2017
Date of Patent:
March 24, 2020
Assignee:
Scholar Rock, Inc.
Inventors:
Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub