Patents Assigned to Saga University
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Patent number: 11827594Abstract: An object of the present invention is to provide a method for producing a fluorinated organic compound, whereby an iodosylbenzene derivative can be easily separated and recovered.Type: GrantFiled: March 29, 2019Date of Patent: November 28, 2023Assignees: DAIKIN INDUSTRIES, LTD., SAGA UNIVERSITYInventors: Masahiro Higashi, Yosuke Kishikawa, Tsugio Kitamura
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Publication number: 20230322649Abstract: The present disclosure relates to a method for producing a fluorinated organic compound comprises reacting a compound represented by formula (1): (wherein R1 and R2 are each independently a hydrogen atom, a halogen atom, or an organic group, or R1 and R2 optionally form a ring together with the two adjacent carbon atoms; n is 1 or 2; and wherein two R1s are optionally the same or different, two R2s are optionally the same or different, or two R?s or two R2s optionally form a ring together with their adjacent carbon atom), with (A) at least one fluorine source selected from the group consisting of hydrogen fluoride, hydrogen fluoride salts, and fluoride salts, and (B) a halogen source other than fluorine represented by the formula: R3(OX)m (wherein R3 is a hydrogen atom, a cation, or an organic group, X is a halogen atom other than a fluorine atom, and m is an integer corresponding to the valence of R3), to add fluorine and a halogen other than fluorine to the double bond or triple bond.Type: ApplicationFiled: June 16, 2023Publication date: October 12, 2023Applicants: DAIKIN INDUSTRIES, LTD., SAGA UNIVERSITYInventors: Masahiro HIGASHI, Yosuke KISHIKAWA, Tsugio KITAMURA, Juzo OYAMADA
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Patent number: 11771735Abstract: An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.Type: GrantFiled: November 19, 2021Date of Patent: October 3, 2023Assignees: KOHJIN LIFE SCIENCES CO., LTD., PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SAGA UNIVERSITYInventors: Takaomi Kessoku, Atsushi Nakajima, Yoshio Sumida, Yuichiro Eguchi, Susumu Saito, Yusuke Sauchi
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Patent number: 11667600Abstract: An object of the present invention is to provide a method for producing a fluorinated organic compound, whereby an iodosylbenzene derivative can be easily separated and recovered. The above object can be achieved by a method for producing a fluorinated organic compound, comprising step A of fluorinating an organic compound (1) by reaction with a fluorine source (3) in the presence of a hypervalent iodine aromatic ring compound (2a), or in the presence of an iodine aromatic ring compound (2b) and an oxidant (2bo); wherein the fluorine source (3) is a fluorine source (3a) represented by formula: MFn, wherein M is H, a metal of Group 1 of the periodic table, or a metal of Group 2 of the periodic table; and n is 1 or 2; and step B of separating the iodine aromatic ring compound from a reaction liquid after step A is started.Type: GrantFiled: March 29, 2019Date of Patent: June 6, 2023Assignees: DAIKIN INDUSTRIES, LTD., SAGA UNIVERSITYInventors: Masahiro Higashi, Yosuke Kishikawa, Tsugio Kitamura
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Publication number: 20230097969Abstract: A method for producing a phosphate diester or a phosphate triester is provided in which the phosphate diester or the phosphate triester can be produced from phosphoric acid and a hydroxy compound. Phosphoric acid and a phenol, which is used in excess with respect to the phosphoric acid, are subjected to dehydrating condensation with heating and refluxing. Water released during this dehydrating condensation is adsorbed onto a dehydrating material, which is an adsorbent derived from concrete sludge, disposed somewhere in the refluxing channel, thereby producing a phosphate diester or a phosphate triester.Type: ApplicationFiled: October 1, 2020Publication date: March 30, 2023Applicants: SAGA UNIVERSITY, NIPPON CONCRETE INDUSTRIES CO., LTD.Inventors: Shin-ichi KAWAGUCHI, Takeshi SASAKI, Yasuyuki HAYAKAWA
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Patent number: 11577006Abstract: Provided is a bioimplant which is capable to inhibit the biofilm formation over a long period of time after an operation. The bioimplant of the present invention comprises a base material of metal, ceramic, or plastic and a thermal spraying film of a calcium phosphate-based material formed at least partially thereon and the silver concentration in the thermal-spray film is 0.05 wt % to 3.00 wt %.Type: GrantFiled: October 26, 2020Date of Patent: February 14, 2023Assignees: KYOCERA CORPORATION, SAGA UNIVERSITYInventors: Masaaki Mawatari, Masatsugu Tsukamoto, Iwao Noda
