Patents Assigned to Rowan University
  • Publication number: 20250101634
    Abstract: The present disclosure provides a system and method for producing nanofibers. The system includes an automated track system including a first track having a first face; and a second track having a second face facing the first face of the first track. The first track and the second track are positioned to define a proximal gap and a distal gap. The first track and the second track are adapted and configured to transfer a nanofiber coupled to the first face and the second face from the proximal gap to the distal gap. The system also includes a roving belt that is positioned to be partially disposed within the distal gap and is adapted and configured to decouple the nanofiber from the first face and the second face.
    Type: Application
    Filed: January 25, 2023
    Publication date: March 27, 2025
    Applicant: Rowan University
    Inventor: Vince BEACHLEY
  • Patent number: 12198334
    Abstract: A method and computer-based system is provided that assists physicians in detecting early tumor growth and allowing modification of treatment to have a positive impact on medical management, patient morbidity, outcomes and survival times. The method comprises measuring tumor volumes from radiological images to predict growth by a statistical method. The methods allow detection of increases in tumor size earlier than is currently possible and, therefore, advantageous in modifying or optimizing treatment.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: January 14, 2025
    Assignees: The UAB Research Foundation, Rowan University
    Inventors: Hassan Fathallah-Shaykh, Nidhal Bouaynaya
  • Patent number: 12174187
    Abstract: Methods for detecting Multiple Sclerosis (MS) diagnostic autoantibodies in a subject and generating a subject-specific, MS diagnostic autoantibody profile are described. The methods include contacting an immunoglobulin-containing biological sample from the subject with a system comprising antigens that form immunocomplexes with MS diagnostic autoantibodies, the antigens including general transcription factor II-I, splicing factor 1, and inducible T-cell co-stimulator (ICOS), to form a reaction mixture, under conditions that allow for formation in the reaction mixture of an immunocomplex between each antigen and its corresponding MS diagnostic autoantibody, if its corresponding MS diagnostic autoantibody is present in the sample; and detecting presence or absence of immunocomplexes in the reaction mixture, wherein formation of immunocomplexes between the antigens and their corresponding MS diagnostic autoantibodies indicates presence of the MS diagnostic autoantibodies in the biological sample.
    Type: Grant
    Filed: August 18, 2022
    Date of Patent: December 24, 2024
    Assignee: Rowan University
    Inventor: Robert G. Nagele
  • Publication number: 20240285266
    Abstract: A device for harvesting cartilage from a subject in a minimally invasive manner, and methods of use thereof, are provided.
    Type: Application
    Filed: November 6, 2023
    Publication date: August 29, 2024
    Applicants: Rowan University, Trice Medical, Inc.
    Inventors: Erik C. Brewer, Jacob Mahon, Maura Francis, Brennen Covely, Stephanie Fanok, Frederick Hardenbrook, Joseph Oteri, Samantha Struble, Sean McMillan, Alfred Intintoli, Angelo Patrinicola
  • Patent number: 12018099
    Abstract: The present disclosure provides methods of controlling the size of cellulose crystals by mixing a first composition comprising cellulose and coagulating this mixture with varying concentrations of hydrogen peroxide.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: June 25, 2024
    Assignees: Rutgers, The State University of New Jersey, Rowan University
    Inventors: David Salas de la Cruz, Xiao Hu, Stacy Love, David Verrill
  • Publication number: 20240200234
    Abstract: In one aspect, the present disclosure is related to system and method of manufacturing nanomaterials and particularly to system and method for zone-drawing and/or zone-annealing fibers.
    Type: Application
    Filed: April 25, 2022
    Publication date: June 20, 2024
    Applicant: Rowan University
    Inventors: Matthew Flamini, Vince Beachley
  • Publication number: 20230391837
    Abstract: The present disclosure relates in part to methods of treating, preventing, and/or ameliorating SARS-CoV-2 infection and/or related inflammatory syndromes by administration of a Maackia amurensis seed lectin (MASL). MASL has a strong affinity for sialic acid modified proteins and may be used as an antiviral agent. This lectin targets the ACE2 receptor, decreases ACE2 expression and glycosylation, suppresses binding of the SARS-CoV-2 spike protein, and decreases expression of inflammatory mediators by oral epithelial cells that cause ARDS in COVID-19 patients.
