Patents Assigned to Rutgers, The State University
  • METHODS FOR INDUCING AN IMMUNE RESPONSE
    Publication number: 20210236558
    Abstract: The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs).
    Type: Application
    Filed: January 15, 2021
    Publication date: August 5, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Yufang Shi, Guangwen Ren, Liying Zhang
  • Methods and apparatus for express estimation of the arterial elastic property in a subject
    Patent number: 11076762
    Abstract: Methods and systems for express estimation of the arterial elasticity in a subject are presented. The methods and systems provide simplicity in measurement and the opportunity to measure the arterial elasticity through HRV. The method includes imposing a rhythmical stimulation at a frequency between about 0.06 Hz and 0.081 Hz to cause an oscillation on the cardiovascular system of a subject. The method further include measuring a response associated with the oscillation on the cardiovascular system and determining the arterial elasticity of the subject based on a level of the response associated with the oscillation.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: August 3, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Evgeny G. Vaschillo, Bronya Vaschillo
  • Methods, Devices and Systems for Quantifying Biomarkers
    Publication number: 20210223234
    Abstract: Described herein are methods, systems and devices for rapidly detecting biomarkers in a biological sample.
    Type: Application
    Filed: May 31, 2019
    Publication date: July 22, 2021
    Applicants: Colgate-Palmolive Company, Rutgers, the State University of New Jersey
    Inventors: Michael FITZGERALD, Shamim ANSARI, Zhongtian LIN, Jianye SUI, Mehdi JAVANMARD, Donghui WU
  • Hollow particles formed from 2-dimensional materials
    Patent number: 11069890
    Abstract: The present invention relates to methods of fabrication of hollow shells/spheres/particles, core-shell particles and composite materials made from these particles.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: July 20, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Maria S. Tomassone, Kurt B. Smith
  • TRANSECTION DEVICE
    Publication number: 20210212716
    Abstract: A transection device including a hollow tubular body extending from a proximal end to a distal end. A plurality of stabilizing members extend from the distal end of the tubular body and define a reduced diameter opening into a receiving chamber adjacent the distal end of the tubular body. A blade is positioned within the tubular body and moveable between an initial position within the tubular body to an extended position wherein at least a portion of the blade extends into the receiving chamber. A depressible member extends from the proximal end and is configured to move the blade between the initial position and the extended position. A compression member may be positioned between the plunger member and the blade.
    Type: Application
    Filed: March 26, 2021
    Publication date: July 15, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventor: Dorian J. Wilson
  • METHODS FOR ENHANCING IMMUNOSUPPRESSION
    Publication number: 20210213067
    Abstract: The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs).
    Type: Application
    Filed: January 15, 2021
    Publication date: July 15, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Yufang Shi, Guangwen Ren, Liying Zhang
  • In situ bonding of carbon fibers and nanotubes to polymer matrices
    Patent number: 11059945
    Abstract: A method for forming a carbon fiber-reinforced polymer matrix composite by distributing carbon fibers or nanotubes into a molten polymer phase comprising one or more molten polymers; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase breaks the carbon fibers successively with each event, producing reactive edges on the broken carbon fibers that react with and cross-link the one or more polymers. The composite shows improvements in mechanical properties, such as stiffness, strength and impact energy absorption.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: July 13, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Thomas Nosker, Jennifer K. Lynch, Bernard Kear, Nofel Whieb
  • CRISPR enzymes and systems
    Patent number: 11060115
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: July 13, 2021
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, Rutgers, the State University of New Jersey, Skolkovo Institute of Science and Technology, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Konstantin Severinov, Feng Zhang, Yuri I. Wolf, Sergey Shmakov, Ekaterina Semenova, Leonid Minakhin, Kira S. Makarova, Eugene Koonin, Silvana Konermann, Julia Joung, Jonathan S. Gootenberg, Omar O. Abudayyeh, Eric S. Lander
  • Systems and Methods for Cognitive Diagnostics in Connection with Major Depressive Disorder and Response to Antidepressants
    Publication number: 20210204853
    Abstract: A system for diagnosing a mental health condition. The system comprises a smart device and a device including a memory and a processor. The smart device allows a participant to perform a cognitive task and the device receives data collected from the smart device in connection with the cognitive task performed by the participant. The device determines whether the participant has the mental health condition based on the data collected and via a classification algorithm or an artificial intelligence approach. If the participant has the mental health condition, the device determines whether the participant will respond to medication for treating the mental health condition via the classification algorithm or the artificial intelligence approach.
