Abstract: The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbability and processibility are useful in a variety of medical applications, such as in medical devices and con-trolled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
Type:
Application
Filed:
February 12, 2021
Publication date:
June 1, 2023
Applicant:
Rutgers, The State University of New Jersey
Inventors:
Joachim B. Kohn, Durgadas Bolikal, Julian Chesterman, Jarrod Cohen
Abstract: Disclosed is a method and system that receives sensor information from each of a plurality of sensors. Each sensor in the plurality is associated with a vehicle. The sensor information includes location coordinates of each vehicle in the plurality. The sensor information associated with each vehicle in the plurality then is translated to parking statistics information. In one embodiment, the translation is based on an aggregate of sensor information corresponding to the plurality of vehicles. The system then communicates parking statistics information to the vehicle.
Type:
Grant
Filed:
March 5, 2020
Date of Patent:
May 30, 2023
Assignee:
Rutgers, The State University of New Jersey
Abstract: The invention provides methods and compositions that are useful for treating allergic diseases, bacterial infections, fungal infections, viral infections, mastocytosis, mast cell-mediated inflammation and parasite infections (e.g., helminth infections).
Type:
Application
Filed:
June 30, 2022
Publication date:
May 18, 2023
Applicant:
Rutgers, the State University of New Jersey
Abstract: Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.
Type:
Grant
Filed:
August 4, 2020
Date of Patent:
May 16, 2023
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Abstract: Systems and methods for joint reconstruction and segmentation of organs from magnetic resonance imaging (MRI) data are provided. Sparse MRI data is received at a computer system, which jointly processes the MRI data using a plurality of reconstruction and segmentation processes. The MRI data is processed using a joint reconstruction and segmentation process to identify an organ from the MRI data. Additionally, the MRI data is processed using a channel-wise attention network to perform static reconstruction of the organ from the MRI data. Further, the MRI data can is processed using a motion-guided network to perform dynamic reconstruction of the organ from the MRI data. The joint processing allows for rapid static and dynamic reconstruction and segmentation of organs from sparse MRI data, with particular advantage in clinical settings.
Type:
Grant
Filed:
October 16, 2020
Date of Patent:
May 9, 2023
Assignee:
Rutgers, The State University of New Jersey
Abstract: Systems and methods for detecting placement of an object in a digital image are provided. The system receives a digital image and processes the digital image to generate one or more candidate regions within the digital image using a first neural network. The system then selects a proposed region from the one or more candidate regions using the first neural network and assigns a score to the proposed region using the first neural network. Lastly, the system processes the proposed region using a second neural network to detect an object in the proposed region.
Type:
Grant
Filed:
June 10, 2019
Date of Patent:
May 2, 2023
Assignee:
Rutgers, The State University of New Jersey
Inventors:
Cosmas Mwikirize, John L. Nosher, Ilker Hacihaliloglu
Abstract: In one aspect, the present disclosure relates to a masked fluorogenic compound comprising a small molecule protecting group that can be cleaved following a reaction with a biomarker. In some embodiments, cleavage of the small molecule protecting group provides a fluorogenic ligand that binds to an aptamer, leading to fluorescence emission. In another aspect, the present disclosure relates to a method of detecting a disease or a disorder in a subject and/or in a biological sample from the subject.
Type:
Application
Filed:
August 30, 2022
Publication date:
April 20, 2023
Applicant:
Rutgers, The State University of New Jersey
Abstract: Methods of generating mature ssDNA LASSO probes using DNA recombinase mediated assembly are provided. Also provided are mature ssDNA LASSO probes made by the methods, methods of their use, and kits including such.
Type:
Application
Filed:
October 14, 2022
Publication date:
April 20, 2023
Applicant:
Rutgers, The State University of New Jersey
Abstract: The present disclosure is directed to a series of target-selective chemotherapeutic ester prodrugs comprising PSA-cleavable peptides that promote the delivery of free doxorubicin and other chemotherapeutic agents into the prostate and/or prostate tumors with greater efficiency.
Type:
Grant
Filed:
September 21, 2021
Date of Patent:
April 18, 2023
Assignee:
Rutgers, The State University of New Jersey
Abstract: The present invention relates to solvothermal vapor synthesis methods for the crystallization of a phase from a mixture of selected inorganic or organic precursors in an unsaturated vapor-phase reaction medium.
Type:
Application
Filed:
May 17, 2022
Publication date:
April 13, 2023
Applicant:
Rutgers, The State University of New Jersey
Abstract: The present disclosure relates to a continuous process for melt-coating active pharmaceutical ingredients, including introducing at least one active pharmaceutical ingredient (API) and at least one surfactant into a processor; and continuously and simultaneously heating and shearing the API and surfactant in the processor at a temperature close to the melting point of the surfactant so as to continuously form melt-coated API particles having at least a partial coating of surfactant. The disclosure also relates to melt-coated API particles prepared by the disclosed continuous melt-coating process, and pharmaceutical drug products prepared from such melt-coated API particles.
