Abstract: Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.

Abstract: The invention provides compounds of formula (I): and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).

Abstract: Light-emitting devices having an emitting layer containing a light-emitting organic or organometallic material and a nanostructure, the nanostructure having strong local electric fields at visible electromagnetic wavelengths that spectrally and spatially overlap with the light-emitting material. The spectral and spatial overlap of the electric fields of the nanostructure with the light emitting material uses high LDOS provided by the nanostructures to enable excited triplet electronic states in the material to emit light faster than without the nanostructure. This faster light emission from triplet-excited states leads to more stable emission from the light emitting material because it prevents buildup of triplet-excited states, which ordinarily can lead to quenching of light emission from the light emitting material. Among the many different possibilities contemplated, the nanostructure may advantageously be made of a dielectric material or a plasmonic metal material, such as SiO2, TiO2, ZnO, Al or Ag.

Abstract: A device to detect an object in a medical image is described. An image analysis application, executed by the device, receives the medical image as an input. The medical image is next partitioned to sub-regions. Parts of the object are detected in a selection of the sub-regions using a deep-learning neural network (DNN) model. Bounding boxes for the selection are also determined. The bounding boxes are evaluated based on a confidence score detected as above a threshold level. The confidence score designates the parts as contained within the selection. Next, a region of interest (ROI) is determined as a group including the selection. Similar orientations associated with the bounding boxes are comparable to similar orientations of a positive training model of the DNN model. Furthermore, the selection is designated as the ROI within the medical image. The medical image is provided with the ROI to a user.

Abstract: Disclosed are cathodes comprising a conductive support substrate having a catalyst coating containing nickel phosphide nanoparticles. The conductive support substrate is capable of incorporating a material to be reduced, such as CO2 or CO. Also disclosed are electrochemical methods for generating hydrocarbon and/or carbohydrate products from CO2 or CO using water as a source of hydrogen.

Abstract: A method of generating a set of examples for explaining decisions made by a machine learning program, involving receiving a set of training data for training the program, and for given subsets of the training data, determining each of (a) a probability of a user correctly inferring a future decision of the program after observing the respective decisions of the program for the given subset of the training data, (b) a suitability of a size of the given subset, and (c) an average probability of the user correctly inferring a future decision of the program after observing the respective decisions of the program for an unspecified subset of the training data. The determinations (a), (b) and (c) are used to score each of the given subsets of training data, and a subset of training data is selected as the generated set of examples based on the scores.

Abstract: A device for detecting a biomarker for inflammation in a respiratory system includes a sample collection and/or holding area to receive an exhaled breath condensate (EBC) sample obtained from a respiratory system; an electrode system coupled to the sample collection area, the electrode system including reduced graphene oxide (rGO); and circuitry coupled to the electrode system. The circuitry is configured to apply a voltage to the EBC sample in the sample collection area via the electrode system and to measure a current via the electrode system in response to the voltage applied, in order to determine a concentration of nitrite in the EBC sample based on the current measured. The concentration of nitrite is a biomarker for inflammation in the respiratory system.

Abstract: This application discloses alginate microencapsulation-mediated differentiation of embryonic stem cells and use of the stem cell differentiation method for the development of effective treatment of various diseases and disorders. The microencapsulation of embryonic stem (ES) cells results in decreased cell aggregation and enhanced neural lineage differentiation through incorporating the soluble inducer retinoic acid (RA) into the permeable microcapsule system. This differentiation process can be augmented by differentiation pathway regulators such as PPAR agonists.

Abstract: The invention provides a polymer comprising two or more residues of formula III or IV or salts thereof: wherein dash line, X, Y, Q, L, M, n, R1, R2, Ra, Rb, Rc and Rd have any of the values defined in the specification, as well as synthetic intermediates and synthetic methods useful for preparing the compounds. The polymer is useful to treat contaminated water by chelating metal.

Abstract: A clearing agent and mounting solution for microscopy is disclosed comprising at least trichloroethanol and/or derivatives thereof, where the refractive index of the solution is greater than or equal to about 1.3810. Also disclosed are methods of preparing specimens for microscopy.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus configured to separate particles of varying size within a fluid flow, or filter particles from a fluid flow, via an array of anchored-liquid drops or anchored-gas drops.

