Patents Assigned to Roussel-UCLAF
  • Patent number: 5985292
    Abstract: An active phospholipid of the formula ##STR1## wherein R.sub.1 is aliphatic of 14 to 24 carbon atoms saturated or containing 1 or 2 unsaturations, R.sub.3 is a residue selected from the group consisting of choline, ethanolamine, glycerol, serine, inositol, ethanol, n-propanol, n-butanol and ethylene glycol and ##STR2## is an active group in the 2-position of the glycerol released by phospholipases and cosmetic and dermatological compositions containing the same useful for treating or caring for the skin.
    Type: Grant
    Filed: December 24, 1996
    Date of Patent: November 16, 1999
    Assignee: Roussel-UCLAF
    Inventors: Jean-Dominique Fourneron, Alain Fructus
  • Patent number: 5770192
    Abstract: A recombinant baculovirus which, in insect cells infected therewith, expresses a foreign protein comprising an insecticidal toxin, or a functional derivative thereof, provided with a signal peptide such that the toxin or derivative thereof is secreted from the insect cells. This recombinant baculovirus can be used in insect control.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: June 23, 1998
    Assignees: Roussel-Uclaf, Natural Environment Research Council
    Inventors: Patricia Jane Cayley, Lorna Mary Dyet Stewart, Robert David Possee, Miguel Lopez Ferber
  • Patent number: 5705494
    Abstract: Disclosed is a method of inducing anti-estrogenic activity in warm-blooded animals by the administration of a compound of the formula ##STR1## wherein the substituents are as defined in the specification.
    Type: Grant
    Filed: August 8, 1995
    Date of Patent: January 6, 1998
    Assignee: Roussel-Uclaf
    Inventors: Francois Nique, Jean-Georges Teutsch, Patrick Van de Velde
  • Patent number: 5532375
    Abstract: Compounds useful in the treatment of Alzheimer's disease, senile dementia, or memory disorders which have the formula ##STR1## in which R represents a hydrogen atom, a linear, branched or cyclic alkyl radical, saturated or unsaturated, containing up to 8 carbon atoms, possibly substituted by a free or esterified carboxy radical or R represents an aralkyl radical containing up to 10 carbon atoms and R' represents a linear or branched, saturated or unsaturated, alkyl radical, containing up to 8 carbon atoms, a radical --COalk.sub.1 or a radical --(CH.sub.2).sub.2 N(alk.sub.2).sub.2, alk.sub.1 and alk.sub.2 representing an alkyl radical containing up to 8 carbon atoms, as well as their addition salts with acids. Also compositions containing the same, method of preparation and method of treatment using the same.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: July 2, 1996
    Assignee: Roussel-UCLAF
    Inventors: Giulio Galliani, Fernando Barzashi, Alina Butti, Carla Bonetti, Emilio Toja
  • Patent number: 5530022
    Abstract: A compound in all possible stereoisomeric forms and their mixtures of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## having excellent pesticidal, particularly insecticidal, properties.
    Type: Grant
    Filed: August 9, 1994
    Date of Patent: June 25, 1996
    Assignee: Roussel-Uclaf
    Inventors: Didier Babin, Marc Benoit, Jean P. Demoute
  • Patent number: 5493046
    Abstract: The novel process of the invention for the preparation of a compound of the formula ##STR1##
    Type: Grant
    Filed: October 27, 1994
    Date of Patent: February 20, 1996
    Assignee: Roussel-Uclaf
    Inventors: Neerja Bhatnagar, Jean Buendia, Christine Griffoul
  • Patent number: 5478957
    Abstract: A process for the preparation of 6.alpha.,9.alpha.-difluoro steroids of the formula ##STR1## wherein R is hydrogen or an ester remainder.
    Type: Grant
    Filed: January 26, 1994
    Date of Patent: December 26, 1995
    Assignee: Roussel-UCLAF
    Inventors: Jean-Yves Godard, Philippe Mackiewicz, Denis Prat, Christian Richard
  • Patent number: 5473087
    Abstract: Mixtures of compounds of ##STR1## or a mixture of the latter and a compound of the formula ##STR2## which are useful intermediates for the preparation 20-keto-21(S)-hydroxy steroids.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: December 5, 1995
    Assignee: Roussel-Uclaf
    Inventors: Jean Buendia, Jean-Yves Godard, Philippe Mackiewicz, Christian Richard
  • Patent number: 5470867
    Abstract: Imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
    Type: Grant
    Filed: October 17, 1994
    Date of Patent: November 28, 1995
    Assignee: Roussel-Uclaf
    Inventors: Michel Fortin, Daniel Frechet, Gilles Hamon, Simone Jouquey, Jean-Paul Vevert
  • Patent number: 5451696
    Abstract: A compound of the formula ##STR1##
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: September 19, 1995
    Assignee: Roussel-UCLAF
    Inventors: Marc Benoit, Sylvain Laugraud, Jean-Louis Brayer
  • Patent number: 5439887
    Abstract: A peptide derivative having the formula: ##STR1## wherein X.sub.1 is hydrogen or cysteine residue,X.sub.3 is a cysteine or alanine residue,X.sub.4 is a residue of asparagine, phenylalanine, leucine, isoleucine, alanine, valine, glycine and their homologues in the D series,X.sub.6 is a residue of tryptophan, phenylalanine, leucine, isoleucine, alanine, valine, glycine, serine, lysine, aspartic acid, tyrosine, threonine and their homologues in the D series,X.sub.9 and X.sub.17 are a residue of glutamic acid, aspartic acid, lysine, arginine, tyrosine, leucine and their homologues in the D series,X.sub.11 is a cysteine or alanine residue,X.sub.14 is a residue of tyrosine, phenylalanine, leucine, isoleucine, alanine, valine, glycine, serine, lysine, aspartic acid, threonine and their homologues in the D series,X.sub.21 is hydrogen or a tryptophan or D-tryptophan residue, and the derivatives possessing, where appropriate, one or two disulfide bridges, with the proviso that X.sub.