Type:
Application
Filed:
March 16, 2021
Publication date:
April 13, 2023
Applicant:
Rutgers,The State University of New Jersey
Inventors:
Fernando J. Muzzio, Zhanjie Liu, Gerardo Callegari, Douglas Hausner
Abstract: The present disclosure relates to compositions and methods useful for the functionalization of surfaces in the absence of a metal catalyst. The compositions include compounds of formula (I), which react with strained alkene-containing compounds, before or after molecular assembly catalyzed by tyrosinase, to afford cycloadducts. The strained alkene-containing compound may further comprise any molecule of interest, including small molecules and macromolecules, thereby enabling surface functionalization. In certain embodiments, the strained alkene-containing molecule comprises a moiety selected from the group consisting of a trans-cyclooctene (TCO), cyclopropene, cyclobutene, and norbornene.
Type:
Application
Filed:
September 30, 2022
Publication date:
April 6, 2023
Applicant:
Rutgers, The state University of New Jersey
Abstract: Inorganic-organic hybrid structures having both ionic and coordinate bonds in a molecular cluster possessing the features of structural diversity, high luminescence and stability, and excellent dispersibility, suitable for use as lighting phosphors.
Type:
Grant
Filed:
May 2, 2018
Date of Patent:
March 28, 2023
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Abstract: This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
Type:
Grant
Filed:
April 1, 2021
Date of Patent:
March 28, 2023
Assignees:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, ACTINOBAC BIOMED, INC.
Inventors:
Scott C. Kachlany, Benjamin A. Belinka, Jr.
Abstract: A railroad tie formed of a polymeric or polymeric composite material and configured for enhanced mechanical interaction with an underlying ballast. The tie includes at least a top longitudinal surface, a pair of side longitudinal surfaces, a bottom longitudinal surface, and two end faces. At least the bottom longitudinal surface includes a plurality of indentations formed along a length thereof. Additionally, the tie includes at least one serrated edge portion having a plurality of serrations, the at least one serrated edge portion formed along at least part of the longitudinal length of the tie at an edge between at least one of the side longitudinal surfaces and the bottom longitudinal surface to provide for enhanced mechanical interaction with the ballast.
Type:
Grant
Filed:
October 24, 2018
Date of Patent:
March 28, 2023
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for determining a subsequent time slot position for each of a plurality of spatially distributed relays configured for time slot based beamforming supporting a communication channel between a source and a destination.
Type:
Application
Filed:
August 15, 2022
Publication date:
March 16, 2023
Applicant:
Rutgers, The State University of New Jersey
Abstract: Disclosed is a concise, inexpensive and scalable method for preparing elastomers filled with conductive 2D nanoparticies. The method comprises independently filling elastomer polymer precursors and/or corresponding elastomer polymer curing agents or their precursors with conductive 2D nanoparticles by shear exfoliation of a layered material, followed by mixing the two components nd curing to form the elastomer. Such filled elastomers have utility in preparing various types of sensors which are useful in a variety of practical applications and devices.
Type:
Application
Filed:
January 28, 2021
Publication date:
March 16, 2023
Applicant:
Rutgers, The State University of New Jersey
Abstract: This disclosure provides methods and systems for classifying biological particles, e.g., blood cells, microbes, circulating tumor cells (CTCs). Using impedance flow cytometry, such as multi-frequency impedance cytometry, in conjunction with supervised machine learning, the disclosed methods and systems demonstrated improved accuracy in classifying biological particles.
Type:
Grant
Filed:
April 17, 2020
Date of Patent:
March 14, 2023
Assignee:
Rutgers, the State University of New Jersey
Inventors:
Mehdi Javanmard, Karan Ahuja, Jianye Sui, Joseph R. Bertino
Abstract: Compositions, recombinant viral vectors, recombinant viruses, and nanoparticles for treating a subject having a spinal cord injury include a therapeutically effective amount of a nucleic acid sequence encoding pre-microRNA-7 (pre-miR-7). Methods of using these compositions, recombinant viral vectors, recombinant viruses, and nanoparticles are also described herein. These compositions, recombinant viral vectors, recombinant viruses, and nanoparticles and methods of use provide novel therapies for SCI based on the discovery that miR-7 expression provides neuroprotection and recovery of locomotor function in subjects having SCI.
Type:
Application
Filed:
February 1, 2021
Publication date:
March 9, 2023
Applicant:
Rutgers, The State University of New Jersey
Inventors:
Eunsung Junn, Mary M. Mouradian, Myung-Sik Yoo
Abstract: In one aspect, the present disclosure provides a method of treating, preventing, and/or ameliorating premature ovarian failure (POF) in a subject in need thereof, wherein the subject is a female cancer patient being administered at least one chemotherapeutic drug, the method comprising administering to the subject at least one c-Jun N-terminal Kinase (JNK) inhibitor. In certain embodiments, the JNK inhibitor is SP600125. In another aspect, the present disclosure provides a pharmaceutical composition comprising a JNK inhibitor.
Type:
Application
Filed:
September 2, 2022
Publication date:
March 2, 2023
Applicant:
Rutgers, The State University of New Jersey