Patents Assigned to Roussel-UCLAF
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Patent number: 5554604Abstract: A method of controlling male fertility in warm-blooded male animals comprising administering to male warm-blooded animals an amount of a compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of alkyl of 1 to 8 carbon atoms and benzyl or taken together with the nitrogen form a saturated 5 to 6 ring heterocycle optionally containing a second nitrogen or oxygen in the ring, R.sub.3 is .alpha.- or .beta.- methyl, n is an integer from 2 to 10, R.sub.4 and R.sub.5 together are .dbd.0 or R.sub.4 is selected from the group consisting of hydrogen, --OH and acyloxy of an organic carboxylic acid of up to 12 carbon atoms and R.sub.5 is selected from the group consisting of hydrogen, --OH, acyloxy of an organic carboxylic acid of up to 12 carbon atoms and alkyl, alkenyl and alkynyl of up to 8 carbon atoms, R.sub.6 and R.sub.7 together are .dbd.Type: GrantFiled: March 8, 1995Date of Patent: September 10, 1996Assignee: Roussel UclafInventors: Armelle Bonfils, Daniel Philibert
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Patent number: 5547869Abstract: Recombinant plasmids capable of replicating themselves in Escherichia coli containing a complete or partial sequence of the double or single strand DNA or a Densovirus causing a densovirosis in a sensitive insect, a process for obtaining said plasmids and a method of combatting ravager insects.Type: GrantFiled: February 14, 1994Date of Patent: August 20, 1996Assignee: Roussel UclafInventors: Bruno Dumas, Monica Gervais, Max Bergoin, Mireille Jourdan, Francoise X. Jousset
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Patent number: 5543400Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is ##STR2## m and n are individually integers from 0 to 6, A and B are individually a member selected from the group consisting of hydrogen, halogen and alkyl of 1 to 8 carbon atoms, the double bond geometry being E or Z or E+Z or A and B form a third bond between the carbon atoms to which they are attached, Ar is selected from the group consisting of a) carbocyclic aryl of up to 18 carbon atoms optionally substituted with at least one member of the group consisting of free carboxy, alkoxycarbonyl, carboxy salified with a non-toxic, pharmaceutically acceptable base, amidified carboxy, --OH, halogen, --NO.sub.2, --CN, alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio and alkynylthio of up to 12 carbon atoms, N-alkyl, N-alkenyl and N-alkynyl of up to 12 carbon atoms and cycloalkyl of 3 to 12 carbon atoms, all optionally substituted with at least one halogen and ##STR3## R.sub.1 and R.sub.Type: GrantFiled: November 1, 1993Date of Patent: August 6, 1996Assignee: Roussel UclafInventors: Constantin Agouridas, Alain Bonnefoy, Jean-Fran.cedilla.ois Chantot, Alexis Denis, Odile Le Martret
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Patent number: 5541318Abstract: A compound selected from the group consisting of a syn isomer of a compound of the formula: ##STR1## in the R or S form or in the form of an R, S mixture wherein the variables are herein below defined, and their non-toxic, pharmaceutically acceptable acid addition salts having anti-bacterial activity.Type: GrantFiled: May 24, 1995Date of Patent: July 30, 1996Assignee: ROUSSEL UCLAFInventors: Jozsef Aszodi, Jean-Francois Chantot, Solange G. D'Ambrieres
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Patent number: 5538963Abstract: The syn isomer of a compound of the formula ##STR1## in the R or S form or a mixture of R and S forms wherein selected from the group consisting of ##STR2## and their non-toxic, pharmaceutically acceptable acid addition salts wherein the substituents are defined as in the specification having antibacterial activity and their preparation.Type: GrantFiled: September 27, 1994Date of Patent: July 23, 1996Assignee: Roussel UclafInventors: Jean-Francois Chantot, Solange G. D'Ambrieres, Daniel Humbert, Jean-Georges Teutsch
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Patent number: 5532375Abstract: Compounds useful in the treatment of Alzheimer's disease, senile dementia, or memory disorders which have the formula ##STR1## in which R represents a hydrogen atom, a linear, branched or cyclic alkyl radical, saturated or unsaturated, containing up to 8 carbon atoms, possibly substituted by a free or esterified carboxy radical or R represents an aralkyl radical containing up to 10 carbon atoms and R' represents a linear or branched, saturated or unsaturated, alkyl radical, containing up to 8 carbon atoms, a radical --COalk.sub.1 or a radical --(CH.sub.2).sub.2 N(alk.sub.2).sub.2, alk.sub.1 and alk.sub.2 representing an alkyl radical containing up to 8 carbon atoms, as well as their addition salts with acids. Also compositions containing the same, method of preparation and method of treatment using the same.Type: GrantFiled: September 30, 1994Date of Patent: July 2, 1996Assignee: Roussel-UCLAFInventors: Giulio Galliani, Fernando Barzashi, Alina Butti, Carla Bonetti, Emilio Toja