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Publication number: 20220213424Abstract: A cell culture apparatus having a cell-holding container and a pinholder-shaped member comprising needle-shaped bodies arranged on a substrate, wherein a protruding part is formed in the center of the bottom surface of the cell-holding container, a recessed part is formed between the center and a side wall, and through-holes through which the needle-shaped bodies penetrate are established on the bottom surface of the recessed part; the needle-shaped bodies are arranged in correspondence with the positions of the through-holes; and the pinholder-shaped member is arranged, such that a tip-side portion of each of the needle-shaped bodies penetrates through the corresponding through-hole from the bottom surface side or upper surface side of the cell-holding container.Type: ApplicationFiled: March 13, 2020Publication date: July 7, 2022Applicant: SAGA UNIVERSITYInventor: Koichi NAKAYAMA
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Publication number: 20220154123Abstract: A jig member for use in the manufacture of a luminal cell structure, in which needle-shaped bodies are arranged in a comb-like form on a thickness-direction surface of a plate-like support having a length direction, wherein a surface which is adjacent to the thickness-direction surface and is along the length direction is formed in a tapered shape toward tips of the needle-shaped bodies; and a jig for use in the manufacture of a luminal cell structure, in which the member is arranged on a circumference of a circle with the tips of the needle-shaped bodies facing in the direction toward the center of the circle.Type: ApplicationFiled: March 13, 2020Publication date: May 19, 2022Applicant: SAGA UNIVERSITYInventor: Koichi Nakayama
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Publication number: 20220072083Abstract: An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.Type: ApplicationFiled: November 19, 2021Publication date: March 10, 2022Applicants: KOHJIN LIFE SCIENCES CO., LTD., PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SAGA UNIVERSITYInventors: Takaomi KESSOKU, Atsushi NAKAJIMA, Yoshio SUMIDA, Yuichiro EGUCHI, Susumu SAITO, Yusuke SAUCHI
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Publication number: 20220064098Abstract: The present disclosure addresses the problem of providing a novel method for producing a fluorinated iodinated organic compound. The problem can be solved by a method for producing a fluorinated iodinated organic compound, comprising reacting a compound represented by formula (1): wherein R1 and R2 are each independently a hydrogen atom, a halogen atom, or an organic group, or R1 and R2 optionally form a ring together with the two adjacent carbon atoms; and n is 1 or 2, with a fluorine source, an iodine source, and an oxidizing agent or radical generator to add fluorine and iodine to the double bond or triple bond.Type: ApplicationFiled: November 9, 2021Publication date: March 3, 2022Applicants: DAIKIN INDUSTRIES, LTD., SAGA UNIVERSITYInventors: Masahiro HIGASHI, Yosuke KISHIKAWA, Tsugio KITAMURA
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Patent number: 11207371Abstract: An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.Type: GrantFiled: June 1, 2020Date of Patent: December 28, 2021Assignees: KOHJIN LIFE SCIENCES CO., LTD., PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SAGA UNIVERSITYInventors: Takaomi Kessoku, Atsushi Nakajima, Yoshio Sumida, Yuichiro Eguchi, Susumu Saito, Yusuke Sauchi
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Publication number: 20210206740Abstract: A method for producing a fluoromethyl derivative represented by formula (1), the method including step A of reacting an alkene compound represented by formula (2) with a fluorine source represented by formula MFn, in the presence of a hypervalent-iodine aromatic compound (1a), or in the presence of an aromatic iodine compound (1b) and an oxidant (A) to fluorinate the alkene compound.Type: ApplicationFiled: May 10, 2019Publication date: July 8, 2021Applicants: DAIKIN INDUSTRIES, LTD., SAGA UNIVERSITYInventors: Masahiro HIGASHI, Yosuke KISHIKAWA, Tsugio KITAMURA
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Publication number: 20210114966Abstract: An object of the present invention is to provide a method for producing a fluorinated organic compound, whereby an iodosylbenzene derivative can be easily separated and recovered.Type: ApplicationFiled: March 29, 2019Publication date: April 22, 2021Applicants: DAIKIN INDUSTRIES, LTD., SAGA UNIVERSITYInventors: Masahiro HIGASHI, Yosuke KISHIKAWA, Tsugio KITAMURA