    Type: Application
    Filed: May 17, 2019
    Publication date: July 8, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventor: Mohammad Herzallah
  • ANTIBACTERIAL AGENTS: DUAL-TARGETED RNA POLYMERASE INHIBITORS
    Publication number: 20210198279
    Abstract: The invention provides bipartite, dual-targeted inhibitors of bacterial RNA polymerase having the general structural formula (I): X-?-Y (I) wherein X is an moiety that binds to the Rif target of a bacterial RNA polymerase; Y is a moiety that binds to the bridge-helix N-terminus target of a bacterial RNA polymerase; and is a covalent bond or a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.
    Type: Application
    Filed: May 23, 2019
    Publication date: July 1, 2021
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Richard H. EBRIGHT, Yon W. EBRIGHT, Chih-Tsung LIN
  • RECOMBINANT NEWCASTLE DISEASE VIRUSES AND USES THEREOF FOR THE PREVENTION OF RSV DISEASE OR HUMAN METAPNEUMOVIRUS DISEASE
    Publication number: 20210198323
    Abstract: Described herein are recombinant Newcastle disease viruses (“NDVs”) comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a respiratory syncytial virus (“RSV”) F protein or human metapneumovirus (“hMPV”) F protein. Also described herein are recombinant NDVs comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a chimeric F protein, wherein the chimeric F protein comprises (i) an RSV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains; or (ii) an hMPV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains. The recombinant NDVs and compositions thereof are useful for the immunizing against RSV or hMPV as well as the prevention of RSV disease or hMPV disease.
    Type: Application
    Filed: August 16, 2019
    Publication date: July 1, 2021
    Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joan E. DURBIN, Russell K. DURBIN, Adolfo GARCIA-SASTRE, Ignacio MENA, Peter PALESE
  • FULL-SCALE DYNAMIC DETECTION OF BACTERIAL BIOFILM FORMATION USING MGZNO NANOSTRUCTURE MODIFIED MULTIFUNCTIONAL SENSORS
    Publication number: 20210190717
    Abstract: This document discloses a hybrid and multifunctional biosensing technology consisting of a dual gate thin-film transistor (DGTFT) biosensor with an extended gate covered with magnesium zinc oxide nanostructures (MZOnano) and an MZOnano modified bulk acoustic wave resonator (MZOnano BAW). The technology is used for the full-scale dynamic monitoring of bacterial biofilm formation from its early stage to the maturation stage.
    Type: Application
    Filed: December 24, 2020
    Publication date: June 24, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Yicheng Lu, Pavel I. Reyes, Guangyuan Li, Yifan Wu, Xilin Zhao
  • Neural network-based object detection in visual input
    Patent number: 11043297
    Abstract: A device to detect an object in a medical image is described. An image analysis application, executed by the device, receives the medical image as an input. The medical image is next partitioned to sub-regions. Parts of the object are detected in a selection of the sub-regions using a deep-learning neural network (DNN) model. Bounding boxes for the selection are also determined. The bounding boxes are evaluated based on a confidence score detected as above a threshold level. The confidence score designates the parts as contained within the selection. Next, a region of interest (ROI) is determined as a group including the selection. Similar orientations associated with the bounding boxes are comparable to similar orientations of a positive training model of the DNN model. Furthermore, the selection is designated as the ROI within the medical image. The medical image is provided with the ROI to a user.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: June 22, 2021
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Christine I. Podilchuk, Richard Mammone
  • TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIES
    Publication number: 20210177985
    Abstract: The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising a matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.