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Patent number: 5530022Abstract: A compound in all possible stereoisomeric forms and their mixtures of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## having excellent pesticidal, particularly insecticidal, properties.Type: GrantFiled: August 9, 1994Date of Patent: June 25, 1996Assignee: Roussel-UclafInventors: Didier Babin, Marc Benoit, Jean P. Demoute
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Patent number: 5527823Abstract: A formulation suitable for spraying or for dilution with water to form a sprayable preparation, the formulation comprising an active ingredient, optionally a carrier or solvent for the active ingredient, an emulsifier and an evaporation retardant, characterized in that the formulation satisfies formula ##EQU1## where L is less than or equal to 15, A=700376, B=-1.51, C=0.8472, M.sub.oil is the weighted average relative molar mass of the oil phase M.sub.retardant is the weighted average relative molar mass of the retardant, and X=(M.sub.oil) 1.8/Y, where Y is the molar solubility ration of the formulation, defined as the minimum number of moles of the oil phase which will dissolve the retardant, divided by the number of moles of retardant, provided that, in the formula above, any solvent which has no liquid phase at 27.degree. C. at atmospheric pressure is excluded. The formulation may comprise a pesticide or herbicide. The action of the evaporation retardant is improved.Type: GrantFiled: February 8, 1994Date of Patent: June 18, 1996Assignee: Roussel UCLAFInventors: Robert Martin, David A. Jeffries, Denise K. North, John M. Groome, Peter L. Crampton, Andrew J. Huson
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Patent number: 5527780Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is --(CH.sub.2).sub.n --Ar.sub.1 or --XAr.sub.2, n is an integer from 1 to 6, Ar.sub.1 and Ar.sub.2 are individually selected from the group consisting of a) carbocyclic aryl of up to 18 carbon atoms substituted by at least one member of the group consisting of free carboxy, alkoxy carbonyl and carboxyl salified with a pharmaceutically acceptable base, --OH, halogen, --NO.sub.2, --CN, ##STR2## and alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, N-alkyl, N-alkenyl and N-alkynyl of up to 12 carbon atoms optionally substituted with at least one halogen, R.sub.1 and R.sub.2 are individually hydrogen or alkyl of 1 to 12 carbon atoms, b) ##STR3## wherein R.sub.Type: GrantFiled: November 1, 1993Date of Patent: June 18, 1996Assignee: Roussel UclafInventors: Constantin Agouridas, Alain Bonnefoy, Jean-Francois Chantot, Alexis Denis, Odile Le Martret
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Patent number: 5527919Abstract: A novel process for the preparation of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the text.Type: GrantFiled: January 4, 1994Date of Patent: June 18, 1996Assignee: Roussel UclafInventors: Neerja Bhatnagar, Jean Buendia, Christine Griffoul, Holger Heitsch, Adalbert Wagner
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Patent number: 5525594Abstract: A method of treating hyperandrogenism in warm-blooded animals comprising administering to warm-blooded animals an antiandro genically effective amount of oenotheine B and a process for the preparation of oenotheine B.Type: GrantFiled: November 14, 1994Date of Patent: June 11, 1996Assignee: Roussel UclafInventors: Jean-Francois Gourvest, Alexander Kasal, Dominique Lesuisse, Jean-Georges Teutsch
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Patent number: 5523322Abstract: A method of inhibiting blood-platelet aggregation in warm-blooded animals comprising administering to warm-blooded animals a blood-platelet aggregation inhibiting effective amount of a compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of --NH--CO--NH.sub.2, --NH--CO--CH.sub.3, --OH and their non-toxic, pharmaceutically acceptable acid addition salts.Type: GrantFiled: June 30, 1994Date of Patent: June 4, 1996Assignee: Roussel UCLAFInventors: Denis Blache, Christian Bloy, Bernard Hercelin
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Patent number: 5510331Abstract: Peptides of the formulaR.sub.1 --HX.sub.1 DX.sub.2 IX.sub.3 Iwherein R.sub.1, X.sub.1, X.sub.2 and X.sub.3 are defined as in the specification having antihypertensive activity without vascoconstricting activity.Type: GrantFiled: October 13, 1994Date of Patent: April 23, 1996Assignee: Roussel UCLAFInventors: Gilles Hamon, Eve Mahe, Dung Le-Nguyen
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Patent number: 5508452Abstract: A process for the preparation of a compound of the formula ##STR1## in which rings A and B are a remainder: ##STR2## in which the 3-ketone function is optionally protected in the form of a ketal, thioketal, hemithioketal or enol ether, or a remainder: ##STR3## wherein R is methyl or --CH.sub.2 --OR', R' is hydrogen or ether remainder or ester remainder, R.sub.1 and R.sub.2 together form a second bond, or R.sub.1 and R.sub.2 form together an epoxide in beta position, or R.sub.1 is hydrogen, ketone or .alpha.- or .beta.- hydroxy, free or protected in the form of an ether or ester and R.sub.2 is hydrogen, or R.sub.1 is hydrogen and R.sub.2 is .alpha.-hydroxy function, or R.sub.1 is .beta.-hydroxy, free or protected in the form of an ether or ester and R.sub.2 is .alpha.-fluorine or bromine and R.sub.3 is hydrogen or .alpha. or .beta. fluorine or methyl comprising reacting a compound of the formula ##STR4## in which A, B, R, R.sub.1, R.sub.2 and R.sub.Type: GrantFiled: January 12, 1994Date of Patent: April 16, 1996Assignee: Roussel UclafInventors: Patrick Roussel, Michel Vivat
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Patent number: 5508414Abstract: A compound of the formula ##STR1## wherein Ar is phenyl optionally substituted with at least one member of the group consisting of halogen, methylenedioxy, phenyl, phenoxy, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, Z is selected from the group consisting of hydrogen, chlorine, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, R.sub.1 and R.sub.2 are individually alkyl of 1 to 6 carbon atoms and the exocyclic double bonds independently have (E) or (Z) geometry having fungicidal activity and a process for their preparation.Type: GrantFiled: November 18, 1994Date of Patent: April 16, 1996Assignee: Roussel UCLAFInventors: Jean-Louis Brayer, Jean-Pierre Demoute, Gilles Mourioux
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Patent number: 5506249Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is cycloalkyl of 3 to 6 carbon atoms; R.sub.4 is selected from the group consisting of halogen, nitrile, nitro, --SCH.sub.3, -alkylcarbonyl of 1 to 6 carbon atoms, cycloalkylcarbonyl of 3 to 6 carbon atoms, --CX.sub.3, 'WCX.sub.3, --(CH.sub.2).sub.n CX.sub.3, --(CX.sub.2).sub.n CX.sub.3, --W(CX.sub.2).sub.n CX.sub.3 and a --W(CH.sub.2).sub.n CX.sub.3, in which X is halogen, W is oxygen or sulfur, and n is 1, 2 or 3; and R.sub.5 is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms and cycloalkyl of 3 to 6 carbon atoms; with the proviso that if R.sub.5 is hydrogen, R.sub.4 is not --SCH.sub.3 or --CF.sub.3 and their non-toxic pharmaceutically acceptable salts having anti-prolifera-tive, anti-inflammatory and anti-tumor activity.Type: GrantFiled: December 5, 1994Date of Patent: April 9, 1996Assignee: Roussel UCLAFInventors: Elizabeth A. Kuo, Robert Westwood
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Patent number: 5504203Abstract: A compound of the formula ##STR1## wherein R is=0 or ##STR2## and the rings A and B are selected from the group consisting of ##STR3## K is oxo or a protector group of oxo of the formula ##STR4## n is 2 or 3 and R.sub.1 is an ether or ester remainder, K' is oxo or a protector oxime, hydrazone or semicarbazone group and the wavy lines symbolize an isomer mixture, a process for their preparation and their use as intermediates.Type: GrantFiled: March 9, 1995Date of Patent: April 2, 1996Assignee: Roussel UclafInventors: Jean Buendia, Remi Chauvin, Michel Vivat
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Patent number: 5504112Abstract: A compound in all possible stereoisomeric forms and their mixtures of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, --CN, alkyl, alkenyl and alkynyl of up to 4 carbon atoms and aralkynyl of up to 10 carbon atoms, Y is selected from the group consisting of halogen, --CF.sub.3, --CH.sub.2 F and --CHF.sub.2 and R.sub.1 is hydrogen and R.sub.2 is halogen or R.sub.1 and R.sub.2 are --CF.sub.3 or R.sub.1 and R.sub.2 are individually halogen.Type: GrantFiled: May 15, 1995Date of Patent: April 2, 1996Assignee: Roussel UclafInventors: Didier Babin, Marc Benoit, Raphael Bouchet, Jean-Pierre Demoute
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Patent number: 5502182Abstract: A compound of the formula ##STR1## wherein K represents a protective group of the oxo of the formula ##STR2## wherein n is 2 or 3, and M is chlorine, bromine, or ##STR3## wherein R.sub.a and R.sub.b are individually selected from the group consisting of hydrogen, --OH, and alkyl and alkoxy of 1 to 4 carbon atoms and R is selected from the group consisting of alkyl of 1 to 6 carbon atoms, aralkyl of 7 to 15 carbon atoms, trialkyl silyl triphenyl silyl and diphenyl alkyl silyl.Type: GrantFiled: December 22, 1994Date of Patent: March 26, 1996Assignee: Roussel UclafInventors: Francis Brion, Jean Buendia, Christian Diolez, Michel Vivat
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Patent number: 5502223Abstract: A process for the preparation of a compound of the formula ##STR1## wherein R.sub.1 is acyl of an organic carboxylic acid of 1 to 8 carbon atoms useful as intermediates for synthesis of therapeutically active steroids.Type: GrantFiled: February 21, 1995Date of Patent: March 26, 1996Assignee: Roussel UclafInventors: Francis Brion, Jean Buendia, Christian Diolez, Michel Vivat