Abstract: A compound selected from the group consisting of a syn isomer of a compound of the formula ##STR1## in the R or S form or in the form of a R, S mixture wherein the various substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable acid addition salts having anti-bacterial activity.
Type:
Grant
Filed:
July 22, 1993
Date of Patent:
December 13, 1994
Assignee:
Roussel Uclaf
Inventors:
Jozsef Aszodi, Jean-Francois Chantot, Solange G. D'Ambrieres
Abstract: Bicyclo-[2,2,1]-heptanes, bicyclo-[2,2,2,]-octanes and bicyclo-[2,2,3]-nonanes having 2 or 3 ring hetero atoms selected from O, S and N, substituted at the 1-position by a 4-alkynylphenyl group and at the 4-position and optionally at the 3 and/or 5-position are valuable pesticides, particularly insecticides and acaracides. The compounds may be prepared by reacting an alkyne with the corresponding 4-iodophenyl substituted compound or by debromination of the corresponding 4-dibromomethylphenyl substituted compound.
Type:
Grant
Filed:
July 29, 1992
Date of Patent:
December 6, 1994
Assignees:
Roussel-Uclaf, University of California
Inventors:
John E. Casida, Christopher J. Palmer, John P. Larkin, Ian H. Smith
Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms, R.sub.2 is alkyl of 1 to 3 carbon atoms or cycloalkyl of 3 to 6 carbon atoms, R.sub.3 is --COOR.sub.6, R.sub.6 is hydrogen or alkyl of 1 to 3 carbon atoms, R.sub.4 is selected from the group consisting of halogen, --CN, --NO.sub.2, --SCH.sub.3, alkylcarbonyl of 1 to 6 alkyl carbon atoms, --CX.sub.3, --WCX.sub.3, --(CH.sub.2).sub.n --CX.sub.3, --(CX.sub.2).sub.n --CX.sub.3, --W--(CX.sub.2).sub.n --CX.sub.3, and --W--(CH.sub.2).sub.n --CX.sub.3, X is halogen, W is --O-- or --S--, n is 1, 2 or 3, R.sub.5 is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms and cycloalkyl of 3 to 6 carbon atoms and their salts with non-toxic pharmaceutically acceptable bases with the proviso that if R.sub.2 is alkyl of 1 to 3 carbon atoms, R.sub.1 is hydrogen and R.sub.4 is selected from the group consisting of halogen, --CX.sub.3, --(CH.sub.2).sub.n --CX.sub.
Type:
Grant
Filed:
April 28, 1993
Date of Patent:
December 6, 1994
Assignee:
Roussel-Uclaf
Inventors:
Robert R. Bartlett, Matharu S. Singh, Elizabeth A. Kuo, Rudolf Schleyerbach, Robert Westwood
Abstract: The present invention concerns the use of fructosyl oligosaccharides as low-calorie sweeteners, and the foods, dietetic products and drinks containing them.
Type:
Grant
Filed:
October 9, 1990
Date of Patent:
November 22, 1994
Assignee:
Roussel Uclaf
Inventors:
Jacques Biton, Gerard Gellf, Jean-Marc Michel, Francois B. Paul, Pierre F. Monsan
Abstract: A method and apparatus for metering and dispensing an active ingredient, such as an insecticide, fumigant, fertilizer or room freshener. The active ingredient is placed in a container (6) and a pressurised propellant is subsequently introduced from a source (1) via conduits (3, 9). The propellant serves to absorb the active ingredient which is dispersed from the container via conduit (5) through a dispensing outlet (8) so that the active ingredient is dispersed in an airborne dispersion. In an ejector (4), a pressure differential is created across a propellant inlet port (4a) which is sufficient to draw the active ingredient from the active ingredient container (6) but is less than the pressure differential required to cause a cooling effect in the mixing chamber (4) and is less than that pressure differential that gives rise to an erratic dispersion of the active ingredient from the dispensing outlet (8).
Abstract: The use of a polypeptide having human interleukin 2 activity for preparing a pharmaceutical composition for treating malignant epithelial tumours of the upper respiratory/alimentary tract or the thymus, is described.
Abstract: A compound selected from the group consisting of all possible racemic, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein E and G together form a group selected from the group: ##STR2## consisting of a) ##STR3## wherein, A is a cycloalkyl of 3-6 carbon optionally substituted, R, R.sub.1, R.sub.2 and Y are defined in the specification.