Abstract: The present invention provides novel methods of diagnosing and determining treatment strategies for Lyme disease and other tick-borne illnesses.

Abstract: This invention relates to nucleic acids, reagents and methods for detecting Rifampicin-resistant Mycobacterium tuberculosis in a sample from a subject. In one aspect, the invention provides methods of detecting Rifampicin resistant M. tuberculosis in a sample comprising (a) amplifying a nucleic acid containing the rifampicin resistance determining region (RRDR) of the rpoB gene in a sample to provide an amplified nucleic acid; (b) probing the amplified nucleic acid with at least three molecular beacon probes for an RRDR mutant target; (c) conducting melting temperature (Tm) analysis to determine a Tm value for each probe; and (d) comparing the Tm value for each probe with a Tm value for a wild-type RRDR region, wherein a Tm value for at least one of the molecular beacon probes that is greater than the Tm value for the wild-type RRDR indicates the presence of rifampicin resistant M. tuberculosis in the sample.

Abstract: Disclosed is a method and system that receives sensor information from each of a plurality of sensors. Each sensor in the plurality is associated with a vehicle. The sensor information includes location coordinates of each vehicle in the plurality. The sensor information associated with each vehicle in the plurality then is translated to parking statistics information. In one embodiment, the translation is based on an aggregate of sensor information corresponding to the plurality of vehicles. The system then communicates parking statistics information to the vehicle.

Abstract: Magnesium Zinc Oxide (MZO)—based high voltage thin film transistor (MZO-HVTFT) is built on a transparent substrate, such as glass. The device has the circular drain and ring-shaped source and gate to reduce non-uniformity of the electric field distribution. Controlled Mg doping in the channel and modulated Mg doping in a transition layer located at the channel-gate dielectric interface improve the device's operating stability and increase its blocking voltage capability over 600V. The MZO HVTFT can be used for fabricating the micro-inverter in photovoltaic system on glass (PV-SOG), and for self-powered smart glass.

Abstract: The disclosure provides seed, tissue cultures, essential oil extracts, and plants of catnip hybrid ‘CR3’, as well as methods for producing a catnip plants by crossing ‘CR3’plants with themselves or with another catnip plant, such as a plant of another genotype, variety, or cultivar. The disclosure further provides seed, tissue cultures, essential oil extracts, and plants produced by such crossing. Methods of using the plants and extracts as insect repellents and in pet toys, are also provided.

Abstract: A method for forming a carbon fiber-reinforced polymer matrix composite by distributing carbon fibers or nanotubes into a molten polymer phase comprising one or more molten polymers; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase breaks the carbon fibers successively with each event, producing reactive edges on the broken carbon fibers that react with and cross-link the one or more polymers. The composite shows improvements in mechanical properties, such as stiffness, strength and impact energy absorption.

Abstract: A system includes a device that is disposed within an environment and is adapted to communicate over a radio frequency communication link. The system also includes a wireless access point disposed within the environment, including a wireless transceiver in communication with the device over a radio frequency communication link using a plurality of channels, and recording a channel state information data set for the radio frequency communication link. The system also includes a monitoring device including a memory storing a plurality of activity profiles, each of which includes an activity and a channel state information profile corresponding to the activity, and a processor receiving, from the wireless access point, the channel state information data set and determining, based on a comparison of the channel state information data set to the channel state information profile of each of the plurality of activity profiles, the activity of the person in the environment.

Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.

Abstract: The present disclosure provides improved stripfilm based pharmaceutical products (e.g., for enhancing dissolution and bioavailability). More particularly, the present disclosure provides improved systems/methods for fabricating stripfilm based pharmaceutical products by utilizing higher viscosity film forming precursors and drying methods that accomplish improved/faster drying and provide improved/excellent content uniformity of active pharmaceutical agents in the stripfilm based pharmaceutical products. Exemplary systems/methods advantageously use high viscosity, bio-compatible polymeric precursors, (optional use of surface modified drug powders), and convective drying for fabrication of thin films loaded with nano and/or micro sized particles of poorly water-soluble active pharmaceutical ingredients (APIs) to achieve improved active content uniformity and very fast dissolution from poorly water soluble actives, while accomplishing fast drying during the fabrication process.