    Type: Application
    Filed: February 24, 2021
    Publication date: June 17, 2021
    Applicants: Rutgers, The State University of New Jersey, Georgetown University
    Inventors: Siang-Yo Lin, Joseph R. Bertino, Chen-Yong Lin
  • SAFE WIRELESS POWER TRANSFER AND SECURE COMMUNICATIONS THROUGH DISTRIBUTED PHASE ALIGNMENT
    Publication number: 20210167887
    Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for wireless secret communication with a device.
    Type: Application
    Filed: April 5, 2019
    Publication date: June 3, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Xiaoran FAN, Yanyong ZHANG, Wade K. TRAPPE, Richard E. HOWARD
  • METHODS FOR IDENTIFYING CLASS 2 CRISPR-CAS SYSTEMS
    Publication number: 20210166783
    Abstract: Disclosed here is a method of identifying novel CRISPR effectors, comprising: identifying sequences in a genomic or metagenomic database encoding a CRISPR array; identifying one or more Open Reading Frames (ORFs) in said selected sequences within 10 kb of the CRISPR array; discarding all loci encoding proteins which are assigned to known CRISPR-Cas subtypes and, optionally, all loci encoding a protein of less than 700 amino acids; and identifying putative novel CRISPR effectors, and optionally classifying them based on structure analysis.
    Type: Application
    Filed: August 16, 2017
    Publication date: June 3, 2021
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH
    Inventors: Sergey SHMAKOV, Kira S. MAKAROVA, Yuri I. WOLF, Aaron SMARGON, Neena PYZOCHA, David COX, Winston YAN, David SCOTT, Konstantin SEVERINOV, Feng ZHANG, Eugene V. KOONIN
  • HIGHLY SELECTIVE NUCLEIC ACID AMPLIFICATION PRIMERS
    Publication number: 20210164009
    Abstract: This invention discloses multi-part primers for primer-dependent nucleic acid amplification methods. Also disclosed are primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions, reaction mixtures and reagent Kits for such reactions. This invention relates to primer-dependent nucleic acid amplification reactions, particularly DNA amplification relations such as PCR, and primers, reaction mixtures and reagent kits for such reactions and assays employing same.
    Type: Application
    Filed: October 23, 2020
    Publication date: June 3, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Salvatore A. Marras, Diana Vargas-Gold, Sanjay Tyagi, Fred R. Kramer
  • Catalysts for selective coupling of olefins, and methods of making and using same
    Patent number: 11020731
    Abstract: The present invention relates in part to the unexpected discovery of novel complexes capable of catalyzing the selective dehydrogenative coupling of olefins. The invention further relates to the use of these complexes for the selective coupling of olefins.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: June 1, 2021
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Alan S. Goldman, Yang Gao
  • In vivo radical-mediated polymerization for targeted delivery of trophic factors
    Patent number: 11020491
    Abstract: The present invention provides a biocompatible conjugate for treating a disease or an injury. The conjugate contains a polymer covalently linked to one or more moieties each containing a polymerizable functional group. The conjugate forms a cross-linked polymer network after being exposed to an elevated level of free radicals associated with the disease or injury.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: June 1, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Christopher Lowe, David I. Shreiber, Emily DiMartini, Adam Gormley
  • Compositions and methods for altering second messenger signaling
    Patent number: 11014956
    Abstract: The present disclosure provides, among other things, compounds comprising cyclic dinucleotides containing a 2',5' linkage useful in the design of research tools, as research tools, and as therapeutic modalities such as enzyme modulators.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: May 25, 2021
    Assignees: Memorial Sloan Kettering Cancer Center; The Rockefeller, University; Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao