Patents Assigned to Rutgers, The State University
  • METHODS FOR PREPARING TISSUE GRAFTS WITH ANTIMICROBIAL PROPERTIES
    Publication number: 20220088271
    Abstract: The present invention is a method for producing allograft tissue by applying an antimicrobial solution to allograft tissue. The antimicrobial solution exhibits antimicrobial activity to make allograft resistant to microbial organisms, such as a bacterium.
    Type: Application
    Filed: December 2, 2021
    Publication date: March 24, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Sheldon S. Lin, Joseph Benevenia, Michael J. Vives, Pradeep Kumar, David Alland, James Patrick O'Connor
  • Compositions and methods for wound healing
    Patent number: 11278597
    Abstract: Compositions of insulin-secreting cells and stem cells and methods for their use as well as use of insulin and stem cell products in wound healing and/or reducing scar and/or scab formation are provided.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: March 22, 2022
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Ronke Olabisi, Ayesha Aijaz
  • Aptamers, biosensors and detection methods for common azole-class antifungal drugs
    Patent number: 11279936
    Abstract: Aptamers having a G-quadruplex structure that bind specifically to the most commonly used azole-class antifungal drugs, biosensors that comprise those aptamers, and invitro methods for determining the level of one of those drugs utilizing those aptamers or biosensors.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: March 22, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: David S. Perlin, Gregory R. Weidman, Yanan Zhao
  • Anti-LAM and anti-PIM6/LAM monoclonal antibodies for diagnosis and treatment of infections
    Patent number: 11273220
    Abstract: The present invention broadly provides different compositions, kits, vectors, and methods including monoclonal antibodies directed to epitopes found within lipoarabinomannan (LAM) and phosphatidyl-myo-inositol mannoside 6 (PIM6) for the diagnosis and treatment of Mycobacterium tuberculosis infections.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: March 15, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Abraham Pinter, Alok Choudhary
  • Methods of mitigating toxic effects of vesicants and caustic gas
    Patent number: 11273203
    Abstract: Methods and kits for mitigating a toxic effect of at least one of vesicants and caustic gases in a subject in need thereof are described. In particular, an effective amount of a thrombopoietin (TPO) mimetic, such as RWJ-800088 or romiplostim, is used to mitigate the toxic effect of the vesicant or caustic gas.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: March 15, 2022
    Assignees: Janssen Pharmaceutica NV, Rutgers, The State University of New Jersey
    Inventors: Gary Eichenbaum, Edward John Yurkow
  • Molluscan shellfish produced by controlled crossbreeding
    Patent number: 11266131
    Abstract: Improved molluscan shellfish in diploid, tetraploid and triploid forms are provided. Also provided are methods for improving molluscan shellfish through progressive rotational crossbreeding and/or coalesced interploidy breeding.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: March 8, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Ximing Guo
  • Methods for the diagnosis and treatment of neurological disorders
    Patent number: 11270790
    Abstract: The present invention provides objective methods of diagnosis and behavioural treatments of neurological disorders such as autism spectral disorders and Parkinson's disease.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: March 8, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Elizabeth B. Torres
  • D3 dopamine receptor agonists to treat dyskinesia in Parkinson's disease
    Patent number: 11266612
    Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: March 8, 2022
    Assignees: Drexel University, Rutgers, The State University of New Jersey
    Inventors: Sandhya Kortagere, Eldo V. Kuzhikandahil
  • Polymerase Chain Reaction Primers and Probes for Mycobacterium Tuberculosis
    Publication number: 20220064715
    Abstract: The present invention relates to novel primers and sloppy molecular beacon and molecular beacon probes for amplifying segments from different genes in Mycobacterium tuberculosis for identifying the presence of M.tb DNA and/or resistance to anti-tuberculosis drugs.
    Type: Application
    Filed: November 16, 2021
    Publication date: March 3, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: David Alland, Soumitesh Chakravorty
  • EphA5-binding antibodies and uses thereof and selection of phage-displayed accessible recombinant targeted antibodies
    Patent number: 11254751
    Abstract: Isolated or recombinant Eph A5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: February 22, 2022
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Renata Pasqualini, Wadih Arap, Fernanda Iamassaki Staquicini, Fortunato Ferrara, Sara D'Angelo, Andrew R. M. Bradbury
  • CR3022 CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE
    Publication number: 20220048978
    Abstract: Chimeric antigen receptors (CARs) including an antigen binding domain specifically binding to coronavirus spike protein, nucleic acids encoding the CARs, vectors including nucleic acids encoding the CARs, and immune cells expressing the CARs are provided. Methods of treating a subject with coronavirus, including administering to the subject an immune cell expressing a disclosed CAR are also provided.
    Type: Application
    Filed: August 11, 2021
    Publication date: February 17, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Dongfang Liu, Minh Ma, Saiaditya Badeti
  • Synthetic Matrix Assembled and Rapidly Templated Spheroids, Organoids and 3D Cell Cultures
    Publication number: 20220049238
    Abstract: Disclosed are spheroidal hybrid biodegradable materials containing low dimensional manganese dioxide (MnO2) support structures and cells, methods of manufacture thereof, and methods of use thereof.