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Publication number: 20210024450Abstract: An object of the present invention is to provide a method for producing a fluorinated organic compound, whereby an iodosylbenzene derivative can be easily separated and recovered. The above object can be achieved by a method for producing a fluorinated organic compound, comprising step A of fluorinating an organic compound (1) by reaction with a fluorine source (3) in the presence of a hypervalent iodine aromatic ring compound (2a), or in the presence of an iodine aromatic ring compound (2b) and an oxidant (2bo); wherein the fluorine source (3) is a fluorine source (3a) represented by formula: MFn, wherein M is H, a metal of Group 1 of the periodic table, or a metal of Group 2 of the periodic table; and n is 1 or 2; and step B of separating the iodine aromatic ring compound from a reaction liquid after step A is started.Type: ApplicationFiled: March 29, 2019Publication date: January 28, 2021Applicants: DAIKIN INDUSTRIES, LTD., SAGA UNIVERSITYInventors: Masahiro HIGASHI, Yosuke KISHIKAWA, Tsugio KITAMURA
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Patent number: 10863752Abstract: A plasma sterilization apparatus includes a voltage-applying unit that applies a voltage to a sterilization target having conductivity; a pair of electrodes that apply, in a discharged state, the voltage applied by the voltage-applying unit to the sterilization target via a dielectric; and a position changing unit that changes a relative position between the pair of electrodes and the sterilization target.Type: GrantFiled: October 27, 2016Date of Patent: December 15, 2020Assignees: National Institute of Technology, Saga University, University of the RyukyusInventors: Yoshihito Yagyu, Tatsuya Misawa, Akikazu Sakudo
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Patent number: 10832410Abstract: The present invention is to provide a computer system, a method, and a program for diagnosing a subject that improve the accuracy of diagnosis by combining a plurality of time-series image data more than that by a conventional single image analysis. The computer system for diagnosing a subject acquires a plurality of first subject images with time series variation of the subject, analyzes the acquired first subject images, acquires a plurality of second subject images with time series variation of another subject in the past, analyzes the acquired second subject images, checks the analysis result of the first subject images and the analysis result of the second subject images, and diagnoses the subject based on the check result.Type: GrantFiled: May 19, 2017Date of Patent: November 10, 2020Assignees: OPTIM CORPORATION, SAGA UNIVERSITYInventors: Shunji Sugaya, Yoshio Okumura, Hiroshi Enaida, Mika Sakaguchi, Eizaburo Sueoka
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Patent number: 10814039Abstract: Provided is a bioimplant which is capable to inhibit the biofilm formation over a long period of time after an operation. The bioimplant of the present invention comprises a base material of metal, ceramic, or plastic and a thermal spraying film of a calcium phosphate-based material formed at least partially thereon and the silver concentration in the thermal-spray film is 0.05 wt % to 3.00 wt %.Type: GrantFiled: January 12, 2017Date of Patent: October 27, 2020Assignees: KYOCERA CORPORATION, SAGA UNIVERSITYInventors: Masaaki Mawatari, Masatsugu Tsukamoto, Iwao Noda
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Publication number: 20200289605Abstract: An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.Type: ApplicationFiled: June 1, 2020Publication date: September 17, 2020Applicants: KOHJIN LIFE SCIENCES CO., LTD., PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SAGA UNIVERSITYInventors: Takaomi KESSOKU, Atsushi NAKAJIMA, Yoshio SUMIDA, Yuichiro EGUCHI, Susumu SAITO, Yusuke SAUCHI
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Patent number: 10460934Abstract: According to an aspect of a present inventive subject matter, a crystalline film includes a crystalline metal oxide as a major component, the crystalline film includes a corundum structure, a surface area that is 9 ?m2 or more, and a dislocation density that is less than 5×106 cm?2.Type: GrantFiled: August 21, 2018Date of Patent: October 29, 2019Assignees: FLOSFIA INC., NATIONAL INSTITUTE FOR MATERIALS SCIENCE, KYOTO UNIVERSITY, SAGA UNIVERSITYInventors: Yuichi Oshima, Shizuo Fujita, Kentaro Kaneko, Makoto Kasu, Katsuaki Kawara, Takashi Shinohe, Tokiyoshi Matsuda, Toshimi Hitora
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Publication number: 20190241681Abstract: Provided is a method of separating a catalyst of a hydrogenated nitrile rubber, the method including: a water-soluble polymer addition step of adding an aqueous solution of a water-soluble polymer to a water-soluble organic solvent solution of the hydrogenated nitrile rubber obtained by hydrogenating a nitrile rubber in the presence of a platinum group element-containing catalyst; and a water-soluble polymer precipitating step of precipitating the water-soluble polymer while incorporating the platinum group element in the water-soluble polymer by stirring the water-soluble organic solvent solution of the hydrogenated nitrile rubber to which the aqueous solution of the water-soluble polymer is added.Type: ApplicationFiled: July 12, 2017Publication date: August 8, 2019Applicants: ZEON CORPORATION, SAGA UNIVERSITYInventors: Akito NAKAI, Hidetaka KAWAKITA, Keisuke OHTO, Shintaro MORISADA