Type:
Grant
Filed:
October 1, 1992
Date of Patent:
October 18, 1994
Assignee:
Roussel UCLAF
Inventors:
Francois Clemence, Michel Fortin, Odile Le Martret
Abstract: A process for the preparation of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted by halogen or a nitrogen or oxygen function and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.2 is alkyl of 1 to 4 carbon atoms and the A, B, C and D rings are optionally substituted by at least one member of the group consisting of optionally protected --OH or .dbd.0, halogen, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms comprising reacting a compound of the formula ##STR2## wherein R.sub.1 and R.sub.2 and the A, B, C and D rings are defined as above with an oxidizing agent in the presence of water and an at least partially water-miscible solvent to obtain a compound of the formula ##STR3## wherein R.sub.1 and R.sub.
Abstract: The present invention discloses pesticidally active compounds of formula (II) ##STR1## or a salt thereof, wherein Q is an monocyclic aromatic ring, or fused bicyclic ring system of which at least one ring is aromatic containing 9 or 10 atoms of which one may be nitrogen and the rest carbon each ring system being optionally substituted, or Q is a dihalovinyl group or a group R.sup.6 --C.tbd.C-- where R.sup.6 is C.sub.1-4 alkyl, tri C.sub.1-4 alkylsilyl, halogen or hydrogen; R.sup.2, R.sup.3 , R.sup.4 and R.sup.5 are the same or different with at least one being hydrogen and the others being independently selected from hydrogen, halo, C.sub.1-4 alkyl or C.sub.1-4 haloalkyl; and R.sup.1 is selected from hydrogen and C.sub.1-8 hydrocarbyl optionally substituted by dioxalanyl, halo, cyano, trifluoromethyl, trifluoromethylthio or C.sub.1-6 alkoxy and X.sup.1 is hydrogen, fluoro or chloro.
Type:
Grant
Filed:
April 7, 1993
Date of Patent:
October 4, 1994
Assignee:
Roussel Uclaf
Inventors:
Robert J. Blade, George S. Cockerill, John E. Robinson
Abstract: Novel indanes in all possible stereoisomer forms of the formula ##STR1## wherein the substrates are as defined in the application and their non-toxic, pharmaceutically acceptable acid addition salts and their hydrates are disclosed as having central analgesic properties as well as antiarrhythmic and diuretic activities.
Type:
Grant
Filed:
August 9, 1993
Date of Patent:
September 20, 1994
Assignee:
Roussel Uclaf
Inventors:
Francois Clemence, Michel Fortin, Gilles Hamon, Odile Le Martret, Anne-Marie Moura
Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein A, B and E are individually selected from the group consisting of .dbd.CH-- and .dbd.N-- with at least one being .dbd.N--, R is selected from the group consisting of cycloalkyl of 3 to 6 carbon atoms, and alkenyl and alkynyl of 2 to 6 carbon atoms, R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms, R.sub.2 and R.sub.3 together are --O--CH.sub.2 --O-- or are individually selected from the group consisting of hydrogen, halogen, --NO.sub.2, --CN, alkyl, alkylthio and alkoxy of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, --COR.sub.4, --(CH.sub.2).sub.m --CX.sub.3, --O--(CH.sub.2).sub.m --CX.sub.3, --S--(CH.sub.2).sub.m --CX.sub.3, --O--(CX.sub.2).sub.m --CX.sub.3 and --S--(CX.sub.2).sub.m --CX.sub.3, R.sub.
Abstract: A stabilized composition comprising an effective amount of non-glycosylated recombinant human IL2 in reduced form, citric acid, mannitol and a preservative effective amount of a mixture of dextran and mono-calcium and disodium ethylenediamine tetraacetate, particularly in lyophilized form.
Abstract: A compound selected from the group consisting of all stereoisomeric forms and mixtures thereof of a compound of the formula ##STR1## wherein Y and Z are individually selected from the groups consisting of hydrogen, halogen, --CF.sub.3, alkyl, alkoxy and alkylthio of 1 to 8 carbon atoms and aryl, aryloxy and arylthio of up to 14 carbon atoms optionally substituted with at least one member of the group consisting of halogen, hydroxy optionally esterified etherified, --CF.sub.3 and alkyl of 1 to 8 carbon atoms and R is alkyl of 1 to 8 carbon atoms or the remainder of a pyrethrinoid alcohol having excellent pesticidal properties and their preparation and intermediates.
