Abstract: Disclosed are methods and compositions for treating cognitive impairment due to frontotemporal dementia caused by progranulin mutations. More specifically, the invention relates to antisense oligonucleotides (ASOs) and their administration to subjects to increase progranulin protein levels in brain tissue, to treat cognitive impairment due to frontotemporal dementia caused by progranulin mutations.
Abstract: The present invention provides compositions and methods for generation of an anti-influenza immune response. In particular, conserved T cell epitopes within matrix protein and nucleoprotein components of influenza virus have been identified and further screened for those structures that will bind either or both of HLA I and II molecules. Methods for vaccinating subjects with formulations of such peptides for the treatment or prevention of influenza infection also are described.
Type:
Application
Filed:
October 25, 2019
Publication date:
December 9, 2021
Applicants:
Saint Louis University, EpiVax, Inc.
Inventors:
Daniel F. HOFT, Christopher S. EICKHOFF, Annie DE GROOT
Abstract: The present disclosure relates to identification of inhibitors of hepatitis and herpesvirus replication including compounds of the formula: wherein the variables are as defined herein. Also provided are methods of treatment using agents so identified.
Type:
Grant
Filed:
August 6, 2019
Date of Patent:
December 7, 2021
Assignee:
Saint Louis University
Inventors:
John Edwin Tavis, Lynda Anne Morrison, Marvin Meyers
Abstract: The present disclosure is directed to methods of treating Zika virus infections using selective estrogen receptor modulators (SERMs), such as Tamoxifen, or a compound selected from CALP-1, A7, PMA, Chelerythrine, PHTPP, Tariquidar or S-Equol.
Type:
Application
Filed:
October 28, 2019
Publication date:
November 18, 2021
Applicant:
Saint Louis University
Inventors:
Christopher ARNATT, James BRIEN, Amelia PINTO
Abstract: The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ???1 and/or ?5?1. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ???3, ???5, ???6, ???8, and/or ?IIb?3.
Type:
Application
Filed:
June 27, 2019
Publication date:
September 16, 2021
Applicants:
Saint Louis University, Indalo Therapeutics, Inc.
Inventors:
Peter G. RUMINSKI, David W. GRIGGS, Scott SEIWERT
Abstract: Described are compounds and methods useful in measuring membrane permeability and efflux transporter activity in bacteria, including multidrug resistance Gram negative bacteria.
Type:
Grant
Filed:
May 22, 2019
Date of Patent:
August 17, 2021
Assignees:
Saint Louis University, The Board of Regents of the University of Oklahoma
Inventors:
John K. Walker, Keith Haynes, Narges Abdali, Valentin V. Rybenkov, Helen I. Zgurskaya
Abstract: The present disclosure relates to a system for positioning a patient on a medical device. More specifically, the present disclosure relates to a system for aligning a patient's head, spine, and shoulders for providing radiation treatment to a head and neck area of the patient.
Abstract: Provided herein are methods of preparing a template nucleic acid for next-generation sequencing. The methods comprise performing primer extension using c7dGTP instead of dGTP, which then allows for the input nucleic acids to be selectively digested by c7dGTP-resistant restriction enzymes, thereby enriching the template nucleic acid prior to next-generation sequencing library preparation.
Type:
Application
Filed:
February 11, 2021
Publication date:
August 12, 2021
Applicant:
Saint Louis University
Inventors:
Xiaofeng FAN, Adrian Michael DI BISCEGLIE
Abstract: Compositions and methods for regulating the blood coagulation pathway are disclosed. More particularly, the present disclosure relates to thrombin-thrombomodulin fusion proteins and their use as blood anticoagulants and for treating sepsis.
Type:
Grant
Filed:
April 28, 2017
Date of Patent:
August 10, 2021
Assignee:
Saint Louis University
Inventors:
Sergio Barranco-Medina, Enrico Di Cera, Nicola Pozzi
Abstract: Disclosed are fluidic devices and methods for preparing fluidic devices. More particularly, disclosed are fluidic devices having fiber scaffolds and methods for their preparation. Also disclosed are methods for culturing cells using the fluidic devices having fiber scaffolds.
Type:
Application
Filed:
April 18, 2017
Publication date:
July 22, 2021
Applicant:
Saint Louis University
Inventors:
Robert Scott MARTIN, Chengpeng CHEN, Scott Allen SELL
Abstract: Compositions and methods for delivering enzymes in enzyme hydrogel formulations are disclosed. More particularly, the present disclosure relates to injectable enzyme hydrogel formulations and delivery of injectable enzyme hydrogel formulations. Also disclosed are methods for GALNS enzyme replacement therapy and lysosomal enzyme replacement therapy.
Type:
Grant
Filed:
November 2, 2018
Date of Patent:
June 15, 2021
Assignee:
Saint Louis University
Inventors:
Adriana M. MontaƱo, Silviya Petrova Zustiak, Era Jain
Abstract: Methods of determining an immune status of a subject are provided. Specifically, methods for determining whether a subject has been exposed to an immunogenic antigen are provided as well as methods for determining efficacy of a vaccine are described.
Type:
Application
Filed:
October 12, 2020
Publication date:
May 20, 2021
Applicant:
Saint Louis University
Inventors:
Richard DiPaolo, Kyle Wolf, Tae Hyuk Ahn
Abstract: In one aspect, the present disclosure provides a compound of the formula: In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.
Type:
Application
Filed:
April 10, 2019
Publication date:
May 20, 2021
Applicant:
Saint Louis University
Inventors:
Ryan D. MCCULLA, Ankita ISOR, Christopher Kent ARNATT
Abstract: Described are glutathione adducts of fatty aldehydes (FALD-GSH) and methods useful in the detection of FALD-GSH in the identification of pathologies associated with leukocyte-mediated disease conditions, including eosinophil and neutrophil activation. Thus, the present disclosure provides methods of diagnosing a subject as having or being at risk of developing a leukocyte-mediated disease (LMD) comprising (a) detecting the level of glutathione adducts of 2-halofatty aldehydes (FALD-GSH) in a sample; (b) comparing the amount of FALD-GSH with a control or standard reflective of diseased and/or healthy levels of FALD-GSH; and (c) diagnosing the subject as having or being at risk of developing LMD if the level of FALD-GSH in the sample is higher than the control or standard.
Abstract: The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.
Type:
Grant
Filed:
April 19, 2017
Date of Patent:
April 20, 2021
Assignees:
SAINT LOUIS UNIVERSITY, RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
Inventors:
Maureen J. Donlin, John Edwin Tavis, Ryan Murelli, Marvin J. Meyers
Abstract: The present disclosure provides compositions and method targeting GPER for the treatment of cancers, such as breast cancers and leukemias, gallstone disease, and for conferring of neuroprotection on a subject. Also disclosed are high throughput assays for identifying antagonists of GPER.
Type:
Application
Filed:
March 29, 2018
Publication date:
March 25, 2021
Applicant:
Saint Louis University
Inventors:
Christopher Kent ARNATT, Chelsea Sondergard
Abstract: Compositions and methods for regulating the blood coagulation pathway are disclosed. More particularly, the present disclosure relates to thrombin-thrombomodulin fusion proteins, vectors, host cells and methods for preparing the thrombin-thrombomodulin fusion proteins. The present disclosure further relates to methods for measuring protein C in plasma and kits for measuring protein C in plasma.
Type:
Grant
Filed:
April 28, 2016
Date of Patent:
March 23, 2021
Assignee:
Saint Louis University
Inventors:
Sergio Barranco-Medina, Nicola Pozzi, Enrico Di Cera
Abstract: In one aspect, the present disclosure provides a compound of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.
Type:
Application
Filed:
April 10, 2019
Publication date:
March 18, 2021
Applicant:
Saint Louis University
Inventors:
Ryan D. MCCULLA, Ankita ISOR, Christopher Kent ARNATT
Abstract: The disclosure provides methods and compositions for inhibiting pain by administering a GPR160 antagonist to a subject in need thereof. Also provided are methods of using GPR160 antagonists in combination with other pain therapies.
Type:
Grant
Filed:
July 15, 2016
Date of Patent:
December 1, 2020
Assignee:
Saint Louis University
Inventors:
Daniela Salvemini, Gina L. C. Yosten, Willis K. Samson