    Type: Application
    Filed: October 19, 2021
    Publication date: December 7, 2023
    Applicant: Rowan University
    Inventors: Gary S. Goldberg, Paola Leone
  • Patent number: 11667669
    Abstract: The present invention relates to the unexpected discovery of novel monomer compounds capable of crosslinking interpenetrating polymer networks (IPNs). In certain embodiments, the monomer compounds of the invention each comprise at least one methacrylate functionality capable of forming polymeric bonds with other methacrylate and vinyl functionalities, and at least one epoxide functionality capable of forming polymeric bonds with epoxide functionalities, amine functionalities, and/or reactive oxygen species.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: June 6, 2023
    Assignees: Rowan University, The United States of America as represented by the Secretary of the Army
    Inventors: Alexander W. Bassett, Joseph F. Stanzione, III, John J. La Scala
  • Patent number: 11644473
    Abstract: The present disclosure is directed to methods and kits for using serum biomarkers, including C-X-C Motif Chemokine Ligand 10 (CXCL10), C-X-C Motif Chemokine Ligand 13 (CXCL13), and/or soluble CD27 (sCD27), in predicting and evaluating therapeutic response to Tumor Necrosis Factor (TNF) inhibitor therapy in a patient in need thereof.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: May 9, 2023
    Assignee: Rowan University
    Inventors: Kwanghoon Han, Andrea Bottaro, Nancy J. Olsen
  • Publication number: 20230140691
    Abstract: In one aspect, the present invention relates to thermo-reversible hydrogel drug delivery compositions comprising at least one biodegradable copolymer drug carrier. In certain embodiments, the hydrogel compositions of the invention are optically clear and suitable for use in local delivery of ocular therapeutics. In other embodiments, the hydrogel compositions of the invention provide a means for controlled or sustained drug delivery.
    Type: Application
    Filed: December 30, 2022
    Publication date: May 4, 2023
    Applicant: Rowan University
    Inventors: Mark E. Byrne, Mindy George-Weinstein, Laura L. Osorno
  • Patent number: 11619632
    Abstract: The present invention provides methods, compositions, and kits for the detection of Early-Stage Alzheimer's disease (AD) autoantibody biomarkers, for the diagnosis of Early-Stage AD, for the identification of a subject at risk for developing Early-Stage AD, and/or for the generation of patient-specific Early-Stage AD autoantibody biomarker profiles.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: April 4, 2023
    Assignee: Rowan University
    Inventor: Robert G. Nagele
  • Patent number: 11605508
    Abstract: The present invention relates in part to a polymer functionalized with a bio-ionic liquid to form a gel electrolyte. The gel electrolyte thus formed is biocompatible and biodegradable. In certain embodiments, the electrolyte is used for making implantable 3D printed energy storage devices.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: March 14, 2023
    Assignee: Rowan University
    Inventors: Iman Noshadi, Vaishali Krishnadoss
  • Patent number: 11555326
    Abstract: An impact shield for earthquake protection is described herein. The impact shield may include a canopy constructed of a puncture-resistant material, the canopy defining a first internal volume accessible via a first opening, the canopy being structured to form a semispherical shape when in an inflated state, the semispherical shape defining a space dimensioned for sheltering at least one human body; a support joined to the canopy and constructed of the puncture-resistant material, the support defining a second internal volume accessible via the first opening and a second opening, the support located within the space, the support structured to form a column when in the inflated state; and a fitting joined to the support for closing the second opening to fix the first internal volume and the second internal volume after inflation of the support and the canopy.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: January 17, 2023
    Assignee: Rowan University
    Inventors: Charles D. McGlynn, Cheng Zhu
  • Patent number: 11549198
    Abstract: The invention relates to non-woven protein fibers and to methods for forming and producing the same. In certain embodiments, the invention provides a method of processing a protein comprising dissolving a protein in a solution, optionally removing any insoluble materials from the solution, and spraying the solution under an applied pressure. In other embodiments, the protein can be derived from a range of sources, including but not limited to arthropod silks, animal keratin (e.g. hair and wool), tissue elastin, collagen, resilin, and plant protein. In certain embodiments, the methods of the invention are an alternative to electrospinning methods known in the art.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: January 10, 2023
    Assignee: Rowan University
    Inventors: Xiao Hu, Xiaoyang Mou
  • Patent number: 11546572
    Abstract: Methods and systems for digitally reconstructing a patient tissue sample are described herein. In one embodiment, the method may include projecting a first structured light pattern onto the patient tissue sample, receiving a first reflection of the first structured light pattern from the patient tissue sample, and reconstructing the patient tissue sample based on the first reflection and the projected first structured light pattern. In another embodiment, the system may include a projector adapted or configured to project the first structured light onto the patient tissue sample, a charge-coupled device (CCD) adapted or configured to receive the first reflection from the patient tissue sample, and a reconstruction device adapted or configured to reconstruct the patient tissue sample based on the first reflection and the projected first structured light pattern.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: January 3, 2023
    Assignee: Rowan University
    Inventors: Ben Wu, Ying Tang, Xiao Hu
  • Patent number: 11538256
    Abstract: The present invention provides a data collection system comprising: a camera; a location module; a plurality of sensors; and a first processor communicatively coupled to the camera and the location module, the first processor programmed to: obtain a plurality of frames from the camera; obtain a plurality of locations from the location module; obtain a plurality of data measurements from the plurality of sensors; apply a previously trained first neural network model for identifying problematic road segments to frames captured by the camera; and if the first neural network model indicates that a frame is a problematic road segment, save the frame in association with a location provided by the location module.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: December 27, 2022
    Assignee: Rowan University
    Inventors: Parth Bhavsar, Nidhal Bouaynaya, Yusuf Mehta, Mashrur Chowdhury
  • Patent number: 11471496
    Abstract: The present invention provides compositions and methods for treating, ameliorating, and/or preventing cocaine addiction in a subject. Immunization by M. vaccae alters serotonin signaling in the brain, reducing stress- and anxiety-like responding in animal models of post-traumatic stress disorder and other anxiety disorders. In certain embodiments, the immunoregulatory, anti-stress, and anxiolytic effects of M. vaccae immunization reduces addiction- and relapse-like responding in models of cocaine addiction and alter the development of cocaine-induced neuroinflammation.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: October 18, 2022
    Assignees: Rowan University, The Regents of the University of Colorado
    Inventors: Thomas M. Keck, Christopher A. Lowry
  • Patent number: 11435361
    Abstract: The present invention provides methods, compositions, and kits for the detection of neurodegenerative disease specific autoantibodies for the diagnosis of neurodegenerative diseases and risk for developing neurodegenerative diseases, and for the generation of patient-specific neurodegenerative disease diagnostic autoantibody profiles.
    Type: Grant
    Filed: June 8, 2019
    Date of Patent: September 6, 2022
    Assignee: Rowan University
    Inventor: Robert G. Nagele
  • Patent number: 11389256
    Abstract: A surgical robot includes a fixed frame and a moving frame, each having an open space in a center region and may be formed as a partially open ring. The robot also includes three leg structures connecting the fixed frame and the moving frame, and enabling the moving frame to move relative to the fixed frame. The robot also includes a stabilizer for holding an anatomical structure in the open space of each frame. Each leg structure may include a linear component coupled to the moving frame, a rotary component mounted to the fixed frame, and a connector connecting between the two. Each of the linear component and the rotary component may have a rotary actuator that can be controlled by a computer. The robot may be controllable by a computer to assist a reduction procedure of long bone fractures or pelvis surgery.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: July 19, 2022
    Assignee: Rowan University
    Inventor: Mohammad Abedin-Nasab
  • Patent number: 11389583
    Abstract: The present invention relates to novel biocompatible oxygen gas generating devices that can be implanted into a living subject. In certain embodiments, the oxygen gas generating devices can be used to deliver oxygen gas to tissue in a subject, thereby stimulating tissue growth and repair. In other embodiments, the devices operate by electrolytically splitting endogenous water in a subject. In yet other embodiments, the device further comprises an implantable supercapacitor capable of supplying energy to the oxygen gas generating device.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: July 19, 2022
    Assignee: Rowan University
    Inventor: Iman Noshadi