Abstract: Novel imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
Type:
Grant
Filed:
June 7, 1991
Date of Patent:
August 16, 1994
Assignee:
Roussel Uclaf
Inventors:
Michel Fortin, Daniel Frechet, Gilles Hamon, Simone Jouquey, Jean-Paul Vevert
Abstract: Compounds of the formula ##STR1## wherein X is hydrogen, halogen or an optionally substituted alkyl, Y is selected from the group consisting of hydrogen, halogen optionally substituted alkyl, an optionally substituted aryl or arylalkyl, --(CH.sub.2).sub.m Si (Alk.sub.1).sub.3, --(CH.sub.2).sub.n OAlk.sub.2 or --(CH.sub.2).sub.p SAlk.sub.3, m, n and p are an integer from 0 to 6, Alk.sub.1, Alk.sub.2 and Alk.sub.3 are alkyl and R is alkyl of 1 to 18 carbon atoms or the remainder of an alcohol used in the pyrethrinoid series having pesticide properties.
Type:
Grant
Filed:
December 17, 1992
Date of Patent:
August 9, 1994
Assignee:
Roussel-Uclaf
Inventors:
Marc Benoit, Jean-Pierre Demoute, Jean-Marc Girodeau
Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the application having antiglucocorticoid and antiprogestomimetic properties and a process and intermediates for their preparation.
Type:
Grant
Filed:
February 19, 1993
Date of Patent:
August 9, 1994
Assignee:
Roussel-Uclaf
Inventors:
Lucien Nedelec, Francois Nique, Daniel Philibert
Abstract: A compound and all possible racemic or optically active isomer forms, selected from the group consisting of compound of the formula ##STR1## wherein the substituents are defined as set forth in the application as filed. Useful for treating cerebral insufficiencies of anoxic or ischemic origin.
Type:
Grant
Filed:
January 19, 1993
Date of Patent:
July 26, 1994
Assignee:
Roussel-Uclaf
Inventors:
Nurgun Aktogu, Francois Clemence, Claude Oberlander
Abstract: Novel all possible stereoisomers and mixtures thereof of vinylsulfone nor-pyrethric compounds of the formula ##STR1## wherein R.sub.a is selected from the group consisting of alkyl of 1 to 18 carbon atoms, alkenyl and alkynyl of 2 to 18 carbon atoms, cycloalkyl of 3 to 18 carbon atoms, cycloalkylalkyl of 4 to 18 carbon atoms and aryl of 6 to 14 carbon atoms unsubstituted or substituted with at least one functional group, n is 0, 1 or 2, R.sub.b is selected from the group consisting of alkyl of 1 to 18 carbon atoms, alkenyl and alkynyl of 2 to 18 carbon atoms, cycloalkyl of 3 to 18 carbon atoms, cycloalkylalkyl of 4 to 18 carbon atoms and aryl of 6 to 14 carbon atoms, all unsubstituted or unsubstituted with at least one functional group or R.sub.a and R.sub.
Type:
Grant
Filed:
April 22, 1993
Date of Patent:
July 12, 1994
Assignee:
Roussel-UCLAF
Inventors:
Didier Babin, Jean-Pierre Demoute, Jean Tessier
Abstract: A method and apparatus for metering and dispensing an active ingredient, such as an insecticide, fumigant, fertilizer or room freshener. The active ingredient is placed in a container 6 and a pressurized propellant is subsequently introduced from a source 1 via conduits 3, 9. The propellant serves to absorb the active ingredient which is dispersed from the container via conduit 5 through a dispensing outlet 8 so that the active ingredient is dispersed in an airborne dispersion. In an ejector 4, a pressure differential is created across a propellant inlet port 4a which is sufficient to draw the active ingredient from the active ingredient container 6 but is less than the pressure differential required to cause a cooling effect in the mixing chamber 4 and is less than that pressure differential that gives rise to an erratic dispersion of the active ingredient from the dispensing outlet 8. The system is particularly suitable for the spraying of insecticides into large spaces such as warehouses and supermarkets.