Abstract: The present invention generally concerns isolated nanoparticles via the decomposition of a ternary metal hydride. More specifically, the present invention harnesses increased energy densities from two distinct nanoparticles isolated by a precise decomposition of LiAlH4. The singular material is air stable and is a nanocomposite of Li3AlH6 nanoparticles, elemental Al nanoparticles, an amount of Ti metal, and a nanoscale organic layer, which we call nMx. The nanocomposite protects and preserves the high energy densities of the core metals isolated from the controlled reaction and makes the nanoparticles safe to handle in air. The final composite is devoid of byproducts or phase transitions that will decrease the energy output of the nanocomposite. The method of the present invention creates a narrow distribution of nanoparticles that have unique burning characteristics useful for many applications.
Type:
Grant
Filed:
December 27, 2017
Date of Patent:
December 31, 2019
Assignee:
Saint Louis University
Inventors:
Steven Wayne Buckner, Paul Jelliss, Stephen Chung, Jacob M. Laktas, Gregory J. Place
Abstract: The present invention generally concerns decomposing a ternary metal hydride to isolate nanoparticles to use in a fuel grain. More specifically, the present invention harnesses increased energy densities from two distinct nanoparticles isolated by a precise decomposition of LiAlH4. The singular material is air stable and is a nanocomposite of Li3AlH6 nanoparticles, elemental Al nanoparticles, an amount of Ti metal, and a nanoscale organic layer. We call this nanocomposite nMx, which protects and preserves the high energy densities of the core metals isolated from the controlled reaction, making the nanoparticles safe to handle in air. The narrow distribution of nanoparticles has no byproducts or phase transitions that decrease energy output. The unique burning characteristics of nMx enhance the combustion of solid propellant formulations compatible with solid or hybrid rocket motors, where fuel grains are cast, pressed, or 3D printed with nMx powder, a polymeric binder, or optional additives.
Type:
Grant
Filed:
August 19, 2017
Date of Patent:
December 10, 2019
Assignee:
Saint Louis University
Inventors:
Steven Wayne Buckner, Paul Jelliss, Stephen Chung, Jacob M Laktas, Gregory J Place, Albert Michael Becksted, Jr.
Abstract: The present disclosure relates to identification of inhibitors of hepatitis and herpesvirus replication including compounds of the formula: wherein the variables are as defined herein. Also provided are methods of treatment using agents so identified.
Type:
Application
Filed:
August 6, 2019
Publication date:
December 5, 2019
Applicant:
Saint Louis University
Inventors:
John Edwin TAVIS, Lynda Anne MORRISON, Marvin MEYERS
Abstract: The present invention generally concerns a method for isolating nanoparticles via the decomposition of a ternary metal hydride. More specifically, the present invention harnesses increased energy densities from two distinct nanoparticles isolated by a precise decomposition of LiAlH4. The singular material is air stable and is a nanocomposite of Li3AlH6 nanoparticles, elemental Al nanoparticles, an amount of Ti metal, and a nanoscale organic layer, which we call nMx. The nanocomposite protects and preserves the high energy densities of the core metals isolated from the controlled reaction and makes the nanoparticles safe to handle in air. The final composite is devoid of byproducts or phase transitions that will decrease the energy output of the nanocomposite. The method of the present invention creates a narrow distribution of nanoparticles that have unique burning characteristics useful for many applications.
Type:
Grant
Filed:
August 14, 2017
Date of Patent:
December 3, 2019
Assignee:
SAINT LOUIS UNIVERSITY
Inventors:
Steven Wayne Buckner, Paul Jelliss, Stephen Chung, Jacob M Laktas, Gregory J Place
Abstract: The disclosure provides methods and compositions for inhibiting neurodegeneration by administering an A3AR agonist that ameliorates mitochondrial injury and dysfunction
Abstract: Disclosed are methods and compositions for reduced immunogenic proteins used in enzyme replacement therapy for lysosomal storage disorders. More specifically disclosed are genetically engineered variants of N-acetylgalactosamine-6-sulfatase (GALNS), which are less immunogenetic then wild-type GALNS, but maintain enzymatic activity, and may be used to treat Mucopolysaccharidosis IVA (Morquio A disease, MPS IVA).
Abstract: The present invention involves identification of inhibitors of herpesvirus nucleic acid metabolism. Also provided are methods of treatment using agents identified.
Type:
Grant
Filed:
November 25, 2014
Date of Patent:
November 5, 2019
Assignee:
Saint Louis University
Inventors:
John Edwin Tavis, Lynda Anne Morrison, Marvin J. Meyers
Abstract: The present invention provides molecular biosensors capable of signal amplification, and methods of using the molecular biosensors to detect the presence of a target molecule.
Type:
Grant
Filed:
September 21, 2017
Date of Patent:
September 17, 2019
Assignees:
Mediomics LLC, Saint Louis University
Inventors:
Yie-Hwa Chang, Ling Tian, Tomasz Heyduk
Abstract: Systems and methods for inhibiting atherosclerosis using FoxP3+ CD8 T-cells (TcREG). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (TcREG) through introduction of a low-dose of a RANK agonist suck as RANKL. The RANKL was found to best work when provided in accordance with a schedule resulting in a pulsed administration.
Type:
Grant
Filed:
July 25, 2017
Date of Patent:
June 25, 2019
Assignee:
Saint Louis University
Inventors:
Rajeev Aurora, Anna Smith, Angel Baldan
Abstract: Provided herein are methods for the obtention of an active HBV RNaseH preparation and its use in screening methods to identify potential inhibitors of the enzyme for possible use as therapeutic agents. Also provided are methods of treatment using agents identified according to the screen.
Abstract: The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.
Type:
Application
Filed:
April 19, 2017
Publication date:
April 4, 2019
Applicants:
SAINT LOUIS UNIVERSITY, Research Foundation of the City University of New York
Inventors:
Maureen J. DONLIN, John Edwin TAVIS, Ryan MURELLI, Marvin J. MEYERS
Abstract: The present disclosure provides for peptides derived from membrane-anchored ubiquitin-fold proteins (MUB), particularly those containing a Lap-Bar-Lopp motif, for use in inhibiting ubiquitinylation.
Type:
Application
Filed:
March 24, 2017
Publication date:
March 21, 2019
Applicant:
Saint Louis University
Inventors:
Brian DOWNES, Sergey V. KOROLEV, Xiaolong LU
Abstract: In some aspects, the present disclosure provides compounds of the formula: Formula (I) wherein the variables are defined herein are provided, which may be used to inhibit viral replication. In some embodiments, these compounds may be used to treat an infection of hepatitis B virus.
Abstract: The present invention generally relates to various dibenzothiophene compounds, processes for preparing these compounds, and use of these compounds in organic light-emitting diodes and as cellular imaging agents. In particular, the compounds of the present invention include various sulfoxide and sulfone analogs of various dibenzothiophene compounds. The present invention also relates to cell imaging agents comprising one or more of the dibenzothiophene compounds and processes for imaging a cell using the compounds. The present invention also relates to organic light-emitting diodes comprising one or more of the dibenzothiophene compounds and processes for preparing these organic light-emitting diodes.
Type:
Grant
Filed:
May 3, 2018
Date of Patent:
March 5, 2019
Assignee:
Saint Louis University
Inventors:
John T. Petroff, II, Ryan D. McCulla, Christopher Arnatt
Abstract: In some aspects, the present disclosure provides new nanomaterials which are passivized by the polymerization of an olefin catalyzed by the nanomaterial. In some embodiments, these nanomaterials exhibit increased stability in the ambient atmosphere. In other aspects, the present disclosure provides methods of preparing nanomaterials as well as use of these nanomaterials in a fuel such as a rocket fuel.
Type:
Application
Filed:
August 12, 2016
Publication date:
January 10, 2019
Applicant:
Saint Louis University
Inventors:
Paul A. JELLISS, Steven W. BUCKNER, Brandon J. THOMAS, Evan LLOYD
Abstract: The present invention generally relates to various dibenzothiophene compounds, processes for preparing these compounds, and use of these compounds in organic light-emitting diodes and as cellular imaging agents. In particular, the compounds of the present invention include various sulfoxide and sulfone analogs of various dibenzothiophene compounds. The present invention also relates to cell imaging agents comprising one or more of the dibenzothiophene compounds and processes for imaging a cell using the compounds. The present invention also relates to organic light-emitting diodes comprising one or more of the dibenzothiophene compounds and processes for preparing these organic light-emitting diodes.
Type:
Application
Filed:
May 3, 2018
Publication date:
November 8, 2018
Applicant:
Saint Louis University
Inventors:
John T. Petroff, II, Ryan D. McCulla, Christopher Arnatt
Abstract: A method for monitoring the metabolic state of an organism, cell, tissue, group of cells, organelles or organelle with or without a metabolic modulating agent or with or without a genetic alteration capable of modulating metabolism is disclosed. The biological material of interest is placed in a conductive solution in close proximity to a first electrode that is electrically coupled to a second electrode. A potential is applied to the electrodes sufficient enough to create a potential gradient between the two. If the biological material of interest is undergoing oxidation reactions, reduction reactions, or producing electrochemically active compounds as a result of metabolism, these will react at the first electrode, and in some cases, achieve direct electron transfer to the first electrode and generate a detectable electrical current. This current is directly proportional to the metabolic rate of the biological material of interest.
Type:
Application
Filed:
November 8, 2016
Publication date:
November 8, 2018
Applicant:
Saint Louis University
Inventors:
Robert Louis ARECHEDERRA, Abdul WAHEED, William S. SLY