Abstract: Disclosed herein is a dispenser for adhesive fabrics or tapes, such as bandages or other adhesive medical fabrics or correction tapes. The dispenser has a case in which a supply reel and a take-up reel are mounted. A belt having adhesive fabrics or tapes thereon extends from the supply reel through one or more openings to the exterior of the case, and thence to a take-up reel. The supply reel and the take-up reel are coupled so that the belt is wrapped around the take-up reel as it is unwound from the supply reel and advances to move an adhesive fabric or tape to the exterior of the case for dispensing. The dispenser may optionally have an activation device that allows a user to extend a portion of an adhesive fabric outside the dispenser and dispense and apply the adhesive fabric to a human skin with one hand.

Abstract: The present invention relates to diagnostic methods, reagents, and kits for detecting and diagnosing Early Stage Parkinson's disease.

Abstract: The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, N-acetylaspatic acid (NAA) and further supply extraphysiological levels of ATP to neurons via the targeted expression of the NAA catabolic enzyme aspartoacylase (ASPA) in neurons and astrocytes.

Abstract: Provided are methods and compositions for treatment of cancer. In particular, these methods and compositions may include a compound that induces the translocation of cyclin C from the cell nucleus to the cytoplasm. Also provided are methods of screening tumor cells for susceptibility to compounds that induce the translocation of cyclin C.

Abstract: A surgical robot includes a fixed frame and a moving frame, each having an open space in a center region and may be formed as a partially open ring. The robot also includes three leg structures connecting the fixed frame and the moving frame, and enabling the moving frame to move relative to the fixed frame. The robot also includes a stabilizer for holding an anatomical structure in the open space of each frame. Each leg structure may include a linear component coupled to the moving frame, a rotary component mounted to the fixed frame, and a connector connecting between the two. Each of the linear component and the rotary component may have a rotary actuator that can be controlled by a computer. The robot may be controllable by a computer to assist a reduction procedure of long bone fractures or pelvis surgery.

Abstract: The present invention provides methods, compositions and kits for the detection of Alzheimer's disease (AD) diagnostic biomarkers, for the diagnosis of AD, for the identification of a subject at risk for developing AD, and for the generation of patient-specific AD diagnostic biomarker profiles.

Abstract: Disclosed is a thermoconductive material comprising a protein and having a thermal conductivity of more than 0.6 W/(m·K). Also disclosed is a method for producing a thermoconductive material comprising a protein at least a part of which forms crystalline ?-pleated sheets, the crystalline ?-pleated sheets being present in an amount of 10% by weight or more, based on the total weight of the protein, and the thermoconductive material having a thermal conductivity of more than 0.6 W/(m·K), the method comprising dissolving a raw material protein in a formic acid solution containing calcium chloride to obtain a protein solution, and evaporating the formic acid from the protein solution.

Abstract: The invention provides a system and process for manufacturing nanofibers that integrate a post-drawing process in a continuous electro spinning manufacturing process. In certain embodiments, the system and process are capable of post-drawing multiple individual electrospun nanofibers simultaneously. In certain embodiments, the system can be configured and controlled to accommodate various materials that can be electrospun.

Abstract: The present invention relates novel slice culture systems which provide a quick, simple, and effective tool for investigating pathological changes associated with AD. Also provided are methods of diagnosing AD and identifying potentially therapeutic compounds.

Abstract: A method of making asphalt concrete mixtures including reclaimed asphalt pavement (RAP). Variability in the fraction of binder that occurs in RAP that is able to melt and mix with virgin binder included in the concrete mixture previously made it difficult to select an appropriate amount of virgin binder. Methods described herein permit an asphalt concrete mix designer to determine the amount of virgin binder that can be combined with RAP and virgin aggregate in order to satisfy the minimum effective binder content of a job mix formula for such a concrete mix. The subject matter described herein thus permits more efficient use of RAP and permits use of RAP in higher amounts in asphalt concrete mixtures.

Abstract: The present invention is directed to a medical implant, methods of use and making of such implants. A method of making an implantable device may include obtaining an anatomical model in a computer aided design (CAD) system, customizing the anatomical model per patient specific parameters and creating a virtual image of the anatomical model, incorporating at least one microchannel geometry within said anatomical model, adjusting the density infill to a measurement ranging per patient specific parameters, and using three-dimensional printing to form the implantable device based on the anatomical model. The implant can be made of suitable metallic or polymeric material, such as PLA.

Abstract: The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, N-acetylaspatic acid (NAA) and further supply extraphysiological levels of ATP to neurons via the targeted expression of the NAA catabolic enzyme aspartoacylase (ASPA) in neurons and astrocytes.

Abstract: Tissue samples embedded in settable, sectionable media such as paraffin can be cut into sections. Embedding one or more sectionable fiducial indicia in the medium permits identification of the plane along which the medium has been cut. However, prior methods of inserting indicia into embedded tissue sample blocks are cumbersome and difficult to perform. Sectionable fiducial indicia can be embedded in a block of medium by releasibly fixing the indicia to the sidewall or base of a mold used to shape the tissue block during embedding of a tissue sample in the medium block.

Abstract: A method of processing a protein in an acid solution is disclosed. The processed protein exhibits various optimized properties including crystallinity, thermal stability, bio-stability, and elastic modulus.

Abstract: The disclosure relates to methods of making asphalt concrete mixtures including reclaimed asphalt pavement (RAP). Variability in the fraction of binder that occurs in RAP that is able to melt and mix with virgin binder included in the concrete mixture previously made it difficult to select an appropriate amount of virgin binder. Methods described herein permit an asphalt concrete mix designer to determine the amount of virgin binder that can be combined with RAP and virgin aggregate in order to satisfy the minimum effective binder content of a job mix formula for such a concrete mix. The subject matter described herein thus permits more efficient use of RAP and permits use of RAP in higher amounts in asphalt concrete mixtures.

Abstract: The present invention provides methods, compositions, and kits for the detection of neurodegenerative disease specific autoantibodies for the diagnosis of neurodegenerative diseases and risk for developing neurodegenerative diseases, and for the generation of patient-specific neurodegenerative disease diagnostic autoantibody profiles.

Abstract: The present invention provides methods, compositions and kits for the detection of Parkinson' disease (PD) diagnostic biomarkers, for the diagnosis of PD, for the identification of a subject at risk for developing PD, and for the generation of patient-specific PD diagnostic biomarker profiles.

Abstract: A compound is provided according to structure 4, (4) wherein n has a value from 0 to 48 and Z is hydroxyl or a benzene ring bearing substituents R11-R15, wherein R1-R15 are each individually selected from the group consisting of H, allyl, alkyl, alkoxy, phenyl, phenoxy, halide, hydroxyl, glycidyl, (meth)acryloyl, 3-(meth)acryloyl-2-hydroxy-1-propoxy, 2,3-epoxypropyl, maleate, and structure (a) wherein at least one of R1-R5, at least one of R6-R10, and at least one of R11-R15 is hydroxyl or an ether or ester derived from it.

Abstract: The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, N-acetylaspatic acid (NAA) and further supply extraphysiological levels of ATP to neurons via the targeted expression of the NAA catabolic enzyme aspartoacylase (ASPA) in neurons and astrocytes.

Abstract: The present invention provides methods, compositions, and kits for the detection of neurodegenerative disease specific autoantibodies for the diagnosis of neurodegenerative diseases and risk for developing neurodegenerative diseases, and for the generation of patient-specific neurodegenerative disease diagnostic autoantibody profiles.