    Type: Application
    Filed: August 17, 2021
    Publication date: February 17, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Ki-Bum Lee, Christopher Rathman, Letao Yang
  • Creative GAN generating music deviating from style norms
    Patent number: 11250608
    Abstract: A method and system for generating music uses artificial intelligence to analyze existing musical compositions and then creates a musical composition that deviates from the learned styles. Known musical compositions created by humans are presented in digitized form along with a style designator to a computer for analysis, including recognition of musical elements and association of particular styles. A music generator generates a draft musical composition for similar analysis by the computer. The computer ranks such draft musical composition for correlation with known musical elements and known styles. The music generator modifies the draft musical composition using an iterative process until the resulting musical composition is recognizable as music but is distinctive in style.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: February 15, 2022
    Assignee: Rutgers, the State University of New Jersey
    Inventor: Ahmed Elgammal
  • Systems and methods for real time measurement of surface curvature and thermal expansion of small samples
    Patent number: 11248904
    Abstract: Systems and methods for measuring a curvature radius of a sample. The methods comprise: emitting a light beam from a laser source in a direction towards a beam expander; expanding a size of the light beam emitted from the laser source to create a broad laser beam; reflecting the broad laser beam off of a curved surface of the sample; creating a plurality of non-parallel laser beams by passing the reflected broad laser beam through a grating mask or a biprism; using the plurality of non-parallel laser beams to create an interference pattern at a camera image sensor; capturing a first image by the camera image sensor; and processing the first image by an image processing device to determine the curvature radius of the sample.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: February 15, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Alexei Ermakov, Xiuyan Li, Eric Garfunkel, Leonard C. Feldman, Torgny Gustafsson
  • Inherently radiopaque polymeric products for embolotherapy
    Patent number: 11246884
    Abstract: Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: February 15, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Donald K. Brandom, Eric Schmid, Joan Zeltinger, Durgadas Bolikal, Joachim B. Kohn
  • Engineered carbohydrate-active enzymes for glycan polymers synthesis
    Patent number: 11248217
    Abstract: The present invention relates to engineered carbohydrate-active enzyme constructs that are useful for glycan polymers synthesis. The construct comprises a CD domain from a GH, wherein the domain is conjugated to CBM3a via a peptidic linker. The invention also relates to a method of improving glycan polymer synthesis by using engineered carbohydrate active enzymes comprising a CD domain and CBM3a.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: February 15, 2022
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Shishir Chundawat, Chandra Kanth Bandi
  • Quality protein maize based on increased sulfur reduction in leaf cells
    Patent number: 11242536
    Abstract: Compositions and methods to produce maize with improved nutritional content are disclosed.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: February 8, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim Messing, Jose Planta
  • SYSTEM AND METHOD FOR MAKING PERSONALIZED FIBROCARTILAGE IMPLANTS
    Publication number: 20220031463
    Abstract: Systems (500, 1000) and methods (1700) for fabricating a soft tissue implant (100, 400). The methods generally involve: receiving implant data representative of the target implant; determining a planned weaving path for forming the soft tissue implant; and communicating the planned weaving path to an output device.
    Type: Application
    Filed: October 15, 2021
    Publication date: February 3, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Jay M. Patel, Michael G. Dunn, Charles J. Gatt
  • Electroosmotic High Fidelity Acoustic Transducer
    Publication number: 20220032340
    Abstract: An acoustic transducer system for projecting and sensing acoustic waves or sound in fluid is disclosed in accordance with the present disclosure and figures herein. The system includes a transducer array of a plurality of channels, each channel having an inlet and an outlet, and a reservoir containing a liquid solution. A first electrode is disposed proximate to the inlet and a second electrode is disposed proximate to the outlet. A voltage source, connected to the first and second electrodes, is configured to apply voltage across a length of the array of the channels to generate an electric field parallel to each channel. The electric field causes an electroosmotic flow of ions from the reservoir to the outlet, producing a plurality of acoustic waves or sound at the outlet. A method for projecting and sensing acoustic waves or sound in fluid using the acoustic transducer system is also disclosed herein.
    Type: Application
    Filed: July 17, 2019
    Publication date: February 3, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Francisco J. Diez-Garias, Thomas E. Hansen
  • Compositions and methods for identifying and sorting antigen-specific B cells
    Patent number: 11236153
    Abstract: The present disclosure relates to constructs useful in expressing biotinylated monomers and tetramers produced from these monomers. Specifically, the disclosure provides a construct useful in expressing biotinylated antigen monomers, said construct comprising a viral protein of an ectodomain of Hepatitis C Virus (HCV) envelope glycoprotein E2 or Human Immunodeficiency Virus (HIV) gp140. Further disclosed are methods for production and use of these tetramers in identifying and isolating antigen specific B cells and cloning antibodies thereto.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: February 1, 2022
    Assignees: Emory University, Rutgers, the State University of New Jersey
    Inventors: Arash Grakoui, Joseph Marcotrigiano