    Type: Grant
    Filed: February 10, 1993
    Date of Patent: August 8, 1995
    Assignee: Roussel-Uclaf
    Inventors: Gilles Hamon, Eve Mahe, Dung Le-Nguyen
  • Patent number: 5439890
    Abstract: A compound of the formula ##STR1## wherein A and B are both hydrogen or A is hydrogen and B is --OH or A and B form a carbon-carbon double bond and Z is hydrogen or acyl of an organic carboxylic acid of 1 to 6 carbon atoms and their nontoxic, pharmaceutically acceptable acid addition salts having antibiotic activity.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: August 8, 1995
    Assignee: Roussel-Uclaf
    Inventors: Constantin Agouridas, Jean-Francois Chantot, Nicole Tessot
  • Patent number: 5424314
    Abstract: A compound in all racemic or optionally active forms selected from the group consisting of a compound of the formula ##STR1## where the substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable acid addition salts having anti-anoxic activity and a novel process and intermediates for their preparation.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: June 13, 1995
    Assignee: Roussel-Uclaf
    Inventors: Francois Clemence, Jean-Luc Haesslein, Claude Oberlander
  • Patent number: 5420159
    Abstract: All possible stereoisomeric forms and mixtures thereof of a compound of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, alkyl, alkenyl and alkynyl of up to 4 carbon atoms, --CN and aralkynyl of up to 10 carbon atoms, Y is selected from the group consisting of halogen, --CH.sub.2 F, --CHF.sub.2, and --CF.sub.3, A is selected from the group consisting of ##STR2## having pesticidal properties.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: May 30, 1995
    Assignee: Roussel-Uclaf
    Inventors: Didier Babin, Marc Benoit, Jean-Pierre Demoute
  • Patent number: 5420138
    Abstract: The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are inhibitors of angiotensin II effects, particularly a vasoconstrictor activity.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: May 30, 1995
    Assignee: Roussel-UCLAF
    Inventors: Alain Corbier, Michel Fortin, Jacques Guillaume, Jean-Luc Haesslein, Jean-Paul Vevert
  • Patent number: 5416080
    Abstract: A compound selected from the group consisting of a syn isomer of a compound of the formula ##STR1## in the R or S form or in the form of an R, S mixture wherein the substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable acid addition salts having anti-bacterial activity.
    Type: Grant
    Filed: June 21, 1993
    Date of Patent: May 16, 1995
    Assignee: Roussel-UCLAF
    Inventors: Jozsef Aszodi, Jean-Francois Chantot, Solange Gouin D'Ambrieres
  • Patent number: 5412101
    Abstract: The invention relates to the products: ##STR1## in which: R.sub.1 =alkyl, alkenyl, alkynyl and alkylthio,R.sub.2B, R.sub.3B are defined in the specification,m=0 to 2,Y.sub.B =--Y.sub.1B --B--Y.sub.2B,Y.sub.1B =aryl,B=a single bond or --CO--, --O--, --NH--CO--, --CO--NH--, --O--(CH.sub.2).sub.p --,p=1 to 3,Y.sub.2B represents hydrogen, cyano, carboxy, in all isomer forms and salts, their use as medicaments.
    Type: Grant
    Filed: July 24, 1992
    Date of Patent: May 2, 1995
    Assignee: Roussel-Uclaf
    Inventors: Jean C. Caille, Alain Corbier, Michel Fortin, Gilles Hamon, Simone Jouquey, Jean Vevert
  • Patent number: 5405865
    Abstract: A compound in all possible stereoisomeric forms and mixtures thereof of the formula ##STR1## wherein the substituents are defined as in the specification having pesticidal properties.
    Type: Grant
    Filed: February 3, 1993
    Date of Patent: April 11, 1995
    Assignee: Roussel-Uclaf
    Inventors: Marc Benoit, Jacques Demassey, Jean-Pierre Demoute
  • Patent number: 5401840
    Abstract: Novel compounds of the formula ##STR1## wherein either K' is oxygen or a K, a protective group of the oxo of the formula ##STR2## wherein n is 2 or 3, the 17-position dotted line is a bond, R.sub.a and R.sub.b are individually selected from the group consisting of hydrogen, hydroxy, alkyl and alkoxy of 1 to 4 carbon atoms or K' is an oxygen, the 17-position dotted line is an epoxy and R.sub.a and R.sub.b have the meaning indicated above which are useful intermediates for the preparation of hydrocortisone.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: March 28, 1995
    Assignee: Roussel-Uclaf
    Inventors: Francis Brion, Jean Buendia, Christian Diolez, Michel Vivat
  • Patent number: 5401773
    Abstract: All possible isomeric forms, racemic mixtures and enantiomeric and diastereoisomeric forms of a compound selected from the group consisting of a compound of the formula ##STR1## wherein R is alkenyl of 10 carbon atoms, n is an integer from 1 to 3 and their non-toxic salts useful for treating comedones.
    Type: Grant
    Filed: February 6, 1991
    Date of Patent: March 28, 1995
    Assignee: Roussel-Uclaf
    Inventor: Hugues Noel